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Select item 108367331.

Discoveries of GPR39 as an evolutionarily conserved receptor for bile acids and of its involvement in biliary acute pancreatitis

Zhentao Zi, Yi Rao

Sci Adv. 2024 Feb 2; 10(5): eadj0146. Published online 2024 Feb 2. doi: 10.1126/sciadv.adj0146

PMCID:: PMC10836733

Article PDF–2.2M

Select item 100659462.

GPR39 Knockout Worsens Microcirculatory Response to Experimental Stroke in a Sex-Dependent Manner

Yifan Xu, Wenri H. Zhang, Elyse M. Allen, Lev M. Fedorov, Anthony P. Barnes, Zu Yuan Qian, Thierno Madjou Bah, Yuandong Li, Ruikang K. Wang, Robert E. Shangraw, Nabil J. Alkayed

Transl Stroke Res. Author manuscript; available in PMC 2024 Oct 1.

Published in final edited form as: Transl Stroke Res. 2023 Oct; 14(5): 766–775. Published online 2022 Oct 1. doi: 10.1007/s12975-022-01093-6

PMCID:: PMC10065946

Article PDF–734K

Select item 92988373.

GPR39 Deficiency Impairs Memory and Alters Oxylipins and Inflammatory Cytokines Without Affecting Cerebral Blood Flow in a High-Fat Diet Mouse Model of Cognitive Impairment

Thierno M. Bah, Elyse M. Allen, Manuel Garcia-Jaramillo, Ruby Perez, Yalda Zarnegarnia, Catherine M. Davis, Madeline B. Bloom, Armando A. Magana, Jaewoo Choi, Gerd Bobe, Martin M. Pike, Jacob Raber, Claudia S. Maier, Nabil J. Alkayed

Front Cell Neurosci. 2022; 16: 893030. Published online 2022 Jul 6. doi: 10.3389/fncel.2022.893030

PMCID:: PMC9298837

Article PDF–9.1M

Select item 92557044.

Control of coronary vascular resistance by eicosanoids via a novel GPCR

Nabil J. Alkayed, Zhiping Cao, Zu Yuan Qian, Shanthi Nagarajan, Xuehong Liu, Jonathan W. Nelson, Fuchun Xie, Bingbing Li, Wei Fan, Lijuan Liu, Marjorie R. Grafe, Catherine M. Davis, Xiangshu Xiao, Anthony P. Barnes, Sanjiv Kaul

Am J Physiol Cell Physiol. 2022 May 1; 322(5): C1011–C1021. Published online 2022 Apr 6. doi: 10.1152/ajpcell.00454.2021

Correction in:: Am J Physiol Cell Physiol. 2022 Jun 1; 322(6): C1270.

PMCID:: PMC9255704

Article

Select item 44901445.

HOMEOSTATIC REGULATION OF KCC2 ACTIVITY BY THE ZINC RECEPTOR mZnR/GPR39 DURING SEIZURES

David Gilad, Sharon Shorer, Maya Ketzef, Alon Friedman, Israel Sekler, Elias Aizenman, Michal Hershfinkel

Neurobiol Dis. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Neurobiol Dis. 2015 Sep; 81: 4–13. Published online 2015 Jan 3. doi: 10.1016/j.nbd.2014.12.020

PMCID:: PMC4490144

Article PDF–1.4M

Select item 43602466.

GPR39 (Zinc Receptor) Knockout Mice Exhibit Depression-Like Behavior and CREB/BDNF Down-Regulation in the Hippocampus

Katarzyna Młyniec, Bogusława Budziszewska, Birgitte Holst, Beata Ostachowicz, Gabriel Nowak

Int J Neuropsychopharmacol. 2015 Feb; 18(3): pyu002. Published online 2015 Jan 17. doi: 10.1093/ijnp/pyu002

PMCID:: PMC4360246

Article PDF–767K

Select item 43004887.

GPR39 marks specific cells within the sebaceous gland and contributes to skin wound healing

Huashan Zhao, Jingqiao Qiao, Shoubing Zhang, Huishan Zhang, Xiaohua Lei, Xinyue Wang, Zhili Deng, Lina Ning, Yujing Cao, Yong Guo, Shuang Liu, Enkui Duan

Sci Rep. 2015; 5: 7913. Published online 2015 Jan 21. doi: 10.1038/srep07913

PMCID:: PMC4300488

Article PDF–13M

Select item 108367218.

GPR39 regulated spinal glycinergic inhibition and mechanical inflammatory pain

Hu-Hu Bai, Kang-Li Wang, Xiang-Ru Zeng, Jing Li, Yuan Li, Jia-Yu Xu, Yue Zhang, Hai-Feng Jiang, Xian Yang, Zhan-Wei Suo, Xiao-Dong Hu

Sci Adv. 2024 Feb 2; 10(5): eadj3808. Published online 2024 Feb 2. doi: 10.1126/sciadv.adj3808

PMCID:: PMC10836721

Article PDF–8.3M

Select item 99106119.

Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis

Sai Pranathi Meda Venkata, Hainan Li, Liping Xu, Jia Yi Koh, Huong Nguyen, Morgan Minjares, Chunying Li, Anjaneyulu Kowluru, Graeme Milligan, Jie-Mei Wang

Proc Natl Acad Sci U S A. 2023 Jan 3; 120(1): e2208541120. Published online 2022 Dec 27. doi: 10.1073/pnas.2208541120

PMCID:: PMC9910611

Article PDF–8.3M

Select item 922709910.

Activation of the zinc-sensing receptor GPR39 promotes T-cell reconstitution after hematopoietic cell transplant in mice

Lorenzo Iovino, Kirsten Cooper, Paul deRoos, Sinéad Kinsella, Cindy Evandy, Tamas Ugrai, Francesco Mazziotta, Kathleen S. Ensbey, David Granadier, Kayla Hopwo, Colton Smith, Alex Gagnon, Sara Galimberti, Mario Petrini, Geoffrey R. Hill, Jarrod A. Dudakov

Blood. 2022 Jun 23; 139(25): 3655–3666. doi: 10.1182/blood.2021013950

PMCID:: PMC9227099

Article

Select item 880669611.

G protein-coupled receptor 39 activation alleviates oxidized low-density lipoprotein-induced macrophage inflammatory response, lipid accumulation and apoptosis by inducing A20 expression

Lu Chen, Zhengdong Fang, Xiaotian Wang, Xiaojie Sun, Xinbao Ge, Can Cheng, Hejie Hu

Bioengineered. 2021; 12(1): 4070–4080. Published online 2021 Jul 21. doi: 10.1080/21655979.2021.1952917

PMCID:: PMC8806696

Article PDF–2.5M

Select item 804240312.

Selective release of gastrointestinal hormones induced by an orally active GPR39 agonist

Kaare V. Grunddal, Thi A. Diep, Natalia Petersen, Iain R. Tough, Louise J. Skov, Lingzhi Liu, Jesse A. Buijink, Franziska Mende, Chunyu Jin, Sara L. Jepsen, Louis M.E. Sørensen, Michael P. Achiam, Rune B. Strandby, Anders Bach, Bolette Hartmann, Thomas M. Frimurer, Siv A. Hjorth, Michel Bouvier, Helen Cox, Birgitte Holst

Mol Metab. 2021 Jul; 49: 101207. Published online 2021 Mar 9. doi: 10.1016/j.molmet.2021.101207

PMCID:: PMC8042403

Article PDF–1.8M

Select item 493802113.

The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis

Laxmi Sunuwar, Michal Medini, Limor Cohen, Israel Sekler, Michal Hershfinkel

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5; 371(1700): 20150420. doi: 10.1098/rstb.2015.0420

Correction in:: Philos Trans R Soc Lond B Biol Sci. 2016 Sep 19; 371(1703): 20160331.

PMCID:: PMC4938021

Article PDF–1.4M

Select item 461173414.

The zinc sensing receptor, ZnR/GPR39, controls proliferation and differentiation of colonocytes and thereby tight junction formation in the colon

L Cohen, I Sekler, M Hershfinkel

Cell Death Dis. 2014 Jun; 5(6): e1307. Published online 2014 Jun 26. doi: 10.1038/cddis.2014.262

PMCID:: PMC4611734

Article PDF–1.8M

Select item 273228615.

G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction

Birgitte Holst, Kristoffer L. Egerod, Chunyu Jin, Pia Steen Petersen, Mette Viberg Østergaard, Jacob Hald, A. M. Ejernaes Sprinkel, Joachim Størling, Thomas Mandrup-Poulsen, Jens J. Holst, Peter Thams, Cathrine Ørskov, Nils Wierup, Frank Sundler, Ole D. Madsen, Thue W. Schwartz

Endocrinology. 2009 Jun; 150(6): 2577–2585. Published online 2009 Feb 12. doi: 10.1210/en.2008-1250

PMCID:: PMC2732286

Article

Select item 541954316.

Obestatin Induction of Early-Response Gene Expression in Gastrointestinal and Adipose Tissues and the Mediatory Role of G Protein-Coupled Receptor, GPR39

Jian V. Zhang, Holger Jahr, Chin-Wei Luo, Cynthia Klein, Kristof Van Kolen, Luc Ver Donck, Ananya De, Esther Baart, Jing Li, Dieder Moechars, Aaron J. W. Hsueh

Mol Endocrinol. June 1, 2008; 22(6): 1464–1475. doi: 10.1210/me.2007-0569

PMCID:: PMC5419543

Article

Select item 333587017.

Zinc Sensing Receptor Signaling, Mediated by GPR39, Reduces Butyrate-Induced Cell Death in HT29 Colonocytes via Upregulation of Clusterin

Limor Cohen, Hagit Azriel-Tamir, Natan Arotsker, Israel Sekler, Michal Hershfinkel

PLoS One. 2012; 7(4): e35482. Published online 2012 Apr 24. doi: 10.1371/journal.pone.0035482

PMCID:: PMC3335870

Article PDF–666K

Select item 665849218.

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Keigo Nishida, Aiko Hasegawa, Satoru Yamasaki, Ryota Uchida, Wakana Ohashi, Yosuke Kurashima, Jun Kunisawa, Shunsuke Kimura, Toshihiko Iwanaga, Hiroshi Watarai, Koji Hase, Hideki Ogura, Manabu Nakayama, Jun-ichi Kashiwakura, Yoshimichi Okayama, Masato Kubo, Osamu Ohara, Hiroshi Kiyono, Haruhiko Koseki, Masaaki Murakami, Toshio Hirano

Sci Rep. 2019; 9: 10842. Published online 2019 Jul 25. doi: 10.1038/s41598-019-47132-5