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Items: 1 to 20 of 58

1.
MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus
Xiu Mei Ma, Kang Geng, Peng Wang, Zongzhe Jiang, Betty Yuen-Kwan Law, Yong Xu
Cardiovasc Diabetol. 2024; 23: 96. Published online 2024 Mar 14. doi: 10.1186/s12933-024-02178-2
PMCID:
PMC10941417
AbstractArticlePDF–17M
2.
Identification of Intron Retention in the Slc16a3 Gene Transcript Encoding the Transporter MCT4 in the Brain of Aged and Alzheimer-Disease Model (APPswePS1dE9) Mice
Ayman EL-Seedy, Luc Pellerin, Guylène Page, Veronique Ladeveze
Genes (Basel) 2023 Oct; 14(10): 1949. Published online 2023 Oct 17. doi: 10.3390/genes14101949
PMCID:
PMC10606527
AbstractArticlePDF–2.9M
3.
Monocarboxylate Transporter 4 (MCT4) Knockout Mice Have Attenuated 4NQO Induced Carcinogenesis; A Role for MCT4 in Driving Oral Squamous Cell Cancer
Sara Bisetto, Diana Whitaker-Menezes, Nicole A. Wilski, Madalina Tuluc, Joseph Curry, Tingting Zhan, Christopher M. Snyder, Ubaldo E. Martinez-Outschoorn, Nancy J. Philp
Front Oncol. 2018; 8: 324. Published online 2018 Aug 28. doi: 10.3389/fonc.2018.00324
PMCID:
PMC6120975
AbstractArticlePDF–7.1M
4.
Prolonged hypoxia induces MCT4 expression in MSCs resulting in a secretome that is deleterious to cardiovascular repair
Sarika Saraswati, Yan Guo, James Atkinson, Pampee P. Young
Stem Cells. Author manuscript; available in PMC 2016 Apr 1.
Published in final edited form as: Stem Cells. 2015 Apr; 33(4): 1333–1344. doi: 10.1002/stem.1935
PMCID:
PMC4376598
AbstractArticlePDF–2.5M
5.
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
Yu Qian, Ana Galan-Cobo, Irene Guijarro, Minghao Dang, David Molkentine, Alissa Poteete, Fahao Zhang, Qi Wang, Jing Wang, Edwin Parra, Apekshya Panda, Jacy Fang, Ferdinandos Skoulidis, Ignacio I. Wistuba, Svena Verma, Taha Merghoub, Jedd D. Wolchok, Kwok-Kin Wong, Ralph J. DeBerardinis, John D. Minna, Natalie I. Vokes, Catherine B. Meador, Justin F. Gainor, Linghua Wang, Alexandre Reuben, John V. Heymach
Cancer Cell. Author manuscript; available in PMC 2024 Jun 7.
Published in final edited form as: Cancer Cell. 2023 Jul 10; 41(7): 1363–1380.e7. Published online 2023 Jun 15. doi: 10.1016/j.ccell.2023.05.015
PMCID:
PMC11161201
AbstractArticlePDF–1.8M
6.
Expression of monocarboxylate transporter (MCT) 1 and MCT4 in overloaded mice plantaris muscle
Yu Kitaoka, Masanao Machida, Tohru Takemasa, Hideo Hatta
J Physiol Sci. 2011 Nov; 61(6): 467. Published online 2011 Aug 9. doi: 10.1007/s12576-011-0167-6
PMCID:
PMC10717019
AbstractArticlePDF–1.6M
7.
Lactate secreted via MCT4 from bone-colonizing breast cancer excites sensory neurons via GPR81
Tatsuo Okui, Masahiro Hiasa, Kazuaki Hasegawa, Tomoya Nakamura, Kisho Ono, Soichiro Ibaragi, Takahiro Kanno, Akira Sasaki, Toshiyuki Yoneda
Int J Oncol. 2023 Mar; 62(3): 39. Published online 2023 Feb 8. doi: 10.3892/ijo.2023.5487
PMCID:
PMC9946803
AbstractArticlePDF–5.2M
8.
Cigarette Smoke Induces Metabolic Reprogramming of the Tumor Stroma in Head and Neck Squamous Cell Carcinoma
Marina Domingo-Vidal, Diana Whitaker-Menezes, Cristina Martos-Rus, Patrick Tassone, Christopher M. Snyder, Madalina Tuluc, Nancy Philp, Joseph Curry, Ubaldo Martinez-Outschoorn
Mol Cancer Res. Author manuscript; available in PMC 2020 Mar 1.
Published in final edited form as: Mol Cancer Res. 2019 Sep; 17(9): 1893–1909. Published online 2019 Jun 25. doi: 10.1158/1541-7786.MCR-18-1191
PMCID:
PMC6726526
AbstractArticlePDF–2.5M
9.
The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages
Zheng Tan, Na Xie, Sami Banerjee, Huachun Cui, Mingui Fu, Victor J. Thannickal, Gang Liu
J Biol Chem. 2015 Jan 2; 290(1): 46–55. Published online 2014 Nov 18. doi: 10.1074/jbc.M114.603589
PMCID:
PMC4281748
AbstractArticlePDF–1.3M
10.
Advanced Maternal Age Differentially Affects Embryonic Tissues with the Most Severe Impact on the Developing Brain
Caroline Kokorudz, Bethany N. Radford, Wendy Dean, Myriam Hemberger
Cells. 2023 Jan; 12(1): 76. Published online 2022 Dec 24. doi: 10.3390/cells12010076
PMCID:
PMC9818809
AbstractArticlePDF–3.0M
11.
Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion
John Y. S. Han, Junzo Kinoshita, Sara Bisetto, Brent A. Bell, Romana A. Nowak, Neal S. Peachey, Nancy J. Philp
FASEB J. Author manuscript; available in PMC 2021 Apr 1.
Published in final edited form as: FASEB J. 2020 Apr; 34(4): 5401–5419. Published online 2020 Feb 28. doi: 10.1096/fj.201902961R
PMCID:
PMC7849204
AbstractArticlePDF–3.0M
12.
Disruption of placental ACKR3 impairs growth and hematopoietic development of offspring
Ayumi Fukuoka, Gillian J. Wilson, Elise Pitmon, Lily Koumbas Foley, Hanna Johnsson, Marieke Pingen, Gerard J. Graham
Development. 2024 Feb 15; 151(4): dev202333. Published online 2024 Feb 23. doi: 10.1242/dev.202333
PMCID:
PMC10911115
AbstractArticle
13.
Adrenomedullin has a pivotal role in trophoblast differentiation: A promising nanotechnology-based therapeutic target for early-onset preeclampsia
Qingqing Zhang, Cheuk-Lun Lee, Tingyu Yang, Jianlin Li, Qunxiong Zeng, Xiaofeng Liu, Zhongzhen Liu, Degong Ruan, Zhuoxuan Li, Anita S. Y. Kan, Ka-Wang Cheung, Annisa S. L. Mak, Vivian W. Y. Ng, Huashan Zhao, Xiujun Fan, Yong-Gang Duan, Liuying Zhong, Min Chen, Meirong Du, Raymond H. W. Li, Pengtao Liu, Ernest H. Y. Ng, William S. B. Yeung, Ya Gao, Yuanqing Yao, Philip C. N. Chiu
Sci Adv. 2023 Nov 3; 9(44): eadi4777. Published online 2023 Nov 3. doi: 10.1126/sciadv.adi4777
PMCID:
PMC10624351
AbstractArticlePDF–3.2M
14.
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice
Katia Monsorno, Kyllian Ginggen, Andranik Ivanov, An Buckinx, Arnaud L. Lalive, Anna Tchenio, Sam Benson, Marc Vendrell, Angelo D’Alessandro, Dieter Beule, Luc Pellerin, Manuel Mameli, Rosa Chiara Paolicelli
Nat Commun. 2023; 14: 5749. Published online 2023 Sep 16. doi: 10.1038/s41467-023-41502-4
PMCID:
PMC10505217
AbstractArticlePDF–3.2M
15.
Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B
Simon Andrews, Christel Krueger, Maravillas Mellado-Lopez, Myriam Hemberger, Wendy Dean, Vicente Perez-Garcia, Courtney W. Hanna
Nat Commun. 2023; 14: 371. Published online 2023 Jan 23. doi: 10.1038/s41467-023-36019-9
PMCID:
PMC9870994
AbstractArticlePDF–4.1M
16.
Diverse species-specific phenotypic consequences of loss of function sorting nexin 14 mutations
Dale Bryant, Marian Seda, Emma Peskett, Constance Maurer, Gideon Pomeranz, Marcus Ghosh, Thomas A. Hawkins, James Cleak, Sanchari Datta, Hanaa Hariri, Kaitlyn M. Eckert, Daniyal J. Jafree, Claire Walsh, Charalambos Demetriou, Miho Ishida, Cristina Alemán-Charlet, Letizia Vestito, Rimante Seselgyte, Jeffrey G. McDonald, Maria Bitner-Glindzicz, Myriam Hemberger, Jason Rihel, Lydia Teboul, W. Mike Henne, Dagan Jenkins, Gudrun E. Moore, Philip Stanier
Sci Rep. 2020; 10: 13763. Published online 2020 Aug 13. doi: 10.1038/s41598-020-70797-2
PMCID:
PMC7427099
AbstractArticlePDF–2.0M
17.
New Insights into the Lactate Shuttle: Role of MCT4 in the Modulation of the Exercise Capacity
Sara Bisetto, Megan C. Wright, Romana A. Nowak, Angelo C. Lepore, Tejvir S. Khurana, Emanuele Loro, Nancy J. Philp
iScience. 2019 Dec 20; 22: 507–518. Published online 2019 Nov 26. doi: 10.1016/j.isci.2019.11.041
PMCID:
PMC6920289
AbstractArticlePDF–4.4M
18.
MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4
Candice Sun Hong, Nicholas A. Graham, Wen Gu, Carolina Espindola Camacho, Vei Mah, Erin L. Maresh, Mohammed Alavi, Lora Bagryanova, Pascal A. L. Krotee, Brian K. Gardner, Iman Saramipoor Behbahan, Steve Horvath, David Chia, Ingo K. Mellinghoff, Sara A. Hurvitz, Steven M. Dubinett, Susan E. Critchlow, Siavash K. Kurdistani, Lee Goodglick, Daniel Braas, Thomas G. Graeber, Heather R. Christofk
Cell Rep. Author manuscript; available in PMC 2016 Mar 31.
Published in final edited form as: Cell Rep. 2016 Feb 23; 14(7): 1590–1601. Published online 2016 Feb 11. doi: 10.1016/j.celrep.2016.01.057
PMCID:
PMC4816454
AbstractArticlePDF–633K
19.
CLICK: one-step generation of conditional knockout mice
Yoshiki Miyasaka, Yoshihiro Uno, Kazuto Yoshimi, Yayoi Kunihiro, Takuji Yoshimura, Tomohiro Tanaka, Harumi Ishikubo, Yuichi Hiraoka, Norihiko Takemoto, Takao Tanaka, Yoshihiro Ooguchi, Paul Skehel, Tomomi Aida, Junji Takeda, Tomoji Mashimo
BMC Genomics. 2018; 19: 318. Published online 2018 May 2. doi: 10.1186/s12864-018-4713-y
PMCID:
PMC5930688
AbstractArticlePDF–1.4M
20.
Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion
Yang Zhang, Pengfei Liang, Liheng Yang, Ke Zoe Shan, Liping Feng, Yong Chen, Wolfgang Liedtke, Carolyn B Coyne, Huanghe Yang
eLife. 2022; 11: e78840. Published online 2022 Jun 7. doi: 10.7554/eLife.78840
PMCID:
PMC9236608
AbstractArticlePDF–5.3M

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