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Select item 110435101.

O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis

Shia Vang, Eric Scott Helton, Yiming Guo, Bailey Burpee, Elex Rose, Molly Easter, Seth Bollenbecker, Meghan June Hirsch, Emma Lea Matthews, Luke Isaac Jones, Patrick Henry Howze, IV, Vasanthi Rajasekaran, Rebecca Denson, Phillip Cochran, Isaac Kwame Attah, Heather Olson, Geremy Clair, Girish Melkani, Stefanie Krick, Jarrod Wesley Barnes

Front Immunol. 2024; 15: 1387197. Published online 2024 Apr 11. doi: 10.3389/fimmu.2024.1387197

PMCID:: PMC11043510

Abstract Article PDF–4.5M

Select item 104839922.

O-GlcNAc Cycling: A Link Between Metabolism and Chronic Disease

Michelle R. Bond, John A. Hanover

Annu Rev Nutr. Author manuscript; available in PMC 2023 Sep 7.

Published in final edited form as: Annu Rev Nutr. 2013; 33: 205–229. Published online 2013 Apr 29. doi: 10.1146/annurev-nutr-071812-161240

PMCID:: PMC10483992

Abstract Article PDF–842K

Select item 98396433.

O-GlcNAc transferase contributes to sex-specific placental deregulation in gestational diabetes

Yiwen CUI, Meredith CRUZ, Anna PALATNIK, Stephanie OLIVIER-VAN STICHELEN

Placenta. Author manuscript; available in PMC 2024 Jan 1.

Published in final edited form as: Placenta. 2023 Jan; 131: 1–12. Published online 2022 Nov 19. doi: 10.1016/j.placenta.2022.11.006

PMCID:: PMC9839643

Abstract Article PDF–1.8M

Select item 88070244.

Inhibition of mechanistic target of rapamycin signaling decreases levels of O-GlcNAc transferase and increases serotonin release in the human placenta

Amy C. Kelly, Anita Kramer, Fredrick J. Rosario, Theresa L Powell, Thomas Jansson

Clin Sci (Lond) Author manuscript; available in PMC 2022 Feb 1.

Published in final edited form as: Clin Sci (Lond). 2020 Dec 11; 134(23): 3123–3136. doi: 10.1042/CS20201050

PMCID:: PMC8807024

Abstract Article PDF–607K

Select item 86993455.

Inhibition of O-GlcNAc Transferase Alters the Differentiation and Maturation Process of Human Monocyte Derived Dendritic Cells

Matjaž Weiss, Marko Anderluh, Martina Gobec

Cells. 2021 Dec; 10(12): 3312. Published online 2021 Nov 26. doi: 10.3390/cells10123312

PMCID:: PMC8699345

Abstract Article PDF–2.8M

Select item 80371016.

Feedback Regulation of O-GlcNAc Transferase through Translation Control to Maintain Intracellular O-GlcNAc Homeostasis

Chia-Hung Lin, Chen-Chung Liao, Mei-Yu Chen, Teh-Ying Chou

Int J Mol Sci. 2021 Apr; 22(7): 3463. Published online 2021 Mar 27. doi: 10.3390/ijms22073463

PMCID:: PMC8037101

Abstract Article PDF–3.9M

Select item 71391167.

Epigenetic activation of O-linked β-N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia

K.M. Kampa-Schittenhelm, T. Haverkamp, M. Bonin, V. Tsintari, H.J. Bühring, L. Haeusser, G. Blumenstock, S.T. Dreher, T. Ganief, F. Akmut, B. Illing, U.A. Mau-Holzmann, I. Bonzheim, E. Schleicher, W. Vogel, M.M. Schittenhelm

EBioMedicine. 2020 Apr; 54: 102678. Published online 2020 Apr 6. doi: 10.1016/j.ebiom.2020.102678

PMCID:: PMC7139116

Abstract Article PDF–4.8M

Select item 71279628.

O-GlcNAc Transferase Regulates Cancer Stem-like Potential of Breast Cancer Cells

Neha M. Akella, Giang Le Minh, Lorela Ciraku, Ayonika Mukherjee, Zachary A. Bacigalupa, Dimpi Mukhopadhyay, Valerie L. Sodi, Mauricio J. Reginato

Mol Cancer Res. Author manuscript; available in PMC 2020 Oct 1.

Published in final edited form as: Mol Cancer Res. 2020 Apr; 18(4): 585–598. Published online 2020 Jan 23. doi: 10.1158/1541-7786.MCR-19-0732

PMCID:: PMC7127962

Abstract Article PDF–675K

Select item 70420889.

A missense mutation in the catalytic domain of O‐GlcNAc transferase links perturbations in protein O‐GlcNAcylation to X‐linked intellectual disability

Veronica M. Pravata, Mehmet Gundogdu, Sergio G. Bartual, Andrew T. Ferenbach, Marios Stavridis, Katrin Õunap, Sander Pajusalu, Riina Žordania, Monica H. Wojcik, Daan M. F. van Aalten

FEBS Lett. 2020 Feb; 594(4): 717–727. Published online 2019 Nov 7. doi: 10.1002/1873-3468.13640

PMCID:: PMC7042088

Abstract Article PDF–881K

Select item 696120410.

Salomé Llabrés, Maxim I. Tsenkov, Stuart A. MacGowan, Geoffrey J. Barton, Ulrich Zachariae

J Struct Biol. 2020 Jan 1; 209(1): 107405. doi: 10.1016/j.jsb.2019.107405

PMCID:: PMC6961204

Abstract Article PDF–2.2M

Select item 694115611.

O-GlcNAc Transferase Regulates Angiogenesis in Idiopathic Pulmonary Arterial Hypertension

Jarrod W. Barnes, Liping Tian, Stefanie Krick, E. Scott Helton, Rebecca S. Denson, Suzy A. A. Comhair, Raed A. Dweik

Int J Mol Sci. 2019 Dec; 20(24): 6299. Published online 2019 Dec 13. doi: 10.3390/ijms20246299

PMCID:: PMC6941156

Abstract Article PDF–4.3M

Select item 685133812.

O-GlcNAcylation of Thr¹²/Ser⁵⁶ in short-form O-GlcNAc transferase (sOGT) regulates its substrate selectivity

Li Liu, Ling Li, Cheng Ma, Yangde Shi, Congcong Liu, Zikang Xiao, Yong Zhang, Fang Tian, Yang Gao, Jie Zhang, Wantao Ying, Peng George Wang, Lianwen Zhang

J Biol Chem. 2019 Nov 8; 294(45): 16620–16633. Published online 2019 Sep 16. doi: 10.1074/jbc.RA119.009085

PMCID:: PMC6851338

Abstract Article PDF–3.0M

Select item 684937513.

Aspartate residues far from the active site drive O-GlcNAc transferase substrate selection

Cassandra M. Joiner, Zebulon G. Levine, Chanat Aonbangkhen, Christina M. Woo, Suzanne Walker

J Am Chem Soc. Author manuscript; available in PMC 2020 Aug 21.

Published in final edited form as: J Am Chem Soc. 2019 Aug 21; 141(33): 12974–12978. Published online 2019 Aug 7. doi: 10.1021/jacs.9b06061

PMCID:: PMC6849375

Abstract Article PDF–1.0M

Select item 653129414.

High OGT activity is essential for MYC-driven proliferation of prostate cancer cells

Harri M Itkonen, Alfonso Urbanucci, Sara ES Martin, Aziz Khan, Anthony Mathelier, Bernd Thiede, Suzanne Walker, Ian G Mills

Theranostics. 2019; 9(8): 2183–2197. Published online 2019 Apr 12. doi: 10.7150/thno.30834

PMCID:: PMC6531294

Abstract Article PDF–1.9M

Select item 624561115.

Suppressed OGT expression inhibits cell proliferation while inducing cell apoptosis in bladder cancer

Longsheng Wang, Shaojun Chen, Ziwei Zhang, Junfeng Zhang, Shiyu Mao, Jiayi Zheng, Yang Xuan, Mengnan Liu, Keke Cai, Wentao Zhang, Yadong Guo, Wei Zhai, Xudong Yao

BMC Cancer. 2018; 18: 1141. Published online 2018 Nov 20. doi: 10.1186/s12885-018-5033-y

PMCID:: PMC6245611

Abstract Article PDF–6.4M

Select item 603621816.

O-GlcNAc transferase missense mutations linked to X-linked intellectual disability deregulate genes involved in cell fate determination and signaling

Nithya Selvan, Stephan George, Fatema J. Serajee, Marie Shaw, Lynne Hobson, Vera Kalscheuer, Nripesh Prasad, Shawn E. Levy, Juliet Taylor, Salim Aftimos, Charles E. Schwartz, Ahm M. Huq, Jozef Gecz, Lance Wells

J Biol Chem. 2018 Jul 6; 293(27): 10810–10824. Published online 2018 May 16. doi: 10.1074/jbc.RA118.002583

PMCID:: PMC6036218

Abstract Article PDF–1.9M

Select item 596797117.

The O-GlcNAc Transferase Intellectual Disability Mutation L254F Distorts the TPR Helix

Mehmet Gundogdu, Salomé Llabrés, Andrii Gorelik, Andrew T. Ferenbach, Ulrich Zachariae, Daan M.F. van Aalten

Cell Chem Biol. 2018 May 17; 25(5): 513–518.e4. doi: 10.1016/j.chembiol.2018.03.004

PMCID:: PMC5967971

Abstract Article PDF–1.7M

Select item 544812718.

Identification and characterization of a missense mutation in the O-linked β-N-acetylglucosamine (O-GlcNAc) transferase gene that segregates with X-linked intellectual disability

Krithika Vaidyanathan, Tejasvi Niranjan, Nithya Selvan, Chin Fen Teo, Melanie May, Sneha Patel, Brent Weatherly, Cindy Skinner, John Opitz, John Carey, David Viskochil, Jozef Gecz, Marie Shaw, Yunhui Peng, Emil Alexov, Tao Wang, Charles Schwartz, Lance Wells

J Biol Chem. 2017 May 26; 292(21): 8948–8963. Published online 2017 Mar 16. doi: 10.1074/jbc.M116.771030