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Select item 108588861.

Dynamic nucleolar phase separation influenced by non-canonical function of LIN28A instructs pluripotent stem cell fate decisions

Tianyu Tan, Bo Gao, Hua Yu, Hongru Pan, Zhen Sun, Anhua Lei, Li Zhang, Hengxing Lu, Hao Wu, George Q. Daley, Yu Feng, Jin Zhang

Nat Commun. 2024; 15: 1256. Published online 2024 Feb 10. doi: 10.1038/s41467-024-45451-4

PMCID:: PMC10858886

Abstract Article PDF–4.5M

Select item 104099082.

Surface Lin28A expression consistent with cellular stress parallels indicators of senescence

Kathleen Broughton, Carolina Esquer, Oscar Echeagaray, Fareheh Firouzi, Grant Shain, David Ebeid, Megan Monsanto, Dena Yaareb, Leila Golgolab, Natalie Gude, Mark A Sussman

Cardiovasc Res. 2023 Mar; 119(3): 743–758. Published online 2022 Jul 26. doi: 10.1093/cvr/cvac122

PMCID:: PMC10409908

Abstract Article PDF–54M

Select item 92262203.

LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells

Zhen Sun, Hua Yu, Jing Zhao, Tianyu Tan, Hongru Pan, Yuqing Zhu, Lang Chen, Cheng Zhang, Li Zhang, Anhua Lei, Yuyan Xu, Xianju Bi, Xin Huang, Bo Gao, Longfei Wang, Cristina Correia, Ming Chen, Qiming Sun, Yu Feng, Li Shen, Hao Wu, Jianlong Wang, Xiaohua Shen, George Q. Daley, Hu Li, Jin Zhang

Protein Cell. 2022 Jul; 13(7): 490–512. Published online 2021 Jul 31. doi: 10.1007/s13238-021-00864-5

PMCID:: PMC9226220

Abstract Article PDF–3.5M

Select item 86060904.

Overexpression of Lin28A in neural progenitor cells in vivo does not lead to brain tumor formation but results in reduced spine density

Maximilian Middelkamp, Lisa Ruck, Christoph Krisp, Piotr Sumisławski, Behnam Mohammadi, Matthias Dottermusch, Valerie Meister, Lukas Küster, Hartmut Schlüter, Sabine Windhorst, Julia E. Neumann

Acta Neuropathol Commun. 2021; 9: 185. Published online 2021 Nov 20. doi: 10.1186/s40478-021-01289-1

PMCID:: PMC8606090

Abstract Article PDF–9.9M

Select item 75092665.

Regulation of Lin28a-miRNA let-7b-5p pathway in skeletal muscle cells by peroxisome proliferator-activated receptor delta

Hygor N. Araujo, Tanes I. Lima, Dimitrius Santiago P. S. F. Guimarães, Andre G. Oliveira, Bianca C. Favero-Santos, Renato C. S. Branco, Rafaela Mariano da Silva Araújo, Alvaro F. B. Dantas, Alex Castro, Mara Patrícia T. Chacon-Mikahil, Elaine Minatel, Murilo V. Geraldo, Everardo Magalhães Carneiro, Alice C. Rodrigues, Vihang A. Narkar, Leonardo R. Silveira

Am J Physiol Cell Physiol. 2020 Sep 1; 319(3): C541–C551. Published online 2020 Jul 22. doi: 10.1152/ajpcell.00233.2020

PMCID:: PMC7509266

Abstract Article

Select item 74033486.

Upregulating Lin28a Promotes Axon Regeneration in Adult Mice with Optic Nerve and Spinal Cord Injury

Fatima M. Nathan, Yosuke Ohtake, Shuo Wang, Xinpei Jiang, Armin Sami, Hua Guo, Feng-Quan Zhou, Shuxin Li

Mol Ther. 2020 Aug 5; 28(8): 1902–1917. Published online 2020 Apr 15. doi: 10.1016/j.ymthe.2020.04.010

PMCID:: PMC7403348

Abstract Article PDF–6.9M

Select item 64045607.

The RNA-binding protein LIN28 controls progenitor and neuronal cell fate during postnatal neurogenesis

Jennifer S. Romer-Seibert, Nathaniel W. Hartman, Eric G. Moss

FASEB J. 2019 Mar; 33(3): 3291–3303. Published online 2018 Nov 13. doi: 10.1096/fj.201801118R

PMCID:: PMC6404560

Abstract Article

Select item 55218638.

Hypothalamic Ventromedial Lin28a Enhances Glucose Metabolism in Diet-Induced Obesity

Jung Dae Kim, Chitoku Toda, Cristina M. Ramírez, Carlos Fernández-Hernando, Sabrina Diano

Diabetes. 2017 Aug; 66(8): 2102–2111. Published online 2017 May 26. doi: 10.2337/db16-1558

PMCID:: PMC5521863

Abstract Article PDF–1.7M

Select item 51820919.

LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency

Kaloyan M. Tsanov, Daniel S. Pearson, Zhaoting Wu, Areum Han, Robinson Triboulet, Marc T. Seligson, John T. Powers, Jihan K. Osborne, Susan Kane, Steven P. Gygi, Richard I. Gregory, George Q. Daley

Nat Cell Biol. Author manuscript; available in PMC 2017 Jun 19.

Published in final edited form as: Nat Cell Biol. 2017 Jan; 19(1): 60–67. Published online 2016 Dec 19. doi: 10.1038/ncb3453

PMCID:: PMC5182091

Abstract Article PDF–1.7M

Select item 419699010.

Lin28a Protects against Hypoxia/Reoxygenation Induced Cardiomyocytes Apoptosis by Alleviating Mitochondrial Dysfunction under High Glucose/High Fat Conditions

Mingming Zhang, Xiaolin Niu, Jianqiang Hu, Yuan Yuan, Shuhong Sun, Jiaxing Wang, Wenjun Yu, Chen Wang, Dongdong Sun, Haichang Wang

PLoS One. 2014; 9(10): e110580. Published online 2014 Oct 14. doi: 10.1371/journal.pone.0110580

PMCID:: PMC4196990

Abstract Article PDF–4.9M

Select item 403528411.

Lin28a regulates neuronal differentiation and controls miR-9 production

Jakub S. Nowak, Nila Roy Choudhury, Flavia de Lima Alves, Juri Rappsilber, Gracjan Michlewski

Nat Commun. Author manuscript; available in PMC 2014 Oct 11.

Published in final edited form as: Nat Commun. 2014; 5: 3687. Published online 2014 Apr 11. doi: 10.1038/ncomms4687

PMCID:: PMC4035284

Abstract Article PDF–6.4M

Select item 271523712.

Histone H2a mRNA interacts with Lin28 and contains a Lin28-dependent posttranscriptional regulatory element

Bingsen Xu, Yingqun Huang

Nucleic Acids Res. 2009 Jul; 37(13): 4256–4263. Published online 2009 May 13. doi: 10.1093/nar/gkp372

PMCID:: PMC2715237

Abstract Article PDF–7.9M

Select item 265700913.

Lin28 modulates cell growth and associates with a subset of cell cycle regulator mRNAs in mouse embryonic stem cells

Bingsen Xu, Kexiong Zhang, Yingqun Huang

RNA. 2009 Mar; 15(3): 357–361. doi: 10.1261/rna.1368009

PMCID:: PMC2657009

Abstract Article PDF–835K

Select item 249146214.

Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing

Martin A. Newman, J. Michael Thomson, Scott M. Hammond

RNA. 2008 Aug; 14(8): 1539–1549. doi: 10.1261/rna.1155108

PMCID:: PMC2491462

Abstract Article PDF–732K

Select item 987094515.

RNA-binding protein LIN28a regulates new myocyte formation in the heart via lncRNA-H19

Vagner Oliveira Carvalho Rigaud, Robert Hoy, Justin Kurian, Clare Zarka, Michael Behanan, Isabella Brosious, Jen Pennise, Tej Patel, Tao Wang, Jaslyn Johnson, Lindsay Kraus, Sadia Mohsin, Steven Houser, Mohsin Khan

Circulation. Author manuscript; available in PMC 2024 Jan 24.

Published in final edited form as: Circulation. 2023 Jan 24; 147(4): 324–337. Published online 2022 Oct 31. doi: 10.1161/CIRCULATIONAHA.122.059346

PMCID:: PMC9870945

Abstract Article PDF–3.5M

Select item 941717416.

Lin28a induces SOX9 and chondrocyte reprogramming via HMGA2 and blunts cartilage loss in mice

Yohan Jouan, Zohra Bouchemla, Benoit Bardèche-Trystram, Joanna Sana, Caroline Andrique, Hang-Korng Ea, Pascal Richette, Augustin Latourte, Martine Cohen-Solal, Eric Hay

Sci Adv. 2022 Aug; 8(34): eabn3106. Published online 2022 Aug 26. doi: 10.1126/sciadv.abn3106

PMCID:: PMC9417174

Abstract Article PDF–5.6M

Select item 851548717.

LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury

Antonia Elizabeth Yuko, Vagner Oliveira Carvalho Rigaud, Justin Kurian, Ji H. Lee, Nicole Kasatkin, Michael Behanan, Tao Wang, Anna Maria Luchesse, Sadia Mohsin, Walter J. Koch, Hong Wang, Mohsin Khan

Redox Biol. 2021 Nov; 47: 102162. Published online 2021 Oct 8. doi: 10.1016/j.redox.2021.102162

PMCID:: PMC8515487

Abstract Article PDF–9.8M

Select item 779799218.

Overexpression of p53 accelerates puberty in high-fat diet–fed mice through Lin28/let-7 system

Ting Chen, Cailong Chen, Haiying Wu, Xiuli Chen, Rongrong Xie, Fengyun Wang, Hui Sun, Linqi Chen

Exp Biol Med (Maywood) 2021 Jan; 246(1): 66–71. Published online 2020 Sep 30. doi: 10.1177/1535370220961320

PMCID:: PMC7797992

Abstract Article PDF–390K

Select item 677767819.

MicroRNA-379-5p suppresses renal fibrosis by regulating the LIN28/let-7 axis in diabetic nephropathy

Nan Li, Li-Juan Wang, Wei-Long Xu, Su Liu, Jiang-Yi Yu

Int J Mol Med. 2019 Nov; 44(5): 1619–1628. Published online 2019 Aug 30. doi: 10.3892/ijmm.2019.4325

PMCID:: PMC6777678

Abstract Article PDF–1.8M

Select item 660551320.

Lin28B and Let-7 in the Control of Sympathetic Neurogenesis and Neuroblastoma Development

Melanie Hennchen, Jutta Stubbusch, Ikram Abarchan-El Makhfi, Marco Kramer, Thomas Deller, Cécile Pierre-Eugene, Isabelle Janoueix-Lerosey, Olivier Delattre, Uwe Ernsberger, Johannes B. Schulte, Hermann Rohrer

J Neurosci. 2015 Dec 16; 35(50): 16531–16544. doi: 10.1523/JNEUROSCI.2560-15.2015

PMCID:: PMC6605513

Abstract Article PDF–4.6M

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