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Items: 1 to 20 of 53

1.
Kinetic characterization of human mRNA guanine-N7 methyltransferase
Sumera Perveen, Aliakbar Khalili Yazdi, Taraneh Hajian, Fengling Li, Masoud Vedadi
Sci Rep. 2024; 14: 4509. Published online 2024 Feb 24. doi: 10.1038/s41598-024-55184-5
PMCID:
PMC10894281
AbstractArticlePDF–1.2M
2.
Identification and characterization of the interaction between the methyl-7-guanosine cap maturation enzyme RNMT and the cap-binding protein eIF4E
Michael J. Osborne, Laurent Volpon, Mina Memarpoor-Yazdi, Shubhadra Pillay, Aksharh Thambipillai, Sylwia Czarnota, Biljana Culjkovic-Kraljacic, Christian Trahan, Marlene Oeffinger, Victoria H. Cowling, Katherine L. B. Borden
J Mol Biol. Author manuscript; available in PMC 2022 Jul 17.
Published in final edited form as: J Mol Biol. 2022 Mar 15; 434(5): 167451. Published online 2022 Jan 10. doi: 10.1016/j.jmb.2022.167451
PMCID:
PMC9288840
AbstractArticlePDF–1.9M
3.
RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs
Jackson B. Trotman, Andrew J. Giltmier, Chandrama Mukherjee, Daniel R. Schoenberg
Nucleic Acids Res. 2017 Oct 13; 45(18): 10726–10739. Published online 2017 Sep 13. doi: 10.1093/nar/gkx801
PMCID:
PMC5737702
AbstractArticlePDF–5.4M
4.
Human cap methyltransferase (RNMT) N-terminal non-catalytic domain mediates recruitment to transcription initiation sites
Michael Aregger, Victoria H. Cowling
Biochem J. 2013 Oct 1; 455(Pt 1): 67–73. Prepublished online 2013 Jul 18. Published online 2013 Sep 13. doi: 10.1042/BJ20130378
PMCID:
PMC3778707
AbstractArticlePDF–786K
5.
Human mRNA Cap Methyltransferase: Alternative Nuclear Localization Signal Motifs Ensure Nuclear Localization Required for Viability
Beth Shafer, Chun Chu, Aaron J. Shatkin
Mol Cell Biol. 2005 Apr; 25(7): 2644–2649. doi: 10.1128/MCB.25.7.2644-2649.2005
PMCID:
PMC1061643
AbstractArticlePDF–345K
6.
Mechanism of allosteric activation of human mRNA cap methyltransferase (RNMT) by RAM: insights from accelerated molecular dynamics simulations
Juan A Bueren-Calabuig, Marcus G. Bage, Victoria H Cowling, Andrei V Pisliakov
Nucleic Acids Res. 2019 Sep 19; 47(16): 8675–8692. Published online 2019 Jul 22. doi: 10.1093/nar/gkz613
PMCID:
PMC7145595
AbstractArticlePDF–6.6M
7.
Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells
Sianadh Dunn, Olivia Lombardi, Radoslaw Lukoszek, Victoria H. Cowling
Open Biol. 2019 Apr; 9(4): 190052. Published online 2019 Apr 17. doi: 10.1098/rsob.190052
PMCID:
PMC6501644
AbstractArticlePDF–1.5M
8.
mRNA Cap Methyltransferase, RNMT-RAM, Promotes RNA Pol II-Dependent Transcription
Dhaval Varshney, Olivia Lombardi, Gabriele Schweikert, Sianadh Dunn, Olga Suska, Victoria H. Cowling
Cell Rep. 2018 May 1; 23(5): 1530–1542. Published online 2018 May 2. doi: 10.1016/j.celrep.2018.04.004
PMCID:
PMC5946721
AbstractArticlePDF–3.1M
9.
Cap methyltransferase selective binding and methylation of GpppG-RNA are stimulated by importin-α
Yingxia Wen, Aaron J. Shatkin
Genes Dev. 2000 Dec 1; 14(23): 2944–2949. doi: 10.1101/gad.848200
PMCID:
PMC317093
AbstractArticlePDF–1.7M
10.
MYC Mediates mRNA Cap Methylation of Canonical Wnt/β-catenin Signaling Transcripts by Recruiting CDK7 and RNA Methyltransferase
Valeriya Posternak, Matthew H. Ung, Chao Cheng, Michael D. Cole
Mol Cancer Res. Author manuscript; available in PMC 2018 Feb 1.
Published in final edited form as: Mol Cancer Res. 2017 Feb; 15(2): 213–224. Published online 2016 Nov 29. doi: 10.1158/1541-7786.MCR-16-0247
PMCID:
PMC5290160
AbstractArticlePDF–1.3M
11.
c-Myc co-ordinates mRNA cap methylation and ribosomal RNA production
Sianadh Dunn, Olivia Lombardi, Victoria H. Cowling
Biochem J. 2017 Feb 1; 474(3): 377–384. Prepublished online 2016 Dec 1. Published online 2017 Jan 20. doi: 10.1042/BCJ20160930
PMCID:
PMC5247799
AbstractArticlePDF–563K
12.
CDK1-Cyclin B1 Activates RNMT, Coordinating mRNA Cap Methylation with G1 Phase Transcription
Michael Aregger, Aneesa Kaskar, Dhaval Varshney, Maria Elena Fernandez-Sanchez, Francisco A. Inesta-Vaquera, Simone Weidlich, Victoria H. Cowling
Mol Cell. 2016 Mar 3; 61(5): 734–746. doi: 10.1016/j.molcel.2016.02.008
PMCID:
PMC4781437
AbstractArticlePDF–2.3M
13.
RAM function is dependent on Kapβ2-mediated nuclear entry
Thomas Gonatopoulos-Pournatzis, Victoria H. Cowling
Biochem J. 2014 Feb 1; 457(Pt 3): 473–484. Prepublished online 2013 Nov 7. Published online 2014 Jan 10. doi: 10.1042/BJ20131359
PMCID:
PMC3898117
AbstractArticlePDF–3.2M
14.
Molecular basis of RNA guanine-7 methyltransferase (RNMT) activation by RAM
Dhaval Varshney, Alain-Pierre Petit, Juan A. Bueren-Calabuig, Chimed Jansen, Dan A. Fletcher, Mark Peggie, Simone Weidlich, Paul Scullion, Andrei V. Pisliakov, Victoria H. Cowling
Nucleic Acids Res. 2016 Dec 1; 44(21): 10423–10436. Published online 2016 Jul 15. doi: 10.1093/nar/gkw637
PMCID:
PMC5137418
AbstractArticlePDF–4.5M
15.
RAM/Fam103a1 Is Required for mRNA Cap Methylation
Thomas Gonatopoulos-Pournatzis, Sianadh Dunn, Rebecca Bounds, Victoria H. Cowling
Mol Cell. 2011 Nov 18; 44(4): 585–596. doi: 10.1016/j.molcel.2011.08.041
PMCID:
PMC3235549
AbstractArticle
16.
Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.
T Yamada-Okabe, R Doi, O Shimmi, M Arisawa, H Yamada-Okabe
Nucleic Acids Res. 1998 Apr 1; 26(7): 1700–1706. doi: 10.1093/nar/26.7.1700
PMCID:
PMC147440
SummaryPDF–287K
17.
AP-SWATH Reveals Direct Involvement of VCP/p97 in Integrated Stress Response Signaling Through Facilitating CReP/PPP1R15B Degradation
Julia Hülsmann, Bojana Kravic, Matthias Weith, Matthias Gstaiger, Ruedi Aebersold, Ben C. Collins, Hemmo Meyer
Mol Cell Proteomics. 2018 Jul; 17(7): 1295–1307. Published online 2018 Mar 29. doi: 10.1074/mcp.RA117.000471
PMCID:
PMC6030730
AbstractArticlePDF–3.8M
18.
Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression
Peng-bo Yang, Pei-pei Hou, Fu-yuan Liu, Wen-bin Hong, Hang-zi Chen, Xiao-yu Sun, Peng Li, Yi Zhang, Cui-yu Ju, Li-juan Luo, Sheng-fu Wu, Jia-xin Zhou, Zhi-jing Wang, Jian-ping He, Li Li, Tong-Jin Zhao, Xianming Deng, Tianwei Lin, Qiao Wu
Proc Natl Acad Sci U S A. 2020 Nov 3; 117(44): 27412–27422. Published online 2020 Oct 21. doi: 10.1073/pnas.2002997117
PMCID:
PMC7959534
AbstractArticlePDF–3.1M
19.
Endoglin Protein Interactome Profiling Identifies TRIM21 and Galectin-3 as New Binding Partners
Eunate Gallardo-Vara, Lidia Ruiz-Llorente, Juan Casado-Vela, María J. Ruiz-Rodríguez, Natalia López-Andrés, Asit K. Pattnaik, Miguel Quintanilla, Carmelo Bernabeu
Cells. 2019 Sep; 8(9): 1082. Published online 2019 Sep 13. doi: 10.3390/cells8091082
PMCID:
PMC6769930
AbstractArticlePDF–4.3M
20.
Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner
Lucía García-Gutiérrez, Emma Fallahi, Nourhan Aboud, Niall Quinn, David Matallanas
Cell Death Dis. 2022 Aug; 13(8): 692. Published online 2022 Aug 8. doi: 10.1038/s41419-022-05147-3
PMCID:
PMC9360443
AbstractArticlePDF–5.8M

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