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Select item 81840611.

Cbl-b is upregulated and plays a negative role in activated human NK cells

Ting Lu, Li Chen, Anthony G. Mansour, Melissa J. Yu, Noah Brooks, Kun-Yu Teng, Zhenlong Li, Jianying Zhang, Tasha Barr, Jianhua Yu, Michael A. Caligiuri

J Immunol. Author manuscript; available in PMC 2021 Aug 15.

Published in final edited form as: J Immunol. 2021 Feb 15; 206(4): 677–685. Published online 2021 Jan 8. doi: 10.4049/jimmunol.2000177

PMCID:: PMC8184061

Abstract Article PDF–1.2M

Select item 79868882.

CBLB ablation with CRISPR/Cas9 enhances cytotoxicity of human placental stem cell-derived NK cells for cancer immunotherapy

Xuan Guo, Tanel Mahlakõiv, Qian Ye, Srinivas Somanchi, Shuyang He, Hemlata Rana, Andrea DiFiglia, Joseph Gleason, William van der Touw, Robert Hariri, Xiaokui Zhang

J Immunother Cancer. 2021; 9(3): e001975. Published online 2021 Mar 19. doi: 10.1136/jitc-2020-001975

PMCID:: PMC7986888

Abstract Article PDF–2.4M

Select item 65593603.

Gene expression and linkage analysis implicate CBLB as a mediator of rituximab resistance

J Jack, GW Small, CC Brown, TM Havener, HL McLeod, AA Motsinger-Reif, KL Richards

Pharmacogenomics J. Author manuscript; available in PMC 2019 Jun 11.

Published in final edited form as: Pharmacogenomics J. 2018 May 22; 18(3): 467–473. Published online 2017 Dec 5. doi: 10.1038/tpj.2017.41

PMCID:: PMC6559360

Abstract Article PDF–1.0M

Select item 65046304.

Regulation of immune responses by E3 ubiquitin ligase Cbl-b

Rong Tang, Wallace Y. Langdon, Jian Zhang

Cell Immunol. Author manuscript; available in PMC 2020 Jun 1.

Published in final edited form as: Cell Immunol. 2019 Jun; 340: 103878. Published online 2018 Nov 7. doi: 10.1016/j.cellimm.2018.11.002

PMCID:: PMC6504630

Abstract Article PDF–1.6M

Select item 57212395.

Lys63‐polyubiquitination by the E3 ligase casitas B‐lineage lymphoma‐b (Cbl‐b) modulates peripheral regulatory T cell tolerance in patients with systemic lupus erythematosus

J. Romo‐Tena, S. Rajme‐López, L. Aparicio‐Vera, J. Alcocer‐Varela, D. Gómez‐Martín

Clin Exp Immunol. 2018 Jan; 191(1): 42–49. Published online 2017 Oct 19. doi: 10.1111/cei.13054

PMCID:: PMC5721239

Abstract Article PDF–296K

Select item 41117516.

E3 ubiquitin ligase Cbl-b in innate and adaptive immunity

Qingjun Liu, Hong Zhou, Wallace Y Langdon, Jian Zhang

Cell Cycle. 2014 Jun 15; 13(12): 1875–1884. Published online 2014 May 14. doi: 10.4161/cc.29213

PMCID:: PMC4111751

Abstract Article PDF–1.2M

Select item 38761187.

Cbl-b Enhances Sensitivity to 5-Fluorouracil via EGFR- and Mitochondria-Mediated Pathways in Gastric Cancer Cells

Dan Feng, Yanju Ma, Jing Liu, Ling Xu, Ye Zhang, Jinglei Qu, Yunpeng Liu, Xiujuan Qu

Int J Mol Sci. 2013 Dec; 14(12): 24399–24411. Published online 2013 Dec 16. doi: 10.3390/ijms141224399

PMCID:: PMC3876118

Abstract Article PDF–1.8M

Select item 36155968.

Ubiquitin Ligase Cbl-b Is Involved in Icotinib (BPI-2009H)-Induced Apoptosis and G1 Phase Arrest of EGFR Mutation-Positive Non-Small-Cell Lung Cancer

Xiaodong Mu, Ye Zhang, Xiujuan Qu, Kezuo Hou, Jian Kang, Xuejun Hu, Yunpeng Liu

Biomed Res Int. 2013; 2013: 726375. Published online 2013 Mar 19. doi: 10.1155/2013/726375

PMCID:: PMC3615596

Abstract Article PDF–1.9M

Select item 95668869.

Immune dysregulation caused by homozygous mutations in CBLB

Erin Janssen, Zachary Peters, Mohammed F. Alosaimi, Emma Smith, Elena Milin, Kelsey Stafstrom, Jacqueline G. Wallace, Craig D. Platt, Janet Chou, Yasmeen S. El Ansari, Tariq Al Farsi, Najim Ameziane, Ruslan Al-Ali, Maria Calvo, Maria Eugenia Rocha, Peter Bauer, Nouriya Abbas Al-Sannaa, Nashat Faud Al Sukaiti, Abdullah A. Alangari, Aida M. Bertoli-Avella, Raif S. Geha

J Clin Invest. 2022 Oct 17; 132(20): e154487. Published online 2022 Oct 17. doi: 10.1172/JCI154487

PMCID:: PMC9566886

Abstract Article PDF–4.2M

Select item 896155410.

miR-27b-3p Attenuates Muscle Atrophy by Targeting Cbl-b in Skeletal Muscles

Xin Yang, Zhenhui Li, Zhijun Wang, Jiaao Yu, Manting Ma, Qinghua Nie

Biomolecules. 2022 Feb; 12(2): 191. Published online 2022 Jan 23. doi: 10.3390/biom12020191

PMCID:: PMC8961554

Abstract Article PDF–3.6M

Select item 781329811.

Deletion of Cbl-b inhibits CD8⁺ T-cell exhaustion and promotes CAR T-cell function

Jitendra Kumar, Ritesh Kumar, Amir Kumar Singh, Elviche L Tsakem, Mahesh Kathania, Matthew J Riese, Arianne L Theiss, Marco L Davila, K Venuprasad

J Immunother Cancer. 2021; 9(1): e001688. Published online 2021 Jan 18. doi: 10.1136/jitc-2020-001688

PMCID:: PMC7813298

Abstract Article PDF–2.7M

Select item 580232512.

Expression and Comparison of Cbl-b in Lung Squamous Cell Carcinoma and Adenocarcinoma

Peng Li, Hongliang Liu, Zhiqiang Zhang, Xiaodong Lv, Huijuan Wang, Jie Ma, Zhiyong Ma, Xiujuan Qu, Yue-e Teng

Med Sci Monit. 2018; 24: 623–635. Published online 2018 Jan 31. doi: 10.12659/MSM.908076

PMCID:: PMC5802325

Abstract Article PDF–4.5M

Select item 536215213.

E3 Ubiquitin Ligase Cbl-b Prevents Tumor Metastasis by Maintaining the Epithelial Phenotype in Multiple Drug-Resistant Gastric and Breast Cancer Cells

Ling Xu, Ye Zhang, Xiujuan Qu, Xiaofang Che, Tianshu Guo, Ying Cai, Aodi Li, Danni Li, Ce Li, Ti Wen, Yibo Fan, Kezuo Hou, Yanju Ma, Xuejun Hu, Yunpeng Liu

Neoplasia. 2017 Apr; 19(4): 374–382. Published online 2017 Mar 20. doi: 10.1016/j.neo.2017.01.011

PMCID:: PMC5362152

Abstract Article PDF–1.3M

Select item 534769514.

MicroRNA-891b is an independent prognostic factor of pancreatic cancer by targeting Cbl-b to suppress the growth of pancreatic cancer cells

Qian Dong, Ce Li, Xiaofang Che, Jinglei Qu, Yibo Fan, Xiaohan Li, Yue Li, Qian Wang, Yunpeng Liu, Xianghong Yang, Xiujuan Qu

Oncotarget. 2016 Dec 13; 7(50): 82338–82353. Published online 2016 Aug 2. doi: 10.18632/oncotarget.11001

PMCID:: PMC5347695

Abstract Article PDF–9.3M

Select item 495018415.

Cbl-b promotes cell detachment via ubiquitination of focal adhesion kinase

Yibo Fan, Xiujuan Qu, Yanju Ma, Yunpeng Liu, Xuejun Hu

Oncol Lett. 2016 Aug; 12(2): 1113–1118. Published online 2016 Jun 15. doi: 10.3892/ol.2016.4730

PMCID:: PMC4950184

Abstract Article PDF–678K

Select item 467320916.

The E3 ubiquitin ligase Cbl-b improves the prognosis of RANK positive breast cancer patients by inhibiting RANKL-induced cell migration and metastasis

Lingyun Zhang, Yuee Teng, Yibo Fan, Yan Wang, Wei Li, Jing Shi, Yanju Ma, Ce Li, Xiaonan Shi, Xiujuan Qu, Yunpeng Liu

Oncotarget. 2015 Sep 8; 6(26): 22918–22933. Published online 2015 Jun 8. doi: 10.18632/oncotarget.4382

PMCID:: PMC4673209

Abstract Article PDF–12M

Select item 446664617.

Cbl-b inhibits P-gp transporter function by preventing its translocation into caveolae in multiple drug-resistant gastric and breast cancers

Ye Zhang, Xiujuan Qu, Yuee Teng, Zhi Li, Ling Xu, Jing Liu, Yanju Ma, Yibo Fan, Ce Li, Shizhou Liu, Zhenning Wang, Xuejun Hu, Jingdong Zhang, Yunpeng Liu

Oncotarget. 2015 Mar 30; 6(9): 6737–6748. Published online 2015 Feb 17. doi: 10.18632/oncotarget.3253

Correction in:: Oncotarget. 2021 Aug 3; 12(16): 1634–1637.

PMCID:: PMC4466646

Abstract Article PDF–6.8M

Select item 367682918.

The Role of E3 Ubiquitin Ligase Cbl Proteins in β-Elemene Reversing Multi-Drug Resistance of Human Gastric Adenocarcinoma Cells

Ye Zhang, Xiao-Dong Mu, En-Zhe Li, Ying Luo, Na Song, Xiu-Juan Qu, Xue-Jun Hu, Yun-Peng Liu

Int J Mol Sci. 2013 May; 14(5): 10075–10089. Published online 2013 May 10. doi: 10.3390/ijms140510075

PMCID:: PMC3676829

Abstract Article PDF–1.2M

Select item 325113719.

Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b

Yoshihiro Kobashigawa, Akira Tomitaka, Hiroyuki Kumeta, Nobuo N. Noda, Masaya Yamaguchi, Fuyuhiko Inagaki

Proc Natl Acad Sci U S A. 2011 Dec 20; 108(51): 20579-20584. Published online 2011 Dec 7. doi: 10.1073/pnas.1110712108

PMCID:: PMC3251137

Abstract Article PDF–2.0M

Select item 192476820.

Novel c-CBL and CBL-b ubiquitin ligase mutations in human acute myeloid leukemia

Michael A. Caligiuri, Roger Briesewitz, Jianhua Yu, Lisheng Wang, Min Wei, Kristy J. Arnoczky, Trent B. Marburger, Jing Wen, Danilo Perrotti, Clara D. Bloomfield, Susan P. Whitman

Blood. 2007 Aug 1; 110(3): 1022–1024. Prepublished online 2007 May 2. doi: 10.1182/blood-2006-12-061176