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Select item 73780791.

A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases

Sven T. Sowa, Carlos Vela-Rodríguez, Albert Galera-Prat, Mariana Cázares-Olivera, Renata Prunskaite-Hyyryläinen, Alexander Ignatev, Lari Lehtiö

Sci Rep. 2020; 10: 12357. Published online 2020 Jul 23. doi: 10.1038/s41598-020-69229-y

PMCID:: PMC7378079

Abstract Article PDF–1.6M

Select item 110309282.

Human tankyrases are aberrantly expressed in colon tumors and contain multiple epitopes that induce humoral and cellular immune responses in cancer patients

Yuriy V. Shebzukhov, Inna N. Lavrik, Julia Karbach, Svetlana V. Khlgatian, Ekaterina P. Koroleva, Pavel V. Belousov, Kirill N. Kashkin, Alexander Knuth, Elke Jager, Nai-Wen Chi, Dmitry V. Kuprash, Sergei A. Nedospasov

Cancer Immunol Immunother. 2008 Jun; 57(6): 871–881. Published online 2007 Nov 20. doi: 10.1007/s00262-007-0423-z

PMCID:: PMC11030928

Abstract Article PDF–587K

Select item 88416333.

Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis

Min Wu, Zhibin Liu, Shaojun Zhang

Innate Immun. 2022 Jan; 28(1): 11–18. Published online 2021 Dec 3. doi: 10.1177/17534259211064285

PMCID:: PMC8841633

Abstract Article PDF–1.9M

Select item 82792554.

MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2

Gayan Bamunuarachchi, Xiaoyun Yang, Chaoqun Huang, Yurong Liang, Yujie Guo, Lin Liu

Cell Microbiol. Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Cell Microbiol. 2021 Feb; 23(2): e13281. Published online 2020 Nov 4. doi: 10.1111/cmi.13281

PMCID:: PMC8279255

Abstract Article PDF–989K

Select item 81941705.

Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease

Ming Li, Chen Lyu, Manyan Huang, Catherine Do, Benjamin Tycko, Philip J. Lupo, Stewart L. MacLeod, Christopher E. Randolph, Nianjun Liu, John S. Witte, Charlotte A. Hobbs

BMC Genom Data. 2021; 22: 20. Published online 2021 Jun 10. doi: 10.1186/s12863-021-00975-2

PMCID:: PMC8194170

Abstract Article PDF–960K

Select item 80452836.

MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2

Jing Li, Rubing Mo, Linmei Zheng

World J Surg Oncol. 2021; 19: 117. Published online 2021 Apr 13. doi: 10.1186/s12957-021-02226-1

Correction in:: World J Surg Oncol. 2023; 21: 346.

PMCID:: PMC8045283

Abstract Article PDF–2.2M

Select item 61320697.

Regulation of Tankyrase activity by a catalytic domain dimer interface

Chen Fan, Nageswari Yarravarapu, Hua Chen, Ozlem Kulak, Pranathi Dasari, Jeremiah Herbert, Kiyoshi Yamaguchi, Lawrence Lum, Xuewu Zhang

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Sep 10.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Sep 10; 503(3): 1780–1785. Published online 2018 Jul 26. doi: 10.1016/j.bbrc.2018.07.113

PMCID:: PMC6132069

Abstract Article PDF–1.0M

Select item 59642058.

Coupling bimolecular PARylation biosensors with genetic screens to identify PARylation targets

Dragomir B. Krastev, Stephen J. Pettitt, James Campbell, Feifei Song, Barbara E. Tanos, Stoyno S. Stoynov, Alan Ashworth, Christopher J. Lord

Nat Commun. 2018; 9: 2016. Published online 2018 May 22. doi: 10.1038/s41467-018-04466-4

PMCID:: PMC5964205

Abstract Article PDF–2.2M

Select item 57384419.

Whole proteome analysis of human tankyrase knockout cells reveals targets of tankyrase-mediated degradation

Amit Bhardwaj, Yanling Yang, Beatrix Ueberheide, Susan Smith

Nat Commun. 2017; 8: 2214. Published online 2017 Dec 20. doi: 10.1038/s41467-017-02363-w

PMCID:: PMC5738441

Abstract Article PDF–2.3M

Select item 498043310.

Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling

Laura Mariotti, Catherine M. Templeton, Michael Ranes, Patricia Paracuellos, Nora Cronin, Fabienne Beuron, Edward Morris, Sebastian Guettler

Mol Cell. 2016 Aug 4; 63(3): 498–513. doi: 10.1016/j.molcel.2016.06.019

PMCID:: PMC4980433

Abstract Article PDF–7.1M

Select item 106954111.

Inhibition of Epstein-Barr Virus OriP Function by Tankyrase, a Telomere-Associated Poly-ADP Ribose Polymerase That Binds and Modifies EBNA1

Zhong Deng, Constandache Atanasiu, Kehao Zhao, Ronen Marmorstein, Juan I. Sbodio, Nai-Wen Chi, Paul M. Lieberman

J Virol. 2005 Apr; 79(8): 4640–4650. doi: 10.1128/JVI.79.8.4640-4650.2005

PMCID:: PMC1069541

Abstract Article PDF–365K

Select item 807305612.

Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex

Gleb Simanov, Irene Dang, Artem I. Fokin, Ksenia Oguievetskaia, Valérie Campanacci, Jacqueline Cherfils, Alexis M. Gautreau

Int J Mol Sci. 2021 Apr; 22(8): 4115. Published online 2021 Apr 16. doi: 10.3390/ijms22084115

PMCID:: PMC8073056

Abstract Article PDF–4.6M

Select item 794864813.

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

Kevin Ryan, Ben Bolaňos, Marissa Smith, Prakash B. Palde, Paulina Delgado Cuenca, Todd L. VanArsdale, Sherry Niessen, Lianglin Zhang, Douglas Behenna, Martha A. Ornelas, Khanh T. Tran, Stephen Kaiser, Lawrence Lum, Al Stewart, Ketan S. Gajiwala

J Biol Chem. 2021 Jan-Jun; 296: 100251. Published online 2021 Jan 9. doi: 10.1074/jbc.RA120.016573

PMCID:: PMC7948648

Abstract Article PDF–2.3M

Select item 736760014.

Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma

PAULIUS VAICIULIS, RASA LIUTKEVICIENE, VYKINTAS LIUTKEVICIUS, ALVITA VILKEVICIUTE, GRETA GEDVILAITE, VIRGILIJUS ULOZA

Cancer Genomics Proteomics. 2020 Jul-Aug; 17(4): 431–439. Published online 2020 Jul 3. doi: 10.21873/cgp.20202

PMCID:: PMC7367600

Abstract Article PDF–193K

Select item 469483915.

Tankyrase inhibitors attenuate WNT/β-catenin signaling and inhibit growth of hepatocellular carcinoma cells

Li Ma, Xiaolin Wang, Tao Jia, Wei Wei, Mei-Sze Chua, Samuel So

Oncotarget. 2015 Sep 22; 6(28): 25390–25401. Published online 2015 Jun 27. doi: 10.18632/oncotarget.4455

PMCID:: PMC4694839

Abstract Article PDF–7.3M

Select item 533822816.

Structural insights into SAM domain‐mediated tankyrase oligomerization

Paul A. DaRosa, Sergey Ovchinnikov, Wenqing Xu, Rachel E. Klevit

Protein Sci. 2016 Sep; 25(9): 1744–1752. Published online 2016 Jul 4. doi: 10.1002/pro.2968

PMCID:: PMC5338228

Abstract Article PDF–2.1M

Select item 474740717.

E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling

Sharon McGonigle, Zhihong Chen, Jiayi Wu, Paul Chang, Donna Kolber-Simonds, Karen Ackermann, Natalie C. Twine, Jue-Lon Shie, Jingzang Tao Miu, Kuan-Chun Huang, George A. Moniz, Kenichi Nomoto

Oncotarget. 2015 Dec 1; 6(38): 41307–41323. Published online 2015 Oct 20. doi: 10.18632/oncotarget.5846

PMCID:: PMC4747407

Abstract Article PDF–2.0M

Select item 447591718.

Disruption of Wnt/β-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells

Ozlem Kulak, Hua Chen, Brody Holohan, Xiaofeng Wu, Huawei He, Dominika Borek, Zbyszek Otwinowski, Kiyoshi Yamaguchi, Lauren A. Garofalo, Zhiqiang Ma, Woodring Wright, Chuo Chen, Jerry W. Shay, Xuewu Zhang, Lawrence Lum

Mol Cell Biol. 2015 Jul; 35(14): 2425–2435. Prepublished online 2015 May 4. Published online 2015 Jun 19. doi: 10.1128/MCB.00392-15

PMCID:: PMC4475917

Abstract Article PDF–3.4M

Select item 356987919.

Factor-inhibiting hypoxia-inducible factor (FIH) catalyses the post-translational hydroxylation of histidinyl residues within ankyrin repeat domains

Ming Yang, Rasheduzzaman Chowdhury, Wei Ge, Refaat B Hamed, Michael A McDonough, Timothy D W Claridge, Benedikt M Kessler, Matthew E Cockman, Peter J Ratcliffe, Christopher J Schofield

FEBS J. 2011 Apr; 278(7): 1086–1097. Published online 2011 Feb 23. doi: 10.1111/j.1742-4658.2011.08022.x