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Select item 110614351.

Elevated sortilin expression discriminates functional from non-functional neuroendocrine tumors and enables therapeutic targeting

Felix Bolduan, Alexandra Wetzel, Yvonne Giesecke, Ines Eichhorn, Natalia Alenina, Michael Bader, Thomas E. Willnow, Bertram Wiedenmann, Michael Sigal

Front Endocrinol (Lausanne) 2024; 15: 1331231. Published online 2024 Apr 17. doi: 10.3389/fendo.2024.1331231

PMCID:: PMC11061435

Abstract Article PDF–1.7M

Select item 108559412.

Sortilin Expression Levels and Peripheral Immunity: A Potential Biomarker for Segregation between Parkinson’s Disease Patients and Healthy Controls

Maria Georgoula, Panagiotis Ntavaroukas, Anastasia Androutsopoulou, Georgia Xiromerisiou, Fani Kalala, Matthaios Speletas, Eftihia Asprodini, Anna Vasilaki, Stamatia Papoutsopoulou

Int J Mol Sci. 2024 Feb; 25(3): 1791. Published online 2024 Feb 1. doi: 10.3390/ijms25031791

PMCID:: PMC10855941

Abstract Article PDF–1.8M

Select item 107114793.

Missense variants in SORT1 are associated with LDL-C in an Amish population

Kelly A. Mitok, Kathryn L. Schueler, Sarah M. King, Joseph Orr, Kathleen A. Ryan, Mark P. Keller, Ronald M. Krauss, Braxton D. Mitchell, Alan R. Shuldiner, Alan D. Attie

J Lipid Res. 2023 Dec; 64(12): 100468. Published online 2023 Oct 31. doi: 10.1016/j.jlr.2023.100468

PMCID:: PMC10711479

Abstract Article PDF–2.5M

Select item 95704734.

Deciphering Mechanisms of Action of Sortilin/Neurotensin Receptor-3 in the Proliferation Regulation of Colorectal and Other Cancers

Jean Mazella

Int J Mol Sci. 2022 Oct; 23(19): 11888. Published online 2022 Oct 6. doi: 10.3390/ijms231911888

PMCID:: PMC9570473

Abstract Article PDF–1.1M

Select item 91627505.

Emerging roles of sortilin in affecting the metabolism of glucose and lipid profiles

Xin Su, Linjian Chen, Xiang Chen, Cuilian Dai, Bin Wang

Bosn J Basic Med Sci. 2022 Jun; 22(3): 340–352. Published online 2021 Nov 15. doi: 10.17305/bjbms.2021.6601

PMCID:: PMC9162750

Abstract Article PDF–1.2M

Select item 82223726.

Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p

Min Liang, Wenxia Yao, Boyun Shi, Xiongjie Zhu, Rui Cai, Zhongjian Yu, Weihong Guo, Huaiming Wang, Zhijie Dong, Mingzhen Lin, Xinke Zhou, Yanfang Zheng

Cell Death Dis. 2021 Jul; 12(7): 639. Published online 2021 Jun 23. doi: 10.1038/s41419-021-03903-5

PMCID:: PMC8222372

Abstract Article PDF–7.7M

Select item 78109287.

Overexpression of sortilin is associated with 5‐FU resistance and poor prognosis in colorectal cancer

Sabrina Blondy, Hugo Talbot, Sofiane Saada, Niki Christou, Serge Battu, Julie Pannequin, Marie‐Odile Jauberteau, Fabrice Lalloué, Mireille Verdier, Muriel Mathonnet, Aurélie Perraud

J Cell Mol Med. 2021 Jan; 25(1): 47–60. Published online 2020 Dec 16. doi: 10.1111/jcmm.15752

PMCID:: PMC7810928

Abstract Article PDF–913K

Select item 76742698.

An Allosteric Binding Site on Sortilin Regulates the Trafficking of VLDL, PCSK9 and LDLR in Hepatocytes

Robert P. Sparks, Andres S. Arango, Jermaine L. Jenkins, Wayne C. Guida, Emad Tajkhorshid, Charles E. Sparks, Janet D. Sparks, Rutilio A. Fratti

Biochemistry. Author manuscript; available in PMC 2021 Nov 17.

Published in final edited form as: Biochemistry. 2020 Nov 17; 59(45): 4321–4335. Published online 2020 Nov 5. doi: 10.1021/acs.biochem.0c00741

PMCID:: PMC7674269

Abstract Article PDF–2.4M

Select item 72778389.

Upregulation of Sortilin, a Lysosomal Sorting Receptor, Corresponds with Reduced Bioavailability of Latent TGFβ in Mucolipidosis II Cells

Jarrod W. Barnes, Megan Aarnio-Peterson, Joy Norris, Mark Haskins, Heather Flanagan-Steet, Richard Steet

Biomolecules. 2020 May; 10(5): 670. Published online 2020 Apr 26. doi: 10.3390/biom10050670

PMCID:: PMC7277838

Abstract Article PDF–2.5M

Select item 674228610.

Involvement of the Neurotensin Receptor-3 in the Neurotensin-Induced Migration of Human Microglia

Stéphane Martin, Jean-Pierre Vincent, Jean Mazella

J Neurosci. 2003 Feb 15; 23(4): 1198–1205. doi: 10.1523/JNEUROSCI.23-04-01198.2003

PMCID:: PMC6742286

Abstract Article PDF–402K

Select item 672499211.

ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75^NTR and Sortilin

Henry K. Teng, Kenneth K. Teng, Ramee Lee, Saundrene Wright, Seema Tevar, Ramiro D. Almeida, Pouneh Kermani, Risa Torkin, Zhe-Yu Chen, Francis S. Lee, Rosemary T. Kraemer, Anders Nykjaer, Barbara L. Hempstead

J Neurosci. 2005 Jun 1; 25(22): 5455–5463. doi: 10.1523/JNEUROSCI.5123-04.2005

PMCID:: PMC6724992

Abstract Article PDF–520K

Select item 632910812.

Sortilin levels are associated with peripheral arterial disease in type 2 diabetic subjects

Federico Biscetti, Nicola Bonadia, Francesco Santini, Flavia Angelini, Elisabetta Nardella, Dario Pitocco, Angelo Santoliquido, Marco Filipponi, Raffaele Landolfi, Andrea Flex

Cardiovasc Diabetol. 2019; 18: 5. Published online 2019 Jan 11. doi: 10.1186/s12933-019-0805-5

PMCID:: PMC6329108

Abstract Article PDF–1.0M

Select item 588400413.

Neurotensin Receptor 3/Sortilin Contributes to Tumorigenesis of Neuroendocrine Tumors Through Augmentation of Cell Adhesion and Migration

Ji Tae Kim, Dana L. Napier, Heidi L. Weiss, Eun Y. Lee, Courtney M. Townsend, Jr., B. Mark Evers

Neoplasia. 2018 Feb; 20(2): 175–181. Published online 2017 Dec 19. doi: 10.1016/j.neo.2017.11.012

PMCID:: PMC5884004

Abstract Article PDF–1.1M

Select item 586826914.

Dimerization of sortilin regulates its trafficking to extracellular vesicles

Shinsuke Itoh, Ken Mizuno, Masanori Aikawa, Elena Aikawa

J Biol Chem. 2018 Mar 23; 293(12): 4532–4544. Published online 2018 Jan 30. doi: 10.1074/jbc.RA117.000732

PMCID:: PMC5868269

Abstract Article PDF–2.4M

Select item 540793515.

Serum sortilin associates with aortic calcification and cardiovascular risk in men

Claudia Goettsch, Hiroshi Iwata, Joshua D. Hutcheson, Christopher J. O’Donnell, Roland Chapurlat, Nancy R. Cook, Masanori Aikawa, Pawel Szulc, Elena Aikawa

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2017 May; 37(5): 1005–1011. Published online 2017 Mar 9. doi: 10.1161/ATVBAHA.116.308932

PMCID:: PMC5407935

Abstract Article PDF–230K

Select item 514750716.

A Genetic Variant of the Sortilin 1 Gene is Associated with Reduced Risk of Alzheimer’s Disease

Carl-Henrik Andersson, Oskar Hansson, Lennart Minthon, Niels Andreasen, Kaj Blennow, Henrik Zetterberg, Ingmar Skoog, Anders Wallin, Staffan Nilsson, Petronella Kettunen

J Alzheimers Dis. 2016; 53(4): 1353–1363. Prepublished online 2016 Jul 1. Published online 2016 Aug 8. doi: 10.3233/JAD-160319

PMCID:: PMC5147507

Abstract Article PDF–377K

Select item 456551617.

Sortilin And Lipoprotein Metabolism: Making Sense Out Of Complexity

Alanna Strong, Kevin Patel, Daniel J. Rader

Curr Opin Lipidol. Author manuscript; available in PMC 2015 Oct 1.

Published in final edited form as: Curr Opin Lipidol. 2014 Oct; 25(5): 350–357. doi: 10.1097/MOL.0000000000000110

PMCID:: PMC4565516

Abstract Article PDF–891K

Select item 455029818.

SORT1 Mutation Resulting in Sortilin Deficiency and p75^NTR Upregulation in a Family With Essential Tremor

Elena Sánchez, Alberto Bergareche, Catharine E. Krebs, Ana Gorostidi, Vladimir Makarov, Javier Ruiz-Martinez, Alejo Chorny, Adolfo Lopez de Munain, Jose Felix Marti-Masso, Coro Paisán-Ruiz

ASN Neuro. 2015 Jul-Aug; 7(4): 1759091415598290. Published online 2015 Aug 20. doi: 10.1177/1759091415598290

PMCID:: PMC4550298

Abstract Article PDF–833K

Select item 383966719.

SORL1 predicts longitudinal cognitive change

Chandra A. Reynolds, Catalina Zavala, Margaret Gatz, Loryana Vie, Boo Johansson, Bo Malmberg, Erik Ingelsson, Jonathan A. Prince, Nancy L. Pedersen

Neurobiol Aging. Author manuscript; available in PMC 2014 Jun 1.

Published in final edited form as: Neurobiol Aging. 2013 Jun; 34(6): 10.1016/j.neurobiolaging.2012.12.006. Published online 2013 Jan 11. doi: 10.1016/j.neurobiolaging.2012.12.006

PMCID:: PMC3839667

Abstract Article PDF–1.2M

Select item 369097020.

A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm

Gregory T. Jones, Matthew J. Bown, Solveig Gretarsdottir, Simon P.R. Romaine, Anna Helgadottir, Grace Yu, Gerard Tromp, Paul E. Norman, Cao Jin, Annette F. Baas, Jan D. Blankensteijn, Iftikhar J. Kullo, L. Victoria Phillips, Michael J.A. Williams, Ruth Topless, Tony R. Merriman, Thodor M. Vasudevan, David R. Lewis, Ross D. Blair, Andrew A. Hill, Robert D. Sayers, Janet T. Powell, Panagiotis Deloukas, Gudmar Thorleifsson, Stefan E. Matthiasson, Unnur Thorsteinsdottir, Jonathan Golledge, Robert A. Ariëns, Anne Johnson, Soroush Sohrabi, D. Julian Scott, David J. Carey, Robert Erdman, James R. Elmore, Helena Kuivaniemi, Nilesh J. Samani, Kari Stefansson, Andre M. van Rij

Hum Mol Genet. 2013 Jul 15; 22(14): 2941–2947. Published online 2013 Mar 27. doi: 10.1093/hmg/ddt141

PMCID:: PMC3690970

Abstract Article PDF–166K

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