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Select item 101533461.

Hanjuan Gong, Hailun Xie, Zhimin Huangfu, Shuxian Zhang, Yi Tang, Ming Xiao, Ming Li, Yalan Wang

FEBS Open Bio. 2023 May; 13(5): 881–897. Published online 2023 Apr 5. doi: 10.1002/2211-5463.13598

PMCID:: PMC10153346

Abstract Article PDF–5.3M

Select item 94823482.

iRhom2 regulates ERBB signalling to promote KRAS-driven tumour growth of lung cancer cells

Boris Sieber, Fangfang Lu, Stephen M. Stribbling, Adam G. Grieve, Anderson J. Ryan, Matthew Freeman

J Cell Sci. 2022 Sep 1; 135(17): jcs259949. Published online 2022 Sep 8. doi: 10.1242/jcs.259949

PMCID:: PMC9482348

Abstract Article

Select item 78783833.

The Threshold Effect: Lipopolysaccharide-Induced Inflammatory Responses in Primary Macrophages Are Differentially Regulated in an iRhom2-Dependent Manner

Joseph Skurski, Garima Dixit, Carl P. Blobel, Priya D. Issuree, Thorsten Maretzky

Front Cell Infect Microbiol. 2020; 10: 620392. Published online 2021 Jan 29. doi: 10.3389/fcimb.2020.620392

PMCID:: PMC7878383

Abstract Article PDF–3.0M

Select item 72398324.

iRhom2 in the pathogenesis of oral squamous cell carcinoma

Matthew E. Agwae, Richard J. Shaw, Asterios Triantafyllou, Frances S. T. Greaney, Khaled Ben Salah, Janet M. Risk

Mol Biol Rep. 2020; 47(5): 3987–3992. Published online 2020 Mar 31. doi: 10.1007/s11033-020-05381-y

PMCID:: PMC7239832

Abstract Article PDF–900K

Select item 64513685.

The molecular, cellular and pathophysiological roles of iRhom pseudoproteases

Iqbal Dulloo, Sonia Muliyil, Matthew Freeman

Open Biol. 2019 Mar; 9(3): 190003. Published online 2019 Mar 20. doi: 10.1098/rsob.190003

PMCID:: PMC6451368

Abstract Article PDF–960K

Select item 109910586.

iRhom2 regulates ectodomain shedding and surface expression of the major histocompatibility complex (MHC) class I

Matteo Calligaris, Donatella P. Spanò, Simone Bonelli, Stephan A. Müller, Claudia Carcione, Danilo D’apolito, Giandomenico Amico, Monica Miele, Mariangela Di Bella, Giovanni Zito, Elisa Nuti, Armando Rossello, Carl P. Blobel, Stefan F. Lichtenthaler, Simone D. Scilabra

Cell Mol Life Sci. 2024 Dec; 81(1): 163. Published online 2024 Apr 4. doi: 10.1007/s00018-024-05201-7

PMCID:: PMC10991058

Abstract Article PDF–5.6M

Select item 105586577.

Palmitoyltransferase ZDHHC3 Aggravates Nonalcoholic Steatohepatitis by Targeting S‐Palmitoylated IRHOM2

Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Yi Zhang, Fufeng Gao, Xianling Dai, Qin Kuang, Jie Chai, Benkui Zou, Bochu Wang

Adv Sci (Weinh) 2023 Oct; 10(28): 2302130. Published online 2023 Aug 6. doi: 10.1002/advs.202302130

Correction in:: Adv Sci (Weinh). 2023 Dec; 10(36): 2308024.

PMCID:: PMC10558657

Abstract Article PDF–8.2M

Select item 93173808.

Deficiency in Inactive Rhomboid Protein2 (iRhom2) Alleviates Alcoholic Liver Fibrosis by Suppressing Inflammation and Oxidative Stress

Yangwenshu Liu, Qin Kuang, Xianling Dai, Minxia Zhan, Li Zhou, Liancai Zhu, Bochu Wang

Int J Mol Sci. 2022 Jul; 23(14): 7701. Published online 2022 Jul 12. doi: 10.3390/ijms23147701

PMCID:: PMC9317380

Abstract Article PDF–6.2M

Select item 91082609.

Attenuation of Excess TNF-α Release in Crohn’s Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking

Taylor J. Louis, Ahmad Qasem, Saleh A. Naser

Front Immunol. 2022; 13: 887830. Published online 2022 May 2. doi: 10.3389/fimmu.2022.887830

PMCID:: PMC9108260

Abstract Article PDF–3.7M

Select item 868842010.

Inflammatory activation of surface molecule shedding by upregulation of the pseudoprotease iRhom2 in colon epithelial cells

Anja Adelina Giese, Aaron Babendreyer, Peter Krappen, Annika Gross, Pavel Strnad, Stefan Düsterhöft, Andreas Ludwig

Sci Rep. 2021; 11: 24230. Published online 2021 Dec 20. doi: 10.1038/s41598-021-03522-2

PMCID:: PMC8688420

Abstract Article PDF–2.3M

Select item 750328011.

The iRhom2/ADAM17 Axis Attenuates Bacterial Uptake by Phagocytes in a Cell Autonomous Manner

Anke Seifert, Justyna Wozniak, Stefan Düsterhöft, Petr Kasparek, Radislav Sedlacek, Stephan Dreschers, Thorsten W. Orlikowsky, Daniela Yildiz, Andreas Ludwig

Int J Mol Sci. 2020 Sep; 21(17): 5978. Published online 2020 Aug 19. doi: 10.3390/ijms21175978

PMCID:: PMC7503280

Abstract Article PDF–2.6M

Select item 690894012.

Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways

Qin Xu, Chuanben Chen, Bin Liu, Yibin Lin, Peng Zheng, Dongmei Zhou, Yunqing Xie, Ya Lin, Ciren Guo, Jing Liu, Li Li

Oncol Rep. 2020 Jan; 43(1): 41–54. Published online 2019 Oct 25. doi: 10.3892/or.2019.7389

PMCID:: PMC6908940

Abstract Article PDF–1011K

Select item 411048313.

iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function

Matthew A. Brooke, Sarah L. Etheridge, Nihal Kaplan, Charlotte Simpson, Edel A. O'Toole, Akemi Ishida-Yamamoto, Olivier Marches, Spiro Getsios, David P. Kelsell

Hum Mol Genet. 2014 Aug 1; 23(15): 4064–4076. Published online 2014 Mar 18. doi: 10.1093/hmg/ddu120

PMCID:: PMC4110483

Abstract Article PDF–1.4M

Select item 327666114.

RHBDF2 Mutations Are Associated with Tylosis, a Familial Esophageal Cancer Syndrome

Diana C. Blaydon, Sarah L. Etheridge, Janet M. Risk, Hans-Christian Hennies, Laura J. Gay, Rebecca Carroll, Vincent Plagnol, Fiona E. McRonald, Howard P. Stevens, Nigel K. Spurr, D. Timothy Bishop, Anthony Ellis, Janusz Jankowski, John K. Field, Irene M. Leigh, Andrew P. South, David P. Kelsell

Am J Hum Genet. 2012 Feb 10; 90(2): 340–346. doi: 10.1016/j.ajhg.2011.12.008

PMCID:: PMC3276661

Abstract Article PDF–1.3M

Select item 1003127915.

The deubiquitinating enzyme 13 retards non-alcoholic steatohepatitis via blocking inactive rhomboid protein 2-dependent pathway

Minxuan Xu, Jun Tan, Liancai Zhu, Chenxu Ge, Wei Dong, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Jing Feng, Bochu Wang

Acta Pharm Sin B. 2023 Mar; 13(3): 1071–1092. Published online 2022 Dec 12. doi: 10.1016/j.apsb.2022.12.006

PMCID:: PMC10031279

Abstract Article PDF–8.1M

Select item 720246616.

Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17

Sathish K. Maney, David R. McIlwain, Robin Polz, Aleksandra A. Pandyra, Balamurugan Sundaram, Dorit Wolff, Kazuhito Ohishi, Thorsten Maretzky, Matthew A. Brooke, Astrid Evers, Ananda A. Jaguva Vasudevan, Nima Aghaeepour, Jürgen Scheller, Carsten Münk, Dieter Häussinger, Tak W. Mak, Garry P. Nolan, David P. Kelsell, Carl P. Blobel, Karl S. Lang, Philipp A. Lang

Sci Signal. Author manuscript; available in PMC 2020 May 6.

Published in final edited form as: Sci Signal. 2015 Nov 3; 8(401): ra109. Published online 2015 Nov 3. doi: 10.1126/scisignal.aac5356

PMCID:: PMC7202466

Abstract Article PDF–1.2M

Select item 572234217.

iRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA

Wei-Wei Luo, Shu Li, Chen Li, Zhou-Qin Zheng, Pan Cao, Zhen Tong, Huan Lian, Su-Yun Wang, Hong-Bing Shu, Yan-Yi Wang

PLoS Pathog. 2017 Nov; 13(11): e1006693. Published online 2017 Nov 20. doi: 10.1371/journal.ppat.1006693

PMCID:: PMC5722342

Abstract Article PDF–8.3M

Select item 429279518.

Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci

PL De Jager, G Srivastava, K Lunnon, J Burgess, LC Schalkwyk, L Yu, ML Eaton, BT Keenan, J Ernst, C McCabe, A Tang, T Raj, J Replogle, W Brodeur, S Gabriel, HS Chai, C Younkin, SG Younkin, F Zou, M Szyf, CB Epstein, JA Schneider, BE Bernstein, A Meissner, N Ertekin-Taner, LB Chibnik, M Kellis, J Mill, DA Bennett

Nat Neurosci. Author manuscript; available in PMC 2015 Mar 1.

Published in final edited form as: Nat Neurosci. 2014 Sep; 17(9): 1156–1163. Published online 2014 Aug 17. doi: 10.1038/nn.3786

PMCID:: PMC4292795

Abstract Article PDF–1.3M

Select item 529015419.

Rhomboid family member 2 regulates cytoskeletal stress-associated Keratin 16

Thiviyani Maruthappu, Anissa Chikh, Benjamin Fell, Paul J. Delaney, Matthew A. Brooke, Clemence Levet, Angela Moncada-Pazos, Akemi Ishida-Yamamoto, Diana Blaydon, Ahmad Waseem, Irene M. Leigh, Matthew Freeman, David P. Kelsell

Nat Commun. 2017; 8: 14174. Published online 2017 Jan 27. doi: 10.1038/ncomms14174

PMCID:: PMC5290154

Abstract Article PDF–2.1M

Select item 888160920.

The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes

Minxuan Xu, Jun Tan, Wei Dong, Benkui Zou, Xuepeng Teng, Liancai Zhu, Chenxu Ge, Xianling Dai, Qin Kuang, Shaoyu Zhong, Lili Lai, Chao Yi, Tingting Tang, Junjie Zhao, Longyan Wang, Jin Liu, Hao Wei, Yan Sun, Qiufeng Yang, Qiang Li, Deshuai Lou, Linfeng Hu, Xi Liu, Gang Kuang, Jing Luo, Mingxin Xiong, Jing Feng, Chufeng Zhang, Bochu Wang

Nat Commun. 2022; 13: 1052. Published online 2022 Feb 25. doi: 10.1038/s41467-022-28641-w

PMCID:: PMC8881609

Abstract Article PDF–7.5M

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