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Select item 82923181.

TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy

Ariella Zehender, Yi-Nan Li, Neng-Yu Lin, Adrian Stefanica, Julian Nüchel, Chih-Wei Chen, Hsiao-Han Hsu, Honglin Zhu, Xiao Ding, Jingang Huang, Lichong Shen, Andrea-Hermina Györfi, Alina Soare, Simon Rauber, Christina Bergmann, Andreas Ramming, Markus Plomann, Beate Eckes, Georg Schett, Jörg H. W. Distler

Nat Commun. 2021; 12: 4404. Published online 2021 Jul 20. doi: 10.1038/s41467-021-24601-y

PMCID:: PMC8292318

Abstract Article PDF–8.3M

Select item 80889122.

MOF upregulates the estrogen receptor α signaling pathway by its acetylase activity in hepatocellular carcinoma

Shan Wei, Wei Liu, Ning Sun, Yi Wu, Huijuan Song, Chunyu Wang, Shengli Wang, Renlong Zou, Lin Lin, Kai Zeng, Baosheng Zhou, Manlin Wang, Ruina Luan, Fan Yang, Yue Zhao

Cancer Sci. 2021 May; 112(5): 1865–1877. Published online 2021 Mar 30. doi: 10.1111/cas.14836

PMCID:: PMC8088912

Abstract Article PDF–2.9M

Select item 78305703.

Substrate Scope for Human Histone Lysine Acetyltransferase KAT8

Giordano Proietti, Yali Wang, Chiara Punzo, Jasmin Mecinović

Int J Mol Sci. 2021 Jan; 22(2): 846. Published online 2021 Jan 15. doi: 10.3390/ijms22020846

PMCID:: PMC7830570

Abstract Article PDF–1.9M

Select item 74592634.

Histone Acetyltransferase MOF Orchestrates Outcomes at the Crossroad of Oncogenesis, DNA Damage Response, Proliferation, and Stem Cell Development

Mayank Singh, Albino Bacolla, Shilpi Chaudhary, Clayton R. Hunt, Shruti Pandita, Ravi Chauhan, Ashna Gupta, John A. Tainer, Tej K. Pandita

Mol Cell Biol. 2020 Sep; 40(18): e00232-20. Prepublished online 2020 Jul 13. Published online 2020 Aug 28. doi: 10.1128/MCB.00232-20

PMCID:: PMC7459263

Abstract Article PDF–961K

Select item 70612485.

Estrogen/estrogen receptor promotes the proliferation of endometrial carcinoma cells by enhancing hMOF expression

Yue Qi, Mingzi Tan, Mingjun Zheng, Shan Jin, Huimin Wang, Juanjuan Liu, Peiyao Wang, Xin Nie, Lingling Gao, Bei Lin

Jpn J Clin Oncol. 2020 Mar; 50(3): 241–253. Published online 2020 Jan 28. doi: 10.1093/jjco/hyz174

PMCID:: PMC7061248

Abstract Article PDF–1.9M

Select item 58361416.

Revealing the protein propionylation activity of the histone acetyltransferase MOF (males absent on the first)

Zhen Han, Hong Wu, Sunjoo Kim, Xiangkun Yang, Qianjin Li, He Huang, Houjian Cai, Michael G. Bartlett, Aiping Dong, Hong Zeng, Peter J. Brown, Xiang-jiao Yang, Cheryl H. Arrowsmith, Yingming Zhao, Y. George Zheng

J Biol Chem. 2018 Mar 2; 293(9): 3410–3420. Published online 2018 Jan 10. doi: 10.1074/jbc.RA117.000529

PMCID:: PMC5836141

Abstract Article PDF–1.8M

Select item 50000677.

Structural and Functional Role of Acetyltransferase hMOF K274 Autoacetylation

Cheryl E. McCullough, Shufei Song, Michael H. Shin, F. Brad Johnson, Ronen Marmorstein

J Biol Chem. 2016 Aug 26; 291(35): 18190–18198. Published online 2016 Jul 5. doi: 10.1074/jbc.M116.736264

PMCID:: PMC5000067

Abstract Article PDF–2.1M

Select item 49658438.

KAT8 Regulates Androgen Signaling in Prostate Cancer Cells

Ji-Young Kim, Jindan Yu, Sarki A. Abdulkadir, Debabrata Chakravarti

Mol Endocrinol. 2016 Aug; 30(8): 925–936. Published online 2016 Jun 7. doi: 10.1210/me.2016-1024

PMCID:: PMC4965843

Abstract Article

Select item 40809749.

The histone acetylranseferase hMOF acetylates Nrf2 and regulates anti-drug responses in human non-small cell lung cancer

Zhiwei Chen, Xiangyun Ye, Naiwang Tang, Shengping Shen, Ziming Li, Xiaomin Niu, Shun Lu, Ling Xu

Br J Pharmacol. 2014 Jul; 171(13): 3196–3211. Published online 2014 Jun 10. doi: 10.1111/bph.12661

PMCID:: PMC4080974

Abstract Article PDF–2.5M

Select item 404206710.

Coactivator MYST1 Regulates Nuclear Factor-κB and Androgen Receptor Functions During Proliferation of Prostate Cancer Cells

Anbalagan Jaganathan, Pratima Chaurasia, Guang-Qian Xiao, Marc Philizaire, Xiang Lv, Shen Yao, Kerry L. Burnstein, De-Pei Liu, Alice C. Levine, Shiraz Mujtaba

Mol Endocrinol. 2014 Jun; 28(6): 872–885. Published online 2014 Apr 4. doi: 10.1210/me.2014-1055

PMCID:: PMC4042067

Abstract Article

Select item 363809711.

RNAi screening identifies KAT8 as a key molecule important for cancer cell survival

Shuang Zhang, Xianhong Liu, Yong Zhang, Ying Cheng, Yang Li

Int J Clin Exp Pathol. 2013; 6(5): 870–877. Published online 2013 Apr 15.

PMCID:: PMC3638097

Abstract Article PDF–728K

Select item 319347512.

Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274

Bingfa Sun, Shunling Guo, Qingyu Tang, Chen Li, Rong Zeng, Zhiqi Xiong, Chen Zhong, Jianping Ding

Cell Res. 2011 Aug; 21(8): 1262–1266. Published online 2011 Jun 21. doi: 10.1038/cr.2011.105

PMCID:: PMC3193475

Article PDF–588K

Select item 119033813.

hMOF Histone Acetyltransferase Is Required for Histone H4 Lysine 16 Acetylation in Mammalian Cells

Mikko Taipale, Stephen Rea, Karsten Richter, Ana Vilar, Peter Lichter, Axel Imhof, Asifa Akhtar

Mol Cell Biol. 2005 Aug; 25(15): 6798–6810. doi: 10.1128/MCB.25.15.6798-6810.2005

PMCID:: PMC1190338

Abstract Article PDF–932K

Select item 805618614.

Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcriptional regulation and cellular homeostasis

Aliaksandra Radzisheuskaya, Pavel V. Shliaha, Vasily V. Grinev, Daria Shlyueva, Helene Damhofer, Richard Koche, Vladimir Gorshkov, Sergey Kovalchuk, Yingqian Zhan, Keli L. Rodriguez, Andrea L. Johnstone, Michael-C Keogh, Ronald C. Hendrickson, Ole N. Jensen, Kristian Helin

Mol Cell. Author manuscript; available in PMC 2022 Apr 15.

Published in final edited form as: Mol Cell. 2021 Feb 23 : S1097-2765(21)00098-8. Published online 2021 Feb 23. doi: 10.1016/j.molcel.2021.02.012

PMCID:: PMC8056186

Abstract Article PDF–2.3M

Select item 794857215.

Dysregulation of intercellular signaling by MOF deletion leads to liver injury

Hongwei Lei, Aaron D. denDekker, Guobing Li, Zhiguo Zhang, Liang Sha, Matthew A. Schaller, Steven L. Kunkel, Liangyou Rui, Kaixiong Tao, Yali Dou

J Biol Chem. 2021 Jan-Jun; 296: 100235. Published online 2021 Jan 7. doi: 10.1074/jbc.RA120.016079

PMCID:: PMC7948572

Abstract Article PDF–4.4M

Select item 649644916.

hMOF (human males absent on the first), an oncogenic protein of human oral tongue squamous cell carcinoma, targeting EZH2 (enhancer of zeste homolog 2)

Qihong Li, Haiyan Sun, Yao Shu, Xuan Zou, Yantao Zhao, Cheng Ge

Cell Prolif. 2015 Aug; 48(4): 436–442. Published online 2015 Jun 1. doi: 10.1111/cpr.12177

PMCID:: PMC6496449

Abstract Article PDF–949K

Select item 550129317.

Histone acetyltransferase activity of MOF is required for MLL-AF9 leukemogenesis

Daria G. Valerio, Haiming Xu, Chun-Wei Chen, Takayuki Hoshii, Meghan E. Eisold, Christopher Delaney, Monica Cusan, Aniruddha J. Deshpande, Chun-Hao Huang, Amaia Lujambio, George Zheng, Johannes Zuber, Tej K. Pandita, Scott W. Lowe, Scott A. Armstrong

Cancer Res. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Cancer Res. 2017 Apr 1; 77(7): 1753–1762. Published online 2017 Feb 15. doi: 10.1158/0008-5472.CAN-16-2374

PMCID:: PMC5501293

Abstract Article PDF–1.6M

Select item 504530918.

A multifaceted role for MOF histone modifying factor in genome maintenance

Kalpana Mujoo, Clayton R. Hunt, Nobuo Horikoshi, Tej K. Pandita

Mech Ageing Dev. Author manuscript; available in PMC 2018 Jan 1.

Published in final edited form as: Mech Ageing Dev. 2017 Jan; 161(Pt A): 177–180. Published online 2016 Mar 30. doi: 10.1016/j.mad.2016.03.012

PMCID:: PMC5045309

Abstract Article PDF–369K

Select item 347171419.

Autoacetylation of the MYST Lysine Acetyltransferase MOF Protein

Chao Yang, Jiang Wu, Sarmistha H. Sinha, John M. Neveu, Yujun George Zheng

J Biol Chem. 2012 Oct 12; 287(42): 34917–34926. Published online 2012 Aug 23. doi: 10.1074/jbc.M112.359356

PMCID:: PMC3471714

Abstract Article PDF–1.6M

Select item 325258220.

MYST protein acetyltransferase activity requires active site lysine autoacetylation

Hua Yuan, Dorine Rossetto, Hestia Mellert, Weiwei Dang, Madhusudan Srinivasan, Jamel Johnson, Santosh Hodawadekar, Emily C Ding, Kaye Speicher, Nebiyu Abshiru, Rocco Perry, Jiang Wu, Chao Yang, Y George Zheng, David W Speicher, Pierre Thibault, Alain Verreault, F Bradley Johnson, Shelley L Berger, Rolf Sternglanz, Steven B McMahon, Jacques Côté, Ronen Marmorstein

EMBO J. 2012 Jan 4; 31(1): 58–70. Published online 2011 Oct 21. doi: 10.1038/emboj.2011.382

PMCID:: PMC3252582

Abstract Article PDF–1.4M

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