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Select item 112586801.

Mechanistic Insight into Intestinal α-Synuclein Aggregation in Parkinson’s Disease Using a Laser-Printed Electrochemical Sensor

Julia M. Balsamo, Keren Zhou, Vinay Kammarchedu, Aida Ebrahimi, Elizabeth N. Bess

ACS Chem Neurosci. 2024 Jul 17; 15(14): 2623–2632. Published online 2024 Jul 3. doi: 10.1021/acschemneuro.4c00106

PMCID:: PMC11258680

Abstract Article PDF–4.5M

Select item 112358622.

Misfolded alpha‐synuclein in amyotrophic lateral sclerosis: Implications for diagnosis and treatment

Richard Smith, Hanna Hovren, Robert Bowser, Nadine Bakkar, Ralph Garruto, Albert Ludolph, John Ravits, Lia Gaertner, Davan Murphy, Russ Lebovitz

Eur J Neurol. 2024 Apr; 31(4): e16206. Published online 2024 Jan 25. doi: 10.1111/ene.16206

PMCID:: PMC11235862

Abstract Article PDF–2.6M

Select item 111815693.

Alpha-synuclein-induced stress sensitivity renders the Parkinson’s disease brain susceptible to neurodegeneration

Modestos Nakos Bimpos, Katerina Karali, Christine Antoniou, Dionysios Palermos, Maria Fouka, Anastasios Delis, Iason Tzieras, George Panagiotis Chrousos, Yassemi Koutmani, Leonidas Stefanis, Alexia Polissidis

Acta Neuropathol Commun. 2024; 12: 100. Published online 2024 Jun 17. doi: 10.1186/s40478-024-01797-w

PMCID:: PMC11181569

Abstract Article PDF–7.4M

Select item 111801854.

Disease progression modelling reveals heterogeneity in trajectories of Lewy-type α-synuclein pathology

Sophie E. Mastenbroek, Jacob W. Vogel, Lyduine E. Collij, Geidy E. Serrano, Cécilia Tremblay, Alexandra L. Young, Richard A. Arce, Holly A. Shill, Erika D. Driver-Dunckley, Shyamal H. Mehta, Christine M. Belden, Alireza Atri, Parichita Choudhury, Frederik Barkhof, Charles H. Adler, Rik Ossenkoppele, Thomas G. Beach, Oskar Hansson

Nat Commun. 2024; 15: 5133. Published online 2024 Jun 15. doi: 10.1038/s41467-024-49402-x

PMCID:: PMC11180185

Abstract Article PDF–2.7M

Select item 111316485.

Mitochondrial association of alpha-synuclein causes oxidative stress

M. S. Parihar, A. Parihar, M. Fujita, M. Hashimoto, P. Ghafourifar

Cell Mol Life Sci. 2008 Apr; 65(7-8): 1272–1284. Published online 2008 Feb 25. doi: 10.1007/s00018-008-7589-1

PMCID:: PMC11131648

Abstract Article PDF–2.8M

Select item 111075546.

Expanding role of molecular chaperones in regulating α-synuclein misfolding; implications in Parkinson’s disease

Sandeep K. Sharma, Smriti Priya

Cell Mol Life Sci. 2017 Feb; 74(4): 617–629. Published online 2016 Aug 13. doi: 10.1007/s00018-016-2340-9

PMCID:: PMC11107554

Abstract Article PDF–1.6M

Select item 111075027.

Synucleinopathies: common features and hippocampal manifestations

Weiwei Yang, Shun Yu

Cell Mol Life Sci. 2017 Apr; 74(8): 1485–1501. Published online 2016 Nov 8. doi: 10.1007/s00018-016-2411-y

PMCID:: PMC11107502

Abstract Article PDF–536K

Select item 110732938.

A53T mutant α-synuclein fibrils formed in macrophage are spread to neurons

Shogo Moriya, Michiko Hanazono, Takeshi Fukuhara, Katsuro Iwase, Nobutaka Hattori, Masaki Takiguchi

Cell Mol Life Sci. 2022 May; 79(5): 234. Published online 2022 Apr 10. doi: 10.1007/s00018-022-04263-9

PMCID:: PMC11073293

Abstract Article PDF–2.8M

Select item 110722259.

Restricting α-synuclein transport into mitochondria by inhibition of α-synuclein–VDAC complexation as a potential therapeutic target for Parkinson’s disease treatment

Megha Rajendran, María Queralt-Martín, Philip A. Gurnev, William M. Rosencrans, Amandine Rovini, Daniel Jacobs, Kaitlin Abrantes, David P. Hoogerheide, Sergey M. Bezrukov, Tatiana K. Rostovtseva

Cell Mol Life Sci. 2022 Jul; 79(7): 368. Published online 2022 Jun 19. doi: 10.1007/s00018-022-04389-w

PMCID:: PMC11072225

Abstract Article PDF–2.3M

Select item 1098082610.

Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue

Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Deborah A. Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Y. O’Shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer

Nat Commun. 2024; 15: 2750. Published online 2024 Mar 29. doi: 10.1038/s41467-024-46832-5

PMCID:: PMC10980826

Abstract Article PDF–5.5M

Select item 1093233211.

Molecular Behavior of α-Synuclein Is Associated with Membrane Transport, Lipid Metabolism, and Ubiquitin–Proteasome Pathways in Lewy Body Disease

Tomoya Kon, Seojin Lee, Ivan Martinez-Valbuena, Koji Yoshida, Satoshi Tanikawa, Anthony E. Lang, Gabor G. Kovacs

Int J Mol Sci. 2024 Mar; 25(5): 2676. Published online 2024 Feb 26. doi: 10.3390/ijms25052676

PMCID:: PMC10932332

Abstract Article PDF–1.9M

Select item 1091067012.

Multifaceted Interactions Mediated by Intrinsically Disordered Regions Play Key Roles in Alpha Synuclein Aggregation

Sagar D. Khare, Priscilla Chinchilla, Jean Baum

Curr Opin Struct Biol. Author manuscript; available in PMC 2024 Mar 4.

Published in final edited form as: Curr Opin Struct Biol. 2023 Jun; 80: 102579. Published online 2023 Apr 13. doi: 10.1016/j.sbi.2023.102579

PMCID:: PMC10910670

Abstract Article PDF–1.1M

Select item 1090465813.

Dysbiosis of the gut microbiota and its effect on α-synuclein and prion protein misfolding: consequences for neurodegeneration

Nasir Uddin Mahbub, Md Minarul Islam, Seong-Tshool Hong, Hea-Jong Chung

Front Cell Infect Microbiol. 2024; 14: 1348279. Published online 2024 Feb 16. doi: 10.3389/fcimb.2024.1348279

PMCID:: PMC10904658

Abstract Article PDF–2.3M

Select item 1089132914.

Gut microbiome, short-chain fatty acids, alpha-synuclein, neuroinflammation, and ROS/RNS: Relevance to Parkinson's disease and therapeutic implications

Balaraman Kalyanaraman, Gang Cheng, Micael Hardy

Redox Biol. 2024 May; 71: 103092. Published online 2024 Feb 16. doi: 10.1016/j.redox.2024.103092

PMCID:: PMC10891329

Abstract Article PDF–1.7M

Select item 1086447615.

Disease Mechanisms of Multiple System Atrophy: What a Parallel Between the Form of Pasta and the Alpha-Synuclein Assemblies Involved in MSA and PD Tells Us

Ronald Melki

Cerebellum. 2024; 23(1): 13–21. Published online 2022 Jun 3. doi: 10.1007/s12311-022-01417-0

PMCID:: PMC10864476

Abstract Article PDF–971K

Select item 1084893916.

The C-terminus of α-Synuclein Regulates its Dynamic Cellular Internalization by Neurexin 1β

Melissa Birol, Isabella Ioana Douzoglou Muñoz, Elizabeth Rhoades

Mol Biol Cell. 2023 Dec 1; 34(13): br21. Published online 2023 Nov 21. doi: 10.1091/mbc.E22-11-0496

PMCID:: PMC10848939

Abstract Article PDF–890K

Select item 1082943217.

Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

Min Seong Kim, Eun A. Ra, Sin Ho Kweon, Bo Am Seo, Han Seok Ko, Yohan Oh, Gabsang Lee

Cell Stem Cell. Author manuscript; available in PMC 2024 Jan 31.

Published in final edited form as: Cell Stem Cell. 2023 Jul 6; 30(7): 973–986.e11. Published online 2023 Jun 19. doi: 10.1016/j.stem.2023.05.015

PMCID:: PMC10829432

Abstract Article PDF–3.1M

Select item 1082850118.

Dopaminergic neuron loss in mice due to increased levels of wild-type human α-Synuclein only takes place under conditions of accelerated aging

Ana Perez-Villalba, María Salomé Sirerol-Piquer, Raúl Soriano-Cantón, Virginia Folgado, Azucena Pérez-Cañamás, Martina Kirstein, Isabel Fariñas, Francisco Pérez-Sánchez

Sci Rep. 2024; 14: 2490. Published online 2024 Jan 30. doi: 10.1038/s41598-024-53093-1

PMCID:: PMC10828501

Abstract Article PDF–6.1M

Select item 1074134219.

Astrocytes and Alpha-Synuclein: Friend or Foe?

Hakan Ozoran, Rahul Srinivasan

J Parkinsons Dis. 2023; 13(8): 1289–1301. Prepublished online 2023 Nov 18. Published online 2023 Dec 19. doi: 10.3233/JPD-230284

PMCID:: PMC10741342

Abstract Article PDF–394K

Select item 1069651620.

Neuronally Derived Extracellular Vesicle α-Synuclein as a Serum Biomarker for Individuals at Risk of Developing Parkinson Disease

Shijun Yan, Cheng Jiang, Annette Janzen, Thomas R. Barber, Aline Seger, Michael Sommerauer, Jason J. Davis, Kenneth Marek, Michele T. Hu, Wolfgang H. Oertel, George K. Tofaris

JAMA Neurol. 2024 Jan; 81(1): 59–68. Published online 2023 Dec 4. doi: 10.1001/jamaneurol.2023.4398

PMCID:: PMC10696516

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