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Items: 1 to 20 of 168

1.
A pathologically expanded, clonal lineage of IL-21–producing CD4+ T cells drives inflammatory neuropathy
Maryamsadat Seyedsadr, Madison F. Bang, Ethan C. McCarthy, Shirley Zhang, Ho-Chung Chen, Mahnia Mohebbi, Willy Hugo, Jason K. Whitmire, Melissa G. Lechner, Maureen A. Su
J Clin Invest. 2024 Aug 1; 134(15): e178602. Published online 2024 Jun 11. doi: 10.1172/JCI178602
PMCID:
PMC11290969
ArticlePDF–6.1M
2.
IL-21, not IL-17A, exacerbates murine primary biliary cholangitis
Chun-Wen Chan, Hung-Wen Chen, Yu-Wen Wang, Chia-I Lin, Ya-Hui Chuang
Clin Exp Immunol. 2024 Feb; 215(2): 137–147. Published online 2023 Sep 14. doi: 10.1093/cei/uxad107
PMCID:
PMC10847827
ArticlePDF–4.9M
3.
IL-21 and tissue-specific signals instruct Tbet+CD11c+ B cell development following viral infection
Wenzhi Song, Gina M. Sanchez, Daniel P. Mayer, Holly N. Blackburn, Irene Chernova, Richard A. Flavell, Jason S. Weinstein, Joe Craft
J Immunol. Author manuscript; available in PMC 2024 Jun 15.
Published in final edited form as: J Immunol. 2023 Jun 15; 210(12): 1861–1865. doi: 10.4049/jimmunol.2300027
PMCID:
PMC10247523
ArticlePDF–1.0M
4.
IL-21 from high-affinity CD4 T cells drives differentiation of brain-resident CD8 T cells during persistent viral infection
Heather M. Ren, E. Motunrayo Kolawole, Mingqiang Ren, Ge Jin, Colleen S. Netherby-Winslow, Quinn Wade, Shwetank, Ziaur S. M. Rahman, Brian D. Evavold, Aron E. Lukacher
Sci Immunol. Author manuscript; available in PMC 2021 Mar 18.
Published in final edited form as: Sci Immunol. 2020 Sep 18; 5(51): eabb5590. doi: 10.1126/sciimmunol.abb5590
PMCID:
PMC7721466
ArticlePDF–2.0M
5.
Targeting tumors with IL-21 reshapes the tumor microenvironment by proliferating PD-1intTim-3–CD8+ T cells
Sisi Deng, Zhichen Sun, Jian Qiao, Yong Liang, Longchao Liu, Chunbo Dong, Aijun Shen, Yang Wang, Hong Tang, Yang-Xin Fu, Hua Peng
JCI Insight. 2020 Apr 9; 5(7): e132000. Published online 2020 Apr 9. doi: 10.1172/jci.insight.132000
PMCID:
PMC7205272
ArticlePDF–2.4M
6.
Interleukin-21 Controls ILC3 Cytokine Production and Promotes a Protective Phenotype in a Mouse Model of Colitis
Catherine H. Poholek, Sarah J. Dulson, Allan J. Zajac, Laurie E. Harrington
Immunohorizons. Author manuscript; available in PMC 2019 Oct 11.
Published in final edited form as: Immunohorizons. 2019 Jun 4; 3(6): 194–202. Published online 2019 Jun 4. doi: 10.4049/immunohorizons.1900005
PMCID:
PMC6788290
ArticlePDF–1.3M
7.
Angiostatic activity of the antitumor cytokine interleukin-21
Karolien Castermans, Sebastien P. Tabruyn, Rong Zeng, Judy R. van Beijnum, Cheryl Eppolito, Warren J. Leonard, Protul A. Shrikant, Arjan W. Griffioen
Blood. 2008 Dec 15; 112(13): 4940–4947. Prepublished online 2008 May 30. doi: 10.1182/blood-2007-09-113878
PMCID:
PMC6561391
Article
8.
Interleukin-21 Induces Short-Lived Effector CD8+ T Cells but Does Not Inhibit Their Exhaustion after Mycobacterium bovis BCG Infection in Mice
Naoto Noguchi, Risa Nakamura, Shinya Hatano, Hisakata Yamada, Xun Sun, Naoya Ohara, Yasunobu Yoshikai
Infect Immun. 2018 Aug; 86(8): e00147-18. Prepublished online 2018 May 29. Published online 2018 Jul 23. doi: 10.1128/IAI.00147-18
PMCID:
PMC6056876
ArticlePDF–1.9M
9.
IL‐21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration
Kejing Wang, Shuang Wen, Jiao Jiao, Tingting Tang, Xin Zhao, Min Zhang, Bingjie Lv, Yuzhi Lu, Xingdi Zhou, Jingyong Li, Shaofang Nie, Yuhua Liao, Qing Wang, Xin Tu, Ziad Mallat, Ni Xia, Xiang Cheng
Br J Pharmacol. 2018 Apr; 175(8): 1329–1343. Published online 2017 Apr 12. doi: 10.1111/bph.13781
PMCID:
PMC5866974
ArticlePDF–1.9M
10.
Up-regulation of Interleukin-21 Contributes to Liver Pathology of Schistosomiasis by Driving GC Immune Responses and Activating HSCs in Mice
Yanyan Wang, Cai Lin, Yun Cao, Zhongliang Duan, Zhixun Guan, Jing Xu, Xing-Quan Zhu, Chaoming Xia
Sci Rep. 2017; 7: 16682. Published online 2017 Nov 30. doi: 10.1038/s41598-017-16783-7
PMCID:
PMC5709429
ArticlePDF–4.7M
11.
IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis
Sambasivan Venkatasubramanian, Satyanarayana Cheekatla, Padmaja Paidipally, Deepak Tripathi, Elwyn Welch, Amy R. Tvinnereim, Roza Nurieva, Ramakrishna Vankayalapati
Mucosal Immunol. Author manuscript; available in PMC 2017 Jun 19.
Published in final edited form as: Mucosal Immunol. 2017 Jul; 10(4): 1031–1042. Published online 2016 Dec 7. doi: 10.1038/mi.2016.105
PMCID:
PMC5462891
ArticlePDF–2.0M
12.
IL-21 is required for CD4 memory formation in response to viral infection
Yuqing Yuan, Yiping Yang, Xiaopei Huang
JCI Insight. 2017 Apr 6; 2(7): e90652. Published online 2017 Apr 6. doi: 10.1172/jci.insight.90652
PMCID:
PMC5374067
ArticlePDF–1.8M
13.
IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection
Matthew G. Booty, Palmira Barreira-Silva, Stephen M. Carpenter, Cláudio Nunes-Alves, Miye K. Jacques, Britni L. Stowell, Pushpa Jayaraman, Gillian Beamer, Samuel M. Behar
Sci Rep. 2016; 6: 36720. Published online 2016 Nov 7. doi: 10.1038/srep36720
PMCID:
PMC5098191
ArticlePDF–2.2M
14.
IL-21 Promotes Pulmonary Fibrosis through the Induction of Pro-fibrotic CD8+ T Cells
Tia Y. Brodeur, Tara E. Robidoux, Jason S. Weinstein, Joseph Craft, Susan L. Swain, Ann Marshak-Rothstein
J Immunol. Author manuscript; available in PMC 2016 Dec 1.
Published in final edited form as: J Immunol. 2015 Dec 1; 195(11): 5251–5260. Published online 2015 Oct 30. doi: 10.4049/jimmunol.1500777
PMCID:
PMC4655158
ArticlePDF–2.0M
15.
Systems Modeling of the Role of Interleukin-21 in the Maintenance of Effector CD4+ T Cell Responses during Chronic Helicobacter pylori Infection
Adria Carbo, Danyvid Olivares-Villagómez, Raquel Hontecillas, Josep Bassaganya-Riera, Rupesh Chaturvedi, M. Blanca Piazuelo, Alberto Delgado, M. Kay Washington, Keith T. Wilson, Holly M. Scott Algood
mBio. 2014 Jul-Aug; 5(4): e01243-14. Published online 2014 Jul 22. doi: 10.1128/mBio.01243-14
PMCID:
PMC4120195
ArticlePDF–2.3M
16.
T cell–derived interleukin (IL)-21 promotes brain injury following stroke in mice
Benjamin D.S. Clarkson, Changying Ling, Yejie Shi, Melissa G. Harris, Aditya Rayasam, Dandan Sun, M. Shahriar Salamat, Vijay Kuchroo, John D. Lambris, Matyas Sandor, Zsuzsanna Fabry
J Exp Med. 2014 Apr 7; 211(4): 595–604. doi: 10.1084/jem.20131377
PMCID:
PMC3978271
ArticlePDF–2.8M
17.
IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis
Timothy W. Phares, Krista D. DiSano, David R. Hinton, Mihyun Hwang, Allan J. Zajac, Stephen A. Stohlman, Cornelia C. Bergmann
J Neuroimmunol. 2013 Oct 15; 263(1): 43–54. Published online 2013 Aug 6. doi: 10.1016/j.jneuroim.2013.07.019
PMCID:
PMC3796038
ArticlePDF–1.3M
18.
Induction of autoimmune diabetes in non-obese diabetic mice requires interleukin-21-dependent activation of autoreactive CD8+ T cells
X-L Chen, D Bobbala, G M Rodriguez, M Mayhue, Y-G Chen, S Ilangumaran, S Ramanathan
Clin Exp Immunol. 2013 Aug; 173(2): 184–194. Published online 2013 Jul 4. doi: 10.1111/cei.12108
PMCID:
PMC3722919
ArticlePDF–1.0M
19.
Endogenous IL-21 regulates pathogenic mucosal CD4 T-cell responses during enhanced RSV disease in mice
J S Dodd, D Clark, R Muir, C Korpis, P J M Openshaw
Mucosal Immunol. 2013 Jul; 6(4): 704–717. Published online 2012 Nov 21. doi: 10.1038/mi.2012.108
PMCID:
PMC3610641
ArticlePDF–2.4M
20.
IL-21 is critical for graft-versus-host disease in a mouse model
A Meguro, K Ozaki, I Oh, K Hatanaka, H Matsu, R Tatara, K Sato, WJ Leonard, K Ozawa
Bone Marrow Transplant. Author manuscript; available in PMC 2012 Jul 24.
Published in final edited form as: Bone Marrow Transplant. 2010 Apr; 45(4): 723–729. Published online 2009 Aug 31. doi: 10.1038/bmt.2009.223
PMCID:
PMC3403836
ArticlePDF–1.4M

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