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Select item 73181021.

Mutated RAP1GDS1 causes a new syndrome of dysmorphic feature, intellectual disability & speech delay

Abdulaziz Asiri, Essra Aloyouni, Muhammad Umair, Yusra Alyafee, Abeer Al Tuwaijri, Kheloud M. Alhamoudi, Bader Almuzzaini, Abeer Al Baz, Deemah Alwadaani, Marwan Nashabat, Majid Alfadhel

Ann Clin Transl Neurol. 2020 Jun; 7(6): 956–964. Published online 2020 May 19. doi: 10.1002/acn3.51059

PMCID:: PMC7318102

Abstract Article PDF–2.7M

Select item 70354732.

Splice switching an oncogenic ratio of SmgGDS isoforms as a strategy to diminish malignancy

Anthony C. Brandt, Lisa McNally, Ellen L. Lorimer, Bethany Unger, Olivia J. Koehn, Kiall F. Suazo, Lisa Rein, Aniko Szabo, Shirng-Wern Tsaih, Mark D. Distefano, Michael J. Flister, Frank Rigo, Mark T. McNally, Carol L. Williams

Proc Natl Acad Sci U S A. 2020 Feb 18; 117(7): 3627–3636. Published online 2020 Feb 4. doi: 10.1073/pnas.1914153117

PMCID:: PMC7035473

Abstract Article PDF–1.9M

Select item 66827473.

The chaperone SmgGDS-607 has a dual role, both activating and inhibiting farnesylation of small GTPases

Desirée García-Torres, Carol A. Fierke

J Biol Chem. 2019 Aug 2; 294(31): 11793–11804. Published online 2019 Jun 13. doi: 10.1074/jbc.RA119.007438

PMCID:: PMC6682747

Abstract Article PDF–1.1M

Select item 42853784.

The SmgGDS splice variant SmgGDS-558 is a key promoter of tumor growth and RhoA signaling in breast cancer

Andrew D. Hauser, Carmen Bergom, Nathan J. Schuld, Xiuxu Chen, Ellen L. Lorimer, Jian Huang, Alexander C. Mackinnon, Carol L. Williams

Mol Cancer Res. Author manuscript; available in PMC 2015 Jan 6.

Published in final edited form as: Mol Cancer Res. 2014 Jan; 12(1): 130–142. Published online 2013 Nov 6. doi: 10.1158/1541-7786.MCR-13-0362

PMCID:: PMC4285378

Abstract Article PDF–1.8M

Select item 39843175.

SmgGDS-558 regulates the cell cycle in pancreatic, non-small cell lung, and breast cancers

Nathan J Schuld, Andrew D Hauser, Adam J Gastonguay, Jessica M Wilson, Ellen L Lorimer, Carol L Williams

Cell Cycle. 2014 Mar 15; 13(6): 941–952. Published online 2014 Jan 16. doi: 10.4161/cc.27804

PMCID:: PMC3984317

Abstract Article PDF–2.4M

Select item 66861806.

SmgGDS-607 regulation of RhoA GTPase prenylation is nucleotide dependent.

Benjamin C. Jennings, Alexis J. Lawton, Zeinab Rizk, Carol A. Fierke

Biochemistry. Author manuscript; available in PMC 2019 Aug 8.

Published in final edited form as: Biochemistry. 2018 Jul 24; 57(29): 4289–4298. Published online 2018 Jul 10. doi: 10.1021/acs.biochem.8b00567

PMCID:: PMC6686180

Abstract Article PDF–1.0M

Select item 61566247.

GEF mechanism revealed by the structure of SmgGDS-558 and farnesylated RhoA complex and its implication for a chaperone mechanism

Hikaru Shimizu, Sachiko Toma-Fukai, Kenji Kontani, Toshiaki Katada, Toshiyuki Shimizu

Proc Natl Acad Sci U S A. 2018 Sep 18; 115(38): 9563–9568. Published online 2018 Sep 6. doi: 10.1073/pnas.1804740115

PMCID:: PMC6156624

Abstract Article PDF–1.3M

Select item 57304748.

SmgGDS is a transient nucleolar protein that protects cells from nucleolar stress and promotes the cell cycle by regulating DREAM complex gene expression

P Gonyo, C Bergom, A C Brandt, S-W Tsaih, Y Sun, T M Bigley, E L Lorimer, S S Terhune, H Rui, M J Flister, R M Long, C L Williams

Oncogene. 2017 Dec 14; 36(50): 6873–6883. Published online 2017 Aug 14. doi: 10.1038/onc.2017.280

PMCID:: PMC5730474

Abstract Article PDF–3.6M

Select item 55552029.

Structure-based analysis of the guanine nucleotide exchange factor SmgGDS reveals armadillo-repeat motifs and key regions for activity and GTPase binding

Hikaru Shimizu, Sachiko Toma-Fukai, Shinya Saijo, Nobutaka Shimizu, Kenji Kontani, Toshiaki Katada, Toshiyuki Shimizu

J Biol Chem. 2017 Aug 11; 292(32): 13441–13448. Published online 2017 Jun 19. doi: 10.1074/jbc.M117.792556

PMCID:: PMC5555202

Abstract Article PDF–1.2M

Select item 481358510.

The Tumor-suppressive Small GTPase DiRas1 Binds the Noncanonical Guanine Nucleotide Exchange Factor SmgGDS and Antagonizes SmgGDS Interactions with Oncogenic Small GTPases

Carmen Bergom, Andrew D. Hauser, Amy Rymaszewski, Patrick Gonyo, Jeremy W. Prokop, Benjamin C. Jennings, Alexis J. Lawton, Anne Frei, Ellen L. Lorimer, Irene Aguilera-Barrantes, Alexander C. Mackinnon, Kathleen Noon, Carol A. Fierke, Carol L. Williams

J Biol Chem. 2016 Mar 18; 291(12): 6534–6545. Published online 2016 Jan 26. doi: 10.1074/jbc.M115.696831

Correction in:: J Biol Chem. 2016 May 13; 291(20): 10948.

PMCID:: PMC4813585

Abstract Article PDF–3.9M

Select item 321919411.

Breast cancer cell migration is regulated through junctional adhesion molecule-A-mediated activation of Rap1 GTPase

Elaine A McSherry, Kieran Brennan, Lance Hudson, Arnold DK Hill, Ann M Hopkins

Breast Cancer Res. 2011; 13(2): R31. Published online 2011 Mar 23. doi: 10.1186/bcr2853

PMCID:: PMC3219194

Abstract Article PDF–1.5M

Select item 515327912.

Differences in the Phosphorylation-Dependent Regulation of Prenylation of Rap1A and Rap1B

Jessica M. Wilson, Jeremy W. Prokop, Ellen Lorimer, Elizabeth Ntantie, Carol L. Williams

J Mol Biol. Author manuscript; available in PMC 2017 Dec 4.

Published in final edited form as: J Mol Biol. 2016 Dec 4; 428(24 Pt B): 4929–4945. Published online 2016 Oct 17. doi: 10.1016/j.jmb.2016.10.016

PMCID:: PMC5153279

Abstract Article PDF–2.2M

Select item 394534813.

The Chaperone Protein SmgGDS Interacts with Small GTPases Entering the Prenylation Pathway by Recognizing the Last Amino Acid in the CAAX Motif

Nathan J. Schuld, Jeffrey S. Vervacke, Ellen L. Lorimer, Nathan C. Simon, Andrew D. Hauser, Joseph T. Barbieri, Mark D. Distefano, Carol L. Williams

J Biol Chem. 2014 Mar 7; 289(10): 6862–6876. Published online 2014 Jan 10. doi: 10.1074/jbc.M113.527192

PMCID:: PMC3945348

Abstract Article PDF–3.9M

Select item 306941814.

SmgGDS Is a Guanine Nucleotide Exchange Factor That Specifically Activates RhoA and RhoC

Brant Hamel, Elizabeth Monaghan-Benson, Rafael J. Rojas, Brenda R. S. Temple, Daniel J. Marston, Keith Burridge, John Sondek

J Biol Chem. 2011 Apr 8; 286(14): 12141–12148. Published online 2011 Jan 17. doi: 10.1074/jbc.M110.191122

PMCID:: PMC3069418

Abstract Article PDF–1.3M

Select item 275718615.

Epac Activates the Small G Proteins Rap1 and Rab3A to Achieve Exocytosis

María T. Branham, Matías A. Bustos, Gerardo A. De Blas, Holger Rehmann, Valeria E. P. Zarelli, Claudia L. Treviño, Alberto Darszon, Luis S. Mayorga, Claudia N. Tomes

J Biol Chem. 2009 Sep 11; 284(37): 24825–24839. Published online 2009 Jun 22. doi: 10.1074/jbc.M109.015362

PMCID:: PMC2757186

Abstract Article PDF–1.4M

Select item 386354916.

Statins Exert the Pleiotropic Effects Through Small GTP-Binding Protein Dissociation Stimulator Upregulation With a Resultant Rac1 Degradation

Shin-ichi Tanaka, Yoshihiro Fukumoto, Kotaro Nochioka, Tatsuro Minami, Shun Kudo, Nobuyuki Shiba, Yoshimi Takai, Carol L. Williams, James K. Liao, Hiroaki Shimokawa

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2013 Dec 15.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7): 10.1161/ATVBAHA.112.300922. Published online 2013 May 2. doi: 10.1161/ATVBAHA.112.300922

PMCID:: PMC3863549

Abstract Article PDF–2.1M

Select item 385949317.

Transglutaminase 2 Contributes to Apoptosis Induction in Jurkat T Cells by Modulating Ca²⁺ Homeostasis via Cross-Linking RAP1GDS1

Yu-Fan Hsieh, Guang-Yaw Liu, Yi-Ju Lee, Jiann-Jou Yang, Katalin Sándor, Zsolt Sarang, Angela Bononi, Paolo Pinton, László Tretter, Zsuzsa Szondy, Gregory J. Tsay

PLoS One. 2013; 8(12): e81516. Published online 2013 Dec 11. doi: 10.1371/journal.pone.0081516