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Select item 86407231.

Th17 cell master transcription factor RORC2 regulates HIV-1 gene expression and viral outgrowth

Tomas Raul Wiche Salinas, Yuwei Zhang, Daniele Sarnello, Alexander Zhyvoloup, Laurence Raymond Marchand, Augustine Fert, Delphine Planas, Manivel Lodha, Debashree Chatterjee, Katarzyna Karwacz, Sally Oxenford, Jean-Pierre Routy, David Irlbeck, Heather Amrine-Madsen, Petronela Ancuta, Ariberto Fassati

Proc Natl Acad Sci U S A. 2021 Nov 30; 118(48): e2105927118. Published online 2021 Nov 24. doi: 10.1073/pnas.2105927118

PMCID:: PMC8640723

Abstract Article PDF–2.1M

Select item 85563642.

Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement

Timothy S. Strutzenberg, Yingmin Zhu, Scott J. Novick, Ruben D. Garcia-Ordonez, Christelle Doebelin, Yuanjun He, Mi Ra Chang, Theodore M. Kamenecka, Dean P. Edwards, Patrick R. Griffin

J Mol Biol. Author manuscript; available in PMC 2022 Nov 5.

Published in final edited form as: J Mol Biol. 2021 Nov 5; 433(22): 167258. Published online 2021 Sep 20. doi: 10.1016/j.jmb.2021.167258

PMCID:: PMC8556364

Abstract Article PDF–1.5M

Select item 85303223.

Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells

Paul A. Wilson, Sara Santos Franco, Liu He, Nicholas W. Galwey, Jackie Meakin, Rebecca McIntyre, Simon M. McHugh, Michael A. Nolan, Sarah L. Spain, Thaddeus Carlson, Mercedes Lobera, Justin P. Rubio, Bill Davis, Linda C. McCarthy

PLoS One. 2021; 16(10): e0258316. Published online 2021 Oct 21. doi: 10.1371/journal.pone.0258316

PMCID:: PMC8530322

Abstract Article PDF–1.7M

Select item 80177054.

Cooperativity between the orthosteric and allosteric ligand binding sites of RORγt

Rens M. J. M. de Vries, Femke A. Meijer, Richard G. Doveston, Iris A. Leijten-van de Gevel, Luc Brunsveld

Proc Natl Acad Sci U S A. 2021 Feb 9; 118(6): e2021287118. Published online 2021 Feb 3. doi: 10.1073/pnas.2021287118

PMCID:: PMC8017705

Abstract Article PDF–2.0M

Select item 74324065.

RORγ Structural Plasticity and Druggability

Mian Huang, Shelby Bolin, Hannah Miller, Ho Leung Ng

Int J Mol Sci. 2020 Aug; 21(15): 5329. Published online 2020 Jul 27. doi: 10.3390/ijms21155329

PMCID:: PMC7432406

Abstract Article PDF–5.7M

Select item 68749686.

Hepatitis B Virus X Protein-Induced RORγ Expression to Promote the Migration and Proliferation of Hepatocellular Carcinoma

Yu Huang, Huasheng Liang, Chuanxiong He, Fang Peng

Biomed Res Int. 2019; 2019: 5407126. Published online 2019 Nov 3. doi: 10.1155/2019/5407126

PMCID:: PMC6874968

Abstract Article PDF–1.8M

Select item 65906437.

Decreased RORC expression and downstream signaling in HTLV‐1‐associated adult T‐cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?

Kritika Subramanian, Tim Dierckx, Ricardo Khouri, Soraya Maria Menezes, Huseini Kagdi, Graham P. Taylor, Lourdes Farre, Achilea Bittencourt, Keisuke Kataoka, Seishi Ogawa, Johan Van Weyenbergh

Int J Cancer. 2019 Apr 1; 144(7): 1664–1675. Published online 2018 Dec 18. doi: 10.1002/ijc.31922

PMCID:: PMC6590643

Abstract Article PDF–934K

Select item 65795138.

HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists

Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin

eLife. 2019; 8: e47172. Published online 2019 Jun 7. doi: 10.7554/eLife.47172

Correction in:: eLife. 2019; 8: e52847.

PMCID:: PMC6579513

Abstract Article PDF–4.3M

Select item 63150299.

RORγt inhibition selectively targets IL-17 producing iNKT and γδ-T cells enriched in Spondyloarthritis patients

Koen Venken, Peggy Jacques, Céline Mortier, Mark E. Labadia, Tine Decruy, Julie Coudenys, Kathleen Hoyt, Anita L. Wayne, Robert Hughes, Michael Turner, Sofie Van Gassen, Liesbet Martens, Dustin Smith, Christian Harcken, Joseph Wahle, Chao-Ting Wang, Eveline Verheugen, Nadia Schryvers, Gaëlle Varkas, Heleen Cypers, Ruth Wittoek, Yves Piette, Lieve Gyselbrecht, Serge Van Calenbergh, Filip Van den Bosch, Yvan Saeys, Gerald Nabozny, Dirk Elewaut

Nat Commun. 2019; 10: 9. Published online 2019 Jan 2. doi: 10.1038/s41467-018-07911-6

PMCID:: PMC6315029

Abstract Article PDF–2.4M

Select item 607875710.

Expression profiles of transcription factors for special CD4⁺ T-cell subsets in peripheral blood mononuclear cells from patients with hepatitis B virus infection

Yan Xia, Xi Jin, Xueyuan Yu, Xingku Li, Bo Du, Zhen Liu, Yuguang Shi, Na Li, Shuyun Zhang

Medicine (Baltimore) 2018 Jul; 97(30): e11438. Published online 2018 Jul 27. doi: 10.1097/MD.0000000000011438

PMCID:: PMC6078757

Abstract Article PDF–333K

Select item 598763111.

Polymorphisms in the Th17 cell-related RORC gene are associated with spontaneous clearance of HCV in Chinese women

Zhe Xie, Yuantao Li, Lu Long, Hua Liang, Weiping Cai, Tao Shen

BMC Infect Dis. 2018; 18: 254. Published online 2018 Jun 4. doi: 10.1186/s12879-018-3153-2

PMCID:: PMC5987631

Abstract Article PDF–1.0M

Select item 551205912.

Structural studies unravel the active conformation of apo RORγt nuclear receptor and a common inverse agonism of two diverse classes of RORγt inhibitors

Xiang Li, Marie Anderson, Delphine Collin, Ingo Muegge, John Wan, Debra Brennan, Stanley Kugler, Donna Terenzio, Charles Kennedy, Siqi Lin, Mark E. Labadia, Brian Cook, Robert Hughes, Neil A. Farrow

J Biol Chem. 2017 Jul 14; 292(28): 11618–11630. Published online 2017 May 25. doi: 10.1074/jbc.M117.789024

PMCID:: PMC5512059

Abstract Article PDF–2.7M

Select item 503010913.

ROR-? drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer

Junjian Wang, June X. Zou, Xiaoqian Xue, Demin Cai, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C. Yang, Maggie C. Louie, Alexander D. Borowsky, Allen C. Gao, Christopher P. Evans, Kit S. Lam, Jianzhen Xu, Hsing-Jien Kung, Ronald M. Evans, Yong Xu, Hong-Wu Chen

Nat Med. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Nat Med. 2016 May; 22(5): 488–496. Published online 2016 Mar 28. doi: 10.1038/nm.4070

Correction in:: Nat Med. 2016 Jun 7; 22(6): 692.

PMCID:: PMC5030109

Abstract Article PDF–2.7M

Select item 489378214.

A progenitor cell expressing transcription factor RORγt generates all human innate lymphoid cell subsets

Steven D Scoville, Bethany L Mundy-Bosse, Michael H Zhang, Li Chen, Xiaoli Zhang, Karen A Keller, Tiffany Hughes, Luxi Chen, Stephanie Cheng, Stephen M Bergin, Hsiaoyin C Mao, Susan McClory, Jianhua Yu, William E Carson, III, Michael A Caligiuri, Aharon G Freud

Immunity. Author manuscript; available in PMC 2017 May 17.

Published in final edited form as: Immunity. 2016 May 17; 44(5): 1140–1150. Published online 2016 May 10. doi: 10.1016/j.immuni.2016.04.007

PMCID:: PMC4893782

Abstract Article PDF–2.1M

Select item 485674915.

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

Tae Gyu Oh, Shu-Ching M. Wang, Bipul R. Acharya, Joel M. Goode, J. Dinny Graham, Christine L. Clarke, Alpha S. Yap, George E.O. Muscat

EBioMedicine. 2016 Apr; 6: 59–72. Published online 2016 Feb 18. doi: 10.1016/j.ebiom.2016.02.028

PMCID:: PMC4856749

Abstract Article PDF–3.2M

Select item 484894416.

RORC2 Genetic Variants and Serum Levels in Patients with Rheumatoid Arthritis

Agnieszka Paradowska-Gorycka, Barbara Stypinska, Andrzej Pawlik, Katarzyna Romanowska-Prochnicka, Ewa Haladyj, Malgorzata Manczak, Marzena Olesinska

Int J Mol Sci. 2016 Apr; 17(4): 488. Published online 2016 Apr 1. doi: 10.3390/ijms17040488

PMCID:: PMC4848944

Abstract Article PDF–1.3M

Select item 466893817.

Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations

Satoshi Okada, Janet G. Markle, Elissa K. Deenick, Federico Mele, Dina Averbuch, Macarena Lagos, Mohammed Alzahrani, Saleh Al-Muhsen, Rabih Halwani, Cindy S. Ma, Natalie Wong, Claire Soudais, Lauren A. Henderson, Hiyam Marzouqa, Jamal Shamma, Marcela Gonzalez, Rubén Martinez-Barricarte, Chizuru Okada, Danielle T. Avery, Daniela Latorre, Caroline Deswarte, Fabienne Jabot-Hanin, Egidio Torrado, Jeffrey Fountain, Aziz Belkadi, Yuval Itan, Bertrand Boisson, Mélanie Migaud, Cecilia S. Lindestam Arlehamn, Alessandro Sette, Sylvain Breton, James McCluskey, Jamie Rossjohn, Jean-Pierre de Villartay, Despina Moshous, Sophie Hambleton, Sylvain Latour, Peter D. Arkwright, Capucine Picard, Olivier Lantz, Dan Engelhard, Masao Kobayashi, Laurent Abel, Andrea M. Cooper, Luigi D. Notarangelo, Stéphanie Boisson-Dupuis, Anne Puel, Federica Sallusto, Jacinta Bustamante, Stuart G. Tangye, Jean-Laurent Casanova

Science. Author manuscript; available in PMC 2016 Feb 7.

Published in final edited form as: Science. 2015 Aug 7; 349(6248): 606–613. Published online 2015 Jul 9. doi: 10.1126/science.aaa4282

PMCID:: PMC4668938

Abstract Article PDF–2.4M

Select item 1108163318.

Downregulation of Mirlet7 miRNA family promotes Tc17 differentiation and emphysema via de-repression of RORγt

Phillip A Erice, Xinyan Huang, Matthew J Seasock, Matthew J Robertson, Hui-Ying Tung, Melissa A Perez-Negron, Shivani L Lotlikar, David B Corry, Farrah Kheradmand, Antony Rodriguez

eLife. 2024; 13: RP92879. Published online 2024 May 9. doi: 10.7554/eLife.92879

PMCID:: PMC11081633

Abstract Article PDF–2.8M

Select item 733014119.

Lower T Regulatory and Th17 Cell Populations Predicted by RT-PCR-Amplified FOXP3 and RORγt Genes Are Not Rare in Patients With Primary Immunodeficiency Diseases

Wen-I Lee, Jing-Long Huang, Syh-Jae Lin, Kuo-Wei Yeh, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Tang-Her Jaing, Ying-Fan Shih, Chao-Yi Wu

Front Immunol. 2020; 11: 1111. Published online 2020 Jun 25. doi: 10.3389/fimmu.2020.01111

PMCID:: PMC7330141

Abstract Article PDF–1.5M

Select item 586276220.

Concomitant suppression of T_H2 and T_H17 cell responses in allergic asthma by targeting retinoic acid receptor–related orphan receptor ?t

Hyeongjin Na, Hoyong Lim, Garam Choi, Byung-Keun Kim, Sae-Hoon Kim, Yoon-Seok Chang, Roza Nurieva, Chen Dong, Seon Hee Chang, Yeonseok Chung

J Allergy Clin Immunol. Author manuscript; available in PMC 2018 Jun 9.

Published in final edited form as: J Allergy Clin Immunol. 2018 Jun; 141(6): 2061–2073.e5. Published online 2017 Sep 22. doi: 10.1016/j.jaci.2017.07.050

PMCID:: PMC5862762

Abstract Article PDF–2.1M

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