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Select item 62146181.

Multimodal Ligand Binding Studies of Human and Mouse G-Coupled Taste Receptors to Correlate Their Species-Specific Sweetness Tasting Properties

Fariba M. Assadi-Porter, James Radek, Hongyu Rao, Marco Tonelli

Molecules. 2018 Oct; 23(10): 2531. Published online 2018 Oct 3. doi: 10.3390/molecules23102531

PMCID:: PMC6214618

Abstract Article PDF–8.9M

Select item 61977622.

T1R2 receptor-mediated glucose sensing in the upper intestine potentiates glucose absorption through activation of local regulatory pathways

Kathleen Smith, Elnaz Karimian Azari, Traci E. LaMoia, Tania Hussain, Veronika Vargova, Katalin Karolyi, Paula P. Veldhuis, Juan Pablo Arnoletti, Sebastian G. de la Fuente, Richard E. Pratley, Timothy F. Osborne, George A. Kyriazis

Mol Metab. 2018 Nov; 17: 98–111. Published online 2018 Aug 27. doi: 10.1016/j.molmet.2018.08.009

PMCID:: PMC6197762

Abstract Article PDF–2.2M

Select item 71422723.

Neural Isolation of the Olfactory Bulbs Severely Impairs Taste-Guided Behavior to Normally Preferred, But Not Avoided, Stimuli

Chizuko Inui-Yamamoto, Ginger D. Blonde, Fabienne Schmid, Lauren Mariotti, Matias Campora, Tadashi Inui, Lindsey A. Schier, Alan C. Spector

eNeuro. 2020 Mar-Apr; 7(2): ENEURO.0026-20.2020. Prepublished online 2020 Mar 9. Published online 2020 Mar 23. doi: 10.1523/ENEURO.0026-20.2020

PMCID:: PMC7142272

Abstract Article PDF–3.8M

Select item 65896024.

T1R2+T1R3-independent chemosensory inputs contributing to behavioral discrimination of sugars in mice

Lindsey A. Schier, Chizuko Inui-Yamamoto, Ginger D. Blonde, Alan C. Spector

Am J Physiol Regul Integr Comp Physiol. 2019 May 1; 316(5): R448–R462. Published online 2019 Jan 9. doi: 10.1152/ajpregu.00255.2018

PMCID:: PMC6589602

Abstract Article

Select item 56686175.

Detection of maltodextrin and its discrimination from sucrose are independent of the T1R2 + T1R3 heterodimer

Kimberly R. Smith, Alan C. Spector

Am J Physiol Regul Integr Comp Physiol. 2017 Oct 1; 313(4): R450–R462. Published online 2017 Aug 2. doi: 10.1152/ajpregu.00049.2017

PMCID:: PMC5668617

Abstract Article

Select item 48893616.

Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides

Sunil K. Sukumaran, Karen K. Yee, Shusuke Iwata, Ramana Kotha, Roberto Quezada-Calvillo, Buford L. Nichols, Sankar Mohan, B. Mario Pinto, Noriatsu Shigemura, Yuzo Ninomiya, Robert F. Margolskee

Proc Natl Acad Sci U S A. 2016 May 24; 113(21): 6035–6040. Published online 2016 May 9. doi: 10.1073/pnas.1520843113

PMCID:: PMC4889361

Abstract Article PDF–1.5M

Select item 48359417.

Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity

Kathleen R. Smith, Tania Hussain, Elnaz Karimian Azari, Jennifer L. Steiner, Julio E. Ayala, Richard E. Pratley, George A. Kyriazis

Am J Physiol Endocrinol Metab. 2016 Apr 15; 310(8): E688–E698. Published online 2016 Feb 16. doi: 10.1152/ajpendo.00484.2015

PMCID:: PMC4835941

Abstract Article

Select item 45913788.

Sugar-induced cephalic-phase insulin release is mediated by a T1r2+T1r3-independent taste transduction pathway in mice

John I. Glendinning, Sarah Stano, Marlena Holter, Tali Azenkot, Olivia Goldman, Robert F. Margolskee, Joseph R. Vasselli, Anthony Sclafani

Am J Physiol Regul Integr Comp Physiol. 2015 Sep; 309(5): R552–R560. Published online 2015 Jul 8. doi: 10.1152/ajpregu.00056.2015

PMCID:: PMC4591378

Abstract Article

Select item 42627089.

The Importance of the Presence of a 5′-Ribonucleotide and the Contribution of the T1R1 + T1R3 Heterodimer and an Additional Low-Affinity Receptor in the Taste Detection of l-Glutamate as Assessed Psychophysically

Kimberly R. Smith, Alan C. Spector

J Neurosci. 2014 Sep 24; 34(39): 13234–13245. doi: 10.1523/JNEUROSCI.0417-14.2014

PMCID:: PMC4262708

Abstract Article PDF–1.7M

Select item 389925910.

Sweet Taste Receptor Deficient Mice Have Decreased Adiposity and Increased Bone Mass

Becky R. Simon, Brian S. Learman, Sebastian D. Parlee, Erica L. Scheller, Hiroyuki Mori, William P. Cawthorn, Xiaomin Ning, Venkatesh Krishnan, Yanfei L. Ma, Björn Tyrberg, Ormond A. MacDougald

PLoS One. 2014; 9(1): e86454. Published online 2014 Jan 22. doi: 10.1371/journal.pone.0086454

PMCID:: PMC3899259

Abstract Article PDF–1.5M

Select item 340463511.

Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal

Yada Treesukosol, Alan C. Spector

Am J Physiol Regul Integr Comp Physiol. 2012 Jul 15; 303(2): R218–R235. Published online 2012 May 23. doi: 10.1152/ajpregu.00089.2012

PMCID:: PMC3404635

Abstract Article

Select item 325191312.

Behavioral Evidence for a Glucose Polymer Taste Receptor That Is Independent of the T1R2+3 Heterodimer in a Mouse Model

Yada Treesukosol, Kimberly R. Smith, Alan C. Spector

J Neurosci. 2011 Sep 21; 31(38): 13527–13534. doi: 10.1523/JNEUROSCI.2179-11.2011

PMCID:: PMC3251913

Abstract Article PDF–908K

Select item 269860913.

T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to polycose: implications for saccharide taste receptors in mice

Yada Treesukosol, Ginger D. Blonde, Alan C. Spector

Am J Physiol Regul Integr Comp Physiol. 2009 Apr; 296(4): R855–R865. Published online 2009 Jan 21. doi: 10.1152/ajpregu.90869.2008

PMCID:: PMC2698609

Abstract Article

Select item 1116249814.

The TAS1R2 G-protein-coupled receptor is an ambient glucose sensor in skeletal muscle that regulates NAD homeostasis and mitochondrial capacity

Joan Serrano, Jordan Boyd, Ian S. Brown, Carter Mason, Kathleen R. Smith, Katalin Karolyi, Santosh K. Maurya, Nishita N. Meshram, Vanida Serna, Grace M. Link, Stephen J. Gardell, George A. Kyriazis

Nat Commun. 2024; 15: 4915. Published online 2024 Jun 8. doi: 10.1038/s41467-024-49100-8

PMCID:: PMC11162498

Abstract Article PDF–3.4M

Select item 877331615.

Saccharin Stimulates Insulin Secretion Dependent on Sweet Taste Receptor-Induced Activation of PLC Signaling Axis

Joan Serrano, Nishita N. Meshram, Mangala M. Soundarapandian, Kathleen R. Smith, Carter Mason, Ian S. Brown, Björn Tyrberg, George A. Kyriazis

Biomedicines. 2022 Jan; 10(1): 120. Published online 2022 Jan 6. doi: 10.3390/biomedicines10010120

PMCID:: PMC8773316

Abstract Article PDF–2.0M

Select item 603229816.

Taste sensitivity to a mixture of monosodium glutamate and inosine 5′-monophosphate by mice lacking both subunits of the T1R1+T1R3 amino acid receptor

Ginger D. Blonde, Susan P. Travers, Alan C. Spector

Am J Physiol Regul Integr Comp Physiol. 2018 Jun 1; 314(6): R802–R810. Published online 2018 Feb 14. doi: 10.1152/ajpregu.00352.2017

PMCID:: PMC6032298

Abstract Article

Select item 586355317.

Phosphorus Taste Involves T1R2 and T1R3

Michael G. Tordoff

Chem Senses. 2017 Jun; 42(5): 425–433. Published online 2017 Apr 5. doi: 10.1093/chemse/bjx019

PMCID:: PMC5863553

Abstract Article PDF–4.6M

Select item 538097018.

Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity

Koenraad Philippaert, Andy Pironet, Margot Mesuere, William Sones, Laura Vermeiren, Sara Kerselaers, Sílvia Pinto, Andrei Segal, Nancy Antoine, Conny Gysemans, Jos Laureys, Katleen Lemaire, Patrick Gilon, Eva Cuypers, Jan Tytgat, Chantal Mathieu, Frans Schuit, Patrik Rorsman, Karel Talavera, Thomas Voets, Rudi Vennekens

Nat Commun. 2017; 8: 14733. Published online 2017 Mar 31. doi: 10.1038/ncomms14733