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Select item 108383721.

Beyond genetics: Deciphering the impact of missense variants in CAD deficiency

Francisco del Caño-Ochoa, Bobby G. Ng, Antonio Rubio-del-Campo, Sonal Mahajan, Matthew P. Wilson, Marçal Vilar, Daisy Rymen, Paula Sánchez-Pintos, Janna Kenny, Myriam Ley Martos, Teresa Campos, Saskia B. Wortmann, Hudson H. Freeze, Santiago Ramón-Maiques

J Inherit Metab Dis. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: J Inherit Metab Dis. 2023 Nov; 46(6): 1170–1185. Published online 2023 Sep 11. doi: 10.1002/jimd.12667

PMCID:: PMC10838372

Abstract Article PDF–1.6M

Select item 84429682.

Deciphering CAD: Structure and function of a mega‐enzymatic pyrimidine factory in health and disease

Francisco del Caño‐Ochoa, Santiago Ramón‐Maiques

Protein Sci. 2021 Oct; 30(10): 1995–2008. Published online 2021 Jul 22. doi: 10.1002/pro.4158

PMCID:: PMC8442968

Abstract Article PDF–4.3M

Select item 72909233.

The Cellular Protein CAD is Recruited into Ebola Virus Inclusion Bodies by the Nucleoprotein NP to Facilitate Genome Replication and Transcription

Janine Brandt, Lisa Wendt, Bianca S. Bodmer, Thomas C. Mettenleiter, Thomas Hoenen

Cells. 2020 May; 9(5): 1126. Published online 2020 May 1. doi: 10.3390/cells9051126

PMCID:: PMC7290923

Abstract Article PDF–8.9M

Select item 62957374.

Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD

Francisco del Caño-Ochoa, Araceli Grande-García, María Reverte-López, Marco D'Abramo, Santiago Ramón-Maiques

J Biol Chem. 2018 Dec 7; 293(49): 18903–18913. Published online 2018 Oct 12. doi: 10.1074/jbc.RA118.005494

PMCID:: PMC6295737

Abstract Article PDF–3.0M

Select item 56548435.

Charge neutralization in the active site of the catalytic trimer of aspartate transcarbamoylase promotes diverse structural changes

James A. Endrizzi, Peter T. Beernink

Protein Sci. 2017 Nov; 26(11): 2221–2228. Published online 2017 Sep 30. doi: 10.1002/pro.3277

PMCID:: PMC5654843

Abstract Article PDF–1.8M

Select item 38557366.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD

Alba Ruiz-Ramos, Nada Lallous, Araceli Grande-García, Santiago Ramón-Maiques

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Dec 1; 69(Pt 12): 1425–1430. Published online 2013 Nov 29. doi: 10.1107/S1744309113031114

PMCID:: PMC3855736

Abstract Article PDF–774K

Select item 35153777.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD

Nada Lallous, Araceli Grande-García, Rafael Molina, Santiago Ramón-Maiques

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Nov 1; 68(Pt 11): 1341–1345. Published online 2012 Oct 30. doi: 10.1107/S1744309112038857

PMCID:: PMC3515377

Abstract Article PDF–707K

Select item 12145518.

Transcriptional repression of human cad gene by hypoxia inducible factor-1α

Ko-Fan Chen, Yen-Yu Lai, H. Sunny Sun, Shaw-Jenq Tsai

Nucleic Acids Res. 2005; 33(16): 5190–5198. Published online 2005 Sep 9. doi: 10.1093/nar/gki839

PMCID:: PMC1214551

Abstract Article PDF–344K

Select item 3653029.

Transcriptional regulation of the human CAD gene during myeloid differentiation.

G N Rao, E S Buford, J N Davidson

Mol Cell Biol. 1987 May; 7(5): 1961–1966. doi: 10.1128/mcb.7.5.1961

PMCID:: PMC365302

Summary Page Browse PDF–1.3M

Select item 442495110.

Biallelic mutations in CAD, impair de novo pyrimidine biosynthesis and decrease glycosylation precursors

Bobby G. Ng, Lynne A. Wolfe, Mie Ichikawa, Thomas Markello, Miao He, Cynthia J. Tifft, William A. Gahl, Hudson H. Freeze

Hum Mol Genet. 2015 Jun 1; 24(11): 3050–3057. Published online 2015 Feb 12. doi: 10.1093/hmg/ddv057

PMCID:: PMC4424951

Abstract Article PDF–540K

Select item 363984611.

Association of CAD, a multifunctional protein involved in pyrimidine synthesis, with mLST8, a component of the mTOR complexes

Akio Nakashima, Ippei Kawanishi, Sumiko Eguchi, Eugene Hsin Yu, Satoshi Eguchi, Noriko Oshiro, Ken-ichi Yoshino, Ushio Kikkawa, Kazuyoshi Yonezawa

J Biomed Sci. 2013; 20(1): 24. Published online 2013 Apr 18. doi: 10.1186/1423-0127-20-24

PMCID:: PMC3639846

Abstract Article PDF–773K

Select item 429447712.

Rheb Protein Binds CAD (Carbamoyl-phosphate Synthetase 2, Aspartate Transcarbamoylase, and Dihydroorotase) Protein in a GTP- and Effector Domain-dependent Manner and Influences Its Cellular Localization and Carbamoyl-phosphate Synthetase (CPSase) Activity

Tatsuhiro Sato, Hitomi Akasu, Wataru Shimono, Chisa Matsu, Yuki Fujiwara, Yoshio Shibagaki, Jeffrey J. Heard, Fuyuhiko Tamanoi, Seisuke Hattori

J Biol Chem. 2015 Jan 9; 290(2): 1096–1105. Published online 2014 Nov 24. doi: 10.1074/jbc.M114.592402

PMCID:: PMC4294477

Abstract Article PDF–1.4M

Select item 55472513.

Phosphorylation and activation of hamster carbamyl phosphate synthetase II by cAMP-dependent protein kinase. A novel mechanism for regulation of pyrimidine nucleotide biosynthesis.

E A Carrey, D G Campbell, D G Hardie

EMBO J. 1985 Dec 30; 4(13B): 3735–3742. doi: 10.1002/j.1460-2075.1985.tb04142.x

PMCID:: PMC554725

Summary Page Browse PDF–1.6M

Select item 51606114.

The human Rad9 checkpoint protein stimulates the carbamoyl phosphate synthetase activity of the multifunctional protein CAD

Laura A. Lindsey-Boltz, Eric M. Wauson, Lee M. Graves, Aziz Sancar

Nucleic Acids Res. 2004; 32(15): 4524–4530. Published online 2004 Aug 23. doi: 10.1093/nar/gkh789

PMCID:: PMC516061

Abstract Article PDF–207K

Select item 10973515.

Adenovirus Preterminal Protein Binds to the CAD Enzyme at Active Sites of Viral DNA Replication on the Nuclear Matrix

Peter C. Angeletti, Jeffrey A. Engler

J Virol. 1998 Apr; 72(4): 2896–2904. doi: 10.1128/jvi.72.4.2896-2904.1998

PMCID:: PMC109735

Abstract Article PDF–1.3M

Select item 554305516.

Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression

Wendi Sun, Hiroyuki Kato, Shojiro Kitajima, Kian Leong Lee, Katarina Gradin, Takashi Okamoto, Lorenz Poellinger

Sci Rep. 2017; 7: 7190. Published online 2017 Aug 3. doi: 10.1038/s41598-017-05685-3

Correction in:: Sci Rep. 2018; 8: 11239.

PMCID:: PMC5543055

Abstract Article PDF–1.8M

Select item 293342417.

Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data

Peilin Jia, Lily Wang, Herbert Y Meltzer, Zhongming Zhao

Schizophr Res. Author manuscript; available in PMC 2011 Sep 1.

Published in final edited form as: Schizophr Res. 2010 Sep; 122(1-3): 38–42. Published online 2010 Jul 24. doi: 10.1016/j.schres.2010.07.001

PMCID:: PMC2933424

Abstract Article PDF–99K

Select item 20764718.

mSin3A/Histone Deacetylase 2- and PRMT5-Containing Brg1 Complex Is Involved in Transcriptional Repression of the Myc Target Gene cad

Sharmistha Pal, Romy Yun, Antara Datta, Lynne Lacomis, Hediye Erdjument-Bromage, Jitendra Kumar, Paul Tempst, Saïd Sif

Mol Cell Biol. 2003 Nov; 23(21): 7475–7487. doi: 10.1128/MCB.23.21.7475-7487.2003

PMCID:: PMC207647

Abstract Article PDF–559K

Select item 1006216519.

SARS-CoV-2 ORF8 Protein Induces Endoplasmic Reticulum Stress-like Responses and Facilitates Virus Replication by Triggering Calnexin: an Unbiased Study

Xuefeng Wang, Wenqi Wang, Tiecheng Wang, Jianzhong Wang, Yuhang Jiang, Xue Wang, Ze Qiu, Na Feng, Weiyang Sun, Chang Li, Songtao Yang, Xianzhu Xia, Hongbin He, Yuwei Gao

J Virol. 2023 Mar; 97(3): e00011-23. Published online 2023 Mar 6. doi: 10.1128/jvi.00011-23

PMCID:: PMC10062165

Abstract Article PDF–2.9M

Select item 618004120.

Post-translational modification of OCT4 in breast cancer tumorigenesis

Yunhee Cho, Hyeok Gu Kang, Seok-Jun Kim, Seul Lee, Sujin Jee, Sung Gwe Ahn, Min Jueng Kang, Joon Seon Song, Joon-Yong Chung, Eugene C. Yi, Kyung-Hee Chun

Cell Death Differ. 2018 Oct; 25(10): 1781–1795. Published online 2018 Mar 6. doi: 10.1038/s41418-018-0079-6