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Items: 1 to 20 of 167

1.
Pregnane X Receptor and the Gut-Liver Axis: A Recent Update
Moumita Dutta, Joe Jongpyo Lim, Julia Yue Cui
Drug Metab Dispos. 2022 Apr; 50(4): 478–491. Published online 2022 Apr. doi: 10.1124/dmd.121.000415
PMCID:
PMC11022899
AbstractArticlePDF–424K
2.
St. John’s Wort alleviates dextran sodium sulfate-induced colitis through pregnane X receptor-dependent NFκB antagonism
Tingting Yan, Yuhong Luo, Yangliu Xia, Keisuke Hamada, Qiong Wang, Nana Yan, Kristopher W. Krausz, Jerrold M. Ward, Haiping Hao, Ping Wang, Frank J. Gonzalez
FASEB J. Author manuscript; available in PMC 2023 May 9.
Published in final edited form as: FASEB J. 2021 Nov; 35(11): e21968. doi: 10.1096/fj.202001098R
PMCID:
PMC10167919
AbstractArticlePDF–2.7M
3.
Protease-Activated Receptor 1 in Human Carotid Atheroma Is Significantly Related to Iron Metabolism, Plaque Vulnerability, and the Patient’s Age
Wei Li, Ehab Osman, Claes Forssell, Xi-Ming Yuan
Int J Mol Sci. 2022 Jun; 23(12): 6363. Published online 2022 Jun 7. doi: 10.3390/ijms23126363
PMCID:
PMC9223560
AbstractArticlePDF–1.2M
4.
The Outer Membrane Lipoprotein Tp0136 Stimulates Human Platelet Activation and Aggregation Through PAR1 to Enhance Gq/Gi Signaling
Qiu-Yan Xu, Yong-Jing Wang, Li-Rong Lin, Li-Li Liu, Tian-Ci Yang
Front Immunol. 2022; 13: 818151. Published online 2022 Feb 28. doi: 10.3389/fimmu.2022.818151
PMCID:
PMC8918515
AbstractArticlePDF–3.7M
5.
Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia
Mikko Karpale, Janne Hukkanen, Jukka Hakkola
Cells. 2022 Feb; 11(3): 313. Published online 2022 Jan 18. doi: 10.3390/cells11030313
PMCID:
PMC8833906
AbstractArticlePDF–892K
6.
Pregnane X Receptor (PXR) Polymorphisms and Cancer Treatment
Aikaterini Skandalaki, Panagiotis Sarantis, Stamatios Theocharis
Biomolecules. 2021 Aug; 11(8): 1142. Published online 2021 Aug 2. doi: 10.3390/biom11081142
PMCID:
PMC8394562
AbstractArticlePDF–1.4M
7.
Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis
Hanze Guo, Yan Chi, Naiyu Chi
Sci Rep. 2021; 11: 5428. Published online 2021 Mar 8. doi: 10.1038/s41598-021-83742-8
PMCID:
PMC7940411
AbstractArticlePDF–2.0M
8.
NR1I2 genetic polymorphisms and the risk of anti‐tuberculosis drug‐induced hepatotoxicity: A systematic review and meta‐analysis
Miaomiao Yang, Yunliang Qiu, Yanyu Jin, Wenpei Liu, Qingliang Wang, Honggang Yi, Shaowen Tang
Pharmacol Res Perspect. 2020 Dec; 8(6): e00696. Published online 2020 Dec 10. doi: 10.1002/prp2.696
PMCID:
PMC7726956
AbstractArticlePDF–1.6M
9.
Associations between Pregnane X Receptor and Breast Cancer Growth and Progression
Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud, Jeff L. Staudinger
Cells. 2020 Oct; 9(10): 2295. Published online 2020 Oct 15. doi: 10.3390/cells9102295
PMCID:
PMC7602492
AbstractArticlePDF–699K
10.
Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning
Andrew D. Huber, William C. Wright, Wenwei Lin, Kinjal Majumder, Jonathan A. Low, Jing Wu, Cameron D. Buchman, David J. Pintel, Taosheng Chen
Cell Mol Life Sci. 2021 Jan; 78(1): 317–335. Published online 2020 Mar 30. doi: 10.1007/s00018-020-03505-y
PMCID:
PMC7529690
AbstractArticlePDF–6.7M
11.
Rapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction
Beyza Bulutoglu, Safak Mert, Camilo Rey-Bedón, Sarah L. Deng, Martin L. Yarmush, O. Berk Usta
Sci Rep. 2019; 9: 15848. Published online 2019 Nov 1. doi: 10.1038/s41598-019-52174-w
PMCID:
PMC6825149
AbstractArticlePDF–1.6M
12.
Pregnane X receptor activation potentiates ritonavir hepatotoxicity
Amina I. Shehu, Jie Lu, Pengcheng Wang, Junjie Zhu, Yue Wang, Da Yang, Deborah McMahon, Wen Xie, Frank J. Gonzalez, Xiaochao Ma
J Clin Invest. 2019 Jul 1; 129(7): 2898–2903. Published online 2019 Jun 4. doi: 10.1172/JCI128274
PMCID:
PMC6597219
AbstractArticlePDF–5.2M
13.
Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response
Andreas Elentner, Matthias Schmuth, Nikolaos Yannoutsos, Thomas O. Eichmann, Robert Gruber, Franz P.W. Radner, Martin Hermann, Barbara Del Frari, Sandrine Dubrac
J Invest Dermatol. Author manuscript; available in PMC 2019 Jan 1.
Published in final edited form as: J Invest Dermatol. 2018 Jan; 138(1): 109–120. Published online 2017 Sep 18. doi: 10.1016/j.jid.2017.07.846
PMCID:
PMC6217923
AbstractArticlePDF–2.2M
14.
Association between PXR polymorphisms and cancer risk: a systematic review and meta-analysis
Jing Wen, Zhi Lv, Hanxi Ding, Xinxin Fang, Mingjun Sun
Biosci Rep. 2018 Jun 29; 38(3): BSR20171614. Prepublished online 2018 Apr 13. Published online 2018 Jun 12. doi: 10.1042/BSR20171614
PMCID:
PMC5997801
AbstractArticlePDF–505K
15.
A human xenobiotic nuclear receptor contributes to nonresponsiveness of Mycobacterium tuberculosis to the antituberculosis drug rifampicin
Ella Bhagyaraj, Drishti Tiwari, Nancy Ahuja, Ravikanth Nanduri, Ankita Saini, Rashi Kalra, Sumit Kumar, Ashok Kumar Janmeja, Pawan Gupta
J Biol Chem. 2018 Mar 9; 293(10): 3747–3757. Published online 2018 Jan 22. doi: 10.1074/jbc.M117.818377
PMCID:
PMC5846149
AbstractArticlePDF–1.6M
16.
TR47, A PAR1-BASED PEPTIDE, INHIBITS MELANOMA CELL MIGRATION IN VITRO AND METASTASIS IN VIVO
Andreia S. de Oliveira, Vitor H. de Almeida, Fausto G. Gomes, Alireza R. Rezaie, Robson Q. Monteiro
Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Jan 1.
Published in final edited form as: Biochem Biophys Res Commun. 2018 Jan 1; 495(1): 1300–1304. Published online 2017 Nov 28. doi: 10.1016/j.bbrc.2017.11.174
PMCID:
PMC5752140
AbstractArticlePDF–572K
17.
Association of NR1I2 gene polymorphisms and time of progression to AIDS
Rúbia Marília de Medeiros, Carolina Fialho Menti, Jéssica Louise Benelli, Maria Cristina Cotta Matte, Marineide Gonçalves de Melo, Sabrina Esteves de Matos Almeida, Marilu Fiegenbaum
Mem Inst Oswaldo Cruz. 2017 Apr; 112(4): 269–274. doi: 10.1590/0074-02760160382
PMCID:
PMC5354613
AbstractArticlePDF–228K
18.
Pregnane X-receptor promotes stem cell-mediated colon cancer relapse
Chris Planque, Fatemeh Rajabi, Fanny Grillet, Pascal Finetti, François Bertucci, Meritxell Gironella, Juan José Lozano, Bertrand Beucher, Julie Giraud, Véronique Garambois, Charles Vincent, Daniel Brown, Ludovic Caillo, Jovana Kantar, André Pelegrin, Michel Prudhomme, Jérémie Ripoche, Jean François Bourgaux, Christophe Ginestier, Antoni Castells, Frédéric Hollande, Julie Pannequin, Jean Marc Pascussi
Oncotarget. 2016 Aug 30; 7(35): 56558–56573. Published online 2016 Jul 18. doi: 10.18632/oncotarget.10646
PMCID:
PMC5302934
AbstractArticlePDF–8.0M
19.
Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery
Jing-Jing Yuan, Xiao-Jing Ma, Zhi-Song Li, Yan-Zi Chang, Wei Zhang, Quan-Cheng Kan, Jun-Kai Hou, Li-Rong Zhang
BMC Med Genet. 2016; 17: 87. Published online 2016 Nov 23. doi: 10.1186/s12881-016-0348-5
PMCID:
PMC5120516
AbstractArticlePDF–714K
20.
Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket
Aneesh Chandran, Saraswathi Vishveshwara
Protein Sci. 2016 Nov; 25(11): 1989–2005. Published online 2016 Aug 23. doi: 10.1002/pro.3012
PMCID:
PMC5079256
AbstractArticlePDF–2.9M

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