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Select item 108426921.

Human inherited CCR2 deficiency underlies progressive polycystic lung disease

Anna-Lena Neehus, Brenna Carey, Marija Landekic, Patricia Panikulam, Gail Deutsch, Masato Ogishi, Carlos A. Arango-Franco, Quentin Philippot, Mohammadreza Modaresi, Iraj Mohammadzadeh, Melissa Corcini Berndt, Darawan Rinchai, Tom Le Voyer, Jérémie Rosain, Mana Momenilandi, Marta Martin-Fernandez, Taushif Khan, Jonathan Bohlen, Ji Eun Han, Alexandre Deslys, Mathilde Bernard, Tania Gajardo-Carrasco, Camille Soudée, Corentin Le Floc’h, Mélanie Migaud, Yoann Seeleuthner, Mi-Sun Jang, Eirini Nikolouli, Simin Seyedpour, Hugues Begueret, Jean-François Emile, Pierre Le Guen, Guido Tavazzi, Costanza Natalia Julia Colombo, Federico Capra Marzani, Micol Angelini, Francesca Trespidi, Stefano Ghirardello, Nasrin Alipour, Anne Molitor, Raphael Carapito, Mohsen Mazloomrezaei, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Chantal Brouzes, Pablo Vargas, Alessandro Borghesi, Nico Lachmann, Seiamak Bahram, Bruno Crestani, Susanta Pahari, Larry S. Schlesinger, Nico Marr, Dusan Bugonovic, Stéphanie Boisson-Dupuis, Vivien Béziat, Laurent Abel, Raphael Borie, Lisa R. Young, Robin Deterding, Mohammad Shahrooei, Nima Rezaei, Nima Parvaneh, Daniel Craven, Philippe Gros, Danielle Malo, Fernando E. Sepulveda, Lawrence M. Nogee, Nathalie Aladjidi, Bruce C. Trapnell, Jean-Laurent Casanova, Jacinta Bustamante

Cell. Author manuscript; available in PMC 2024 Feb 5.

Published in final edited form as: Cell. 2024 Jan 18; 187(2): 390–408.e23. Published online 2023 Dec 28. doi: 10.1016/j.cell.2023.11.036

Correction in:: Cell. 2024 Jun 20; 187(13): 3460.

PMCID:: PMC10842692

Abstract Article PDF–3.4M

Select item 92106502.

Chemokine (C–C motif) receptor 2 is associated with the pathological grade and inflammatory response in IgAN children

Yanjie Shen, Zhiqing Zhu, Rui Wang, Lili Yan, Shuaichen Sun, Ling Lu, Zhenhua Ren, Qin Zhang

BMC Nephrol. 2022; 23: 215. Published online 2022 Jun 20. doi: 10.1186/s12882-022-02839-y

PMCID:: PMC9210650

Abstract Article PDF–8.9M

Select item 89137203.

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

Shaoping She, Liying Ren, Pu Chen, Mingyang Wang, Dongbo Chen, Ying Wang, Hongsong Chen

Front Immunol. 2022; 13: 812431. Published online 2022 Feb 25. doi: 10.3389/fimmu.2022.812431

PMCID:: PMC8913720

Abstract Article PDF–4.4M

Select item 89104094.

Role of Distinct Macrophage Populations in the Development of Heart Failure in Macrophage Activation Syndrome

Jakub Kuna, Zbigniew Żuber, Grzegorz Chmielewski, Leszek Gromadziński, Magdalena Krajewska-Włodarczyk

Int J Mol Sci. 2022 Mar; 23(5): 2433. Published online 2022 Feb 23. doi: 10.3390/ijms23052433

PMCID:: PMC8910409

Abstract Article PDF–718K

Select item 88066925.

The role of CCR2 in prognosis of patients with endometrial cancer and tumor microenvironment remodeling

Lin Xu, Qin Fang, Youqing Miao, Mengting Xu, Yichun Wang, Lizhou Sun, Xuemei Jia

Bioengineered. 2021; 12(1): 3467–3484. Published online 2021 Jul 12. doi: 10.1080/21655979.2021.1947631

PMCID:: PMC8806692

Abstract Article PDF–4.4M

Select item 82095996.

Prognostic value of CCR2 as an immune indicator in lung adenocarcinoma: A study based on tumor‐infiltrating immune cell analysis

Yi Wan, Xin Wang, Ting Liu, Tianyu Fan, Zugui Zhang, Bin Wang, Bei Zhang, Zibin Tian, Tao Mao, Zheng Gong, Li Zhang

Cancer Med. 2021 Jun; 10(12): 4150–4163. Published online 2021 May 4. doi: 10.1002/cam4.3931

PMCID:: PMC8209599

Abstract Article PDF–3.1M

Select item 72126517.

Phosphoproteomic characterization of the signaling network resulting from activation of the chemokine receptor CCR2

Cheng Huang, Simon R. Foster, Anup D. Shah, Oded Kleifeld, Meritxell Canals, Ralf B. Schittenhelm, Martin J. Stone

J Biol Chem. 2020 May 8; 295(19): 6518–6531. Published online 2020 Apr 2. doi: 10.1074/jbc.RA119.012026

PMCID:: PMC7212651

Abstract Article PDF–2.9M

Select item 70288628.

High‐fat diet‐induced dysbiosis mediates MCP‐1/CCR2 axis‐dependent M2 macrophage polarization and promotes intestinal adenoma‐adenocarcinoma sequence

Tianyu Liu, Zixuan Guo, Xueli Song, Li Liu, Wenxiao Dong, Sinan Wang, Mengque Xu, Cheng Yang, Bangmao Wang, Hailong Cao

J Cell Mol Med. 2020 Feb; 24(4): 2648–2662. Published online 2020 Jan 19. doi: 10.1111/jcmm.14984

PMCID:: PMC7028862

Abstract Article PDF–3.7M

Select item 64867179.

Structural basis for ligand modulation of the CCR2 conformational landscape

Bryn C. Taylor, Christopher T. Lee, Rommie E. Amaro

Proc Natl Acad Sci U S A. 2019 Apr 23; 116(17): 8131–8136. Published online 2019 Apr 11. doi: 10.1073/pnas.1814131116

PMCID:: PMC6486717

Abstract Article PDF–1.0M

Select item 645017010.

In silico Analyses of Skin and Peripheral Blood Transcriptional Data in Cutaneous Lupus Reveals CCR2-A Novel Potential Therapeutic Target

Rama Dey-Rao, Animesh A. Sinha

Front Immunol. 2019; 10: 640. Published online 2019 Mar 29. doi: 10.3389/fimmu.2019.00640

PMCID:: PMC6450170

Abstract Article PDF–4.6M

Select item 635996111.

CCR2 chemokine receptors enhance growth and cell cycle progression of breast cancer cells through SRC and PKC activation

Min Yao, Wei Fang, Curtis Smart, Qingting Hu, Shixia Huang, Nehemiah Alvarez, Patrick Fields, Nikki Cheng

Mol Cancer Res. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Mol Cancer Res. 2019 Feb; 17(2): 604–617. Published online 2018 Nov 16. doi: 10.1158/1541-7786.MCR-18-0750

PMCID:: PMC6359961

Abstract Article PDF–1.2M

Select item 597723212.

Upregulation of the Chemokine Receptor CCR2B in Epstein‒Barr Virus-Positive Burkitt Lymphoma Cell Lines with the Latency III Program

Svetlana Kozireva, Zhanna Rudevica, Mikhail Baryshev, Ainars Leonciks, Elena Kashuba, Irina Kholodnyuk

Viruses. 2018 May; 10(5): 239. Published online 2018 May 3. doi: 10.3390/v10050239

PMCID:: PMC5977232

Abstract Article PDF–2.7M

Select item 540728513.

Phase 1b study targeting tumour associated macrophages with CCR2 inhibition plus FOLFIRINOX in locally advanced and borderline resectable pancreatic cancer

Timothy M Nywening, Andrea Wang-Gillam, Dominic E Sanford, Brian A Belt, Roheena Z Panni, Brian M Cusworth, Adetunji T Toriola, Rebecca K Nieman, Lori A Worley, Motoyo Yano, Kathryn J Fowler, A Craig Lockhart, Rama Suresh, Benjamin R Tan, Kian-Huat Lim, Ryan C Fields, Prof Steven M Strasberg, Prof William G Hawkins, David G DeNardo, S Peter Goedegebuure, Prof David C Linehan

Lancet Oncol. Author manuscript; available in PMC 2017 Apr 27.

Published in final edited form as: Lancet Oncol. 2016 May; 17(5): 651–662. Published online 2016 Apr 4. doi: 10.1016/S1470-2045(16)00078-4

PMCID:: PMC5407285

Abstract Article PDF–1.0M

Select item 515919114.

Structure of CC Chemokine Receptor 2 with Orthosteric and Allosteric Antagonists

Yi Zheng, Ling Qin, Natalia V. Ortiz Zacarías, Henk de Vries, Gye Won Han, Martin Gustavsson, Marta Dabros, Chunxia Zhao, Robert J. Cherney, Percy Carter, Dean Stamos, Ruben Abagyan, Vadim Cherezov, Raymond C. Stevens, Adriaan P. IJzerman, Laura H. Heitman, Andrew Tebben, Irina Kufareva, Tracy M. Handel

Nature. Author manuscript; available in PMC 2017 Jun 7.

Published in final edited form as: Nature. 2016 Dec 15; 540(7633): 458–461. Published online 2016 Dec 7. doi: 10.1038/nature20605

PMCID:: PMC5159191

Abstract Article PDF–2.9M

Select item 502967315.

High expression of C-C chemokine receptor 2 associates with poor overall survival in gastric cancer patients after surgical resection

Ruochen Li, Heng Zhang, Hao Liu, Chao Lin, Yifan Cao, Weijuan Zhang, Zhenbin Shen, Jiejie Xu

Oncotarget. 2016 Apr 26; 7(17): 23909–23918. Published online 2016 Mar 14. doi: 10.18632/oncotarget.8069

PMCID:: PMC5029673

Abstract Article PDF–2.7M

Select item 453772716.

Chemokine Coreceptor-2 Gene Polymorphisms among HIV-1 Infected Individuals in Kenya

Dorcas Wachira, Raphael Lihana, Vincent Okoth, Alex Maiyo, Samoel Ashimosi Khamadi

Dis Markers. 2015; 2015: 952067. Published online 2015 Aug 2. doi: 10.1155/2015/952067

PMCID:: PMC4537727

Abstract Article PDF–476K

Select item 423906517.

Increased C-C Chemokine Receptor 2 Gene Expression in Monocytes of Severe Obstructive Sleep Apnea Patients and under Intermittent Hypoxia

Li-Pang Chuang, Ning-Hung Chen, Shih-Wei Lin, Ying-Ling Chang, Hsiang-Ruei Liao, Yu-Sheng Lin, I-Ju Chao, Yuling Lin, Jong-Hwei S. Pang

PLoS One. 2014; 9(11): e113304. Published online 2014 Nov 20. doi: 10.1371/journal.pone.0113304

PMCID:: PMC4239065

Abstract Article PDF–6.0M

Select item 415867418.

Role of CCR2 in inflammatory conditions of the central nervous system

Hannah X Chu, Thiruma V Arumugam, Mathias Gelderblom, Tim Magnus, Grant R Drummond, Christopher G Sobey

J Cereb Blood Flow Metab. 2014 Sep; 34(9): 1425–1429. Published online 2014 Jul 2. doi: 10.1038/jcbfm.2014.120

PMCID:: PMC4158674

Abstract Article PDF–258K

Select item 400969919.

Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration

Jérôme Moreaux, Dirk Hose, Alboukadel Kassambara, Thierry Rème, Philippe Moine, Guilhem Requirand, Hartmut Goldschmidt, Bernard Klein

Blood. Author manuscript; available in PMC 2014 May 6.

Published in final edited form as: Blood. 2011 Jan; 117(4): 1280–1290. Published online 2010 Nov 19. doi: 10.1182/blood-2010-04-279760

PMCID:: PMC4009699

Abstract Article

Select item 388621920.

Investigation of Chemokine Receptor CCR2V64Il Gene Polymorphism and Migraine without Aura in the Iranian Population

Alireza Zandifar, Maryam Taheriun, Samira Soleimani, Faraidoon Haghdoost, Mohamadhasan Tajaddini, Shaghayegh Haghjooy Javanmard

ScientificWorldJournal. 2013; 2013: 836309. Published online 2013 Dec 25. doi: 10.1155/2013/836309

PMCID:: PMC3886219

Abstract Article PDF–484K

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