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Select item 101961481.

Restoration of coronary microvascular function by OGA overexpression in a high-fat diet with low-dose streptozotocin-induced type 2 diabetic mice

Jody Tori Cabrera, Rui Si, Atsumi Tsuji-Hosokawa, Hua Cai, Jason X-J Yuan, Wolfgang H Dillmann, Ayako Makino

Diab Vasc Dis Res. 2023 May-Jun; 20(3): 14791641231173630. Published online 2023 May 15. doi: 10.1177/14791641231173630

PMCID:: PMC10196148

Abstract Article PDF–1.4M

Select item 96440302.

Pancreatic β-cell hyper-O-GlcNAcylation leads to impaired glucose homeostasis in vivo

Seokwon Jo, Samantha Pritchard, Alicia Wong, Nandini Avula, Ahmad Essawy, John Hanover, Emilyn U. Alejandro

Front Endocrinol (Lausanne) 2022; 13: 1040014. Published online 2022 Oct 26. doi: 10.3389/fendo.2022.1040014

PMCID:: PMC9644030

Abstract Article PDF–3.3M

Select item 78062313.

O-GlcNAcylation ameliorates the pathological manifestations of Alzheimer’s disease by inhibiting necroptosis

Jinsu Park, Hee-Jin Ha, Eun Seon Chung, Seung Hyun Baek, Yoonsuk Cho, Hark Kyun Kim, Jihoon Han, Jae Hoon Sul, Jeongmi Lee, Eunae Kim, Junsik Kim, Yong Ryoul Yang, Mikyoung Park, Sung Hyun Kim, Thiruma V. Arumugam, Hyemin Jang, Sang Won Seo, Pann-Ghill Suh, Dong-Gyu Jo

Sci Adv. 2021 Jan; 7(3): eabd3207. Published online 2021 Jan 13. doi: 10.1126/sciadv.abd3207

PMCID:: PMC7806231

Abstract Article PDF–6.0M

Select item 71816624.

Elevated O-GlcNAcylation induces an antidepressant-like phenotype and decreased inhibitory transmission in medial prefrontal cortex

Yoonjeong Cho, Hongik Hwang, Md. Ataur Rahman, ChiHye Chung, Hyewhon Rhim

Sci Rep. 2020; 10: 6924. Published online 2020 Apr 24. doi: 10.1038/s41598-020-63819-6

PMCID:: PMC7181662

Abstract Article PDF–4.7M

Select item 43581315.

Conditional Knock-out Reveals a Requirement for O-Linked N-Acetylglucosaminase (O-GlcNAcase) in Metabolic Homeostasis

Chithra Keembiyehetty, Dona C. Love, Katryn R. Harwood, Oksana Gavrilova, Marcella E. Comly, John A. Hanover

J Biol Chem. 2015 Mar 13; 290(11): 7097–7113. Published online 2015 Jan 16. doi: 10.1074/jbc.M114.617779

PMCID:: PMC4358131

Abstract Article PDF–3.1M

Select item 90109406.

Chronically Elevated O-GlcNAcylation Limits Nitric Oxide Production and Deregulates Specific Pro-Inflammatory Cytokines

Lara K. Abramowitz, John A. Hanover

Front Immunol. 2022; 13: 802336. Published online 2022 Apr 1. doi: 10.3389/fimmu.2022.802336

PMCID:: PMC9010940

Abstract Article PDF–1.9M

Select item 84580927.

Bacterial O-GlcNAcase genes abundance decreases in ulcerative colitis patients and its administration ameliorates colitis in mice

Xiaolong He, Jie Gao, Liang Peng, Tongtong Hu, Yu Wan, Meijuan Zhou, Peilin Zhen, Hong Cao

Gut. 2021 Oct; 70(10): 1872–1883. Published online 2020 Dec 12. doi: 10.1136/gutjnl-2020-322468

PMCID:: PMC8458092

Abstract Article PDF–14M

Select item 79884898.

Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

Villő Muha, Florence Authier, Zsombor Szoke-Kovacs, Sara Johnson, Jennifer Gallagher, Alison McNeilly, Rory J. McCrimmon, Lydia Teboul, Daan M.F. van Aalten

J Biol Chem. 2021 Jan-Jun; 296: 100439. Published online 2021 Feb 19. doi: 10.1016/j.jbc.2021.100439

PMCID:: PMC7988489

Abstract Article PDF–1.7M

Select item 77039249.

Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction

Sujith Dassanayaka, Kenneth R. Brittian, Bethany W. Long, Lauren A. Higgins, James A. Bradley, Timothy N. Audam, Andrea Jurkovic, Anna M. Gumpert, Linda T. Harrison, István Hartyánszky, Péter Perge, Béla Merkely, Tamás Radovits, John A. Hanover, Steven P. Jones

PLoS One. 2020; 15(11): e0242250. Published online 2020 Nov 30. doi: 10.1371/journal.pone.0242250

PMCID:: PMC7703924

Abstract Article PDF–2.1M

Select item 671581310.

Blocked O-GlcNAc cycling disrupts mouse hematopoeitic stem cell maintenance and early T cell development

Lara K. Abramowitz, Christelle Harly, Arundhoti Das, Avinash Bhandoola, John A. Hanover

Sci Rep. 2019; 9: 12569. Published online 2019 Aug 29. doi: 10.1038/s41598-019-48991-8

PMCID:: PMC6715813

Abstract Article PDF–3.8M

Select item 462893411.

O-GlcNAcase overexpression reverses coronary endothelial cell dysfunction in type 1 diabetic mice

Ayako Makino, Anzhi Dai, Ying Han, Katia D. Youssef, Weihua Wang, Reshma Donthamsetty, Brian T. Scott, Hong Wang, Wolfgang H. Dillmann

Am J Physiol Cell Physiol. 2015 Nov 1; 309(9): C593–C599. Published online 2015 Aug 12. doi: 10.1152/ajpcell.00069.2015

PMCID:: PMC4628934

Abstract Article

Select item 646252712.

Iron down-regulates leptin by suppressing protein O-GlcNAc modification in adipocytes, resulting in decreased levels of O-glycosylated CREB

Yan Gao, Jingfang Liu, Zhenzhong Bai, Sandy Sink, Chengyu Zhao, Felipe Ramos Lorenzo, Donald A. McClain

J Biol Chem. 2019 Apr 5; 294(14): 5487–5495. Published online 2019 Feb 1. doi: 10.1074/jbc.RA118.005183

PMCID:: PMC6462527

Abstract Article PDF–1.1M

Select item 758898213.

Involvement of NDPK-B in Glucose Metabolism-Mediated Endothelial Damage via Activation of the Hexosamine Biosynthesis Pathway and Suppression of O-GlcNAcase Activity

Anupriya Chatterjee, Rachana Eshwaran, Gernot Poschet, Santosh Lomada, Mahmoud Halawa, Kerstin Wilhelm, Martina Schmidt, Hans-Peter Hammes, Thomas Wieland, Yuxi Feng

Cells. 2020 Oct; 9(10): 2324. Published online 2020 Oct 19. doi: 10.3390/cells9102324

PMCID:: PMC7588982

Abstract Article PDF–3.1M

Select item 495704714.

O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the ^Aγ-Globin Promoter

Zhen Zhang, Flávia C. Costa, Ee Phie Tan, Nathan Bushue, Luciano DiTacchio, Catherine E. Costello, Mark E. McComb, Stephen A. Whelan, Kenneth R. Peterson, Chad Slawson

J Biol Chem. 2016 Jul 22; 291(30): 15628–15640. Published online 2016 May 26. doi: 10.1074/jbc.M116.721928

PMCID:: PMC4957047

Abstract Article PDF–1.9M

Select item 371543215.

FGF Signalling Regulates Chromatin Organisation during Neural Differentiation via Mechanisms that Can Be Uncoupled from Transcription

Nishal S. Patel, Muriel Rhinn, Claudia I. Semprich, Pamela A. Halley, Pascal Dollé, Wendy A. Bickmore, Kate G. Storey

PLoS Genet. 2013 Jul; 9(7): e1003614. Published online 2013 Jul 18. doi: 10.1371/journal.pgen.1003614

Correction in:: PLoS Genet. 2013 Aug; 9(8): 10.1371/annotation/c066bb84-13ea-4b36-a481-f149df8ce929.

PMCID:: PMC3715432

Abstract Article PDF–18M

Select item 469222716.

E2F1 Transcription Factor Regulates O-linked N-acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Expression

Senthilkumar Muthusamy, Kyung U. Hong, Sujith Dassanayaka, Tariq Hamid, Steven P. Jones

J Biol Chem. 2015 Dec 25; 290(52): 31013–31024. Published online 2015 Nov 2. doi: 10.1074/jbc.M115.677534

PMCID:: PMC4692227

Abstract Article PDF–2.0M

Select item 420798117.

MicroRNA-539 Is Up-regulated in Failing Heart, and Suppresses O-GlcNAcase Expression

Senthilkumar Muthusamy, Angelica M. DeMartino, Lewis J. Watson, Kenneth R. Brittian, Ayesha Zafir, Sujith Dassanayaka, Kyung U. Hong, Steven P. Jones

J Biol Chem. 2014 Oct 24; 289(43): 29665–29676. Published online 2014 Sep 2. doi: 10.1074/jbc.M114.578682

PMCID:: PMC4207981

Abstract Article PDF–3.2M

Select item 718226318.

O-linked β-N-acetylglucosamine transferase plays an essential role in heart development through regulating angiopoietin-1

Yongxin Mu, Houzhi Yu, Tongbin Wu, Jianlin Zhang, Sylvia M. Evans, Ju Chen

PLoS Genet. 2020 Apr; 16(4): e1008730. Published online 2020 Apr 6. doi: 10.1371/journal.pgen.1008730

PMCID:: PMC7182263

Abstract Article PDF–4.0M

Select item 43978319.

Genomic Analysis of Mouse Retinal Development

Seth Blackshaw, Sanjiv Harpavat, Jeff Trimarchi, Li Cai, Haiyan Huang, Winston P Kuo, Griffin Weber, Kyungjoon Lee, Rebecca E Fraioli, Seo-Hee Cho, Rachel Yung, Elizabeth Asch, Lucila Ohno-Machado, Wing H Wong, Constance L Cepko

PLoS Biol. 2004 Sep; 2(9): e247. Published online 2004 Jun 29. doi: 10.1371/journal.pbio.0020247