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Select item 105700351.

Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits

Daisy J Grove, Daniel J Levine, Michael G Kearse

Nucleic Acids Res. 2023 Oct 13; 51(18): 9983–10000. Published online 2023 Aug 21. doi: 10.1093/nar/gkad683

PMCID:: PMC10570035

Abstract Article PDF–5.4M

Select item 74325142.

Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)

Tiffany J. Rios-Fuller, Melanie Mahe, Beth Walters, Dounia Abbadi, Sandra Pérez-Baos, Abhilash Gadi, John J. Andrews, Olga Katsara, C. Theresa Vincent, Robert J. Schneider

Int J Mol Sci. 2020 Aug; 21(15): 5301. Published online 2020 Jul 26. doi: 10.3390/ijms21155301

PMCID:: PMC7432514

Abstract Article PDF–1.5M

Select item 69704503.

The Integrated Stress Response and Phosphorylated Eukaryotic Initiation Factor 2α in Neurodegeneration

Sarah Bond, Claudia Lopez-Lloreda, Patrick J Gannon, Cagla Akay-Espinoza, Kelly L Jordan-Sciutto

J Neuropathol Exp Neurol. 2020 Feb; 79(2): 123–143. Published online 2020 Jan 8. doi: 10.1093/jnen/nlz129

PMCID:: PMC6970450

Abstract Article PDF–873K

Select item 64841274.

15-Deoxy-Δ^12,14-prostaglandin J2 promotes phosphorylation of eukaryotic initiation factor 2α and activates the integrated stress response

Devin Tauber, Roy Parker

J Biol Chem. 2019 Apr 19; 294(16): 6344–6352. Published online 2019 Feb 5. doi: 10.1074/jbc.RA118.007138

PMCID:: PMC6484127

Abstract Article PDF–2.2M

Select item 3728695.

Mechanism and regulation of eukaryotic protein synthesis.

W C Merrick

Microbiol Rev. 1992 Jun; 56(2): 291–315. doi: 10.1128/mr.56.2.291-315.1992

PMCID:: PMC372869

Summary Page Browse PDF–5.5M

Select item 99270986.

SARS-CoV-2 Harnesses Host Translational Shutoff and Autophagy To Optimize Virus Yields: the Role of the Envelope (E) Protein

Hope Waisner, Brandon Grieshaber, Rabina Saud, Wyatt Henke, Edward B. Stephens, Maria Kalamvoki

Microbiol Spectr. 2023 Jan-Feb; 11(1): e03707-22. Published online 2023 Jan 9. doi: 10.1128/spectrum.03707-22

PMCID:: PMC9927098

Abstract Article PDF–3.3M

Select item 98945587.

The enterovirus genome can be translated in an IRES-independent manner that requires the initiation factors eIF2A/eIF2D

Hyejeong Kim, David Aponte-Diaz, Mohamad S. Sotoudegan, Djoshkun Shengjuler, Jamie J. Arnold, Craig E. Cameron

PLoS Biol. 2023 Jan; 21(1): e3001693. Published online 2023 Jan 23. doi: 10.1371/journal.pbio.3001693

PMCID:: PMC9894558

Abstract Article PDF–5.6M

Select item 97798138.

PKR-Mediated Phosphorylation of eIF2a and CHK1 Is Associated with Doxorubicin-Mediated Apoptosis in HCC1143 Triple-Negative Breast Cancer Cells

Sol Lee, Ha-Yeon Jee, Yoon-Gyeong Lee, Jong-Il Shin, Yong-Joon Jeon, Ji-Beom Kim, Hye-eun Seo, Ji-Yeon Lee, Kyungho Lee

Int J Mol Sci. 2022 Dec; 23(24): 15872. Published online 2022 Dec 14. doi: 10.3390/ijms232415872

PMCID:: PMC9779813

Abstract Article PDF–2.2M

Select item 82709679.

MYC-targeted WDR4 promotes proliferation, metastasis, and sorafenib resistance by inducing CCNB1 translation in hepatocellular carcinoma

Peng Xia, Hao Zhang, Kequan Xu, Xiang Jiang, Meng Gao, Ganggang Wang, Yingyi Liu, Ye Yao, Xi Chen, Weijie Ma, Zhonglin Zhang, Yufeng Yuan

Cell Death Dis. 2021 Jul; 12(7): 691. Published online 2021 Jul 9. doi: 10.1038/s41419-021-03973-5

PMCID:: PMC8270967

Abstract Article PDF–7.0M

Select item 694079310.

ER Stress Induces Cell Cycle Arrest at the G2/M Phase Through eIF2α Phosphorylation and GADD45α

Duckgue Lee, Daniel Hokinson, Soyoung Park, Rosalie Elvira, Fedho Kusuma, Ji-Min Lee, Miyong Yun, Seok-Geun Lee, Jaeseok Han

Int J Mol Sci. 2019 Dec; 20(24): 6309. Published online 2019 Dec 13. doi: 10.3390/ijms20246309

PMCID:: PMC6940793

Abstract Article PDF–2.9M

Select item 652185911.

Expression and Clinical Significance of PERK and Phosphorylated EIF2α in Pancreatic Ductal Adenocarcinoma

Eric M. Wang, Hironari Akasaka, Jun Zhao, Gauri R Varadhachary, Jeffrey E. Lee, Anirban Maitra, Jason B Fleming, Mien-Chien Hung, Huamin Wang, Matthew H Katz

Pancreas. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Pancreas. 2019 Mar; 48(3): 323–328. doi: 10.1097/MPA.0000000000001248

PMCID:: PMC6521859

Abstract Article PDF–2.0M

Select item 651399012.

An integrated stress response via PKR suppresses HER2+ cancers and improves trastuzumab therapy

Cedric Darini, Nour Ghaddar, Catherine Chabot, Gloria Assaker, Siham Sabri, Shuo Wang, Jothilatha Krishnamoorthy, Marguerite Buchanan, Adriana Aguilar-Mahecha, Bassam Abdulkarim, Jean Deschenes, Jose Torres, Josie Ursini-Siegel, Mark Basik, Antonis E. Koromilas

Nat Commun. 2019; 10: 2139. Published online 2019 May 13. doi: 10.1038/s41467-019-10138-8

PMCID:: PMC6513990

Abstract Article PDF–1.7M

Select item 532739813.

Translation of Sindbis Subgenomic mRNA is Independent of eIF2, eIF2A and eIF2D

Miguel Angel Sanz, Esther González Almela, Luis Carrasco

Sci Rep. 2017; 7: 43876. Published online 2017 Feb 27. doi: 10.1038/srep43876

PMCID:: PMC5327398

Abstract Article PDF–6.0M

Select item 453866514.

Baculovirus protein PK2 subverts eIF2α kinase function by mimicry of its kinase domain C-lobe

John J. Li, Chune Cao, Sarah M. Fixsen, Janet M. Young, Chikako Ono, Hisanori Bando, Nels C. Elde, Susumu Katsuma, Thomas E. Dever, Frank Sicheri

Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32): E4364–E4373. Published online 2015 Jul 27. doi: 10.1073/pnas.1505481112

PMCID:: PMC4538665

Abstract Article PDF–1.2M

Select item 852351815.

Downregulation of PHLPP induced by endoplasmic reticulum stress promotes eIF2α phosphorylation and chemoresistance in colon cancer

Bianqin Guo, Xiaopeng Xiong, Sumati Hasani, Yang-An Wen, Austin T. Li, Rebecca Martinez, Ashley T. Skaggs, Tianyan Gao

Cell Death Dis. 2021 Nov; 12(11): 960. Published online 2021 Oct 18. doi: 10.1038/s41419-021-04251-0

PMCID:: PMC8523518

Abstract Article PDF–2.5M

Select item 817084116.

The alternative initiation factor eIF2A plays key role in RAN translation of myotonic dystrophy type 2 CCUG•CAGG repeats

Solaleh Khoramian Tusi, Lien Nguyen, Kiruphagaran Thangaraju, Jian Li, John D Cleary, Tao Zu, Laura P W Ranum

Hum Mol Genet. 2021 Jun 1; 30(11): 1020–1029. Published online 2021 Apr 15. doi: 10.1093/hmg/ddab098

PMCID:: PMC8170841

Abstract Article PDF–1.0M

Select item 698480317.

miR-195 promotes LPS-mediated intestinal epithelial cell apoptosis via targeting SIRT1/eIF2a

Ting Yuan, Li Zhang, Shuo Yao, Shuang-Ya Deng, Ji-Qiang Liu

Int J Mol Med. 2020 Feb; 45(2): 510–518. Published online 2019 Dec 18. doi: 10.3892/ijmm.2019.4431

PMCID:: PMC6984803

Abstract Article PDF–1.2M

Select item 655566818.

ER and Nutrient Stress Promote Assembly of Respiratory Chain Supercomplexes Through PERK/eIF2α Axis

Eduardo Balsa, Meghan S. Soustek, Ajith Thomas, Sara Cogliati, Carolina García-Poyatos, Elena Martín-García, Mark Jedrychowski, Steve P. Gygi, José Antonio Enriquez, Pere Puigserver

Mol Cell. Author manuscript; available in PMC 2020 Jun 6.

Published in final edited form as: Mol Cell. 2019 Jun 6; 74(5): 877–890.e6. Published online 2019 Apr 22. doi: 10.1016/j.molcel.2019.03.031