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Select item 107877461.

Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth

Yong Zuo, Jiawei Bai, Huiyuan Bai, Siyu Tian, Hongtao Sun, Zhenhua Shi, Peng Yu, Guofen Gao, Yuan Li, Yan-Zhong Chang

Cell Death Dis. 2024 Jan; 15(1): 49. Published online 2024 Jan 13. doi: 10.1038/s41419-024-06442-x

PMCID:: PMC10787746

Article PDF–4.8M

Select item 92922622.

Iron distribution in different tissues of homozygous Mask (msk/msk) mice and the effects of oral iron treatments

Michela Asperti, Elisa Brilli, Andrea Denardo, Magdalena Gryzik, Francesca Pagani, Fabiana Busti, Germano Tarantino, Paolo Arosio, Domenico Girelli, Maura Poli

Am J Hematol. 2021 Oct; 96(10): 1253–1263. Published online 2021 Aug 14. doi: 10.1002/ajh.26311

PMCID:: PMC9292262

Article PDF–3.3M

Select item 68864293.

Genetic loss of Tmprss6 alters terminal erythroid differentiation in a mouse model of β-thalassemia intermedia

David B. Stagg, Rebecca L. Whittlesey, Xiuqi Li, Larisa Lozovatsky, Sara Gardenghi, Stefano Rivella, Karin E. Finberg

Haematologica. 2019 Oct; 104(10): e442–e446. doi: 10.3324/haematol.2018.213371

PMCID:: PMC6886429

Article PDF–845K

Select item 68399524.

Low iron promotes megakaryocytic commitment of megakaryocytic-erythroid progenitors in humans and mice

Juliana Xavier-Ferrucio, Vanessa Scanlon, Xiuqi Li, Ping-Xia Zhang, Larisa Lozovatsky, Nadia Ayala-Lopez, Toma Tebaldi, Stephanie Halene, Chang Cao, Mark D. Fleming, Karin E. Finberg, Diane S. Krause

Blood. 2019 Oct 31; 134(18): 1547–1557. Prepublished online 2019 Aug 22. doi: 10.1182/blood.2019002039

PMCID:: PMC6839952

Article

Select item 40007195.

Retinal expression of the serine protease matriptase-2 (Tmprss6) and its role in retinal iron homeostasis

Jaya P. Gnana-Prakasam, Renee B. Baldowski, Sudha Ananth, Pamela M. Martin, Sylvia B. Smith, Vadivel Ganapathy

Mol Vis. 2014; 20: 561–574. Published online 2014 Apr 26.

PMCID:: PMC4000719

Article PDF–3.7M

Select item 37267866.

A Strong Anti-Inflammatory Signature Revealed by Liver Transcription Profiling of Tmprss6−/− Mice

Michela Riba, Marco Rausa, Melissa Sorosina, Davide Cittaro, Jose Manuel Garcia Manteiga, Antonella Nai, Alessia Pagani, Filippo Martinelli-Boneschi, Elia Stupka, Clara Camaschella, Laura Silvestri

PLoS One. 2013; 8(7): e69694. Published online 2013 Jul 29. doi: 10.1371/journal.pone.0069694

PMCID:: PMC3726786

Article PDF–4.0M

Select item 36694397.

Identification and characterization of a novel murine allele of Tmprss6

Thomas B. Bartnikas, Andrea U. Steinbicker, Dean R. Campagna, Sherika Blevins, Lanette S. Woodward, Carolina Herrera, Kenneth D. Bloch, Monica J. Justice, Mark D. Fleming

Haematologica. 2013 Jun; 98(6): 854–861. doi: 10.3324/haematol.2012.074617

PMCID:: PMC3669439

Article PDF–1.2M

Select item 104805448.

Bone marrow sinusoidal endothelial cells are a site of Fgf23 upregulation in a mouse model of iron deficiency anemia

Xiuqi Li, Larisa Lozovatsky, Steven M. Tommasini, Jackie Fretz, Karin E. Finberg

Blood Adv. 2023 Sep 12; 7(17): 5156–5171. Published online 2023 Jul 10. doi: 10.1182/bloodadvances.2022009524

PMCID:: PMC10480544

Article PDF–7.1M

Select item 89406959.

Enteral ferric citrate absorption is dependent on the iron transport protein ferroportin

Mark R. Hanudel, Brian Czaya, Shirley Wong, Maxime Rappaport, Shweta Namjoshi, Kristine Chua, Grace Jung, Victoria Gabayan, Bo Qiao, Elizabeta Nemeth, Tomas Ganz

Kidney Int. Author manuscript; available in PMC 2022 Apr 1.

Published in final edited form as: Kidney Int. 2022 Apr; 101(4): 711–719. Published online 2021 Nov 25. doi: 10.1016/j.kint.2021.10.036

PMCID:: PMC8940695

Article PDF–819K

Select item 820956410.

Correcting β-thalassemia by combined therapies that restrict iron and modulate erythropoietin activity

Carla Casu, Mariateresa Pettinato, Alison Liu, Mariam Aghajan, Vania Lo Presti, Maria Rosa Lidonnici, Kevin A. Munoz, Emir O’Hara, Violante Olivari, Simona Maria Di Modica, Sheri Booten, Shuling Guo, Garry Neil, Reem Miari, Nir Shapir, Inbal Zafir-Lavie, Hagit Domev, Giuliana Ferrari, Despina Sitara, Antonella Nai, Stefano Rivella

Blood. 2020 Oct 22; 136(17): 1968–1979. Prepublished online 2020 Jun 17. doi: 10.1182/blood.2019004719

PMCID:: PMC8209564

Article

Select item 796176211.

Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice

Jan Krijt, Jana Frýdlová, Iuliia Gurieva, Petr Přikryl, Martin Báječný, Andrea U. Steinbicker, Martin Vokurka, Jaroslav Truksa

Int J Mol Sci. 2021 Mar; 22(5): 2650. Published online 2021 Mar 6. doi: 10.3390/ijms22052650

PMCID:: PMC7961762

Article PDF–3.4M

Select item 744117012.

The ectodomain of matriptase-2 plays an important nonproteolytic role in suppressing hepcidin expression in mice

Caroline A. Enns, Shall Jue, An-Sheng Zhang

Blood. 2020 Aug 20; 136(8): 989–1001. Prepublished online 2020 May 8. doi: 10.1182/blood.2020005222

PMCID:: PMC7441170

Article

Select item 589355513.

Matriptase-2 deficiency protects from obesity by modulating iron homeostasis

Alicia R. Folgueras, Sandra Freitas-Rodríguez, Andrew J. Ramsay, Cecilia Garabaya, Francisco Rodríguez, Gloria Velasco, Carlos López-Otín

Nat Commun. 2018; 9: 1350. Published online 2018 Apr 10. doi: 10.1038/s41467-018-03853-1

PMCID:: PMC5893555

Article PDF–1.7M

Select item 586710314.

Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities

Sébastien P. Dion, François Béliveau, Antoine Désilets, Mariana Gabriela Ghinet, Richard Leduc

J Cell Mol Med. 2018 Apr; 22(4): 2498–2509. Published online 2018 Feb 14. doi: 10.1111/jcmm.13562

PMCID:: PMC5867103

Article PDF–1.9M

Select item 540395515.

Ferroportin Is Essential for Iron Absorption During Suckling, But Is Hyporesponsive to the Regulatory Hormone Hepcidin

David M. Frazer, Sarah J. Wilkins, Deepak Darshan, Cornel S.G. Mirciov, Linda A. Dunn, Gregory J. Anderson

Cell Mol Gastroenterol Hepatol. 2017 May; 3(3): 410–421. Published online 2016 Dec 27. doi: 10.1016/j.jcmgh.2016.12.002

PMCID:: PMC5403955

Article PDF–1.3M

Select item 330220716.

Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6

Anne Lenoir, Jean-Christophe Deschemin, Léon Kautz, Andrew J. Ramsay, Marie-Paule Roth, Carlos Lopez-Otin, Sophie Vaulont, Gaël Nicolas

Blood. Author manuscript; available in PMC 2012 Mar 13.

Published in final edited form as: Blood. 2011 Jan; 117(2): 647–650. Published online 2010 Oct 12. doi: 10.1182/blood-2010-07-295147

PMCID:: PMC3302207

Article

Select item 309957517.

Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice

Karin E. Finberg, Rebecca L. Whittlesey, Nancy C. Andrews

Blood. 2011 Apr 28; 117(17): 4590–4599. Prepublished online 2011 Feb 25. doi: 10.1182/blood-2010-10-315507

PMCID:: PMC3099575

Article

Select item 305659318.

Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

An-Sheng Zhang, Sheila A. Anderson, Jiaohong Wang, Fan Yang, Kristina DeMaster, Riffat Ahmed, Christopher P. Nizzi, Richard S. Eisenstein, Hidekazu Tsukamoto, Caroline A. Enns

Blood. 2011 Feb 3; 117(5): 1687–1699. Prepublished online 2010 Nov 29. doi: 10.1182/blood-2010-06-287292

PMCID:: PMC3056593

Article

Select item 286587219.

Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

Karin E. Finberg, Rebecca L. Whittlesey, Mark D. Fleming, Nancy C. Andrews

Blood. 2010 May 6; 115(18): 3817–3826. Prepublished online 2010 Mar 3. doi: 10.1182/blood-2009-05-224808

PMCID:: PMC2865872

Article

Select item 243009720.

The serine protease TMPRSS6 is required to sense iron deficiency

Xin Du, Ellen She, Terri Gelbart, Jaroslav Truksa, Pauline Lee, Yu Xia, Kevin Khovananth, Suzanne Mudd, Navjiwan Mann, Eva Marie Y. Moresco, Ernest Beutler, Bruce Beutler

Science. Author manuscript; available in PMC 2008 Nov 23.

Published in final edited form as: Science. 2008 May 23; 320(5879): 1088–1092. Published online 2008 May 1. doi: 10.1126/science.1157121