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Select item 99389411.

Upregulation of Thioesterase Superfamily Member 2 in Skeletal Muscle Promotes Hepatic Steatosis and Insulin Resistance

Norihiro Imai, Hayley T. Nicholls, Michele Alves-Bezerra, Yingxia Li, Anna A. Ivanova, Eric A. Ortlund, David E. Cohen

Hepatology. Author manuscript; available in PMC 2023 Feb 19.

Published in final edited form as: Hepatology. 2022 Jan; 75(1): 154–169. Published online 2021 Dec 8. doi: 10.1002/hep.32122

PMCID:: PMC9938941

Abstract Article PDF–2.4M

Select item 33367782.

Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism

Hye Won Kang, Michele W. Niepel, Shuxin Han, Yuki Kawano, David E. Cohen

FASEB J. 2012 May; 26(5): 2209–2221. doi: 10.1096/fj.11-202853

PMCID:: PMC3336778

Abstract Article

Select item 63692963.

Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1–induced steatosis

Veronika Tillander, Akihiro Miniami, Michele Alves-Bezerra, Rosalind A. Coleman, David E. Cohen

J Biol Chem. 2019 Feb 8; 294(6): 2009–2020. Published online 2018 Dec 6. doi: 10.1074/jbc.RA118.005184

PMCID:: PMC6369296

Abstract Article PDF–2.9M

Select item 57495174.

Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress

Baran A. Ersoy, Kristal M. Maner-Smith, Yingxia Li, Ipek Alpertunga, David E. Cohen

J Clin Invest. 2018 Jan 2; 128(1): 141–156. Published online 2017 Nov 20. doi: 10.1172/JCI93123

PMCID:: PMC5749517

Abstract Article PDF–6.7M

Select item 55388325.

Phosphatidylcholine transfer protein/StarD2 promotes microvesicular steatosis and liver injury in murine experimental steatohepatitis

Hayley T. Nicholls, Jason L. Hornick, David E. Cohen

Am J Physiol Gastrointest Liver Physiol. 2017 Jul 1; 313(1): G50–G61. Published online 2017 Apr 6. doi: 10.1152/ajpgi.00379.2016

PMCID:: PMC5538832

Abstract Article

Select item 40543216.

Thioesterase Superfamily Member 2 (Them2) and Phosphatidylcholine Transfer Protein (PC-TP) Interact To Promote Fatty Acid Oxidation and Control Glucose Utilization

Yuki Kawano, Baran A. Ersoy, Yingxia Li, Shin Nishiumi, Masaru Yoshida, David E. Cohen

Mol Cell Biol. 2014 Jul; 34(13): 2396–2408. doi: 10.1128/MCB.01601-13

PMCID:: PMC4054321

Abstract Article PDF–1.8M

Select item 39591247.

Phosphatidylcholine Transfer Protein Interacts with Thioesterase Superfamily Member 2 to Attenuate Insulin Signaling

Baran A. Ersoy, Akansha Tarun, Katharine D’Aquino, Nancy J. Hancer, Chinweike Ukomadu, Morris F. White, Thomas Michel, Brendan D. Manning, David E. Cohen

Sci Signal. Author manuscript; available in PMC 2014 Mar 19.

Published in final edited form as: Sci Signal. 2013 Jul 30; 6(286): ra64. Published online 2013 Jul 30. doi: 10.1126/scisignal.2004111

PMCID:: PMC3959124

Abstract Article PDF–1.9M

Select item 65513148.

Thioesterase Superfamily Member 2 Promotes Hepatic VLDL Secretion by Channeling Fatty Acids into Triglyceride Biosynthesis

Michele Alves-Bezerra, Yingxia Li, Mariana Acuña, Anna A. Ivanova, Kathleen E. Corey, Eric A. Ortlund, David E. Cohen

Hepatology. Author manuscript; available in PMC 2020 Aug 1.

Published in final edited form as: Hepatology. 2019 Aug; 70(2): 496–510. Published online 2019 Mar 22. doi: 10.1002/hep.30411

PMCID:: PMC6551314

Abstract Article PDF–1.0M

Select item 38291849.

Thioesterase Superfamily Member 2/Acyl-CoA Thioesterase 13 (Them2/Acot13) Regulates Adaptive Thermogenesis in Mice

Hye Won Kang, Cafer Ozdemir, Yuki Kawano, Katherine B. LeClair, Cecile Vernochet, C. Ronald Kahn, Susan J. Hagen, David E. Cohen

J Biol Chem. 2013 Nov 15; 288(46): 33376–33386. Published online 2013 Sep 26. doi: 10.1074/jbc.M113.481408

PMCID:: PMC3829184

Abstract Article PDF–2.7M

Select item 691650410.

Multiple mitochondrial thioesterases have distinct tissue and substrate specificity and CoA regulation, suggesting unique functional roles

Carmen Bekeova, Lauren Anderson-Pullinger, Kevin Boye, Felix Boos, Yana Sharpadskaya, Johannes M. Herrmann, Erin L. Seifert

J Biol Chem. 2019 Dec 13; 294(50): 19034–19047. Published online 2019 Nov 1. doi: 10.1074/jbc.RA119.010901

PMCID:: PMC6916504

Abstract Article PDF–4.1M

Select item 586818111.

CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice

Jin Li, Su-Ping Deng, Gang Wei, Peng Yu

Database (Oxford) 2018; 2018: bay012. Published online 2018 Mar 23. doi: 10.1093/database/bay012

PMCID:: PMC5868181

Abstract Article PDF–653K

Select item 901455912.

Functional genomic landscape of cancer-intrinsic evasion of killing by T cells

Keith A. Lawson, Cristovão M. Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J. Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R. Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A. Krall, Donald M. Simons, Chloe J. Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E. Goldford, Sarah Martin, Qian Huang, Elizabeth A. Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S. Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H. Brumell, Antonio Finelli, Laurie Ailles, Gary Bader, Gromoslaw A. Smolen, Gillian A. Kingsbury, Traver Hart, Charles Kung, Jason Moffat

Nature. Author manuscript; available in PMC 2022 Apr 18.

Published in final edited form as: Nature. 2020 Oct; 586(7827): 120–126. Published online 2020 Sep 23. doi: 10.1038/s41586-020-2746-2

PMCID:: PMC9014559

Abstract Article PDF–6.6M

Select item 669277013.

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics

Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea

Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253

PMCID:: PMC6692770

Abstract Article PDF–7.7M

Select item 277884414.

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha

Cell. Author manuscript; available in PMC 2009 Nov 18.

Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016

PMCID:: PMC2778844

Abstract Article PDF–1.2M

Select item 793877015.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Abstract Article PDF–2.0M

Select item 1683316.

Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray

Tetsuya S. Tanaka, Saied A. Jaradat, Meng K. Lim, George J. Kargul, Xiaohong Wang, Marija J. Grahovac, Serafino Pantano, Yuri Sano, Yulan Piao, Ramaiah Nagaraja, Hirofumi Doi, William H. Wood, III, Kevin G. Becker, Minoru S. H. Ko

Proc Natl Acad Sci U S A. 2000 Aug 1; 97(16): 9127–9132. doi: 10.1073/pnas.97.16.9127

PMCID:: PMC16833

Abstract Article PDF–847K

Select item 255627017.

Large-scale gene trapping in C57BL/6N mouse embryonic stem cells

Gwenn M. Hansen, Diane C. Markesich, Michael B. Burnett, Qichao Zhu, Karen M. Dionne, Lizabeth J. Richter, Richard H. Finnell, Arthur T. Sands, Brian P. Zambrowicz, Alejandro Abuin

Genome Res. 2008 Oct; 18(10): 1670–1679. doi: 10.1101/gr.078352.108

PMCID:: PMC2556270

Abstract Article PDF–493K

Select item 357241018.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 28355419.

Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention

Brian P. Zambrowicz, Alejandro Abuin, Ramiro Ramirez-Solis, Lizabeth J. Richter, James Piggott, Hector BeltrandelRio, Eric C. Buxton, Joel Edwards, Rick A. Finch, Carl J. Friddle, Anupma Gupta, Gwenn Hansen, Yi Hu, Wenhu Huang, Crystal Jaing, Billie Wayne Key, Jr., Peter Kipp, Buckley Kohlhauff, Zhi-Qing Ma, Diane Markesich, Robert Payne, David G. Potter, Ny Qian, Joseph Shaw, Jeff Schrick, Zheng-Zheng Shi, Mary Jean Sparks, Isaac Van Sligtenhorst, Peter Vogel, Wade Walke, Nianhua Xu, Qichao Zhu, Christophe Person, Arthur T. Sands

Proc Natl Acad Sci U S A. 2003 Nov 25; 100(24): 14109–14114. Published online 2003 Nov 10. doi: 10.1073/pnas.2336103100

Correction in:: Proc Natl Acad Sci U S A. 2004 Mar 23; 101(12): 4332.

PMCID:: PMC283554

Abstract Article PDF–481K

Select item 302253420.

A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo

Graciana Diez-Roux, Sandro Banfi, Marc Sultan, Lars Geffers, Santosh Anand, David Rozado, Alon Magen, Elena Canidio, Massimiliano Pagani, Ivana Peluso, Nathalie Lin-Marq, Muriel Koch, Marchesa Bilio, Immacolata Cantiello, Roberta Verde, Cristian De Masi, Salvatore A. Bianchi, Juliette Cicchini, Elodie Perroud, Shprese Mehmeti, Emilie Dagand, Sabine Schrinner, Asja Nürnberger, Katja Schmidt, Katja Metz, Christina Zwingmann, Norbert Brieske, Cindy Springer, Ana Martinez Hernandez, Sarah Herzog, Frauke Grabbe, Cornelia Sieverding, Barbara Fischer, Kathrin Schrader, Maren Brockmeyer, Sarah Dettmer, Christin Helbig, Violaine Alunni, Marie-Annick Battaini, Carole Mura, Charlotte N. Henrichsen, Raquel Garcia-Lopez, Diego Echevarria, Eduardo Puelles, Elena Garcia-Calero, Stefan Kruse, Markus Uhr, Christine Kauck, Guangjie Feng, Nestor Milyaev, Chuang Kee Ong, Lalit Kumar, MeiSze Lam, Colin A. Semple, Attila Gyenesei, Stefan Mundlos, Uwe Radelof, Hans Lehrach, Paolo Sarmientos, Alexandre Reymond, Duncan R. Davidson, Pascal Dollé, Stylianos E. Antonarakis, Marie-Laure Yaspo, Salvador Martinez, Richard A. Baldock, Gregor Eichele, Andrea Ballabio

PLoS Biol. 2011 Jan; 9(1): e1000582. Published online 2011 Jan 18. doi: 10.1371/journal.pbio.1000582

PMCID:: PMC3022534

Abstract Article PDF–3.8M

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