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Items: 1 to 20 of 344

1.
Vacuolar H+‐ATPase inhibitors overcome Bcl‐xL‐mediated chemoresistance through restoration of a caspase‐independent apoptotic pathway
Yukiko Sasazawa, Yushi Futamura, Etsu Tashiro, Masaya Imoto
Cancer Sci. 2009 Aug; 100(8): 1460–1467. Published online 2009 Apr 21. doi: 10.1111/j.1349-7006.2009.01194.x
PMCID:
PMC11159986
AbstractArticlePDF–2.0M
2.
Modification of BCLX pre-mRNA splicing has antitumor efficacy alone or in combination with radiotherapy in human glioblastoma cells
Zhihui Dou, Huiwen Lei, Wei Su, Taotao Zhang, Xiaohua Chen, Boyi Yu, Xiaogang Zhen, Jing Si, Chao Sun, Hong Zhang, Cuixia Di
Cell Death Dis. 2024 Feb; 15(2): 160. Published online 2024 Feb 21. doi: 10.1038/s41419-024-06507-x
PMCID:
PMC10881996
AbstractArticlePDF–5.0M
3.
Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy
Ling Yin, Xiaoding Hu, Guangsheng Pei, Mengfan Tang, You Zhou, Huimin Zhang, Min Huang, Siting Li, Jie Zhang, Citu Citu, Zhongming Zhao, Bisrat G Debeb, Xu Feng, Junjie Chen
Life Sci Alliance. 2024 Apr; 7(4): e202302353. Published online 2024 Feb 5. doi: 10.26508/lsa.202302353
PMCID:
PMC10844523
AbstractArticlePDF–4.9M
4.
Exploring association of melanoma-specific Bcl-xL with tumor immune microenvironment
Anna Maria Lucianò, Marta Di Martile, Ana B. Pérez-Oliva, Marica Di Caprio, Maria Laura Foddai, Simonetta Buglioni, Victoriano Mulero, Donatella Del Bufalo
J Exp Clin Cancer Res. 2023; 42: 178. Published online 2023 Jul 24. doi: 10.1186/s13046-023-02735-9
PMCID:
PMC10364435
AbstractArticlePDF–4.4M
5.
Bcl-xL is required to protect endothelial cells latently infected with KSHV from virus induced intrinsic apoptosis
Lyndsey N. Moore, Daniel L. Holmes, Anjali Sharma, Joselyn Landazuri Vinueza, Michael Lagunoff
PLoS Pathog. 2023 May; 19(5): e1011385. Published online 2023 May 10. doi: 10.1371/journal.ppat.1011385
PMCID:
PMC10202281
AbstractArticlePDF–1.9M
6.
Bioinformatic Analysis of the BCL-xL/BCL2L1 Interactome in Patients with Pancreatic Cancer
Dimitrios E. Magouliotis, Anna P. Karamolegkou, Prokopis-Andreas Zotos, Evangelos Tatsios, Athina A. Samara, Dimitra Alexopoulou, Fani Koutsougianni, Nikos Sakellaridis, Dimitris Zacharoulis, Konstantinos Dimas
Medicina (Kaunas) 2022 Nov; 58(11): 1663. Published online 2022 Nov 17. doi: 10.3390/medicina58111663
PMCID:
PMC9698957
AbstractArticlePDF–2.3M
7.
Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis
Nicolas Rosa, Hristina Ivanova, Larry E. Wagner, 2nd, Justin Kale, Rita La Rovere, Kirsten Welkenhuyzen, Nikolaos Louros, Spyridoula Karamanou, Victoria Shabardina, Irma Lemmens, Elien Vandermarliere, Kozo Hamada, Hideaki Ando, Frederic Rousseau, Joost Schymkowitz, Jan Tavernier, Katsuhiko Mikoshiba, Anastassios Economou, David W. Andrews, Jan B. Parys, David I. Yule, Geert Bultynck
Cell Death Differ. 2022 Apr; 29(4): 788–805. Published online 2021 Nov 8. doi: 10.1038/s41418-021-00894-w
PMCID:
PMC8990011
AbstractArticlePDF–4.2M
8.
In silico analysis highlighting the prevalence of BCL2L1 gene and its correlation to miRNA in human coronavirus (HCoV) genetic makeup
Agnik Haldar, Keerti K. Yadav, Suchitra Singh, Piyush K. Yadav, Ajay K. Singh
Infect Genet Evol. 2022 Apr; 99: 105260. Published online 2022 Feb 28. doi: 10.1016/j.meegid.2022.105260
PMCID:
PMC8883758
AbstractArticlePDF–8.0M
9.
Roles and Regulation of BCL-xL in Hematological Malignancies
Mario Morales-Martínez, Mario I. Vega
Int J Mol Sci. 2022 Feb; 23(4): 2193. Published online 2022 Feb 16. doi: 10.3390/ijms23042193
PMCID:
PMC8876520
AbstractArticlePDF–25M
10.
BCL-XL blockage in TNBC models confers vulnerability to inhibition of specific cell cycle regulators
Olivier Castellanet, Fahmida Ahmad, Yaron Vinik, Gordon B. Mills, Bianca Habermann, Jean-Paul Borg, Sima Lev, Fabienne Lamballe, Flavio Maina
Theranostics. 2021; 11(19): 9180–9197. Published online 2021 Sep 3. doi: 10.7150/thno.60503
PMCID:
PMC8490507
AbstractArticlePDF–4.1M
11.
Bcl-xL: A Focus on Melanoma Pathobiology
Anna Maria Lucianò, Ana B. Pérez-Oliva, Victoriano Mulero, Donatella Del Bufalo
Int J Mol Sci. 2021 Mar; 22(5): 2777. Published online 2021 Mar 9. doi: 10.3390/ijms22052777
PMCID:
PMC7967179
AbstractArticlePDF–1.7M
12.
The Role of Bcl-xL Protein in Viral Infections
Zbigniew Wyżewski, Weronika Świtlik, Matylda Barbara Mielcarska, Karolina Paulina Gregorczyk-Zboroch
Int J Mol Sci. 2021 Feb; 22(4): 1956. Published online 2021 Feb 16. doi: 10.3390/ijms22041956
PMCID:
PMC7920434
AbstractArticlePDF–569K
13.
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity
Sajid Khan, Xuan Zhang, Dongwen Lv, Qi Zhang, Yonghan He, Peiyi Zhang, Xingui Liu, Dinesh Thummuri, Yaxia Yuan, Janet S. Wiegand, Jing Pei, Weizhou Zhang, Abhisheak Sharma, Christopher R. McCurdy, Vinitha M. Kuruvilla, Natalia Baran, Adolfo A. Ferrando, Yong-mi Kim, Anna Rogojina, Peter J. Houghton, Guangcun Huang, Robert Hromas, Marina Konopleva, Guangrong Zheng, Daohong Zhou
Nat Med. Author manuscript; available in PMC 2020 Jun 2.
Published in final edited form as: Nat Med. 2019 Dec; 25(12): 1938–1947. Published online 2019 Dec 2. doi: 10.1038/s41591-019-0668-z
PMCID:
PMC6898785
AbstractArticlePDF–3.9M
14.
Lipid-Modulation of Membrane Insertion and Refolding of the Apoptotic Inhibitor Bcl-xL
Victor Vasquez-Montes, Mauricio Vargas-Uribe, Nitin K. Pandey, Mykola V. Rodnin, Ralf Langen, Alexey S. Ladokhin
Biochim Biophys Acta Proteins Proteom. Author manuscript; available in PMC 2020 Jul 1.
Published in final edited form as: Biochim Biophys Acta Proteins Proteom. 2019 Jul-Aug; 1867(7-8): 691–700. Published online 2019 Apr 18. doi: 10.1016/j.bbapap.2019.04.006
PMCID:
PMC6589348
AbstractArticlePDF–1.4M
15.
Highly efficient genome editing via CRISPR–Cas9 in human pluripotent stem cells is achieved by transient BCL-XL overexpression
Xiao-Lan Li, Guo-Hua Li, Juan Fu, Ya-Wen Fu, Lu Zhang, Wanqiu Chen, Cameron Arakaki, Jian-Ping Zhang, Wei Wen, Mei Zhao, Weisheng V Chen, Gary D Botimer, David Baylink, Leslie Aranda, Hannah Choi, Rachel Bechar, Prue Talbot, Chang-Kai Sun, Tao Cheng, Xiao-Bing Zhang
Nucleic Acids Res. 2018 Nov 2; 46(19): 10195–10215. Published online 2018 Sep 20. doi: 10.1093/nar/gky804
PMCID:
PMC6212847
AbstractArticlePDF–5.2M
16.
Bcl-xL Affects Group A Streptococcus-Induced Autophagy Directly, by Inhibiting Fusion between Autophagosomes and Lysosomes, and Indirectly, by Inhibiting Bacterial Internalization via Interaction with Beclin 1-UVRAG
Shintaro Nakajima, Chihiro Aikawa, Takashi Nozawa, Atsuko Minowa-Nozawa, Hirotaka Toh, Ichiro Nakagawa
PLoS One. 2017; 12(1): e0170138. Published online 2017 Jan 13. doi: 10.1371/journal.pone.0170138
PMCID:
PMC5235370
AbstractArticlePDF–2.7M
17.
Modulation of Bcl-x Alternative Splicing Induces Apoptosis of Human Hepatic Stellate Cells
Lin Wu, Chengqiong Mao, Xin Ming
Biomed Res Int. 2016; 2016: 7478650. Published online 2016 Aug 7. doi: 10.1155/2016/7478650
PMCID:
PMC4992517
AbstractArticlePDF–2.0M
18.
Dynamic Bcl-xL (S49) and (S62) Phosphorylation/Dephosphorylation during Mitosis Prevents Chromosome Instability and Aneuploidy in Normal Human Diploid Fibroblasts
Prasamit Saurav Baruah, Myriam Beauchemin, Josée Hébert, Richard Bertrand
PLoS One. 2016; 11(7): e0159091. Published online 2016 Jul 11. doi: 10.1371/journal.pone.0159091
PMCID:
PMC4939973
AbstractArticlePDF–7.3M
19.
Human colonic fibroblasts regulate stemness and chemotherapy resistance of colon cancer stem cells
S. Colak, J.P. Medema
Cell Cycle. 2016; 15(12): 1531–1537. Published online 2014 Oct 30. doi: 10.4161/15384101.2014.973321
PMCID:
PMC4934047
AbstractArticlePDF–535K
20.
Characterization of the membrane-inserted C-terminus of cytoprotective BCL-XL
Yong Yao, Danielle Nisan, Lynn M. Fujimoto, Antonella Antignani, Ashley Barnes, Nico Tjandra, Richard J. Youle, Francesca M. Marassi
Protein Expr Purif. Author manuscript; available in PMC 2017 Jun 1.
Published in final edited form as: Protein Expr Purif. 2016 Jun; 122: 56–63. Published online 2016 Feb 23. doi: 10.1016/j.pep.2016.02.010
PMCID:
PMC4842142
AbstractArticlePDF–1.6M

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