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Select item 74406661.

Cryo-EM structure of the human concentrative nucleoside transporter CNT3

Yanxia Zhou, Lianghuan Liao, Chen Wang, Jialu Li, Pengliang Chi, Qingjie Xiao, Qingting Liu, Li Guo, Linfeng Sun, Dong Deng

PLoS Biol. 2020 Aug; 18(8): e3000790. Published online 2020 Aug 10. doi: 10.1371/journal.pbio.3000790

PMCID:: PMC7440666

Abstract Article PDF–1.6M

Select item 69867962.

Inward- and outward-facing homology modeling of human concentrative nucleoside transporter 3 (hCNT3) predicts an elevator-type transport mechanism

Sylvia Y. M. Yao, James D. Young

Channels (Austin) 2018; 12(1): 291–298. Published online 2018 Aug 28. doi: 10.1080/19336950.2018.1506665

PMCID:: PMC6986796

Abstract Article PDF–1.2M

Select item 69175043.

Human concentrative nucleoside transporter 3 (hCNT3, SLC28A3) forms a cyclic homo-trimer

Adrian Stecula, Avner Schlessinger, Kathleen M. Giacomini, Andrej Sali

Biochemistry. Author manuscript; available in PMC 2019 Dec 17.

Published in final edited form as: Biochemistry. 2017 Jul 11; 56(27): 3475–3483. Published online 2017 Jun 29. doi: 10.1021/acs.biochem.7b00339

PMCID:: PMC6917504

Abstract Article PDF–1.5M

Select item 38997684.

SLC28A3 genotype and gemcitabine rate of infusion affect dFdCTP metabolite disposition in patients with solid tumours

A Khatri, B W Williams, J Fisher, R C Brundage, V J Gurvich, L G Lis, K M Skubitz, A Z Dudek, E W Greeno, R A Kratzke, J K Lamba, M N Kirstein

Br J Cancer. 2014 Jan 21; 110(2): 304–312. Published online 2013 Dec 3. doi: 10.1038/bjc.2013.738

PMCID:: PMC3899768

Abstract Article PDF–574K

Select item 32598145.

A Conformationally Mobile Cysteine Residue (Cys-561) Modulates Na⁺ and H⁺ Activation of Human CNT3

Melissa D. Slugoski, Kyla M. Smith, Ras Mulinta, Amy M. L. Ng, Sylvia Y. M. Yao, Ellen L. Morrison, Queenie O. T. Lee, Jing Zhang, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin, James D. Young

J Biol Chem. 2008 Sep 5; 283(36): 24922–24934. doi: 10.1074/jbc.M801793200

PMCID:: PMC3259814

Abstract Article PDF–955K

Select item 27193646.

Substituted Cysteine Accessibility Method Analysis of Human Concentrative Nucleoside Transporter hCNT3 Reveals a Novel Discontinuous Region of Functional Importance within the CNT Family Motif (G/A)XKX₃NEFVA(Y/M/F)

Melissa D. Slugoski, Amy M. L. Ng, Sylvia Y. M. Yao, Colin C. Lin, Ras Mulinta, Carol E. Cass, Stephen A. Baldwin, James D. Young

J Biol Chem. 2009 Jun 19; 284(25): 17281–17292. Published online 2009 Apr 20. doi: 10.1074/jbc.M109.009704

PMCID:: PMC2719364

Abstract Article PDF–1001K

Select item 27193637.

Conserved Glutamate Residues Glu-343 and Glu-519 Provide Mechanistic Insights into Cation/Nucleoside Cotransport by Human Concentrative Nucleoside Transporter hCNT3

Melissa D. Slugoski, Kyla M. Smith, Amy M. L. Ng, Sylvia Y. M. Yao, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin, James D. Young

J Biol Chem. 2009 Jun 19; 284(25): 17266–17280. Published online 2009 Apr 20. doi: 10.1074/jbc.M109.009613

PMCID:: PMC2719363

Abstract Article PDF–1.3M

Select item 24171908.

A Proton-mediated Conformational Shift Identifies a Mobile Pore-lining Cysteine Residue (Cys-561) in Human Concentrative Nucleoside Transporter 3

Melissa D. Slugoski, Amy M. L. Ng, Sylvia Y. M. Yao, Kyla M. Smith, Colin C. Lin, Jing Zhang, Edward Karpinski, Carol E. Cass, Stephen A. Baldwin, James D. Young

J Biol Chem. 2008 Mar 28; 283(13): 8496–8507. doi: 10.1074/jbc.M710433200

PMCID:: PMC2417190

Abstract Article PDF–543K

Select item 20752479.

Role of CNT3 in the transepithelial flux of nucleosides and nucleoside-derived drugs

Ekaitz Errasti-Murugarren, Marçal Pastor-Anglada, F Javier Casado

J Physiol. 2007 Aug 1; 582(Pt 3): 1249–1260. Published online 2007 Apr 5. doi: 10.1113/jphysiol.2007.130138

PMCID:: PMC2075247

Abstract Article PDF–479K

Select item 140866910.

Cysteine-accessibility analysis of transmembrane domains 11–13 of human concentrative nucleoside transporter 3

Jing Zhang, Tracey Tackaberry, Mabel W. L. Ritzel, Taylor Raborn, Gerry Barron, Stephen A. Baldwin, James D. Young, Carol E. Cass

Biochem J. 2006 Mar 1; 394(Pt 2): 389–398. Prepublished online 2005 Nov 7. Published online 2006 Feb 10. doi: 10.1042/BJ20051476

PMCID:: PMC1408669

Abstract Article PDF–951K

Select item 554354011.

Rosetta Broker for membrane protein structure prediction: concentrative nucleoside transporter 3 and corticotropin-releasing factor receptor 1 test cases

Dorota Latek

BMC Struct Biol. 2017; 17: 8. Published online 2017 Aug 3. doi: 10.1186/s12900-017-0078-8

PMCID:: PMC5543540

Abstract Article PDF–5.7M

Select item 457207412.

Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss

Dragana Vuckovic, Sally Dawson, Deborah I. Scheffer, Taina Rantanen, Anna Morgan, Mariateresa Di Stazio, Diego Vozzi, Teresa Nutile, Maria P. Concas, Ginevra Biino, Lisa Nolan, Aileen Bahl, Anu Loukola, Anne Viljanen, Adrian Davis, Marina Ciullo, David P. Corey, Mario Pirastu, Paolo Gasparini, Giorgia Girotto

Hum Mol Genet. 2015 Oct 1; 24(19): 5655–5664. Published online 2015 Jul 17. doi: 10.1093/hmg/ddv279

PMCID:: PMC4572074

Abstract Article PDF–595K

Select item 285952013.

All-trans-retinoic Acid Promotes Trafficking of Human Concentrative Nucleoside Transporter-3 (hCNT3) to the Plasma Membrane by a TGF-β1-mediated Mechanism

Paula Fernández-Calotti, Marçal Pastor-Anglada

J Biol Chem. 2010 Apr 30; 285(18): 13589–13598. Published online 2010 Feb 19. doi: 10.1074/jbc.M109.055673

PMCID:: PMC2859520

Abstract Article PDF–1.6M

Select item 546547914.

Substituted cysteine accessibility method (SCAM) analysis of the transport domain of human concentrative nucleoside transporter 3 (hCNT3) and other family members reveals features of structural and functional importance

Ras Mulinta, Sylvia Y. M. Yao, Amy M. L. Ng, Carol E. Cass, James D. Young

J Biol Chem. 2017 Jun 9; 292(23): 9505–9522. Published online 2017 Apr 6. doi: 10.1074/jbc.M116.743997

PMCID:: PMC5465479

Abstract Article PDF–4.5M

Select item 509103915.

TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3

Rachel A. Hesler, Jennifer J. Huang, Mark D. Starr, Victoria M. Treboschi, Alyssa G. Bernanke, Andrew B. Nixon, Shannon J. McCall, Rebekah R. White, Gerard C. Blobe

Carcinogenesis. 2016 Nov; 37(11): 1041–1051. Published online 2016 Sep 7. doi: 10.1093/carcin/bgw093

PMCID:: PMC5091039

Abstract Article PDF–5.4M

Select item 280265516.

Single Nucleotide Polymorphisms of Gemcitabine Metabolic Genes and Pancreatic Cancer Survival and Drug Toxicity

Taro Okazaki, Milind Javle, Motofumi Tanaka, James L. Abbruzzese, Donghui Li

Clin Cancer Res. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Clin Cancer Res. 2010 Jan 1; 16(1): 320–329. Published online 2009 Dec 22. doi: 10.1158/1078-0432.CCR-09-1555

PMCID:: PMC2802655

Abstract Article PDF–700K

Select item 370421717.

Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women’s Health Initiative SHARe Study

Digna R. Velez Edwards, Adam C. Naj, Keri Monda, Kari E. North, Marian Neuhouser, Oyunbileg Magvanjav, Ibukun Kusimo, Mara Z. Vitolins, JoAnn E. Manson, Mary Jo O’Sullivan, Evadnie Rampersaud, Todd L. Edwards

Hum Genet. Author manuscript; available in PMC 2013 Jul 8.

Published in final edited form as: Hum Genet. 2013 Mar; 132(3): 323–336. Published online 2012 Nov 29. doi: 10.1007/s00439-012-1246-3

PMCID:: PMC3704217

Abstract Article PDF–87K

Select item 284229818.

Genome-Wide Association of Lipid-Lowering Response to Statins in Combined Study Populations

Mathew J. Barber, Lara M. Mangravite, Craig L. Hyde, Daniel I. Chasman, Joshua D. Smith, Catherine A. McCarty, Xiaohui Li, Russell A. Wilke, Mark J. Rieder, Paul T. Williams, Paul M. Ridker, Aurobindo Chatterjee, Jerome I. Rotter, Deborah A. Nickerson, Matthew Stephens, Ronald M. Krauss

PLoS One. 2010; 5(3): e9763. Published online 2010 Mar 22. doi: 10.1371/journal.pone.0009763