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Select item 107672381.

Aldo-keto reductase family member C3 (AKR1C3) promotes hepatocellular carcinoma cell growth by producing prostaglandin F2α

KUO-SHYANG JENG, PO-YU CHENG, YUEH-HSIEN LIN, PO-CHUN LIU, PING-HUI TSENG, YU-CHAO WANG, CHIUNG-FANG CHANG, CHUEN-MIIN LEU

Oncol Res. 2024; 32(1): 163–174. Published online 2023 Nov 15. doi: 10.32604/or.2023.030975

PMCID:: PMC10767238

Abstract Article PDF–6.5M

Select item 100037532.

Establishing a Proteomics-Based Signature of AKR1C3-Related Genes for Predicting the Prognosis of Prostate Cancer

Xiaoli Cui, Changcheng Li, Jipeng Ding, Zhou Yao, Tianyu Zhao, Jiahui Guo, Yaru Wang, Jing Li

Int J Mol Sci. 2023 Mar; 24(5): 4513. Published online 2023 Feb 24. doi: 10.3390/ijms24054513

PMCID:: PMC10003753

Abstract Article PDF–8.8M

Select item 99683133.

Influence of aldo–keto reductase 1C3 polymorphisms in early-onset female psoriasis patients

Yuka Nojiri, Motoki Nakamura, Tetsuya Magara, Aya Yamamoto, Kyoko Ikumi, Reiko Nakamura, Emi Nishida, Thomas Haarmann-Stemmann, Akimichi Morita

Sci Rep. 2023; 13: 3280. Published online 2023 Feb 25. doi: 10.1038/s41598-023-30464-8

PMCID:: PMC9968313

Abstract Article PDF–6.1M

Select item 97065854.

AKR1C3-dependent lipid droplet formation confers hepatocellular carcinoma cell adaptability to targeted therapy

Changqing Wu, Chaoliu Dai, Xinyu Li, Mingju Sun, Hongwei Chu, Qiuhui Xuan, Yalei Yin, Chengnan Fang, Fan Yang, Zhonghao Jiang, Qing Lv, Keqing He, Yiying Qu, Baofeng Zhao, Ke Cai, Shuijun Zhang, Ran Sun, Guowang Xu, Lihua Zhang, Siyu Sun, Yang Liu

Theranostics. 2022; 12(18): 7681–7698. Published online 2022 Nov 7. doi: 10.7150/thno.74974

PMCID:: PMC9706585

Abstract Article PDF–3.0M

Select item 96759785.

Characterization of the major single nucleotide polymorphic variants of aldo-keto reductase 1C3 (type 5 17β-hydroxysteroid dehydrogenase)

Andrea J. Detlefsen, Phumvadee Wangtrakuldee, Trevor M. Penning

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2023 Jul 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2022 Jul; 221: 106121. Published online 2022 Apr 28. doi: 10.1016/j.jsbmb.2022.106121

PMCID:: PMC9675978

Abstract Article PDF–1.0M

Select item 96323146.

Plasma Exosomal AKR1C3 mRNA Expression Is a Predictive and Prognostic Biomarker in Patients with Metastatic Castration-Resistant Prostate Cancer

Sha Zhu, Yuchao Ni, Zilin Wang, Xingming Zhang, Yaowen Zhang, Fengnian Zhao, Jindong Dai, Zhipeng Wang, Xudong Zhu, Junru Chen, Jinge Zhao, Yuhao Zeng, Ni Chen, Peng Zeng, Pengfei Shen, Guangxi Sun, Hao Zeng

Oncologist. 2022 Nov; 27(11): e870–e877. Published online 2022 Sep 6. doi: 10.1093/oncolo/oyac177

PMCID:: PMC9632314

Abstract Article PDF–5.2M

Select item 87420817.

Assessment of factors associated with PSA level in prostate cancer cases and controls from three geographical regions

Nishi Karunasinghe, Tsion Zewdu Minas, Bo-Ying Bao, Arier Lee, Alice Wang, Shuotun Zhu, Jonathan Masters, Megan Goudie, Shu-Pin Huang, Frank J. Jenkins, Lynnette R. Ferguson

Sci Rep. 2022; 12: 55. Published online 2022 Jan 7. doi: 10.1038/s41598-021-04116-8

PMCID:: PMC8742081

Abstract Article PDF–1.2M

Select item 65343108.

Interaction between leukocyte aldo-keto reductase 1C3 activity, genotypes, biological, lifestyle and clinical features in a prostate cancer cohort from New Zealand

Nishi Karunasinghe, Eva Symes, Amy Gamage, Alice Wang, Pam Murray, Shuotun Zhu, Megan Goudie, Jonathan Masters, Lynnette R. Ferguson

PLoS One. 2019; 14(5): e0217373. Published online 2019 May 24. doi: 10.1371/journal.pone.0217373

PMCID:: PMC6534310

Abstract Article PDF–867K

Select item 60079069.

Influence of lifestyle and genetic variants in the aldo-keto reductase 1C3 rs12529 polymorphism in high-risk prostate cancer detection variability assessed between US and New Zealand cohorts

Nishi Karunasinghe, Stefan Ambs, Alice Wang, Wei Tang, Shuotun Zhu, Tiffany H. Dorsey, Megan Goudie, Jonathan G. Masters, Lynnette R. Ferguson

PLoS One. 2018; 13(6): e0199122. Published online 2018 Jun 19. doi: 10.1371/journal.pone.0199122

PMCID:: PMC6007906

Abstract Article PDF–3.7M

Select item 539125610.

Knockdown of AKR1C3 exposes a potential epigenetic susceptibility in prostate cancer cells

Craig L. Doig, Sebastiano Battaglia, Farhat L. Khanim, Christopher M. Bunce, Moray J. Campbell

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2017 Apr 13.

Published in final edited form as: J Steroid Biochem Mol Biol. 2016 Jan; 155(Pt A): 47–55. Published online 2015 Sep 30. doi: 10.1016/j.jsbmb.2015.09.037

PMCID:: PMC5391256

Abstract Article PDF–538K

Select item 521699911.

Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation

Shao-Qian Sun, Xiaobin Gu, Xian-Shu Gao, Yi Li, Hongliang Yu, Wei Xiong, Hao Yu, Wen Wang, Yingbo Li, Yingqi Teng, Demin Zhou

Oncotarget. 2016 Jul 26; 7(30): 48050–48058. Published online 2016 Jun 30. doi: 10.18632/oncotarget.10347

Correction in:: Oncotarget. 2020 Apr 28; 11(17): 1575.

PMCID:: PMC5216999

Abstract Article PDF–9.9M

Select item 508804912.

Impact of nonsynonymous single nucleotide polymorphisms on in vitro metabolism of exemestane by hepatic cytosolic reductases

Amity Platt, Zuping Xia, Ying Liu, Gang Chen, Philip Lazarus

Pharmacogenet Genomics. Author manuscript; available in PMC 2017 Aug 1.

Published in final edited form as: Pharmacogenet Genomics. 2016 Aug; 26(8): 370–380. doi: 10.1097/FPC.0000000000000226

PMCID:: PMC5088049

Abstract Article PDF–1.2M

Select item 497163913.

Quality of life effects of androgen deprivation therapy in a prostate cancer cohort in New Zealand: can we minimize effects using a stratification based on the aldo-keto reductase family 1, member C3 rs12529 gene polymorphism?

Nishi Karunasinghe, Yifei Zhu, Dug Yeo Han, Katja Lange, Shuotun Zhu, Alice Wang, Stephanie Ellett, Jonathan Masters, Megan Goudie, Justin Keogh, Benji Benjamin, Michael Holmes, Lynnette R. Ferguson

BMC Urol. 2016; 16: 48. Published online 2016 Aug 2. doi: 10.1186/s12894-016-0164-4

PMCID:: PMC4971639

Abstract Article PDF–659K

Select item 438369514.

Intracrine androgens and AKR1C3 activation confer resistance to enzalutamide in prostate cancer

Chengfei Liu, Wei Lou, Yezi Zhu, Joy C. Yang, Nagalakshmi Nadiminty, Nilesh W. Gaikwad, Christopher P. Evans, Allen C. Gao

Cancer Res. Author manuscript; available in PMC 2016 Apr 1.

Published in final edited form as: Cancer Res. 2015 Apr 1; 75(7): 1413–1422. Published online 2015 Feb 3. doi: 10.1158/0008-5472.CAN-14-3080

PMCID:: PMC4383695

Abstract Article PDF–1.3M

Select item 424261515.

Elevated Expression of AKR1C3 Increases Resistance of Cancer Cells to Ionizing Radiation via Modulation of Oxidative Stress

Wei Xiong, Jing Zhao, Hongliang Yu, Xiaoying Li, Shaoqian Sun, Yi Li, Qing Xia, Chuanling Zhang, Qiuchen He, Xianshu Gao, Lihe Zhang, Demin Zhou

PLoS One. 2014; 9(11): e111911. Published online 2014 Nov 24. doi: 10.1371/journal.pone.0111911

PMCID:: PMC4242615

Abstract Article PDF–10M

Select item 413503916.

Variation in AKR1C3, which Encodes the Neuroactive Steroid Synthetic Enzyme 3α-HSD Type 2 (17β-HSD Type 5), Moderates the Subjective Effects of Alcohol

Verica Milivojevic, Richard Feinn, Henry R. Kranzler, Jonathan Covault

Psychopharmacology (Berl) Author manuscript; available in PMC 2015 Sep 1.

Published in final edited form as: Psychopharmacology (Berl). 2014 Sep; 231(17): 3597–3608. Published online 2014 May 17. doi: 10.1007/s00213-014-3614-2

PMCID:: PMC4135039

Abstract Article PDF–2.0M

Select item 412543317.

Aldo-keto Reductase 1C3 (AKR1C3) is overexpressed in skin squamous cell carcinoma (SCC) and affects SCC growth via prostaglandin metabolism

Alon Mantel, Amanda Carpenter-Mendini, JoAnne VanBuskirk, Alice P. Pentland

Exp Dermatol. Author manuscript; available in PMC 2015 Aug 1.

Published in final edited form as: Exp Dermatol. 2014 Aug; 23(8): 573–578. Published online 2014 Jul 16. doi: 10.1111/exd.12468

PMCID:: PMC4125433

Abstract Article PDF–927K

Select item 381681118.

Expression of aldo-keto reductase family 1 member C3 (AKR1C3) in neuroendocrine tumors & adenocarcinomas of pancreas, gastrointestinal tract, and lung

Theodore S Chang, Hsueh-Kung Lin, Kyle A Rogers, Lacy S Brame, Matthew M Yeh, Qing Yang, Kar-Ming Fung

Int J Clin Exp Pathol. 2013; 6(11): 2419–2429. Published online 2013 Oct 15.

PMCID:: PMC3816811

Abstract Article PDF–2.1M

Select item 380577719.

AKR1C3 as a Target in Castrate Resistant Prostate Cancer

Adegoke O. Adeniji, Mo Chen, Trevor M. Penning

J Steroid Biochem Mol Biol. Author manuscript; available in PMC 2014 Sep 1.

Published in final edited form as: J Steroid Biochem Mol Biol. 2013 Sep; 137: 136–149. Published online 2013 Jun 6. doi: 10.1016/j.jsbmb.2013.05.012

PMCID:: PMC3805777

Abstract Article PDF–2.5M

Select item 369010820.

Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients

Pei Jye Voon, Hui Ling Yap, Cho-Yee-Thu Ma, Fan Lu, Andrea L A Wong, Nur Sabrina Sapari, Richie Soong, Thomas I P Soh, Boon-Cher Goh, How-Sung Lee, Soo-Chin Lee

Br J Clin Pharmacol. 2013 Jun; 75(6): 1497–1505. Published online 2012 Nov 1. doi: 10.1111/bcp.12021