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Items: 1 to 20 of 103

1.
Caspase-2 protects against ferroptotic cell death
Swati Dawar, Mariana C. Benitez, Yoon Lim, Toby A. Dite, Jumana M. Yousef, Niko Thio, Sylvain Garciaz, Thomas D. Jackson, Julia V. Milne, Laura F. Dagley, Wayne A. Phillips, Sharad Kumar, Nicholas J. Clemons
Cell Death Dis. 2024 Mar; 15(3): 182. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06560-6
PMCID:
PMC10907636
AbstractArticlePDF–8.6M
2.
Bi-allelic truncating variants in CASP2 underlie a neurodevelopmental disorder with lissencephaly
Eyyup Uctepe, Barbara Vona, Fatma Nisa Esen, F. Mujgan Sonmez, Thomas Smol, Sait Tümer, Hanifenur Mancılar, Dilan Ece Geylan Durgun, Odile Boute, Meysam Moghbeli, Ehsan Ghayoor Karimiani, Narges Hashemi, Behnoosh Bakhshoodeh, Hyung Goo Kim, Reza Maroofian, Ahmet Yesilyurt
Eur J Hum Genet. 2024 Jan; 32(1): 52–60. Published online 2023 Oct 26. doi: 10.1038/s41431-023-01461-2
PMCID:
PMC10772072
AbstractArticlePDF–2.1M
3.
Genuine selective caspase-2 inhibition with new irreversible small peptidomimetics
Elodie Bosc, Julie Anastasie, Feryel Soualmia, Pascale Coric, Ju Youn Kim, Lily Q. Wang, Gullen Lacin, Kaitao Zhao, Ronak Patel, Eric Duplus, Philippe Tixador, Andrew A. Sproul, Bernard Brugg, Michelle Reboud-Ravaux, Carol M. Troy, Michael L. Shelanski, Serge Bouaziz, Michael Karin, Chahrazade El Amri, Etienne D. Jacotot
Cell Death Dis. 2022 Nov; 13(11): 959. Published online 2022 Nov 15. doi: 10.1038/s41419-022-05396-2
PMCID:
PMC9666555
AbstractArticlePDF–3.2M
4.
Caspase-2 mRNA levels are not elevated in mild cognitive impairment, Alzheimer’s disease, Huntington’s disease, or Lewy Body dementia
Chris Hlynialuk, Lisa Kemper, Kailee Leinonen-Wright, Ronald C. Petersen, Karen Ashe, Benjamin Smith
PLoS One. 2022; 17(9): e0274784. Published online 2022 Sep 21. doi: 10.1371/journal.pone.0274784
PMCID:
PMC9491574
AbstractArticlePDF–1.2M
5.
Production of Circularly Permuted Caspase-2 for Affinity Fusion-Tag Removal: Cloning, Expression in Escherichia coli, Purification, and Characterization
Monika Cserjan-Puschmann, Nico Lingg, Petra Engele, Christina Kröß, Julian Loibl, Andreas Fischer, Florian Bacher, Anna-Carina Frank, Christoph Öhlknecht, Cécile Brocard, Chris Oostenbrink, Matthias Berkemeyer, Rainer Schneider, Gerald Striedner, Alois Jungbauer
Biomolecules. 2020 Dec; 10(12): 1592. Published online 2020 Nov 24. doi: 10.3390/biom10121592
PMCID:
PMC7760212
AbstractArticlePDF–2.8M
6.
Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface
Daisy Leon-Martinez, Joshua F. Robinson, Tamara Zdravkovic, Olga Genbacev, Matthew Gormley, Michael Mcmaster, Susan J. Fisher, Katherine Bianco
Reprod Sci. 2020 Jan; 27(1): 100–109. Published online 2020 Jan 1. doi: 10.1007/s43032-019-00002-x
PMCID:
PMC7539800
AbstractArticlePDF–4.1M
7.
Caspase-2 mediates triglyceride (TG)-induced macrophage cell death
Jaewon Lim, Hyun-Kyung Kim, Sung Hoon Kim, Ki-Jong Rhee, Yoon Suk Kim
BMB Rep. 2017 Oct; 50(10): 510–515. Published online 2017 Oct 31. doi: 10.5483/BMBRep.2017.50.10.106
PMCID:
PMC5683820
AbstractArticlePDF–1.3M
8.
Caspase-2 regulates oncogene-induced senescence
Delphine Gitenay, Hélène Lallet-Daher, David Bernard
Oncotarget. 2014 Jul; 5(14): 5845–5847. Published online 2014 Jul 31. doi: 10.18632/oncotarget.2286
PMCID:
PMC4170627
AbstractArticlePDF–659K
9.
Analysis of the minimal specificity of caspase-2 and identification of Ac-VDTTD-AFC as a caspase-2-selective peptide substrate
Tanja Kitevska, Sarah J. Roberts, Delara Pantaki-Eimany, Sarah E. Boyd, Fiona L. Scott, Christine J. Hawkins
Biosci Rep. 2014; 34(2): e00100. Prepublished online 2014 Feb 17. Published online 2014 Mar 25. doi: 10.1042/BSR20140025
PMCID:
PMC3966047
AbstractArticlePDF–1003K
10.
The role of caspase-2 in stress-induced apoptosis
Lisa Bouchier-Hayes
J Cell Mol Med. 2010 Jun; 14(6a): 1212–1224. Published online 2010 Feb 16. doi: 10.1111/j.1582-4934.2010.01037.x
PMCID:
PMC3828840
AbstractArticlePDF–564K
11.
Degradomics Reveals That Cleavage Specificity Profiles of Caspase-2 and Effector Caspases Are Alike
Magdalena Wejda, Francis Impens, Nozomi Takahashi, Petra Van Damme, Kris Gevaert, Peter Vandenabeele
J Biol Chem. 2012 Oct 5; 287(41): 33983–33995. Published online 2012 Jul 23. doi: 10.1074/jbc.M112.384552
PMCID:
PMC3464509
AbstractArticlePDF–1.8M
12.
Tumor-suppressing Function of Caspase-2 Requires Catalytic Site Cys-320 and Site Ser-139 in Mice
Keqin Ren, Jing Lu, Aleksey Porollo, Chunying Du
J Biol Chem. 2012 Apr 27; 287(18): 14792–14802. Published online 2012 Mar 6. doi: 10.1074/jbc.M112.347625
PMCID:
PMC3340225
AbstractArticlePDF–3.7M
13.
Structural and Enzymatic Insights into Caspase-2 Protein Substrate Recognition and Catalysis
Yinyan Tang, James A. Wells, Michelle R. Arkin
J Biol Chem. 2011 Sep 30; 286(39): 34147–34154. Published online 2011 Aug 2. doi: 10.1074/jbc.M111.247627
PMCID:
PMC3190824
AbstractArticlePDF–1.8M
14.
CASPASE 2-MEDIATED TUMOR SUPPRESSION INVOLVES SURVIVIN GENE SILENCING
Minakshi Guha, Fang Xia, Christopher M. Raskett, Dario C. Altieri
Oncogene. Author manuscript; available in PMC 2010 Sep 4.
Published in final edited form as: Oncogene. 2010 Mar 4; 29(9): 1280–1292. Published online 2009 Nov 23. doi: 10.1038/onc.2009.428
PMCID:
PMC2832727
AbstractArticlePDF–2.4M
15.
Overexpression of the Anti-Apoptotic Caspase-2 Short Isoform in Macrophage-Derived Foam Cells of Human Atherosclerotic Plaques
Wim Martinet, Michiel W.M. Knaapen, Guido R.Y. De Meyer, Arnold G. Herman, Mark M. Kockx
Am J Pathol. 2003 Mar; 162(3): 731–736. doi: 10.1016/S0002-9440(10)63869-2
PMCID:
PMC1868102
AbstractArticlePDF–511K
16.
Triglyceride induces DNA damage leading to monocyte death by activating caspase-2 and caspase-8
Byung Chul Jung, Hyun-Kyung Kim, Sung Hoon Kim, Yoon Suk Kim
BMB Rep. 2023 Mar 31; 56(3): 166–171. Published online 2023 Feb 2. doi: 10.5483/BMBRep.2022-0201
PMCID:
PMC10068338
AbstractArticlePDF–4.6M
17.
Targeting caspase-2 interactions with tau in Alzheimer’s disease and related dementias
Steffen Pockes, Michael A. Walters, Karen H. Ashe
Transl Res. Author manuscript; available in PMC 2024 Apr 1.
Published in final edited form as: Transl Res. 2023 Apr; 254: 34–40. Published online 2022 Nov 4. doi: 10.1016/j.trsl.2022.10.009
PMCID:
PMC9991976
AbstractArticlePDF–1.2M
18.
Identification of TRIM25 as a Negative Regulator of Caspase-2 Expression Reveals a Novel Target for Sensitizing Colon Carcinoma Cells to Intrinsic Apoptosis
Usman Nasrullah, Kristina Haeussler, Abhiruchi Biyanee, Ilka Wittig, Josef Pfeilschifter, Wolfgang Eberhardt
Cells. 2019 Dec; 8(12): 1622. Published online 2019 Dec 12. doi: 10.3390/cells8121622
PMCID:
PMC6952940
AbstractArticlePDF–4.8M
19.
Inhibition of Caspase-2 Translation by the mRNA Binding Protein HuR: A Novel Path of Therapy Resistance in Colon Carcinoma Cells?
Wolfgang Eberhardt, Usman Nasrullah, Kristina Haeussler
Cells. 2019 Aug; 8(8): 797. Published online 2019 Jul 30. doi: 10.3390/cells8080797
PMCID:
PMC6721497
AbstractArticlePDF–1.2M
20.
A soluble tau fragment generated by caspase-2 is associated with dementia in Lewy body disease
Benjamin R. Smith, Kathryn M. Nelson, Lisa J. Kemper, Kailee Leinonen-Wright, Ashley Petersen, C. Dirk Keene, Karen H. Ashe
Acta Neuropathol Commun. 2019; 7: 124. Published online 2019 Jul 30. doi: 10.1186/s40478-019-0765-8
PMCID:
PMC6668119
AbstractArticlePDF–1006K

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