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Select item 109207031.

Dimerization-dependent serine protease activity of FAM111A prevents replication fork stalling at topoisomerase 1 cleavage complexes

Sowmiya Palani, Yuka Machida, Julia R. Alvey, Vandana Mishra, Allison L. Welter, Gaofeng Cui, Benoît Bragantini , Maria Victoria Botuyan, Anh T. Q. Cong, Georges Mer, Matthew J. Schellenberg, Yuichi J. Machida

Nat Commun. 2024; 15: 2064. Published online 2024 Mar 7. doi: 10.1038/s41467-024-46207-w

PMCID:: PMC10920703

Abstract Article PDF–5.2M

Select item 105516392.

FAM111A regulates replication origin activation and cell fitness

Diana O Rios-Szwed, Vanesa Alvarez, Luis Sanchez-Pulido, Elisa Garcia-Wilson, Hao Jiang, Susanne Bandau, Angus Lamond, Constance Alabert

Life Sci Alliance. 2023 Dec; 6(12): e202302111. Published online 2023 Oct 4. doi: 10.26508/lsa.202302111

PMCID:: PMC10551639

Abstract Article PDF–6.7M

Select item 104757793.

N⁶‐methyladenosine‐modified FAM111A‐DT promotes hepatocellular carcinoma growth via epigenetically activating FAM111A

Jian Pu, Zuoming Xu, Youguan Huang, Jiahui Nian, Meng Yang, Quan Fang, Qing Wei, Zihua Huang, Guoman Liu, Jianchu Wang, Xianjian Wu, Huamei Wei

Cancer Sci. 2023 Sep; 114(9): 3649–3665. Published online 2023 Jul 3. doi: 10.1111/cas.15886

PMCID:: PMC10475779

Abstract Article PDF–8.5M

Select item 104690344.

Human FAM111A inhibits vaccinia virus replication by degrading viral protein I3 and is antagonized by poxvirus host range factor SPI-1

Junda Zhu, Xintao Gao, Yijing Li, Zihui Zhang, Shijie Xie, Shuning Ren, Yarui Li, Hua Li, Kang Niu, Shufang Fu, Yining Deng, Yinü Li, Bernard Moss, Wenxue Wu, Chen Peng

Proc Natl Acad Sci U S A. 2023 Aug 29; 120(35): e2304242120. Published online 2023 Aug 22. doi: 10.1073/pnas.2304242120

PMCID:: PMC10469034

Abstract Article PDF–3.7M

Select item 78574245.

FAM111A induces nuclear dysfunction in disease and viral restriction

Minghua Nie, Martina Oravcová, Yasaman Jami‐Alahmadi, James A Wohlschlegel, Eros Lazzerini‐Denchi, Michael N Boddy

EMBO Rep. 2021 Feb 3; 22(2): e50803. Published online 2020 Dec 28. doi: 10.15252/embr.202050803

PMCID:: PMC7857424

Abstract Article PDF–2.9M

Select item 70678286.

FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Yusuke Kojima, Yuka Machida, Sowmiya Palani, Thomas R. Caulfield, Evette S. Radisky, Scott H. Kaufmann, Yuichi J. Machida

Nat Commun. 2020; 11: 1318. Published online 2020 Mar 12. doi: 10.1038/s41467-020-15170-7

PMCID:: PMC7067828

Abstract Article PDF–2.7M

Select item 36752387.

FAM111A Mutations Result in Hypoparathyroidism and Impaired Skeletal Development

Sheila Unger, Maria W. Górna, Antony Le Béchec, Sonia Do Vale-Pereira, Maria Francesca Bedeschi, Stefan Geiberger, Giedre Grigelioniene, Eva Horemuzova, Faustina Lalatta, Ekkehart Lausch, Cinzia Magnani, Sheela Nampoothiri, Gen Nishimura, Duccio Petrella, Francisca Rojas-Ringeling, Akari Utsunomiya, Bernhard Zabel, Sylvain Pradervand, Keith Harshman, Belinda Campos-Xavier, Luisa Bonafé, Giulio Superti-Furga, Brian Stevenson, Andrea Superti-Furga

Am J Hum Genet. 2013 Jun 6; 92(6): 990–995. doi: 10.1016/j.ajhg.2013.04.020

PMCID:: PMC3675238

Abstract Article PDF–790K

Select item 109319378.

Unravelling the Intricate Roles of FAM111A and FAM111B: From Protease-Mediated Cellular Processes to Disease Implications

Danielle Naicker, Cenza Rhoda, Falone Sunda, Afolake Arowolo

Int J Mol Sci. 2024 Mar; 25(5): 2845. Published online 2024 Feb 29. doi: 10.3390/ijms25052845

PMCID:: PMC10931937

Abstract Article PDF–1.7M

Select item 75346409.

FAM111 protease activity undermines cellular fitness and is amplified by gain‐of‐function mutations in human disease

Saskia Hoffmann, Satyakrishna Pentakota, Andreas Mund, Peter Haahr, Fabian Coscia, Marta Gallo, Matthias Mann, Nicholas MI Taylor, Niels Mailand

EMBO Rep. 2020 Oct 5; 21(10): e50662. Published online 2020 Aug 9. doi: 10.15252/embr.202050662

PMCID:: PMC7534640

Abstract Article PDF–15M

Select item 628834410.

Contribution of DNA Replication to the FAM111A-Mediated Simian Virus 40 Host Range Phenotype

Roxana M. Tarnita, Adrian R. Wilkie, James A. DeCaprio

J Virol. 2019 Jan 1; 93(1): e01330-18. Prepublished online 2018 Oct 17. Published online 2018 Dec 10. doi: 10.1128/JVI.01330-18

PMCID:: PMC6288344

Abstract Article PDF–1.8M

Select item 347565211.

Identification of FAM111A as an SV40 Host Range Restriction and Adenovirus Helper Factor

Debrah A. Fine, Orit Rozenblatt-Rosen, Megha Padi, Anna Korkhin, Robert L. James, Guillaume Adelmant, Rosa Yoon, Luxuan Guo, Christian Berrios, Ying Zhang, Michael A. Calderwood, Soundarapandian Velmurgan, Jingwei Cheng, Jarrod A. Marto, David E. Hill, Michael E. Cusick, Marc Vidal, Laurence Florens, Michael P. Washburn, Larisa Litovchick, James A. DeCaprio

PLoS Pathog. 2012 Oct; 8(10): e1002949. Published online 2012 Oct 18. doi: 10.1371/journal.ppat.1002949

PMCID:: PMC3475652

Abstract Article PDF–2.5M

Select item 869109012.

IRF2 inhibits ZIKV replication by promoting FAM111A expression to enhance the host restriction effect of RFC3

Kai Ren, Ya Zhu, Honggang Sun, Shilin Li, Xiaoqiong Duan, Shuang Li, Yujia Li, Bin Li, Limin Chen

Virol J. 2021; 18: 256. Published online 2021 Dec 20. doi: 10.1186/s12985-021-01724-8

PMCID:: PMC8691090

Abstract Article PDF–1.2M

Select item 428309813.

Chromatin Dynamics During DNA Replication and Uncharacterized Replication Factors determined by Nascent Chromatin Capture (NCC) Proteomics

Constance Alabert, Jimi-Carlo Bukowski-Wills, Sung-Bau Lee, Georg Kustatscher, Kyosuke Nakamura, Flavia de Lima Alves, Patrice Menard, Jakob Mejlvang, Juri Rappsilber, Anja Groth

Nat Cell Biol. Author manuscript; available in PMC 2015 Jan 5.

Published in final edited form as: Nat Cell Biol. 2014 Mar; 16(3): 281–293. Published online 2014 Feb 23. doi: 10.1038/ncb2918

PMCID:: PMC4283098

Abstract Article PDF–2.1M

Select item 631010214.

Interactome and proteome dynamics uncover immune modulatory associations of the pathogen sensing factor cGAS

Krystal K. Lum, Bokai Song, Joel D. Federspiel, Benjamin A. Diner, Timothy Howard, Ileana M. Cristea

Cell Syst. Author manuscript; available in PMC 2019 Dec 26.

Published in final edited form as: Cell Syst. 2018 Dec 26; 7(6): 627–642.e6. Published online 2018 Nov 21. doi: 10.1016/j.cels.2018.10.010

PMCID:: PMC6310102

Abstract Article PDF–3.5M

Select item 484178315.

The cell proliferation antigen Ki-67 organises heterochromatin

Michal Sobecki, Karim Mrouj, Alain Camasses, Nikolaos Parisis, Emilien Nicolas, David Llères, François Gerbe, Susana Prieto, Liliana Krasinska, Alexandre David, Manuel Eguren, Marie-Christine Birling, Serge Urbach, Sonia Hem, Jérôme Déjardin, Marcos Malumbres, Philippe Jay, Vjekoslav Dulic, Denis LJ Lafontaine, Robert Feil, Daniel Fisher

eLife. 2016; 5: e13722. Published online 2016 Mar 7. doi: 10.7554/eLife.13722

PMCID:: PMC4841783

Abstract Article PDF–5.1M

Select item 810809316.

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity

Rajat Gupta, Kumar Somyajit, Takeo Narita, Elina Maskey, Andre Stanlie, Magdalena Kremer, Dimitris Typas, Michael Lammers, Niels Mailand, Andre Nussenzweig, Jiri Lukas, Chunaram Choudhary

Cell. Author manuscript; available in PMC 2021 May 10.

Published in final edited form as: Cell. 2018 May 3; 173(4): 972–988.e23. Published online 2018 Apr 12. doi: 10.1016/j.cell.2018.03.050

PMCID:: PMC8108093

Abstract Article PDF–3.5M

Select item 570387817.

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery

Ramesh Kumar, Román González-Prieto, Zhenyu Xiao, Matty Verlaan-de Vries, Alfred C. O. Vertegaal

Nat Commun. 2017; 8: 1809. Published online 2017 Nov 27. doi: 10.1038/s41467-017-01900-x

PMCID:: PMC5703878

Abstract Article PDF–3.7M

Select item 629516518.

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression

Lei Yu, Natee Jearawiriyapaisarn, Mary P. Lee, Tomonori Hosoya, Qingqing Wu, Greggory Myers, Kim-Chew Lim, Ryo Kurita, Yukio Nakamura, Anne B. Vojtek, Jean-François Rual, James Douglas Engel

Genes Dev. 2018 Dec 1; 32(23-24): 1537–1549. doi: 10.1101/gad.318436.118

PMCID:: PMC6295165

Abstract Article PDF–3.5M

Select item 977255819.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 549522520.

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing

Teng Fei, Yiwen Chen, Tengfei Xiao, Wei Li, Laura Cato, Peng Zhang, Maura B. Cotter, Michaela Bowden, Rosina T. Lis, Shuang G. Zhao, Qiu Wu, Felix Y. Feng, Massimo Loda, Housheng Hansen He, X. Shirley Liu, Myles Brown

Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26): E5207–E5215. Published online 2017 Jun 13. doi: 10.1073/pnas.1617467114

PMCID:: PMC5495225

Abstract Article PDF–1.3M

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