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Select item 106066081.

A Spanish Family with Gordon Syndrome Due to a Variant in the Acidic Motif of WNK1

Ramón Peces, Carlos Peces, Laura Espinosa, Rocío Mena, Carolina Blanco, Jair Tenorio-Castaño, Pablo Lapunzina, Julián Nevado

Genes (Basel) 2023 Oct; 14(10): 1878. Published online 2023 Sep 27. doi: 10.3390/genes14101878

PMCID:: PMC10606608

Abstract Article PDF–919K

Select item 102885852.

WNK1 controls endosomal trafficking through TRIM27-dependent regulation of actin assembly

Ji-Ung Jung, Melanie H. Cobb

Proc Natl Acad Sci U S A. 2023 Jun 20; 120(25): e2300310120. Published online 2023 Jun 12. doi: 10.1073/pnas.2300310120

PMCID:: PMC10288585

Abstract Article PDF–7.9M

Select item 98227393.

Loss of WNK1 Suppressed the Malignant Behaviors of Hepatocellular Carcinoma Cells by Promoting Autophagy and Activating AMPK Pathway

Fang Wang, Xianxia Yan, Guangyan Shi, Lei Zhang, Xu Jing

Dis Markers. 2022; 2022: 6831224. Published online 2022 Dec 30. doi: 10.1155/2022/6831224

PMCID:: PMC9822739

Abstract Article PDF–2.3M

Select item 95080734.

WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway

Masahiro Shimizu, Hiroshi Shibuya

Sci Rep. 2022; 12: 15858. Published online 2022 Sep 23. doi: 10.1038/s41598-022-20271-y

PMCID:: PMC9508073

Abstract Article PDF–6.4M

Select item 90132695.

WNK1 Enhances Migration and Invasion in Breast Cancer Models

Ankita B. Jaykumar, Ji-Ung Jung, Pravat Kumar Parida, Tuyen T. Dang, Chonlarat Wichaidit, Ashari Rashmi Kannangara, Svetlana Earnest, Elizabeth J. Goldsmith, Gray W. Pearson, Srinivas Malladi, Melanie H. Cobb

Mol Cancer Ther. Author manuscript; available in PMC 2022 Apr 16.

Published in final edited form as: Mol Cancer Ther. 2021 Oct; 20(10): 1800–1808. Published online 2021 Jul 12. doi: 10.1158/1535-7163.MCT-21-0174

PMCID:: PMC9013269

Abstract Article PDF–834K

Select item 83796816.

Phosphorylated WNK kinase networks in recoded bacteria recapitulate physiological function

Paula Schiapparelli, Natasha L. Pirman, Kyle Mohler, Pierre A. Miranda-Herrera, Natanael Zarco, Onur Kilic, Chad Miller, Sagar R. Shah, Svetlana Rogulina, William Hungerford, Laura Abriola, Denton Hoyer, Benjamin E. Turk, Hugo Guerrero-Cázares, Farren J. Isaacs, Alfredo Quiñones-Hinojosa, Andre Levchenko, Jesse Rinehart

Cell Rep. Author manuscript; available in PMC 2021 Aug 21.

Published in final edited form as: Cell Rep. 2021 Jul 20; 36(3): 109416. doi: 10.1016/j.celrep.2021.109416

PMCID:: PMC8379681

Abstract Article PDF–1.7M

Select item 76524427.

Prognostic and Clinical Implications of WNK Lysine Deficient Protein Kinase 1 Expression in Patients With Hepatocellular Carcinoma

YI-JUNG HO, JUNGSHAN CHANG, KUN-TU YEH, ZHIYUAN GONG, YUEH-MIN LIN, JENG-WEI LU

In Vivo. 2020 Sep-Oct; 34(5): 2631–2640. Published online 2020 Sep 3. doi: 10.21873/invivo.12081

PMCID:: PMC7652442

Abstract Article PDF–6.5M

Select item 68121358.

Investigating Phosphorylation-Induced Conformational Changes in WNK1 Kinase by Molecular Dynamics Simulations

Nisha Amarnath Jonniya, Md Fulbabu Sk, Parimal Kar

ACS Omega. 2019 Oct 22; 4(17): 17404–17416. Published online 2019 Oct 11. doi: 10.1021/acsomega.9b02187

PMCID:: PMC6812135

Abstract Article PDF–9.7M

Select item 62629719.

A novel nonsense mutation in WNK1/HSN2 associated with sensory neuropathy and limb destruction in four siblings of a large Iranian pedigree

Behrouz Rahmani, Fatemeh Fekrmandi, Keivan Ahadi, Tannaz Ahadi, Afagh Alavi, Abolhassan Ahmadiani, Sareh Asadi

BMC Neurol. 2018; 18: 195. Published online 2018 Nov 29. doi: 10.1186/s12883-018-1201-6

PMCID:: PMC6262971

Abstract Article PDF–3.5M

Select item 516715010.

Multistep regulation of autophagy by WNK1

Sachith Gallolu Kankanamalage, A-Young Lee, Chonlarat Wichaidit, Andres Lorente-Rodriguez, Akansha M. Shah, Steve Stippec, Angelique W. Whitehurst, Melanie H. Cobb

Proc Natl Acad Sci U S A. 2016 Dec 13; 113(50): 14342–14347. Published online 2016 Nov 28. doi: 10.1073/pnas.1617649113

PMCID:: PMC5167150

Abstract Article PDF–1.4M

Select item 434963811.

Exome Sequencing Identifies a Novel Gene, WNK1, for Susceptibility to Pelvic Organ Prolapse (POP)

Shuquan Rao, Jinghe Lang, Lan Zhu, Juan Chen

PLoS One. 2015; 10(3): e0119482. Published online 2015 Mar 4. doi: 10.1371/journal.pone.0119482

PMCID:: PMC4349638

Abstract Article PDF–674K

Select item 432949012.

Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing

Ankita Roy, Joshua H. Goodman, Gulnaz Begum, Bridget F. Donnelly, Gabrielle Pittman, Edward J. Weinman, Dandan Sun, Arohan R. Subramanya

Am J Physiol Renal Physiol. 2015 Feb 15; 308(4): F366–F376. Published online 2014 Dec 4. doi: 10.1152/ajprenal.00612.2014

PMCID:: PMC4329490

Abstract Article

Select item 421141713.

Lack of Family-Based Association between Common Variations in WNK1 and Blood Pressure Level

Fuqiang Liu, Qiufang Lian, Jie Ren, Keyu Ren, Yang Wang, Dan Wang, Chao Chu, Lan Wang, Tongshuai Guo, Enqi Liu, Jianjun Mu, Zuyi Yuan

Med Sci Monit. 2014; 20: 1958–1962. Published online 2014 Oct 16. doi: 10.12659/MSM.890791

PMCID:: PMC4211417

Abstract Article PDF–292K

Select item 329864214.

Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans

Margus Putku, Katrin Kepp, Elin Org, Siim Sõber, David Comas, Margus Viigimaa, Gudrun Veldre, Peeter Juhanson, Pille Hallast, Neeme Tõnisson, Sue Shaw-Hawkins, Mark J Caulfield, Elza Khusnutdinova, Viktor Kožich, Patricia B Munroe, Maris Laan, HYPEST, BRIGHT

Hum Mutat. 2011 Jul; 32(7): 806–814. Published online 2011 Apr 21. doi: 10.1002/humu.21508

PMCID:: PMC3298642

Abstract Article PDF–221K

Select item 323793115.

WNK1 Promotes PIP₂ Synthesis to Coordinate Growth Factor and GPCR-G_q Signaling

Sung-Wan An, Seung-Kuy Cha, Joonho Yoon, Seungwoo Chang, Elliott M. Ross, Chou-Long Huang

Curr Biol. Author manuscript; available in PMC 2012 Dec 6.

Published in final edited form as: Curr Biol. 2011 Dec 6; 21(23): 1979–1987. Published online 2011 Nov 23. doi: 10.1016/j.cub.2011.11.002

PMCID:: PMC3237931

Abstract Article PDF–4.4M

Select item 302976316.

WNK1 is required for mitosis and abscission

Szu-wei Tu, Abhijit Bugde, Katherine Luby-Phelps, Melanie H. Cobb

Proc Natl Acad Sci U S A. 2011 Jan 25; 108(4): 1385–1390. Published online 2011 Jan 10. doi: 10.1073/pnas.1018567108

PMCID:: PMC3029763

Abstract Article PDF–1.2M

Select item 274966217.

Carriers of Recessive WNK1/HSN2 Mutations for Hereditary Sensory and Autonomic Neuropathy Type 2 (HSAN2) Are More Sensitive to Thermal Stimuli

Marco L. Loggia, M. Catherine Bushnell, Martine Tétreault, Isabelle Thiffault, Claude Bhérer, Nazma K. Mohammed, Anil A. Kuchinad, Audrey Laferrière, Marie-Josée Dicaire, Lina Loisel, Jeffrey S. Mogil, Bernard Brais

J Neurosci. 2009 Feb 18; 29(7): 2162–2166. doi: 10.1523/JNEUROSCI.4633-08.2009

PMCID:: PMC2749662

Abstract Article PDF–271K

Select item 266113918.

Polymorphisms in the WNK1 Gene Are Associated with Blood Pressure Variation and Urinary Potassium Excretion

Stephen Newhouse, Martin Farrall, Chris Wallace, Mimoza Hoti, Beverley Burke, Philip Howard, Abiodun Onipinla, Kate Lee, Sue Shaw-Hawkins, Richard Dobson, Morris Brown, Nilesh J. Samani, Anna F. Dominiczak, John M. Connell, G. Mark Lathrop, Jaspal Kooner, John Chambers, Paul Elliott, Robert Clarke, Rory Collins, Maris Laan, Elin Org, Peeter Juhanson, Gudrun Veldre, Margus Viigimaa, Susana Eyheramendy, Francesco P. Cappuccio, Chen Ji, Roberto Iacone, Pasquale Strazzullo, Meena Kumari, Michael Marmot, Eric Brunner, Mark Caulfield, Patricia B. Munroe

PLoS One. 2009; 4(4): e5003. Published online 2009 Apr 4. doi: 10.1371/journal.pone.0005003

PMCID:: PMC2661139

Abstract Article PDF–443K

Select item 206363019.

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

Anna Zagórska, Eulalia Pozo-Guisado, Jérôme Boudeau, Alberto C. Vitari, Fatema H. Rafiqi, Jacob Thastrup, Maria Deak, David G. Campbell, Nick A. Morrice, Alan R. Prescott, Dario R. Alessi

J Cell Biol. 2007 Jan 1; 176(1): 89–100. doi: 10.1083/jcb.200605093

PMCID:: PMC2063630

Abstract Article PDF–5.7M

Select item 128717920.

A New Locus on Chromosome 12p13.3 for Pseudohypoaldosteronism Type II, an Autosomal Dominant Form of Hypertension

Sandra Disse-Nicodème, Jean-Michel Achard, Isabelle Desitter, Anne-Marie Houot, Albert Fournier, Pierre Corvol, Xavier Jeunemaitre

Am J Hum Genet. 2000 Aug; 67(2): 302–310. Published online 2000 Jun 22. doi: 10.1086/303020

PMCID:: PMC1287179

Abstract Article PDF–569K

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