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Select item 103574351.

Low Expression of GIGYF1 Inhibits Metastasis, Proliferation, and Promotes Apoptosis and Autophagy of Gastric Cancer Cells

Linqi Zhu, Zhendong Yao, Qingxin Luo, Yun Liu, Wenjun Zhao, Chen Shao, Shihe Shao, Feilun Cui

Int J Med Sci. 2023; 20(8): 1038–1045. Published online 2023 Jun 12. doi: 10.7150/ijms.82719

PMCID:: PMC10357435

Abstract Article PDF–2.7M

Select item 85664872.

Gene-level analysis of rare variants in 379,066 whole exome sequences identifies an association of GIGYF1 loss of function with type 2 diabetes

Aimee M. Deaton, Margaret M. Parker, Lucas D. Ward, Alexander O. Flynn-Carroll, Lucas BonDurant, Gregory Hinkle, Parsa Akbari, Luca A. Lotta, Regeneron Genetics Center, DiscovEHR Collaboration, Aris Baras, Paul Nioi

Sci Rep. 2021; 11: 21565. Published online 2021 Nov 3. doi: 10.1038/s41598-021-99091-5

PMCID:: PMC8566487

Abstract Article PDF–1.9M

Select item 82637563.

GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health

Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R. Day, Hana Lango Allen, Nicola D. Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J. Wareham, Claudia Langenberg, Ken K. Ong, John R. B. Perry

Nat Commun. 2021; 12: 4178. Published online 2021 Jul 7. doi: 10.1038/s41467-021-24504-y

PMCID:: PMC8263756

Abstract Article PDF–1.2M

Select item 95251144.

GIGYF1-disturbed IGF-1R recycling: a potential contributor to autism spectrum disorder pathogenesis?

Mengen Xing, Qing Zhang, Weihong Song

J Clin Invest. 2022 Oct 3; 132(19): e163553. Published online 2022 Oct 3. doi: 10.1172/JCI163553

PMCID:: PMC9525114

Abstract Article PDF–1.1M

Select item 89846825.

4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay

Ramona Weber, Min-Yi Chung, Csilla Keskeny, Ulrike Zinnall, Markus Landthaler, Eugene Valkov, Elisa Izaurralde, Cátia Igreja

Cell Rep. Author manuscript; available in PMC 2022 Apr 6.

Published in final edited form as: Cell Rep. 2020 Oct 13; 33(2): 108262. doi: 10.1016/j.celrep.2020.108262

PMCID:: PMC8984682

Abstract Article PDF–2.5M

Select item 55384376.

GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression

Daniel Peter, Ramona Weber, Felix Sandmeir, Lara Wohlbold, Sigrun Helms, Praveen Bawankar, Eugene Valkov, Cátia Igreja, Elisa Izaurralde

Genes Dev. 2017 Jun 1; 31(11): 1147–1161. doi: 10.1101/gad.299420.117

PMCID:: PMC5538437

Abstract Article PDF–767K

Select item 34220127.

A Novel 4EHP-GIGYF2 Translational Repressor Complex Is Essential for Mammalian Development

Masahiro Morita, Lian Wee Ler, Marc R. Fabian, Nadeem Siddiqui, Michael Mullin, Valerie C. Henderson, Tommy Alain, Bruno D. Fonseca, Galina Karashchuk, Christopher F. Bennett, Tomohiro Kabuta, Shinji Higashi, Ola Larsson, Ivan Topisirovic, Robert J. Smith, Anne-Claude Gingras, Nahum Sonenberg

Mol Cell Biol. 2012 Sep; 32(17): 3585–3593. doi: 10.1128/MCB.00455-12

PMCID:: PMC3422012

Abstract Article PDF–1.3M

Select item 3107888.

Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes

Gernot Glöckner, Stephen Scherer, Ruben Schattevoy, Andrew Boright, Jacqueline Weber, Lap-Chee Tsui, André Rosenthal

Genome Res. 1998 Oct; 8(10): 1060–1073. doi: 10.1101/gr.8.10.1060

PMCID:: PMC310788

Abstract Article PDF–3.7M

Select item 67713909.

Molecular basis for GIGYF–Me31B complex assembly in 4EHP-mediated translational repression

Daniel Peter, Vincenzo Ruscica, Praveen Bawankar, Ramona Weber, Sigrun Helms, Eugene Valkov, Cátia Igreja, Elisa Izaurralde

Genes Dev. 2019 Oct 1; 33(19-20): 1355–1360. doi: 10.1101/gad.329219.119

PMCID:: PMC6771390

Abstract Article PDF–1.4M

Select item 1088328010.

Systematic discovery of protein interaction interfaces using AlphaFold and experimental validation

Chop Yan Lee, Dalmira Hubrich, Julia K Varga, Christian Schäfer, Mareen Welzel, Eric Schumbera, Milena Djokic, Joelle M Strom, Jonas Schönfeld, Johanna L Geist, Feyza Polat, Toby J Gibson, Claudia Isabelle Keller Valsecchi, Manjeet Kumar, Ora Schueler-Furman, Katja Luck

Mol Syst Biol. 2024 Feb; 20(2): 75–97. Published online 2024 Jan 15. doi: 10.1038/s44320-023-00005-6

PMCID:: PMC10883280

Abstract Article PDF–3.4M

Select item 2974611.

Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5

Michael D. Wilson, Cathy Riemer, Duane W. Martindale, Pamela Schnupf, Andrew P. Boright, Tony L. Cheung, Daniel M. Hardy, Scott Schwartz, Stephen W. Scherer, Lap-Chee Tsui, Webb Miller, Ben F. Koop

Nucleic Acids Res. 2001 Mar 15; 29(6): 1352–1365. doi: 10.1093/nar/29.6.1352

PMCID:: PMC29746

Abstract Article PDF–1.2M

Select item 1002542512.

Protein interaction studies in human induced neurons indicate convergent biology underlying autism spectrum disorders

Greta Pintacuda, Yu-Han H. Hsu, Kalliopi Tsafou, Ka Wan Li, Jacqueline M. Martín, Jackson Riseman, Julia C. Biagini, Joshua K.T. Ching, Daya Mena, Miguel A. Gonzalez-Lozano, Shawn B. Egri, Jake Jaffe, August B. Smit, Nadine Fornelos, Kevin C. Eggan, Kasper Lage

Cell Genom. 2023 Mar 8; 3(3): 100250. Published online 2023 Jan 24. doi: 10.1016/j.xgen.2022.100250

PMCID:: PMC10025425

Abstract Article PDF–22M

Select item 237498513.

Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns

Karol Szafranski, Stefanie Schindler, Stefan Taudien, Michael Hiller, Klaus Huse, Niels Jahn, Stefan Schreiber, Rolf Backofen, Matthias Platzer

Genome Biol. 2007; 8(8): R154. Published online 2007 Aug 1. doi: 10.1186/gb-2007-8-8-r154

PMCID:: PMC2374985

Abstract Article PDF–369K

Select item 759736714.

Exploiting TRIM37-driven centrosome dysfunction to kill breast cancer cells

Zhong Y. Yeow, Bramwell G. Lambrus, Rebecca Marlow, Kevin H. Zhan, Mary-Anne Durin, Lauren T. Evans, Phillip M. Scott, Thao Phan, Elizabeth Park, Lorena A. Ruiz, Daniela Moralli, Eleanor G. Knight, Luned M. Badder, Daniela Novo, Syed Haider, Catherine M. Green, Andrew NJ Tutt, Christopher J Lord, J. Ross Chapman, Andrew J. Holland

Nature. Author manuscript; available in PMC 2021 Sep 9.

Published in final edited form as: Nature. 2020 Sep; 585(7825): 447–452. Published online 2020 Sep 9. doi: 10.1038/s41586-020-2690-1

PMCID:: PMC7597367

Abstract Article PDF–1.7M

Select item 855075915.

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

Tomasz Radaszkiewicz, Michaela Nosková, Kristína Gömöryová, Olga Vondálová Blanářová, Katarzyna Anna Radaszkiewicz, Markéta Picková, Ráchel Víchová, Tomáš Gybeľ, Karol Kaiser, Lucia Demková, Lucia Kučerová, Tomáš Bárta, David Potěšil, Zbyněk Zdráhal, Karel Souček, Vítězslav Bryja

eLife. 2021; 10: e65759. Published online 2021 Oct 27. doi: 10.7554/eLife.65759

PMCID:: PMC8550759

Abstract Article PDF–7.4M

Select item 550434716.

The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs

Aitor Garzia, Seyed Mehdi Jafarnejad, Cindy Meyer, Clément Chapat, Tasos Gogakos, Pavel Morozov, Mehdi Amiri, Maayan Shapiro, Henrik Molina, Thomas Tuschl, Nahum Sonenberg

Nat Commun. 2017; 8: 16056. Published online 2017 Jul 7. doi: 10.1038/ncomms16056

PMCID:: PMC5504347

Abstract Article PDF–1.4M

Select item 831454717.

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Ruona Shi, Xue Shi, Dajiang Qin, Shibing Tang, Michiel Vermeulen, Xiaofei Zhang

Cell Biosci. 2021; 11: 146. Published online 2021 Jul 27. doi: 10.1186/s13578-021-00659-5

PMCID:: PMC8314547

Abstract Article PDF–3.7M

Select item 729072118.

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation

Danielle G. May, Kelsey L. Scott, Alexandre R. Campos, Kyle J. Roux

Cells. 2020 May; 9(5): 1070. Published online 2020 Apr 25. doi: 10.3390/cells9051070

PMCID:: PMC7290721

Abstract Article PDF–9.2M

Select item 288296119.

Human Chromosome 7: DNA Sequence and Biology

Stephen W. Scherer, Joseph Cheung, Jeffrey R. MacDonald, Lucy R. Osborne, Kazuhiko Nakabayashi, Jo-Anne Herbrick, Andrew R. Carson, Layla Parker-Katiraee, Jennifer Skaug, Razi Khaja, Junjun Zhang, Alexander K. Hudek, Martin Li, May Haddad, Gavin E. Duggan, Bridget A. Fernandez, Emiko Kanematsu, Simone Gentles, Constantine C. Christopoulos, Sanaa Choufani, Dorota Kwasnicka, Xiangqun H. Zheng, Zhongwu Lai, Deborah Nusskern, Qing Zhang, Zhiping Gu, Fu Lu, Susan Zeesman, Malgorzata J. Nowaczyk, Ikuko Teshima, David Chitayat, Cheryl Shuman, Rosanna Weksberg, Elaine H. Zackai, Theresa A. Grebe, Sarah R. Cox, Susan J. Kirkpatrick, Nazneen Rahman, Jan M. Friedman, Henry H. Q. Heng, Pier Giuseppe Pelicci, Francesco Lo-Coco, Elena Belloni, Lisa G. Shaffer, Barbara Pober, Cynthia C. Morton, James F. Gusella, Gail A. P. Bruns, Bruce R. Korf, Bradley J. Quade, Azra H. Ligon, Heather Ferguson, Anne W. Higgins, Natalia T. Leach, Steven R. Herrick, Emmanuelle Lemyre, Chantal G. Farra, Hyung-Goo Kim, Anne M. Summers, Karen W. Gripp, Wendy Roberts, Peter Szatmari, Elizabeth J. T. Winsor, Karl-Heinz Grzeschik, Ahmed Teebi, Berge A. Minassian, Juha Kere, Lluis Armengol, Miguel Angel Pujana, Xavier Estivill, Michael D. Wilson, Ben F. Koop, Sabrina Tosi, Gudrun E. Moore, Andrew P. Boright, Eitan Zlotorynski, Batsheva Kerem, Peter M. Kroisel, Erwin Petek, David G. Oscier, Sarah J. Mould, Hartmut Döhner, Konstanze Döhner, Johanna M. Rommens, John B. Vincent, J. Craig Venter, Peter W. Li, Richard J. Mural, Mark D. Adams, Lap-Chee Tsui

Science. Author manuscript; available in PMC 2010 Jun 9.

Published in final edited form as: Science. 2003 May 2; 300(5620): 767–772. Published online 2003 Apr 10. doi: 10.1126/science.1083423

PMCID:: PMC2882961

Abstract Article PDF–1.2M

Select item 943756320.

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird

Cancer Discov. 2022 Sep 2; 12(9): 2158–2179. Published online 2022 Jul 12. doi: 10.1158/2159-8290.CD-21-0205

PMCID:: PMC9437563

Abstract Article PDF–9.5M

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