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Items: 1 to 20 of 125

1.
Uracil-DNA glycosylase efficiency is modulated by substrate rigidity
Paul B. Orndorff, Souvik Poddar, Aerial M. Owens, Nikita Kumari, Bryan T. Ugaz, Samrat Amin, Wade D. Van Horn, Arjan van der Vaart, Marcia Levitus
Sci Rep. 2023; 13: 3915. Published online 2023 Mar 8. doi: 10.1038/s41598-023-30620-0
PMCID:
PMC9995336
AbstractArticlePDF–3.2M
2.
DR0022 from Deinococcus radiodurans is an acid uracil‐DNA glycosylase
Jing Li, Ye Yang, Chenyan Chang, Weiguo Cao
FEBS J. 2022 Oct; 289(20): 6420–6434. Published online 2022 Jun 22. doi: 10.1111/febs.16533
PMCID:
PMC9796141
AbstractArticlePDF–3.2M
3.
The N-Terminal Domain of Uracil-DNA Glycosylase: Roles for Disordered Regions
Jacob L. Perkins, Linlin Zhao
DNA Repair (Amst) Author manuscript; available in PMC 2022 May 1.
Published in final edited form as: DNA Repair (Amst). 2021 May; 101: 103077. Published online 2021 Feb 18. doi: 10.1016/j.dnarep.2021.103077
PMCID:
PMC8026556
AbstractArticlePDF–845K
4.
Macromolecular crowding induces compaction and DNA binding in the disordered N-terminal domain of hUNG2
Gaddiel Rodriguez, Benjamin Orris, Ananya Majumdar, Shridhar Bhat, James T. Stivers
DNA Repair (Amst) Author manuscript; available in PMC 2021 Feb 1.
Published in final edited form as: DNA Repair (Amst). 2020 Feb; 86: 102764. Published online 2019 Dec 10. doi: 10.1016/j.dnarep.2019.102764
PMCID:
PMC6990647
AbstractArticlePDF–814K
5.
Genetic polymorphism (rs246079) of the DNA repair gene uracil N-glycosylase is associated with increased risk of cervical carcinoma in a Chinese population
Feng Ye, Hanzhi Wang, Jia Liu, Qi Cheng, Xiaojing Chen, Huaizeng Chen
Medicine (Baltimore) 2018 Dec; 97(51): e13694. Published online 2018 Dec 21. doi: 10.1097/MD.0000000000013694
PMCID:
PMC6319868
AbstractArticlePDF–221K
6.
N-terminal domain of human uracil DNA glycosylase (hUNG2) promotes targeting to uracil sites adjacent to ssDNA–dsDNA junctions
Brian P Weiser, Gaddiel Rodriguez, Philip A Cole, James T Stivers
Nucleic Acids Res. 2018 Aug 21; 46(14): 7169–7178. Published online 2018 Jun 18. doi: 10.1093/nar/gky525
PMCID:
PMC6101581
AbstractArticlePDF–5.3M
7.
Measurement of nanoscale DNA translocation by uracil DNA glycosylase in human cells
Alexandre Esadze, Gaddiel Rodriguez, Brian P. Weiser, Philip A. Cole, James T. Stivers
Nucleic Acids Res. 2017 Dec 1; 45(21): 12413–12424. Published online 2017 Sep 25. doi: 10.1093/nar/gkx848
PMCID:
PMC5716149
AbstractArticlePDF–3.4M
8.
Disordered N–Terminal Domain of Human Uracil DNA Glycosylase (hUNG2) Enhances DNA Translocation
Gaddiel Rodriguez, Alexandre Esadze, Brian P. Weiser, Joseph D. Schonhoft, Philip A. Cole, James T. Stivers
ACS Chem Biol. Author manuscript; available in PMC 2018 Sep 15.
Published in final edited form as: ACS Chem Biol. 2017 Sep 15; 12(9): 2260–2263. Published online 2017 Aug 15. doi: 10.1021/acschembio.7b00521
PMCID:
PMC5600714
AbstractArticlePDF–1.0M
9.
Inhibition of uracil DNA glycosylase sensitizes cancer cells to 5-fluorodeoxyuridine through replication fork collapse-induced DNA damage
Yan Yan, Xiangzi Han, Yulan Qing, Allison G. Condie, Shashank Gorityala, Shuming Yang, Yan Xu, Youwei Zhang, Stanton L. Gerson
Oncotarget. 2016 Sep 13; 7(37): 59299–59313. Published online 2016 Aug 9. doi: 10.18632/oncotarget.11151
PMCID:
PMC5312313
AbstractArticlePDF–2.5M
10.
G-quadruplex DNA structures can interfere with uracil glycosylase activity in vitro
Nate W. Holton, Erik D. Larson
Mutagenesis. 2016 Jul; 31(4): 385–392. Published online 2015 Dec 14. doi: 10.1093/mutage/gev083
PMCID:
PMC4916999
AbstractArticlePDF–1.4M
11.
Electrostatic Properties of Complexes along a DNA Glycosylase Damage Search Pathway
Shannen L. Cravens, Matthew Hobson, James T. Stivers
Biochemistry. 2014 Dec 9; 53(48): 7680–7692. Published online 2014 Nov 19. doi: 10.1021/bi501011m
PMCID:
PMC4263432
AbstractArticlePDF–1.5M
12.
Uracil DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed
Lachelle D. Weeks, Pingfu Fu, Stanton L. Gerson
Mol Cancer Ther. Author manuscript; available in PMC 2014 Oct 19.
Published in final edited form as: Mol Cancer Ther. 2013 Oct; 12(10): 2248–2260. Published online 2013 Jul 19. doi: 10.1158/1535-7163.MCT-13-0172
PMCID:
PMC4201938
AbstractArticlePDF–1.6M
13.
Excision of Uracil from Transcribed DNA Negatively Affects Gene Expression
Bork Lühnsdorf, Bernd Epe, Andriy Khobta
J Biol Chem. 2014 Aug 8; 289(32): 22008–22018. Published online 2014 Jun 20. doi: 10.1074/jbc.M113.521807
PMCID:
PMC4139217
AbstractArticlePDF–2.3M
14.
DNA Translocation by Human Uracil DNA Glycosylase: The Case of ssDNA and Clustered Uracils
Joseph D. Schonhoft, James T. Stivers
Biochemistry. Author manuscript; available in PMC 2014 Apr 16.
Published in final edited form as: Biochemistry. 2013 Apr 16; 52(15): 2536–2544. Published online 2013 Apr 2. doi: 10.1021/bi301562n
PMCID:
PMC3634584
AbstractArticlePDF–1.4M
15.
DNA Translocation by Human Uracil DNA Glycosylase: Role of DNA Phosphate Charge
Joseph D. Schonhoft, John Kosowicz, James T. Stivers
Biochemistry. Author manuscript; available in PMC 2014 Apr 16.
Published in final edited form as: Biochemistry. 2013 Apr 16; 52(15): 2526–2535. Published online 2013 Apr 2. doi: 10.1021/bi301561d
Correction in:
Biochemistry. 2013 Nov 14; 52(47): 8599.
PMCID:
PMC3628972
AbstractArticlePDF–787K
16.
Cosolute Paramagnetic Relaxation Enhancements Detect Transient Conformations of Human Uracil DNA Glycosylase (hUNG)
Yan Sun, Joshua I. Friedman, James T. Stivers
Biochemistry. Author manuscript; available in PMC 2012 Dec 13.
Published in final edited form as: Biochemistry. 2011 Dec 13; 50(49): 10724–10731. Published online 2011 Nov 15. doi: 10.1021/bi201572g
PMCID:
PMC3232301
AbstractArticlePDF–1.0M
17.
Mutational Analysis of Arginine 276 in the Leucine-loop of Human Uracil-DNA Glycosylase
Cheng-Yao Chen, Dale W. Mosbaugh, Samuel E. Bennett
J Biol Chem. Author manuscript; available in PMC 2011 Feb 17.
Published in final edited form as: J Biol Chem. 2004 Nov 12; 279(46): 48177–48188. Published online 2004 Aug 31. doi: 10.1074/jbc.M407836200
PMCID:
PMC3040516
AbstractArticlePDF–1.0M
18.
Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase
Cheng-Yao Chen, Dale W. Mosbaugh, Samuel E. Bennett
DNA Repair (Amst) Author manuscript; available in PMC 2011 Feb 16.
Published in final edited form as: DNA Repair (Amst). 2005 Jul 12; 4(7): 793–805. doi: 10.1016/j.dnarep.2005.04.019
PMCID:
PMC3039872
AbstractArticlePDF–1.3M
19.
X4 and R5 HIV-1 Have Distinct Post-entry Requirements for Uracil DNA Glycosylase during Infection of Primary Cells
Kate L. Jones, Michael Roche, Michael P. Gantier, Nasim A. Begum, Tasuku Honjo, Salvatore Caradonna, Bryan R. G. Williams, Johnson Mak
J Biol Chem. 2010 Jun 11; 285(24): 18603–18614. Published online 2010 Apr 6. doi: 10.1074/jbc.M109.090126
PMCID:
PMC2881786
AbstractArticlePDF–1.0M
20.
Rotational dynamics of DNA on the nucleosome surface markedly impact accessibility to a DNA repair enzyme
John M. Hinz, Yesenia Rodriguez, Michael J. Smerdon
Proc Natl Acad Sci U S A. 2010 Mar 9; 107(10): 4646–4651. Published online 2010 Feb 22. doi: 10.1073/pnas.0914443107
PMCID:
PMC2842065
AbstractArticlePDF–232K

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