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Select item 106246871.

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

Lin-Lin Zhou, Tao Zhang, Yun Xue, Chuan Yue, Yihui Pan, Pengyu Wang, Teng Yang, Meixia Li, Hu Zhou, Kan Ding, Jianhua Gan, Hongbin Ji, Cai-Guang Yang

Nat Commun. 2023; 14: 7069. Published online 2023 Nov 3. doi: 10.1038/s41467-023-42784-4

PMCID:: PMC10624687

Abstract Article PDF–2.7M

Select item 93067252.

Substrate Profiling of Mitochondrial Caseinolytic Protease P via a Site‐Specific Photocrosslinking Approach

Dr. Tuan‐Anh Nguyen, Dr. Thomas F. Gronauer, Timon Nast‐Kolb, Prof. Dr. Stephan A. Sieber, Prof. Dr. Kathrin Lang

Angew Chem Int Ed Engl. 2022 Mar 1; 61(10): e202111085. Published online 2022 Jan 14. doi: 10.1002/anie.202111085

PMCID:: PMC9306725

Abstract Article PDF–3.1M

Select item 82280313.

Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer

Antonella Cormio, Francesca Sanguedolce, Vito Pesce, Clara Musicco

Int J Mol Sci. 2021 Jun; 22(12): 6228. Published online 2021 Jun 9. doi: 10.3390/ijms22126228

PMCID:: PMC8228031

Abstract Article PDF–597K

Select item 65206374.

Senescent Hepatocytes in Decompensated Liver Show Reduced UPR^MT and Its Key Player, CLPP, Attenuates Senescence In Vitro

Bijoya Sen, Archana Rastogi, Rhisita Nath, Saggere M. Shasthry, Viniyendra Pamecha, Sonika Pandey, Kapuganti Jagadis Gupta, Shiv K. Sarin, Nirupma Trehanpati, Gayatri Ramakrishna

Cell Mol Gastroenterol Hepatol. 2019; 8(1): 73–94. Published online 2019 Mar 13. doi: 10.1016/j.jcmgh.2019.03.001

PMCID:: PMC6520637

Abstract Article PDF–8.4M

Select item 55064015.

Autophagy compensates impaired energy metabolism in CLPXP‐deficient Podospora anserina strains and extends healthspan

Laura Knuppertz, Heinz D. Osiewacz

Aging Cell. 2017 Aug; 16(4): 704–715. Published online 2017 Apr 27. doi: 10.1111/acel.12600

PMCID:: PMC5506401

Abstract Article PDF–1.5M

Select item 51980086.

A Novel Missense Mutation in the CLPP Gene Causing Perrault Syndrome Type 3 in a Turkish Family

Fatma Dursun, Hussein Sheikh Ali Mohamoud, Noreen Karim, Muhammad Naeem, Musharraf Jelani, Heves Kırmızıbekmez

J Clin Res Pediatr Endocrinol. 2016 Dec; 8(4): 472–477. Published online 2016 Dec 1. doi: 10.4274/jcrpe.2717

PMCID:: PMC5198008

Abstract Article PDF–424K

Select item 47881067.

Mitochondrial ClpP activity is required for cisplatin resistance in human cells

Yang Zhang, Michael R. Maurizi

Biochim Biophys Acta. Author manuscript; available in PMC 2017 Feb 1.

Published in final edited form as: Biochim Biophys Acta. 2016 Feb; 1862(2): 252–264. Published online 2015 Dec 7. doi: 10.1016/j.bbadis.2015.12.005

PMCID:: PMC4788106

Abstract Article PDF–2.5M

Select item 36173818.

Perrault Syndrome Is Caused by Recessive Mutations in CLPP, Encoding a Mitochondrial ATP-Dependent Chambered Protease

Emma M. Jenkinson, Atteeq U. Rehman, Tom Walsh, Jill Clayton-Smith, Kwanghyuk Lee, Robert J. Morell, Meghan C. Drummond, Shaheen N. Khan, Muhammad Asif Naeem, Bushra Rauf, Neil Billington, Julie M. Schultz, Jill E. Urquhart, Ming K. Lee, Andrew Berry, Neil A. Hanley, Sarju Mehta, Deirdre Cilliers, Peter E. Clayton, Helen Kingston, Miriam J. Smith, Thomas T. Warner, University of Washington Center for Mendelian Genomics, Graeme C. Black, Dorothy Trump, Julian R.E. Davis, Wasim Ahmad, Suzanne M. Leal, Sheikh Riazuddin, Mary-Claire King, Thomas B. Friedman, William G. Newman

Am J Hum Genet. 2013 Apr 4; 92(4): 605–613. doi: 10.1016/j.ajhg.2013.02.013

PMCID:: PMC3617381

Abstract Article PDF–1.1M

Select item 35624519.

Human CLPP reverts the longevity phenotype of a fungal ClpP deletion strain

Fabian Fischer, Andrea Weil, Andrea Hamann, Heinz D. Osiewacz

Nat Commun. 2013 Jan 29; 4: 1397. Published online 2013 Jan 29. doi: 10.1038/ncomms2397

PMCID:: PMC3562451

Abstract Article PDF–370K

Select item 121935310.

A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization.

T J Corydon, P Bross, H U Holst, S Neve, K Kristiansen, N Gregersen, L Bolund

Biochem J. 1998 Apr 1; 331(Pt 1): 309–316. doi: 10.1042/bj3310309

PMCID:: PMC1219353

Summary PDF–373K

Select item 1098486711.

HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells: Role of HSPA8/CLPP in cisplatin-resistant OC

Xinxin Kou, Xiaoxia Yang, Zheng Zhao, Lei Li

Acta Biochim Biophys Sin (Shanghai) 2024 Mar 25; 56(3): 356–365. Published online 2024 Feb 28. doi: 10.3724/abbs.2023246

PMCID:: PMC10984867

Abstract Article PDF–2.0M

Select item 493671412.

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis

Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, Dario C. Altieri

PLoS Biol. 2016 Jul; 14(7): e1002507. Published online 2016 Jul 7. doi: 10.1371/journal.pbio.1002507

PMCID:: PMC4936714

Abstract Article PDF–11M

Select item 413480813.

Stochastic but highly coordinated protein unfolding and translocation by the CIpXP proteolytic machine

Juan Carlos Cordova, Adrian O. Olivares, Yongdae Shin, Benjamin M. Stinson, Stephane Calmat, Karl R. Schmitz, Marie-Eve Aubin-Tam, Tania A. Baker, Matthew J. Lang, Robert T. Sauer

Cell. Author manuscript; available in PMC 2015 Jul 31.

Published in final edited form as: Cell. 2014 Jul 31; 158(3): 647–658. doi: 10.1016/j.cell.2014.05.043

PMCID:: PMC4134808

Abstract Article PDF–2.1M

Select item 330318314.

Mutations of GIPC3 cause nonsyndromic hearing loss DFNB72 but not DFNB81 that also maps to chromosome 19p

Atteeq U. Rehman, Khitab Gul, Robert J. Morell, Kwanghyuk Lee, Zubair M. Ahmed, Saima Riazuddin, Rana A. Ali, Mohsin Shahzad, Ateeq-ul Jaleel, Paula B. Andrade, Shaheen N. Khan, Saadullah Khan, Carmen C. Brewer, Wasim Ahmad, Suzanne M. Leal, Sheikh Riazuddin, Thomas B. Friedman

Hum Genet. Author manuscript; available in PMC 2012 Mar 14.

Published in final edited form as: Hum Genet. 2011 Dec; 130(6): 759–765. Published online 2011 Jun 10. doi: 10.1007/s00439-011-1018-5

PMCID:: PMC3303183

Abstract Article PDF–2.3M

Select item 493155715.

Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPR^mt

Dominic Seiferling, Karolina Szczepanowska, Christina Becker, Katharina Senft, Steffen Hermans, Priyanka Maiti, Tim König, Alexandra Kukat, Aleksandra Trifunovic

EMBO Rep. 2016 Jul; 17(7): 953–964. Published online 2016 May 6. doi: 10.15252/embr.201642077

PMCID:: PMC4931557

Abstract Article PDF–2.2M

Select item 869911916.

Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA

Jana Key, Sylvia Torres-Odio, Nina C. Bach, Suzana Gispert, Gabriele Koepf, Marina Reichlmeir, A. Phillip West, Holger Prokisch, Peter Freisinger, William G. Newman, Stavit Shalev, Stephan A. Sieber, Ilka Wittig, Georg Auburger

Cells. 2021 Dec; 10(12): 3354. Published online 2021 Nov 29. doi: 10.3390/cells10123354

PMCID:: PMC8699119

Abstract Article PDF–31M

Select item 728320317.

Loss of mitochondrial ClpP, Lonp1, and Tfam triggers transcriptional induction of Rnf213, a susceptibility factor for moyamoya disease

Jana Key, Antonia Maletzko, Aneesha Kohli, Suzana Gispert, Sylvia Torres-Odio, Ilka Wittig, Juliana Heidler, Clea Bárcena, Carlos López-Otín, Yuanjiu Lei, A. Phillip West, Christian Münch, Georg Auburger

Neurogenetics. 2020; 21(3): 187–203. Published online 2020 Apr 28. doi: 10.1007/s10048-020-00609-2

PMCID:: PMC7283203

Abstract Article PDF–1.2M

Select item 653142618.

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity

Di Hu, Xiaoyan Sun, Xudong Liao, Xinwen Zhang, Sara Zarabi, Aaron Schimmer, Yuning Hong, Christopher Ford, Yu Luo, Xin Qi

Acta Neuropathol. 2019; 137(6): 939–960. Published online 2019 Mar 15. doi: 10.1007/s00401-019-01993-2

PMCID:: PMC6531426

Abstract Article PDF–3.1M

Select item 332114919.

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

Andrew W Greene, Karl Grenier, Miguel A Aguileta, Stephanie Muise, Rasoul Farazifard, M Emdadul Haque, Heidi M McBride, David S Park, Edward A Fon

EMBO Rep. 2012 Apr; 13(4): 378–385. Published online 2012 Feb 21. doi: 10.1038/embor.2012.14

PMCID:: PMC3321149

Abstract Article PDF–1.0M

Select item 446183720.

Inhibition of the mitochondrial protease, ClpP, as a therapeutic strategy for human acute myeloid leuekmia

Alicia Cole, Zezhou Wang, Etienne Coyaud, Veronique Voisin, Marcela Gronda, Yulia Jitkova, Rachel Mattson, Rose Hurren, Sonja Babovic, Neil Maclean, Ian Restall, Xiaoming Wang, Danny V. Jeyaraju, Mahadeo A. Sukhai, Swayam Prabha, Shaheena Bashir, Ashwin Ramakrishnan, Elisa Leung, Yi Hua Qia, Nianxian Zhang, Kevin R. Combes, Troy Ketela, Fengshu Lin, Walid A. Houry, Ahmed Aman, Rima Al-awar, Wei Zheng, Erno Wienholds, Chang Jiang Xu, John Dick, Jean C.Y. Wang, Jason Moffat, Mark D. Minden, Connie J. Eaves, Gary D. Bader, Zhenyue Hao, Steven M. Kornblau, Brian Raught, Aaron D. Schimmer

Cancer Cell. Author manuscript; available in PMC 2016 Jun 8.

Published in final edited form as: Cancer Cell. 2015 Jun 8; 27(6): 864–876. doi: 10.1016/j.ccell.2015.05.004

PMCID:: PMC4461837

Abstract Article PDF–2.3M

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