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Select item 110849571.

VRK1 Regulates Sensitivity to Oxidative Stress by Altering Histone Epigenetic Modifications and the Nuclear Phosphoproteome in Tumor Cells

Elena Navarro-Carrasco, Eva Monte-Serrano, Aurora Campos-Díaz, Frank Rolfs, Richard de Goeij-de Haas, Thang V. Pham, Sander R. Piersma, Paula González-Alonso, Connie R. Jiménez, Pedro A. Lazo

Int J Mol Sci. 2024 May; 25(9): 4874. Published online 2024 Apr 30. doi: 10.3390/ijms25094874

PMCID:: PMC11084957

Abstract Article PDF–4.6M

Select item 104033282.

Downregulation of VRK1 Inhibits Progression of Lung Squamous Cell Carcinoma through DNA Damage

Ning Du, Boxiang Zhang, Yunfeng Zhang

Can Respir J. 2023; 2023: 4533504. Published online 2023 Jul 28. doi: 10.1155/2023/4533504

PMCID:: PMC10403328

Abstract Article PDF–2.9M

Select item 96271323.

VRK1 Is a Synthetic–Lethal Target in VRK2-Deficient Glioblastoma

Julie A. Shields, Samuel R. Meier, Madhavi Bandi, Erin E. Mulkearns-Hubert, Nicole Hajdari, Maria Dam Ferdinez, Justin L. Engel, Daniel J. Silver, Binzhang Shen, Wenhai Zhang, Christopher G. Hubert, Kelly Mitchell, Sajina Shakya, Shan-Chuan Zhao, Alborz Bejnood, Minjie Zhang, Robert Tjin Tham Sjin, Erik Wilker, Justin D. Lathia, Jannik N. Andersen, Yingnan Chen, Fang Li, Barbara Weber, Alan Huang, Natasha Emmanuel

Cancer Res. 2022 Nov 2; 82(21): 4044–4057. Published online 2022 Sep 7. doi: 10.1158/0008-5472.CAN-21-4443

PMCID:: PMC9627132

Abstract Article PDF–2.1M

Select item 94911254.

Expression of vaccinia-related kinase 1 (VRK1) accelerates cell proliferation but overcomes cell adhesion mediated drug resistance (CAM-DR) in multiple myeloma

Jing Liu, Yuchan Wang, Song He, Xiaohong Xu, Yuejiao Huang, Jie Tang, Yaxun Wu, Xiaobing Miao, Yunhua He, Qiru Wang, Li Liang, Chun Cheng

Hematology. 2016; 21(10): 603–612. Published online 2016 Jun 18. doi: 10.1080/10245332.2016.1147678

PMCID:: PMC9491125

Abstract Article PDF–1.1M

Select item 91756225.

Dysregulation of Cellular VRK1, BAF, and Innate Immune Signaling by the Vaccinia Virus B12 Pseudokinase

Alexandria C. Linville, Amber B. Rico, Helena Teague, Lucy E. Binsted, Geoffrey L. Smith, Jonas D. Albarnaz, Matthew S. Wiebe

J Virol. 2022 Jun; 96(11): e00398-22. Published online 2022 May 11. doi: 10.1128/jvi.00398-22

PMCID:: PMC9175622

Abstract Article PDF–6.2M

Select item 91525806.

Inhibition of VRK1 suppresses proliferation and migration of vascular smooth muscle cells and intima hyperplasia after injury via mTORC1/β-catenin axis

Xiongshan Sun, Weiwei Zhao, Qiang Wang, Jiaqi Zhao, Dachun Yang, Yongjian Yang

BMB Rep. 2022 May 31; 55(5): 244–249. Published online 2022 May 31. doi: 10.5483/BMBRep.2022.55.5.019

PMCID:: PMC9152580

Abstract Article PDF–3.6M

Select item 71980457.

Phosphorylation of vaccinia-related kinase 1 at threonine 386 transduces glucose stress signal in human liver cells

Kosuke Yokobori, Yuu Miyauchi, Jason G. Williams, Masahiko Negishi

Biosci Rep. 2020 Apr 30; 40(4): BSR20200498. Published online 2020 Apr 23. doi: 10.1042/BSR20200498

PMCID:: PMC7198045

Abstract Article PDF–1.4M

Select item 68566208.

Motor neuron diseases caused by a novel VRK1 variant – A genotype/phenotype study

Maryam Sedghi, Ali‐Reza Moslemi, Montse Olive, Masoud Etemadifar, Behnaz Ansari, Jafar Nasiri, Leila Emrahi, Hamid‐Reza Mianesaz, Nigel G. Laing, Homa Tajsharghi

Ann Clin Transl Neurol. 2019 Nov; 6(11): 2197–2204. Published online 2019 Sep 27. doi: 10.1002/acn3.50912

PMCID:: PMC6856620

Abstract Article PDF–1.9M

Select item 67467219.

VRK1 functional insufficiency due to alterations in protein stability or kinase activity of human VRK1 pathogenic variants implicated in neuromotor syndromes

Elena Martín-Doncel, Ana M. Rojas, Lara Cantarero, Pedro A. Lazo

Sci Rep. 2019; 9: 13381. Published online 2019 Sep 16. doi: 10.1038/s41598-019-49821-7

PMCID:: PMC6746721

Abstract Article PDF–2.8M

Select item 637121110.

Crystal structure of human vaccinia‐related kinase 1 in complex with AMP‐PNP, a non‐hydrolyzable ATP analog

Yeen Shian Ngow, Sreekanth Rajan, Hong Ye, Ho Sup Yoon

Protein Sci. 2019 Mar; 28(3): 524–532. Published online 2018 Dec 20. doi: 10.1002/pro.3552

PMCID:: PMC6371211

Abstract Article PDF–1.4M

Select item 612282011.

Overexpression of the VRK1 kinase, which is associated with breast cancer, induces a mesenchymal to epithelial transition in mammary epithelial cells

Aye M. Mon, A. Craig MacKinnon, Jr., Paula Traktman

PLoS One. 2018; 13(9): e0203397. Published online 2018 Sep 4. doi: 10.1371/journal.pone.0203397

Correction in:: PLoS One. 2024; 19(7): e0307693.

PMCID:: PMC6122820

Abstract Article PDF–10M

Select item 474578612.

Namgyu Lee, Jung-Hee Kwon, Young Bae Kim, Seong-Hoon Kim, Sung Jin Park, Weiguang Xu, Hoe-Yune Jung, Kyong-Tai Kim, Hee Jung Wang, Kwan Yong Choi

Oncotarget. 2015 Oct 6; 6(30): 30130–30148. Published online 2015 Sep 7. doi: 10.18632/oncotarget.4967

PMCID:: PMC4745786

Abstract Article PDF–7.7M

Select item 403929113.

Mutations in VRK1 Associated With Complex Motor and Sensory Axonal Neuropathy Plus Microcephaly

Claudia Gonzaga-Jauregui, Timothy Lotze, Leila Jamal, Samantha Penney, Ian M. Campbell, Davut Pehlivan, Jill V. Hunter, Suzanne L. Woodbury, Gerald Raymond, Adekunle M. Adesina, Shalini N. Jhangiani, Jeffrey G. Reid, Donna M. Muzny, Eric Boerwinkle, James R. Lupski, Richard A. Gibbs, Wojciech Wiszniewski

JAMA Neurol. Author manuscript; available in PMC 2014 May 30.

Published in final edited form as: JAMA Neurol. 2013 Dec; 70(12): 1491–1498. doi: 10.1001/jamaneurol.2013.4598

PMCID:: PMC4039291

Abstract Article PDF–1.1M

Select item 403912414.

Marcella Salzano, Marta Vázquez-Cedeira, Marta Sanz-García, Alberto Valbuena, Sandra Blanco, Isabel F. Fernández, Pedro A. Lazo

Oncotarget. 2014 Apr; 5(7): 1770–1778. Published online 2014 Jan 17. doi: 10.18632/oncotarget.1678

PMCID:: PMC4039124

Abstract Article PDF–1.0M

Select item 272526615.

Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Is Caused by a Mutation in the VRK1 Gene

Paul Renbaum, Efrat Kellerman, Ranit Jaron, Dan Geiger, Reeval Segel, Ming Lee, Mary Claire King, Ephrat Levy-Lahad

Am J Hum Genet. 2009 Aug 14; 85(2): 281–289. doi: 10.1016/j.ajhg.2009.07.006

PMCID:: PMC2725266

Abstract Article PDF–1.3M

Select item 224166916.

Human VRK1 Is an Early Response Gene and Its Loss Causes a Block in Cell Cycle Progression

Alberto Valbuena, Inmaculada López-Sánchez, Pedro A. Lazo

PLoS One. 2008; 3(2): e1642. Published online 2008 Feb 20. doi: 10.1371/journal.pone.0001642

PMCID:: PMC2241669

Abstract Article PDF–590K

Select item 967547017.

VRK1 as a synthetic lethal target in VRK2 promoter–methylated cancers of the nervous system

Jonathan So, Nathaniel W. Mabe, Bernhard Englinger, Kin-Hoe Chow, Sydney M. Moyer, Smitha Yerrum, Maria C. Trissal, Joana G. Marques, Jason J. Kwon, Brian Shim, Sangita Pal, Eshini Panditharatna, Thomas Quinn, Daniel A. Schaefer, Daeun Jeong, David L. Mayhew, Justin Hwang, Rameen Beroukhim, Keith L. Ligon, Kimberly Stegmaier, Mariella G. Filbin, William C. Hahn

JCI Insight. 2022 Oct 10; 7(19): e158755. Published online 2022 Oct 10. doi: 10.1172/jci.insight.158755

PMCID:: PMC9675470

Abstract Article PDF–15M

Select item 819712618.

HNRNP A1 Promotes Lung Cancer Cell Proliferation by Modulating VRK1 Translation

Hye Guk Ryu, Youngseob Jung, Namgyu Lee, Ji-Young Seo, Sung Wook Kim, Kyung-Ha Lee, Do-Yeon Kim, Kyong-Tai Kim

Int J Mol Sci. 2021 Jun; 22(11): 5506. Published online 2021 May 23. doi: 10.3390/ijms22115506

PMCID:: PMC8197126

Abstract Article PDF–2.9M

Select item 660553319.

The Spinal Muscular Atrophy with Pontocerebellar Hypoplasia Gene VRK1 Regulates Neuronal Migration through an Amyloid-β Precursor Protein-Dependent Mechanism

Hadar Vinograd-Byk, Tamar Sapir, Lara Cantarero, Pedro A. Lazo, Sharon Zeligson, Dorit Lev, Tally Lerman-Sagie, Paul Renbaum, Orly Reiner, Ephrat Levy-Lahad

J Neurosci. 2015 Jan 21; 35(3): 936–942. doi: 10.1523/JNEUROSCI.1998-14.2015

PMCID:: PMC6605533

Abstract Article PDF–1.8M

Select item 554878320.

Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations

Rafael M. Couñago, Charles K. Allerston, Pavel Savitsky, Hatylas Azevedo, Paulo H. Godoi, Carrow I. Wells, Alessandra Mascarello, Fernando H. de Souza Gama, Katlin B. Massirer, William J. Zuercher, Cristiano R. W. Guimarães, Opher Gileadi

Sci Rep. 2017; 7: 7501. Published online 2017 Aug 8. doi: 10.1038/s41598-017-07755-y

PMCID:: PMC5548783

Abstract Article PDF–4.6M

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