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Select item 110741181.

Levels of anti-topoisomerase I antibody correlated with short onset of cardiopulmonary involvement in Thai systemic sclerosis patients

Kamonwan Mulalin, Ajanee Mahakkanukrauh, Siraphop Suwannaroj, Patnarin Pongkulkiat, Tippawan Onchan, Sawinee Kasa, Chingching Foocharoen

Sci Rep. 2024; 14: 10354. Published online 2024 May 6. doi: 10.1038/s41598-024-61159-3

PMCID:: PMC11074118

Abstract Article PDF–871K

Select item 109544552.

G-quadruplexes on chromosomal DNA negatively regulates topoisomerase 1 activity

Hui-ting Liang, Jiang-yu Yan, Hao-jun Yao, Xue-nan Zhang, Zhi-ming Xing, Lin Liu, Yao-qing Chen, Guo-rui Li, Jing Huang, Yi-de He, Ke-wei Zheng

Nucleic Acids Res. 2024 Mar 21; 52(5): 2142–2156. Published online 2024 Feb 10. doi: 10.1093/nar/gkae073

PMCID:: PMC10954455

Abstract Article PDF–2.4M

Select item 87488703.

Topoisomerase I (TOP1) dynamics: conformational transition from open to closed states

Diane T. Takahashi, Danièle Gadelle, Keli Agama, Evgeny Kiselev, Hongliang Zhang, Emilie Yab, Stephanie Petrella, Patrick Forterre, Yves Pommier, Claudine Mayer

Nat Commun. 2022; 13: 59. Published online 2022 Jan 10. doi: 10.1038/s41467-021-27686-7

PMCID:: PMC8748870

Abstract Article PDF–2.9M

Select item 83739054.

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation

Yilun Sun, Jiji Chen, Shar-yin N. Huang, Yijun P. Su, Wenjie Wang, Keli Agama, Sourav Saha, Lisa M. Jenkins, John M. Pascal, Yves Pommier

Nat Commun. 2021; 12: 5010. Published online 2021 Aug 18. doi: 10.1038/s41467-021-25252-9

PMCID:: PMC8373905

Abstract Article PDF–4.8M

Select item 82749505.

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks

Agnese Cristini, Giulia Ricci, Sébastien Britton, Simona Salimbeni, Shar-yin Naomi Huang, Jessica Marinello, Patrick Calsou, Yves Pommier, Gilles Favre, Giovanni Capranico, Natalia Gromak, Olivier Sordet

Cell Rep. Author manuscript; available in PMC 2021 Jul 12.

Published in final edited form as: Cell Rep. 2019 Sep 17; 28(12): 3167–3181.e6. doi: 10.1016/j.celrep.2019.08.041

PMCID:: PMC8274950

Abstract Article PDF–3.0M

Select item 80083436.

TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation

Jessica Sook Yuin Ho, Bobo Wing-Yee Mok, Laura Campisi, Tristan Jordan, Soner Yildiz, Sreeja Parameswaran, Joseph A. Wayman, Natasha N. Gaudreault, David A. Meekins, Sabarish V. Indran, Igor Morozov, Jessie D. Trujillo, Yesai S. Fstkchyan, Raveen Rathnasinghe, Zeyu Zhu, Simin Zheng, Nan Zhao, Kris White, Helen Ray-Jones, Valeriya Malysheva, Michiel J. Thiecke, Siu-Ying Lau, Honglian Liu, Anna Junxia Zhang, Andrew Chak-Yiu Lee, Wen-Chun Liu, Sonia Jangra, Alba Escalera, Teresa Aydillo, Betsaida Salom Melo, Ernesto Guccione, Robert Sebra, Elaine Shum, Jan Bakker, David A. Kaufman, Andre L. Moreira, Mariano Carossino, Udeni B.R. Balasuriya, Minji Byun, Randy A. Albrecht, Michael Schotsaert, Adolfo Garcia-Sastre, Sumit K. Chanda, Emily R. Miraldi, Anand D. Jeyasekharan, Benjamin R. TenOever, Mikhail Spivakov, Matthew T. Weirauch, Sven Heinz, Honglin Chen, Christopher Benner, Juergen A. Richt, Ivan Marazzi

Cell. 2021 May 13; 184(10): 2618–2632.e17. Published online 2021 Mar 30. doi: 10.1016/j.cell.2021.03.051

PMCID:: PMC8008343

Abstract Article PDF–7.3M

Select item 74142247.

Topoisomerase 1 prevents replication stress at R-loop-enriched transcription termination sites

Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel Sanz, Anna Biernacka, Anne-Lyne Schmitz, Magdalena Skrzypczak, Amélie Sarrazin, Clément Mettling, Maga Rowicka, Krzysztof Ginalski, Frédéric Chedin, Chun-Long Chen, Yea-Lih Lin, Philippe Pasero

Nat Commun. 2020; 11: 3940. Published online 2020 Aug 7. doi: 10.1038/s41467-020-17858-2

PMCID:: PMC7414224

Abstract Article PDF–2.9M

Select item 73219958.

Topoisomerase I-driven repair of UV-induced damage in NER-deficient cells

Liton Kumar Saha, Mitsuo Wakasugi, Salma Akter, Rajendra Prasad, Samuel H. Wilson, Naoto Shimizu, Hiroyuki Sasanuma, Shar-yin Naomi Huang, Keli Agama, Yves Pommier, Tsukasa Matsunaga, Kouji Hirota, Shigenori Iwai, Yuka Nakazawa, Tomoo Ogi, Shunichi Takeda

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14412–14420. Published online 2020 Jun 8. doi: 10.1073/pnas.1920165117

PMCID:: PMC7321995

Abstract Article PDF–1.5M

Select item 61196209.

Analysis of topoisomerase I expression and identification of predictive markers for efficacy of topotecan chemotherapy in small cell lung cancer

Chunxin Lv, Xiuju Liu, Qiwen Zheng, Hanxiao Chen, Xue Yang, Jia Zhong, Yuyan Wang, Jianchun Duan, Zhijie Wang, Hua Bai, Meina Wu, Jun Zhao, Jie Wang, Ziping Wang, Tongtong An, Minglei Zhuo

Thorac Cancer. 2018 Sep; 9(9): 1166–1173. Published online 2018 Jul 30. doi: 10.1111/1759-7714.12819

PMCID:: PMC6119620

Abstract Article PDF–1.0M

Select item 606692710.

DNA Topoisomerase I differentially modulates R-loops across the human genome

Stefano G. Manzo, Stella R. Hartono, Lionel A. Sanz, Jessica Marinello, Sara De Biasi, Andrea Cossarizza, Giovanni Capranico, Frederic Chedin

Genome Biol. 2018; 19: 100. Published online 2018 Jul 30. doi: 10.1186/s13059-018-1478-1

PMCID:: PMC6066927

Abstract Article PDF–2.7M

Select item 592667611.

CPT‐11 May Provide Therapeutic Efficacy for Esophageal Squamous Cell Cancer and the Effects Correlate with the Level of DNA Topoisomerase I Protein

Yasuaki Nakajima, Satoshi Miyake, Kagami Nagai, Tatsuyuki Kawano, Takehisa Iwai

Jpn J Cancer Res. 2001 Dec; 92(12): 1335–1341. doi: 10.1111/j.1349-7006.2001.tb02158.x

PMCID:: PMC5926676

Summary PDF–170K

Select item 504147712.

Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells

Subhendu K. Das, Ishita Rehman, Arijit Ghosh, Souvik Sengupta, Papiya Majumdar, Biman Jana, Benu Brata Das

Nucleic Acids Res. 2016 Sep 30; 44(17): 8363–8375. Published online 2016 Jul 27. doi: 10.1093/nar/gkw665

PMCID:: PMC5041477

Abstract Article PDF–4.4M

Select item 481524213.

Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations

Niels Frank Jensen, Keli Agama, Amit Roy, David Hersi Smith, Thomas D. Pfister, Maria Unni Rømer, Hong-Liang Zhang, James H. Doroshow, Birgitta R. Knudsen, Jan Stenvang, Nils Brünner, Yves Pommier

J Exp Clin Cancer Res. 2016; 35: 56. Published online 2016 Mar 31. doi: 10.1186/s13046-016-0335-x

PMCID:: PMC4815242

Abstract Article PDF–3.5M

Select item 463645014.

Single-molecule supercoil-relaxation assay as a screening tool to determine the mechanism and efficacy of human topoisomerase IB inhibitors

Yeonee Seol, Hongliang Zhang, Keli Agama, Nicholas Lorence, Yves Pommier, Keir C. Neuman

Mol Cancer Ther. Author manuscript; available in PMC 2016 Nov 1.

Published in final edited form as: Mol Cancer Ther. 2015 Nov; 14(11): 2552–2559. Published online 2015 Sep 8. doi: 10.1158/1535-7163.MCT-15-0454

PMCID:: PMC4636450

Abstract Article PDF–841K

Select item 463500015.

Nitric Oxide Down-Regulates Topoisomerase I and Induces Camptothecin Resistance in Human Breast MCF-7 Tumor Cells

Nilesh K. Sharma, Ashutosh Kumar, Amrita Kumari, Erik J. Tokar, Michael P. Waalkes, Carl D. Bortner, Jason Williams, Marilyn Ehrenshaft, Ronald P. Mason, Birandra K. Sinha

PLoS One. 2015; 10(11): e0141897. Published online 2015 Nov 5. doi: 10.1371/journal.pone.0141897

PMCID:: PMC4635000

Abstract Article PDF–1.9M

Select item 444797816.

Topoisomerase I Alone Is Sufficient to Produce Short DNA Deletions and Can Also Reverse Nicks at Ribonucleotide Sites

Shar-yin Naomi Huang, Sanchari Ghosh, Yves Pommier

J Biol Chem. 2015 May 29; 290(22): 14068–14076. Published online 2015 Apr 17. doi: 10.1074/jbc.M115.653345

PMCID:: PMC4447978

Abstract Article PDF–2.2M

Select item 442265117.

Ligand-dependent Enhancer Activation Regulated by Topoisomerase-I Activity

Janusz Puc, Piotr Kozbial, Wenbo Li, Yuliang Tan, Zhijie Liu, Tom Suter, Kenneth A. Ohgi, Jie Zhang, Aneel K. Aggarwal, Michael G. Rosenfeld

Cell. Author manuscript; available in PMC 2016 Jan 29.

Published in final edited form as: Cell. 2015 Jan 29; 160(3): 367–380. Published online 2015 Jan 22. doi: 10.1016/j.cell.2014.12.023

Correction in:: volume 163 on page 520

PMCID:: PMC4422651

Abstract Article PDF–1.4M

Select item 417290118.

Mutations of human DNA topoisomerase I at poly(ADP-ribose) binding sites: modulation of camptothecin activity by ADP-ribose polymers

Cinzia Tesauro, Grazia Graziani, Barbara Arnò, Laura Zuccaro, Alessia Muzi, Ilda D’Annessa, Elettra Santori, Lucio Tentori, Carlo Leonetti, Paola Fiorani, Alessandro Desideri

J Exp Clin Cancer Res. 2014; 33(1): 71. Published online 2014 Sep 17. doi: 10.1186/s13046-014-0071-z

PMCID:: PMC4172901

Abstract Article PDF–1.0M

Select item 413275819.

Simulations of DNA topoisomerase 1B bound to supercoiled DNA reveal changes in the flexibility pattern of the enzyme and a secondary protein–DNA binding site

Ilda D'Annessa, Andrea Coletta, Thana Sutthibutpong, Jonathan Mitchell, Giovanni Chillemi, Sarah Harris, Alessandro Desideri

Nucleic Acids Res. 2014 Aug 18; 42(14): 9304–9312. Published online 2014 Jul 23. doi: 10.1093/nar/gku654

PMCID:: PMC4132758

Abstract Article PDF–2.7M

Select item 378305620.

Three missense mutations of DNA topoisomerase I in highly camptothecin-resistant colon cancer cell sublines

YASUHIRO ARAKAWA, KOJI OZAKI, YUTAKA OKAWA, HISASHI YAMADA

Oncol Rep. 2013 Sep; 30(3): 1053–1058. Published online 2013 Jul 5. doi: 10.3892/or.2013.2594

PMCID:: PMC3783056

Abstract Article PDF–576K

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