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Select item 111293571.

Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance

Hatim Boughanem, Jesús pilo, Libia Alejandra García-Flores, Isabel Arranz, María Ramos-Fernandez, María Ortega-Castan, Ana B. Crujeiras, Juan Sandoval, Manuel Macias-Gonzalez

J Transl Med. 2024; 22: 509. Published online 2024 May 27. doi: 10.1186/s12967-024-05329-x

PMCID:: PMC11129357

Abstract Article PDF–2.8M

Select item 104127382.

Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Panneerselvam Jayabal, Fuchun Zhou, Xiuye Ma, Kathryn M. Bondra, Barron Blackman, Susan T. Weintraub, Yidong Chen, Patricia Chévez-Barrios, Peter J. Houghton, Brenda Gallie, Yuzuru Shiio

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112103. Published online 2023 Feb 13. doi: 10.1016/j.celrep.2023.112103

PMCID:: PMC10412738

Abstract Article PDF–2.8M

Select item 100531363.

The DNA demethylation-regulated SFRP2 dictates the progression of endometriosis via activation of the Wnt/β-catenin signaling pathway

Mei Yang, Lin Li, Xiaojie Huang, Hui Xing, Li Hong, Chunfan Jiang

BMC Mol Cell Biol. 2023; 24: 12. Published online 2023 Mar 29. doi: 10.1186/s12860-023-00470-9

PMCID:: PMC10053136

Abstract Article PDF–2.9M

Select item 99986504.

Novel method of differentiating human induced pluripotent stem cells to mature cardiomyocytes via Sfrp2

Ying-Chang Hsueh, Richard E. Pratt, Victor J. Dzau, Conrad P. Hodgkinson

Sci Rep. 2023; 13: 3920. Published online 2023 Mar 9. doi: 10.1038/s41598-023-31144-3

PMCID:: PMC9998650

Abstract Article PDF–4.8M

Select item 97774255.

SFRP2 Overexpression Induces an Osteoblast-like Phenotype in Prostate Cancer Cells

Elif Akova Ölken, Attila Aszodi, Hanna Taipaleenmäki, Hiroaki Saito, Veronika Schönitzer, Michael Chaloupka, Maria Apfelbeck, Wolfgang Böcker, Maximilian Michael Saller

Cells. 2022 Dec; 11(24): 4081. Published online 2022 Dec 16. doi: 10.3390/cells11244081

PMCID:: PMC9777425

Abstract Article PDF–4.6M

Select item 86353576.

Downregulation of SFRP2 facilitates cancer stemness and radioresistance of glioma cells via activating Wnt/β-catenin signaling

Quansheng Wu, Xiaofeng Yin, Wenbo Zhao, Wenli Xu, Laizhao Chen

PLoS One. 2021; 16(12): e0260864. Published online 2021 Dec 1. doi: 10.1371/journal.pone.0260864

PMCID:: PMC8635357

Abstract Article PDF–3.8M

Select item 78971957.

Secreted frizzled-related protein 2: a key player in noncanonical Wnt signaling and tumor angiogenesis

Karlijn van Loon, Elisabeth J. M. Huijbers, Arjan W. Griffioen

Cancer Metastasis Rev. 2021; 40(1): 191–203. Published online 2020 Nov 2. doi: 10.1007/s10555-020-09941-3

PMCID:: PMC7897195

Abstract Article PDF–3.0M

Select item 75609478.

Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer

Antoinette S. Perry, Gillian O’Hurley, Omer A. Raheem, Kevin Brennan, Simon Wong, Anthony O’Grady, Anne-Marie Kennedy, Laure Marignol, Therese M. Murphy, Linda Sullivan, Ciara Barrett, Barbara Loftus, John Thornhill, Stephen M. Hewitt, Mark Lawler, Elaine Kay, Thomas Lynch, Donal Hollywood

Int J Cancer. Author manuscript; available in PMC 2020 Oct 15.

Published in final edited form as: Int J Cancer. 2013 Apr 15; 132(8): 1771–1780. Published online 2012 Sep 28. doi: 10.1002/ijc.27798

PMCID:: PMC7560947

Abstract Article PDF–1.9M

Select item 73773649.

The role of secreted frizzled-related protein 2 expression in prostate cancer

Gillian O’Hurley, Antoinette S Perry, Anthony O’Grady, Barbara Loftus, Paul Smyth, John J O’Leary, Orla Sheils, John M Fitzpatrick, Stephen M Hewitt, Mark Lawler, Elaine W Kay

Histopathology. Author manuscript; available in PMC 2020 Jul 23.

Published in final edited form as: Histopathology. 2011 Dec; 59(6): 1240–1248. doi: 10.1111/j.1365-2559.2011.04073.x

PMCID:: PMC7377364

Abstract Article PDF–1.1M

Select item 728575010.

Association between variation of circulating 25-OH vitamin D and methylation of secreted frizzled-related protein 2 in colorectal cancer

Hatim Boughanem, Amanda Cabrera-Mulero, Pablo Hernández-Alonso, Mercedes Clemente-Postigo, Felipe F. Casanueva, Francisco José Tinahones, Sonsoles Morcillo, Ana B. Crujeiras, Manuel Macias-Gonzalez

Clin Epigenetics. 2020; 12: 83. Published online 2020 Jun 9. doi: 10.1186/s13148-020-00875-9

PMCID:: PMC7285750

Abstract Article PDF–1.2M

Select item 722955511.

Secreted Frizzled-Related Protein 2 and Extracellular Volume Fraction in Patients with Heart Failure

Shaomin Yang, Haixiong Chen, Kuan Tan, Fusheng Cai, Yongxing Du, Weibiao Lv, Qiugen Hu, Yunzhao Hu, Yuli Huang

Oxid Med Cell Longev. 2020; 2020: 2563508. Published online 2020 May 6. doi: 10.1155/2020/2563508

PMCID:: PMC7229555

Abstract Article PDF–502K

Select item 721830412.

Feasibility of Plasma-Methylated SFRP2 for Early Detection of Gastric Cancer

Jin Miao, Yi Liu, Guodong Zhao, Xiaoyu Liu, Yong Ma, Hui Li, Shiming Li, Yun Zhu, Shangmin Xiong, Minxue Zheng, Sujuan Fei

Cancer Control. 2020 Apr-Jun; 27(2): 1073274820922559. Published online 2020 May 7. doi: 10.1177/1073274820922559

PMCID:: PMC7218304

Abstract Article PDF–523K

Select item 698566313.

Secreted frizzled‐related protein 2 promotes the osteo/odontogenic differentiation and paracrine potentials of stem cells from apical papilla under inflammation and hypoxia conditions

Haoqing Yang, Guoqing Li, Nannan Han, Xiuli Zhang, Yangyang Cao, Yu Cao, Zhipeng Fan

Cell Prolif. 2020 Jan; 53(1): e12694. Published online 2019 Sep 30. doi: 10.1111/cpr.12694

PMCID:: PMC6985663

Abstract Article PDF–1.3M

Select item 677705314.

The Silencing of SFRP2 Expression in ESCC Is Due to Methylation of the Gene Promoter

Qian Liu, Ya-Xing Zhou, Hui-Wang, Qiao-Xin Li, Miao Wu, Yu-Qing Ma

Technol Cancer Res Treat. 2019; 18: 1533033819877977. Published online 2019 Oct 2. doi: 10.1177/1533033819877977

PMCID:: PMC6777053

Abstract Article PDF–2.4M

Select item 625515215.

Oncogenic role of SFRP2 in p53-mutant osteosarcoma development via autocrine and paracrine mechanism

Huensuk Kim, Seungyeul Yoo, Ruoji Zhou, An Xu, Jeffrey M. Bernitz, Ye Yuan, Andreia M. Gomes, Michael G. Daniel, Jie Su, Elizabeth G. Demicco, Jun Zhu, Kateri A. Moore, Dung-Fang Lee, Ihor R. Lemischka, Christoph Schaniel

Proc Natl Acad Sci U S A. 2018 Nov 20; 115(47): E11128–E11137. Published online 2018 Nov 1. doi: 10.1073/pnas.1814044115

PMCID:: PMC6255152

Abstract Article PDF–2.4M

Select item 591971616.

Decreased expression of SFRP2 promotes development of the pituitary corticotroph adenoma by upregulating Wnt signaling

Jie Ren, Fangfang Jian, Hong Jiang, Yuhao Sun, Sijian Pan, Changwei Gu, Xiao Chen, Weiqing Wang, Guang Ning, Liuguan Bian, Qingfang Sun

Int J Oncol. 2018 Jun; 52(6): 1934–1946. Published online 2018 Apr 3. doi: 10.3892/ijo.2018.4355

PMCID:: PMC5919716

Abstract Article PDF–1.3M

Select item 554750317.

SFRP2 enhances the osteogenic differentiation of apical papilla stem cells by antagonizing the canonical WNT pathway

Luyuan Jin, Yu Cao, Guoxia Yu, Jinsong Wang, Xiao Lin, Lihua Ge, Juan Du, Liping Wang, Shu Diao, Xiaomeng Lian, Songlin Wang, Rui Dong, Zhaochen Shan

Cell Mol Biol Lett. 2017; 22: 14. Published online 2017 Aug 8. doi: 10.1186/s11658-017-0044-2

PMCID:: PMC5547503

Abstract Article PDF–1.7M

Select item 483357918.

sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance

Amanpreet Kaur, Marie R. Webster, Katie Marchbank, Reeti Behera, Abibatou Ndoye, Curtis H. Kugel, III, Vanessa M. Dang, Jessica Appleton, Michael P. O’Connell, Phil Cheng, Alexander A. Valiga, Rachel Morissette, Nazli B. McDonnell, Luigi Ferrucci, Andrew V. Kossenkov, Katrina Meeth, Hsin-Yao Tang, Xiangfan Yin, William H. Wood, III, Elin Lehrmann, Kevin G. Becker, Keith T. Flaherty, Dennie T. Frederick, Jennifer A. Wargo, Zachary A. Cooper, Michael T. Tetzlaff, Courtney Hudgens, Katherine M. Aird, Rugang Zhang, Xiaowei Xu, Qin Liu, Edmund Bartlett, Giorgos Karakousis, Zeynep Eroglu, Roger S. Lo, Matthew Chan, Alexander M. Menzies, Georgina V. Long, Douglas B. Johnson, Jeffrey Sosman, Bastian Schilling, Dirk Schadendorf, David W. Speicher, Marcus Bosenberg, Antoni Ribas, Ashani T. Weeraratna

Nature. Author manuscript; available in PMC 2016 Oct 4.

Published in final edited form as: Nature. 2016 Apr 14; 532(7598): 250–254. Published online 2016 Apr 4. doi: 10.1038/nature17392

PMCID:: PMC4833579

Abstract Article PDF–6.0M

Select item 458353519.

Promoting roles of the secreted frizzled-related protein 2 as a Wnt agonist in lung cancer cells

XIAOMIN XIAO, YINGYING XIAO, RUILING WEN, YUHUA ZHANG, XIAOXIA LI, HAOLI WANG, JIANQIONG HUANG, JIAHUA LIU, TIANDI LONG, JUN TANG

Oncol Rep. 2015 Nov; 34(5): 2259–2266. Published online 2015 Aug 21. doi: 10.3892/or.2015.4221

PMCID:: PMC4583535

Abstract Article PDF–694K

Select item 421435320.

Secreted frizzled-related protein 2 is epigenetically silenced and functions as a tumor suppressor in oral squamous cell carcinoma

CAN XIAO, LILI WANG, LIFANG ZHU, CHENPING ZHANG, JIANHUA ZHOU

Mol Med Rep. 2014 Nov; 10(5): 2293–2298. Published online 2014 Sep 5. doi: 10.3892/mmr.2014.2542

PMCID:: PMC4214353

Abstract Article PDF–781K

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