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Select item 93607871.

IRX3 plays an important role in the pathogenesis of metabolic-associated fatty liver disease by regulating hepatic lipid metabolism

Yongqiang Ma, Guangshun Chen, Junfang Yi, Qiang Li, Zhi Tan, Wenling Fan, Xiaohua Luo, Zhiyong He, Zhongzhou Si, Jiequn Li

Front Endocrinol (Lausanne) 2022; 13: 895593. Published online 2022 Jul 26. doi: 10.3389/fendo.2022.895593

PMCID:: PMC9360787

Abstract Article PDF–6.0M

Select item 63547012.

The partial inhibition of hypothalamic IRX3 exacerbates obesity

Thiago Matos de Araujo, Daniela S. Razolli, Felipe Correa-da-Silva, Jose C. de Lima-Junior, Rodrigo S. Gaspar, Davi Sidarta-Oliveira, Sheila C. Victorio, Jose Donato, Jr, Young-Bum Kim, Licio A. Velloso

EBioMedicine. 2019 Jan; 39: 448–460. Published online 2018 Dec 3. doi: 10.1016/j.ebiom.2018.11.048

PMCID:: PMC6354701

Abstract Article PDF–4.6M

Select item 43582673.

The Proangiogenic Effect of Iroquois Homeobox Transcription Factor Irx3 in Human Microvascular Endothelial Cells

Kisha Scarlett, Vaishnavi Pattabiraman, Petrina Barnett, Dong Liu, Leonard M. Anderson

J Biol Chem. 2015 Mar 6; 290(10): 6303–6315. Published online 2014 Dec 15. doi: 10.1074/jbc.M114.601146

PMCID:: PMC4358267

Abstract Article PDF–2.6M

Select item 96511684.

Interaction analysis of FTO and IRX3 genes with obesity and related metabolic disorders in an admixed Latin American population: a possible risk increases of body weight excess

María Stephany Ruiz-Díaz, Diana Mena-Yi, Doris Gómez-Camargo, Gustavo Mora-García

Colomb Med (Cali) 2022 Apr-Jun; 53(2): e2044874. Published online 2022 Jun 14. doi: 10.25100/cm.v53i2.4874

PMCID:: PMC9651168

Abstract Article PDF–744K

Select item 79882335.

IRX3 Overexpression Enhances Ucp1 Expression In Vivo

Zhiyin Zhang, Qihan Wu, Yang He, Peng Lu, Danjie Li, Minglan Yang, Weiqiong Gu, Ruixin Liu, Jie Hong, Jiqiu Wang

Front Endocrinol (Lausanne) 2021; 12: 634191. Published online 2021 Mar 10. doi: 10.3389/fendo.2021.634191

PMCID:: PMC7988233

Abstract Article PDF–3.0M

Select item 78036106.

Identification of Novel Genetic Variants Related to Trabecular Bone Score in Community-Dwelling Older Adults

Sung Hye Kong, Ji Won Yoon, Jung Hee Kim, JooYong Park, Jiyeob Choi, Ji Hyun Lee, A Ram Hong, Nam H. Cho, Chan Soo Shin

Endocrinol Metab (Seoul) 2020 Dec; 35(4): 801–810. Published online 2020 Nov 24. doi: 10.3803/EnM.2020.735

PMCID:: PMC7803610

Abstract Article PDF–676K

Select item 65348547.

Changes in FTO and IRX3 gene expression in obese and overweight male adolescents undergoing an intensive lifestyle intervention and the role of FTO genotype in this interaction

Saeid Doaei, Naser Kalantari, Pantea Izadi, Tuire Salonurmi, Alireza Mosavi Jarrahi, Shahram Rafieifar, Ghasem Azizi Tabesh, Ghazaleh Rahimzadeh, Maryam Gholamalizadeh, Mark O. Goodarzi

J Transl Med. 2019; 17: 176. Published online 2019 May 24. doi: 10.1186/s12967-019-1921-4

PMCID:: PMC6534854

Abstract Article PDF–836K

Select item 56520248.

IRX3 Promotes the Browning of White Adipocytes and Its Rare Variants are Associated with Human Obesity Risk

Yaoyu Zou, Peng Lu, Juan Shi, Wen Liu, Minglan Yang, Shaoqian Zhao, Na Chen, Maopei Chen, Yingkai Sun, Aibo Gao, Qingbo Chen, Zhiguo Zhang, Qinyun Ma, Tinglu Ning, Xiayang Ying, Jiabin Jin, Xiaxing Deng, Baiyong Shen, Yifei Zhang, Bo Yuan, Sophie Kauderer, Simin Liu, Jie Hong, Ruixin Liu, Guang Ning, Weiqing Wang, Weiqiong Gu, Jiqiu Wang

EBioMedicine. 2017 Oct; 24: 64–75. Published online 2017 Sep 13. doi: 10.1016/j.ebiom.2017.09.010

PMCID:: PMC5652024

Abstract Article PDF–1.3M

Select item 49992319.

FTO Obesity Risk Variants Are Linked to Adipocyte IRX3 Expression and BMI of Children - Relevance of FTO Variants to Defend Body Weight in Lean Children?

Kathrin Landgraf, Markus Scholz, Peter Kovacs, Wieland Kiess, Antje Körner

PLoS One. 2016; 11(8): e0161739. Published online 2016 Aug 25. doi: 10.1371/journal.pone.0161739

PMCID:: PMC4999231

Abstract Article PDF–854K

Select item 489207010.

Is fat mass & obesity-associated (FTO) gene master regulator of obesity ?

Balraj Mittal, Apurva Srivastava, Neena Srivastava

Indian J Med Res. 2016 Mar; 143(3): 264–266. doi: 10.4103/0971-5916.182614

PMCID:: PMC4892070

Article PDF–310K

Select item 895221011.

The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia

Stefan Nagel, Claudia Pommerenke, Corinna Meyer, Roderick A. F. MacLeod

Int J Mol Sci. 2022 Mar; 23(6): 3192. Published online 2022 Mar 16. doi: 10.3390/ijms23063192

PMCID:: PMC8952210

Abstract Article PDF–6.5M

Select item 735174612.

Associations of nicotidamide-N-methyltransferase, FTO, and IRX3 genetic variants with body mass index and resting energy expenditure in Mexican subjects

Maciel Bañales-Luna, Nicté Figueroa-Vega, Carolina Ivet Marín-Aragón, Elva Perez-Luque, Lorena Ibarra-Reynoso, Hugo L. Gallardo-Blanco, Itzel López-Aguilar, Juan Manuel Malacara

Sci Rep. 2020; 10: 11478. Published online 2020 Jul 10. doi: 10.1038/s41598-020-67832-7

PMCID:: PMC7351746

Abstract Article PDF–1.0M

Select item 838600313.

Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of IRX3 and IRX5

Débora R. Sobreira, Amelia C. Joslin, Qi Zhang, Iain Williamson, Grace T. Hansen, Kathryn M. Farris, Noboru J. Sakabe, Nasa Sinnott-Armstrong, Grazyna Bozek, Sharon O. Jensen-Cody, Kyle H. Flippo, Carole Ober, Wendy A. Bickmore, Matthew Potthoff, Mengjie Chen, Melina Claussnitzer, Ivy Aneas, Marcelo A. Nóbrega

Science. Author manuscript; available in PMC 2022 Jun 4.

Published in final edited form as: Science. 2021 Jun 4; 372(6546): 1085–1091. doi: 10.1126/science.abf1008

PMCID:: PMC8386003

Abstract Article PDF–1.3M

Select item 658817014.

The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis

Linda Holmquist Mengelbier, Simon Lindell‐Munther, Hiroaki Yasui, Caroline Jansson, Javanshir Esfandyari, Jenny Karlsson, Kimberly Lau, Chi‐chung Hui, Daniel Bexell, Sevan Hopyan, David Gisselsson

J Pathol. 2019 Jan; 247(1): 86–98. Published online 2018 Nov 29. doi: 10.1002/path.5171

PMCID:: PMC6588170

Abstract Article PDF–5.4M

Select item 495991115.

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

Melina Claussnitzer, Simon N. Dankel, Kyoung-Han Kim, Gerald Quon, Wouter Meuleman, Christine Haugen, Viktoria Glunk, Isabel S. Sousa, Jacqueline L. Beaudry, Vijitha Puviindran, Nezar A. Abdennur, Jannel Liu, Per-Arne Svensson, Yi-Hsiang Hsu, Daniel J. Drucker, Gunnar Mellgren, Chi-Chung Hui, Hans Hauner, Manolis Kellis

N Engl J Med. Author manuscript; available in PMC 2016 Jul 25.

Published in final edited form as: N Engl J Med. 2015 Sep 3; 373(10): 895–907. Published online 2015 Aug 19. doi: 10.1056/NEJMoa1502214

PMCID:: PMC4959911

Abstract Article PDF–1.9M

Select item 117037016.

Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification.

E J Bellefroid, A Kobbe, P Gruss, T Pieler, J B Gurdon, N Papalopulu

EMBO J. 1998 Jan 2; 17(1): 191–203. doi: 10.1093/emboj/17.1.191

PMCID:: PMC1170370

Summary PDF–834K

Select item 315817317.

Iroquois homeobox gene 3 establishes fast conduction in the cardiac His–Purkinje network

Shan-Shan Zhang, Kyoung-Han Kim, Anna Rosen, James W. Smyth, Rui Sakuma, Paul Delgado-Olguín, Mark Davis, Neil C. Chi, Vijitha Puviindran, Nathalie Gaborit, Tatyana Sukonnik, John N. Wylie, Koroboshka Brand-Arzamendi, Gerrie P. Farman, Jieun Kim, Robert A. Rose, Phillip A. Marsden, Yonghong Zhu, Yu-Qing Zhou, Lucile Miquerol, R. Mark Henkelman, Didier Y. R. Stainier, Robin M. Shaw, Chi-chung Hui, Benoit G. Bruneau, Peter H. Backx

Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33): 13576–13581. Published online 2011 Aug 8. doi: 10.1073/pnas.1106911108

PMCID:: PMC3158173

Abstract Article PDF–1.0M

Select item 411348418.

Obesity-associated variants within FTO form long-range functional connections with IRX3

Scott Smemo, Juan J. Tena, Kyoung-Han Kim, Eric R. Gamazon, Noboru J. Sakabe, Carlos Gómez-Marín, Ivy Aneas, Flavia L. Credidio, Débora R. Sobreira, Nora F. Wasserman, Ju Hee Lee, Vijitha Puviindran, Davis Tam, Michael Shen, Joe Eun Son, Niki Alizadeh Vakili, Hoon-Ki Sung, Silvia Naranjo, Rafael D. Acemel, Miguel Manzanares, Andras Nagy, Nancy J. Cox, Chi-Chung Hui, Jose Luis Gomez-Skarmeta, Marcelo A. Nóbrega

Nature. Author manuscript; available in PMC 2014 Sep 20.

Published in final edited form as: Nature. 2014 Mar 20; 507(7492): 371–375. Published online 2014 Mar 12. doi: 10.1038/nature13138

PMCID:: PMC4113484

Abstract Article PDF–3.7M

Select item 281894319.

Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3

Anja Ragvin, Enrico Moro, David Fredman, Pavla Navratilova, Øyvind Drivenes, Pär G. Engström, M. Eva Alonso, Elisa de la Calle Mustienes, José Luis Gómez Skarmeta, Maria J. Tavares, Fernando Casares, Miguel Manzanares, Veronica van Heyningen, Anders Molven, Pål R. Njølstad, Francesco Argenton, Boris Lenhard, Thomas S. Becker

Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2): 775–780. Published online 2009 Dec 22. doi: 10.1073/pnas.0911591107

Correction in:: Proc Natl Acad Sci U S A. 2011 Mar 8; 108(10): 4264.

PMCID:: PMC2818943

Abstract Article PDF–574K

Select item 320295920.

Genome-Wide Association Scan for Survival on Dialysis in African-Americans with Type 2 Diabetes

Mariana Murea, Lingyi Lu, Lijun Ma, Pamela J. Hicks, Jasmin Divers, Caitrin W. McDonough, Carl D. Langefeld, Donald W. Bowden, Barry I. Freedman

Am J Nephrol. 2011 Jun; 33(6): 502–509. Published online 2011 May 5. doi: 10.1159/000327985

PMCID:: PMC3202959

Abstract Article PDF–425K

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