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Select item 99729781.

Syntaxin 11 Contributes to the Interferon-Inducible Restriction of Coxiella burnetii Intracellular Infection

Sandhya Ganesan, Natalie N. Alvarez, Samuel Steiner, Karen M. Fowler, Abigail K. Corona, Craig R. Roy

mBio. 2023 Jan-Feb; 14(1): e03545-22. Published online 2023 Feb 2. doi: 10.1128/mbio.03545-22

PMCID:: PMC9972978

Abstract Article PDF–2.5M

Select item 73708612.

Novel Syntaxin 11 Gene (STX11) Mutation in Three Argentinean Patients with Hemophagocytic Lymphohistiocytosis

Silvia Danielian, Natalia Basile, Carlos Rocco, Emma Prieto, Jorge Rossi, Darío Barsotti, Paul A. Roche, Andrea Bernasconi, Matías Oleastro, Marta Zelazko, Jorge Braier

J Clin Immunol. Author manuscript; available in PMC 2020 Jul 20.

Published in final edited form as: J Clin Immunol. 2010 Mar; 30(2): 330–337. Published online 2009 Dec 5. doi: 10.1007/s10875-009-9350-4

PMCID:: PMC7370861

Abstract Article PDF–580K

Select item 46379993.

STX11 functions as a novel tumor suppressor gene in peripheral T-cell lymphomas

Noriaki Yoshida, Shinobu Tsuzuki, Kennosuke Karube, Taishi Takahara, Miyuki Suguro, Hiroaki Miyoshi, Momoko Nishikori, Masanori Shimoyama, Kunihiro Tsukasaki, Koichi Ohshima, Masao Seto

Cancer Sci. 2015 Oct; 106(10): 1455–1462. Published online 2015 Aug 13. doi: 10.1111/cas.12742

PMCID:: PMC4637999

Abstract Article PDF–1.2M

Select item 40496054.

Analysis of Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL-4) Mutant Proteins Reveals that S-Acylation Is Required for the Function of Syntaxin 11 in Natural Killer Cells

Andrew L. Hellewell, Ombretta Foresti, Nicola Gover, Morwenna Y. Porter, Eric W. Hewitt

PLoS One. 2014; 9(6): e98900. Published online 2014 Jun 9. doi: 10.1371/journal.pone.0098900

PMCID:: PMC4049605

Abstract Article PDF–2.1M

Select item 38230995.

Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules

Alena Dabrazhynetskaya, Jinxia Ma, Andre Ortlieb Guerreiro-Cacais, Zita Arany, Eva Rudd, Jan-Inge Henter, Klas Karre, Jelena Levitskaya, Victor Levitsky

J Cell Mol Med. 2012 Jan; 16(1): 129–141. Published online 2011 Dec 29. doi: 10.1111/j.1582-4934.2011.01280.x

PMCID:: PMC3823099

Abstract Article PDF–1.2M

Select item 19763606.

Defective cytotoxic lymphocyte degranulation in syntaxin-11–deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients

Yenan T. Bryceson, Eva Rudd, Chengyun Zheng, Josefine Edner, Daoxin Ma, Stephanie M. Wood, Anne Grete Bechensteen, Jaap J. Boelens, Tiraje Celkan, Roula A. Farah, Kjell Hultenby, Jacek Winiarski, Paul A. Roche, Magnus Nordenskjöld, Jan-Inge Henter, Eric O. Long, Hans-Gustaf Ljunggren

Blood. 2007 Sep 15; 110(6): 1906–1915. Prepublished online 2007 May 24. doi: 10.1182/blood-2007-02-074468

PMCID:: PMC1976360

Abstract Article

Select item 58461567.

Dynamic cycling of t-SNARE acylation regulates platelet exocytosis

Jinchao Zhang, Yunjie Huang, Jing Chen, Haining Zhu, Sidney W. Whiteheart

J Biol Chem. 2018 Mar 9; 293(10): 3593–3606. Published online 2018 Jan 19. doi: 10.1074/jbc.RA117.000140

PMCID:: PMC5846156

Abstract Article PDF–2.6M

Select item 34482608.

Syntaxin-11, but not syntaxin-2 or syntaxin-4, is required for platelet secretion

Shaojing Ye, Zubair A. Karim, Rania Al Hawas, Jeffery E. Pessin, Alexandra H. Filipovich, Sidney W. Whiteheart

Blood. 2012 Sep 20; 120(12): 2484–2492. Prepublished online 2012 Jul 5. doi: 10.1182/blood-2012-05-430603

PMCID:: PMC3448260

Abstract Article

Select item 27868109.

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

Marjorie Côte, Mickaël M. Ménager, Agathe Burgess, Nizar Mahlaoui, Capucine Picard, Catherine Schaffner, Fahad Al-Manjomi, Musa Al-Harbi, Abdullah Alangari, Françoise Le Deist, Andrew R. Gennery, Nathalie Prince, Astrid Cariou, Patrick Nitschke, Ulrich Blank, Gehad El-Ghazali, Gaël Ménasché, Sylvain Latour, Alain Fischer, Geneviève de Saint Basile

J Clin Invest. 2009 Dec 1; 119(12): 3765–3773. Published online 2009 Nov 2. doi: 10.1172/JCI40732

PMCID:: PMC2786810

Abstract Article PDF–1.7M

Select item 275654810.

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

Udo zur Stadt, Jan Rohr, Wenke Seifert, Florian Koch, Samantha Grieve, Julia Pagel, Julia Strauß, Brigitte Kasper, Gudrun Nürnberg, Christian Becker, Andrea Maul-Pavicic, Karin Beutel, Gritta Janka, Gillian Griffiths, Stephan Ehl, Hans Christian Hennies

Am J Hum Genet. 2009 Oct 9; 85(4): 482–492. doi: 10.1016/j.ajhg.2009.09.005

PMCID:: PMC2756548

Abstract Article PDF–813K

Select item 382428511.

Distinct severity of HLH in both human and murine mutants with complete loss of cytotoxic effector PRF1, RAB27A, and STX11

Fernando E. Sepulveda, Franck Debeurme, Gaël Ménasché, Mathieu Kurowska, Marjorie Côte, Jana Pachlopnik Schmid, Alain Fischer, Geneviève de Saint Basile

Blood. Author manuscript; available in PMC 2013 Nov 12.

Published in final edited form as: Blood. 2013 Jan 24; 121(4): 595–603. Published online 2012 Nov 16. doi: 10.1182/blood-2012-07-440339

PMCID:: PMC3824285

Abstract Article PDF–1.7M

Select item 1108245112.

Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

Tamara Kögl, Hsin-Fang Chang, Julian Staniek, Samuel C.C. Chiang, Gudrun Thoulass, Jessica Lao, Kristoffer Weißert, Viviane Dettmer-Monaco, Kerstin Geiger, Paul T. Manna, Vivien Beziat, Mana Momenilandi, Szu-Min Tu, Selina J. Keppler, Varsha Pattu, Philipp Wolf, Laurence Kupferschmid, Stefan Tholen, Laura E. Covill, Karolina Ebert, Tobias Straub, Miriam Groß, Ruth Gather, Helena Engel, Ulrich Salzer, Christoph Schell, Sarah Maier, Kai Lehmberg, Tatjana I. Cornu, Hanspeter Pircher, Mohammad Shahrooei, Nima Parvaneh, Roland Elling, Marta Rizzi, Yenan T. Bryceson, Stephan Ehl, Peter Aichele, Sandra Ammann

J Exp Med. 2024 Jul 1; 221(7): e20221122. Published online 2024 May 9. doi: 10.1084/jem.20221122

Correction in:: J Exp Med. 2024 Jul 1; 221(7): e2022112205142024c.

PMCID:: PMC11082451

Abstract Article PDF–8.0M

Select item 435208213.

MALT1-Ubiquitination Triggers Non-Genomic NF-κB/IKK Signaling upon Platelet Activation

Zubair A. Karim, Hari Priya Vemana, Fadi T. Khasawneh

PLoS One. 2015; 10(3): e0119363. Published online 2015 Mar 6. doi: 10.1371/journal.pone.0119363

PMCID:: PMC4352082

Abstract Article PDF–720K

Select item 524083914.

The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes

Takashi Nozawa, Atsuko Minowa-Nozawa, Chihiro Aikawa, Ichiro Nakagawa

Autophagy. 2017; 13(1): 57–69. Published online 2016 Oct 28. doi: 10.1080/15548627.2016.1241924

PMCID:: PMC5240839

Abstract Article PDF–1.7M

Select item 642327815.

Network-based prediction of protein interactions

István A. Kovács, Katja Luck, Kerstin Spirohn, Yang Wang, Carl Pollis, Sadie Schlabach, Wenting Bian, Dae-Kyum Kim, Nishka Kishore, Tong Hao, Michael A. Calderwood, Marc Vidal, Albert-László Barabási

Nat Commun. 2019; 10: 1240. Published online 2019 Mar 18. doi: 10.1038/s41467-019-09177-y

PMCID:: PMC6423278

Abstract Article PDF–1.1M

Select item 399653716.

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism

Roser Corominas, Xinping Yang, Guan Ning Lin, Shuli Kang, Yun Shen, Lila Ghamsari, Martin Broly, Maria Rodriguez, Stanley Tam, Shelly A. Wanamaker, Changyu Fan, Song Yi, Murat Tasan, Irma Lemmens, Xingyan Kuang, Nan Zhao, Dheeraj Malhotra, Jacob J. Michaelson, Vladimir Vacic, Michael A. Calderwood, Frederick P. Roth, Jan Tavernier, Steve Horvath, Kourosh Salehi-Ashtiani, Dmitry Korkin, Jonathan Sebat, David E. Hill, Tong Hao, Marc Vidal, Lilia M. Iakoucheva

Nat Commun. 2014; 5: 3650. Published online 2014 Apr 11. doi: 10.1038/ncomms4650

Correction in:: Nat Commun. 2023; 14: 569.

PMCID:: PMC3996537

Abstract Article PDF–1.9M

Select item 804593217.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington

Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331

PMCID:: PMC8045932

Abstract Article PDF–1.9M

Select item 444121518.

Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders

Nidhi Sahni, Song Yi, Mikko Taipale, Juan I. Fuxman Bass, Jasmin Coulombe-Huntington, Fan Yang, Jian Peng, Jochen Weile, Georgios I. Karras, Yang Wang, István A. Kovács, Atanas Kamburov, Irina Krykbaeva, Mandy H. Lam, George Tucker, Vikram Khurana, Amitabh Sharma, Yang-Yu Liu, Nozomu Yachie, Quan Zhong, Yun Shen, Alexandre Palagi, Adriana San-Miguel, Changyu Fan, Dawit Balcha, Amelie Dricot, Daniel M. Jordan, Jennifer M. Walsh, Akash A. Shah, Xinping Yang, Ani Stoyanova, Alex Leighton, Michael A. Calderwood, Yves Jacob, Michael E. Cusick, Kourosh Salehi-Ashtiani, Luke J. Whitesell, Shamil Sunyaev, Bonnie Berger, Albert-László Barabási, Benoit Charloteaux, David E. Hill, Tong Hao, Frederick P. Roth, Yu Xia, Albertha J.M. Walhout, Susan Lindquist, Marc Vidal

Cell. Author manuscript; available in PMC 2016 Apr 23.

Published in final edited form as: Cell. 2015 Apr 23; 161(3): 647–660. doi: 10.1016/j.cell.2015.04.013

PMCID:: PMC4441215

Abstract Article PDF–1.2M

Select item 488219019.

Widespread expansion of protein interaction capabilities by alternative splicing

Xinping Yang, Jasmin Coulombe-Huntington, Shuli Kang, Gloria M. Sheynkman, Tong Hao, Aaron Richardson, Song Sun, Fan Yang, Yun A. Shen, Ryan R. Murray, Kerstin Spirohn, Bridget E. Begg, Miquel Duran-Frigola, Andrew MacWilliams, Samuel J. Pevzner, Quan Zhong, Shelly A. Wanamaker, Stanley Tam, Lila Ghamsari, Nidhi Sahni, Song Yi, Maria D. Rodriguez, Dawit Balcha, Guihong Tan, Michael Costanzo, Brenda Andrews, Charles Boone, Xianghong J. Zhou, Kourosh Salehi-Ashtiani, Benoit Charloteaux, Alyce A. Chen, Michael A. Calderwood, Patrick Aloy, Frederick P. Roth, David E. Hill, Lilia M. Iakoucheva, Yu Xia, Marc Vidal

Cell. Author manuscript; available in PMC 2017 Feb 11.

Published in final edited form as: Cell. 2016 Feb 11; 164(4): 805–817. doi: 10.1016/j.cell.2016.01.029

PMCID:: PMC4882190

Abstract Article PDF–1.9M

Select item 268304720.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

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