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Select item 108053051.

ncRNAs-mediated TIMELESS overexpression in lung adenocarcinoma correlates with reduced tumor immune cell infiltration and poor prognosis

Xinliang Gao, Mingbo Tang, Suyan Tian, Jialin Li, Shixiong Wei, Shucheng Hua, Wei Liu

PLoS One. 2024; 19(1): e0296829. Published online 2024 Jan 23. doi: 10.1371/journal.pone.0296829

PMCID:: PMC10805305

Abstract Article PDF–2.7M

Select item 107683182.

TIMELESS promotes reprogramming of glucose metabolism in oral squamous cell carcinoma

Yafan Chen, Zhengyang Han, Le Zhang, Caihong Gao, Jingyi Wei, Xuyuan Yang, Yabing Han, Yunbo Li, Chunmei Zhang, Yixin Wei, Jiaqi Dong, Wenxing Xun, Weifu Sun, Taotao Zhang, Hui Zhang, Jingtao Chen, Peng Yuan

J Transl Med. 2024; 22: 21. Published online 2024 Jan 4. doi: 10.1186/s12967-023-04791-3

PMCID:: PMC10768318

Abstract Article PDF–6.2M

Select item 106967273.

An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker

Yaocheng Yang, Xianzhe Tang, Zhengjun Lin, Tao Zheng, Sheng Zhang, Tang Liu, Xiaolun Yang

Eur J Med Res. 2023; 28: 563. Published online 2023 Dec 5. doi: 10.1186/s40001-023-01519-3

PMCID:: PMC10696727

Abstract Article PDF–13M

Select item 63281064.

ERK-mediated TIMELESS expression suppresses G2/M arrest in colon cancer cells

Beth K. Neilsen, Danielle E. Frodyma, Jamie L. McCall, Kurt W. Fisher, Robert E. Lewis

PLoS One. 2019; 14(1): e0209224. Published online 2019 Jan 10. doi: 10.1371/journal.pone.0209224

PMCID:: PMC6328106

Abstract Article PDF–2.6M

Select item 50771925.

TIMELESS Suppresses the Accumulation of Aberrant CDC45·MCM2-7·GINS Replicative Helicase Complexes on Human Chromatin

Xiaohua Xu, Jiin-Tarng Wang, Min Li, Yilun Liu

J Biol Chem. 2016 Oct 21; 291(43): 22544–22558. Published online 2016 Sep 1. doi: 10.1074/jbc.M116.719963

PMCID:: PMC5077192

Abstract Article PDF–2.9M

Select item 46180556.

TIMELESS Forms a Complex with PARP1 Distinct from Its Complex with TIPIN and Plays a Role in the DNA Damage Response

Lauren M. Young, Antonio Marzio, Pablo Perez-Duran, Dylan A. Reid, Daniel N. Meredith, Domenico Roberti, Ayelet Star, Eli Rothenberg, Beatrix Ueberheide, Michele Pagano

Cell Rep. Author manuscript; available in PMC 2015 Oct 24.

Published in final edited form as: Cell Rep. 2015 Oct 20; 13(3): 451–459. Published online 2015 Oct 8. doi: 10.1016/j.celrep.2015.09.017

PMCID:: PMC4618055

Abstract Article PDF–795K

Select item 44543957.

TIMELESS is overexpressed in lung cancer and its expression correlates with poor patient survival

Kenya Yoshida, Mitsuo Sato, Tetsunari Hase, Momen Elshazley, Ryo Yamashita, Noriyasu Usami, Tetsuo Taniguchi, Kohei Yokoi, Shigeo Nakamura, Masashi Kondo, Luc Girard, John D. Minna, Yoshinori Hasegawa

Cancer Sci. 2013 Feb; 104(2): 171–177. Published online 2013 Jan 7. doi: 10.1111/cas.12068

Correction in:: Cancer Sci, volume 104 on page 1270

PMCID:: PMC4454395

Abstract Article PDF–1.7M

Select item 39243538.

Potential cancer-related role of circadian gene TIMELESS suggested by expression profiling and in vitro analyses

Yingying Mao, Alan Fu, Derek Leaderer, Tongzhang Zheng, Kun Chen, Yong Zhu

BMC Cancer. 2013; 13: 498. Published online 2013 Oct 25. doi: 10.1186/1471-2407-13-498

PMCID:: PMC3924353

Abstract Article PDF–1.5M

Select item 36241999.

Timeless-Dependent DNA Replication-Coupled Recombination Promotes Kaposi's Sarcoma-Associated Herpesvirus Episome Maintenance and Terminal Repeat Stability

Jayaraju Dheekollu, Horng-Shen Chen, Kenneth M. Kaye, Paul M. Lieberman

J Virol. 2013 Apr; 87(7): 3699–3709. doi: 10.1128/JVI.02211-12

PMCID:: PMC3624199

Abstract Article PDF–2.1M

Select item 338359310.

Timeless preserves telomere length by promoting efficient DNA replication through human telomeres

Adam R. Leman, Jayaraju Dheekollu, Zhong Deng, Seung Woo Lee, Mukund M. Das, Paul M. Lieberman, Eishi Noguchi

Cell Cycle. 2012 Jun 15; 11(12): 2337–2347. doi: 10.4161/cc.20810

PMCID:: PMC3383593

Abstract Article PDF–2.4M

Select item 312716111.

Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts

Stephanie L Smith-Roe, Shivani S Patel, Dennis A Simpson, Ying Chun Zhou, Shangbang Rao, Joseph G Ibrahim, Kathleen A Kaiser-Rogers, Marila Cordeiro-Stone, William K Kaufmann

Cell Cycle. 2011 May 15; 10(10): 1618–1624. Published online 2011 May 15. doi: 10.4161/cc.10.10.15613

PMCID:: PMC3127161

Abstract Article PDF–1.9M

Select item 1119409412.

The TIMELESS and PARP1 interaction suppresses replication-associated DNA gap accumulation

Joanne Saldanha, Julie Rageul, Jinal A Patel, Amy L Phi, Natalie Lo, Jennifer J Park, Hyungjin Kim

Nucleic Acids Res. 2024 Jun 24; 52(11): 6424–6440. Published online 2024 May 27. doi: 10.1093/nar/gkae445

PMCID:: PMC11194094

Abstract Article PDF–2.9M

Select item 1086648813.

SP3-induced Timeless transcription contributes to cell growth of lung adenocarcinoma cells

Ping Tian, Dajun Du, Li Yang, Nan Zhou, Ling Tao

PLoS One. 2024; 19(2): e0298295. Published online 2024 Feb 14. doi: 10.1371/journal.pone.0298295

PMCID:: PMC10866488

Abstract Article PDF–2.4M

Select item 1032592514.

Replisome dysfunction upon inducible TIMELESS degradation synergizes with ATR inhibition to trigger replication catastrophe

Jinal A Patel, Camryn Zezelic, Julie Rageul, Joanne Saldanha, Arafat Khan, Hyungjin Kim

Nucleic Acids Res. 2023 Jul 7; 51(12): 6246–6263. Published online 2023 May 5. doi: 10.1093/nar/gkad363

PMCID:: PMC10325925

Abstract Article PDF–1.9M

Select item 1028084215.

TIMELESS upregulates PD-L1 expression and exerts an immunosuppressive role in breast cancer

Xinrui Dong, Huijuan Dai, Yanping Lin, Xiaonan Sheng, Ye Li, Yaohui Wang, Xueli Zhang, Shuheng Jiang, Wenjin Yin, Jinsong Lu

J Transl Med. 2023; 21: 400. Published online 2023 Jun 20. doi: 10.1186/s12967-023-04257-6

PMCID:: PMC10280842

Abstract Article PDF–9.6M

Select item 934585716.

Loss of circadian gene Timeless induces EMT and tumor progression in colorectal cancer via Zeb1-dependent mechanism

Tommaso Colangelo, Annalucia Carbone, Francesco Mazzarelli, Roberto Cuttano, Elisa Dama, Teresa Nittoli, Jacopo Albanesi, Giovannina Barisciano, Nicola Forte, Orazio Palumbo, Paolo Graziano, Alessandra di Masi, Vittorio Colantuoni, Lina Sabatino, Fabrizio Bianchi, Gianluigi Mazzoccoli

Cell Death Differ. 2022 Aug; 29(8): 1552–1568. Published online 2022 Jan 15. doi: 10.1038/s41418-022-00935-y

PMCID:: PMC9345857

Abstract Article PDF–8.1M

Select item 920586317.

MEX3A promotes the malignant progression of ovarian cancer by regulating intron retention in TIMELESS

Fangfang Li, Chen Zhao, Yuchao Diao, Zixiang Wang, Jiali Peng, Ning Yang, Chunping Qiu, Beihua Kong, Yingwei Li

Cell Death Dis. 2022 Jun; 13(6): 553. Published online 2022 Jun 17. doi: 10.1038/s41419-022-05000-7

PMCID:: PMC9205863

Abstract Article PDF–12M

Select item 872758618.

Germline polymorphisms in genes maintaining the replication fork predict the efficacy of oxaliplatin and irinotecan in patients with metastatic colorectal cancer

Hiroyuki Arai, Yi Xiao, Joshua Millstein, Jingyuan Wang, Francesca Battaglin, Natsuko Kawanishi, Priya Jayachandran, Shivani Soni, Wu Zhang, Christoph Mancao, Bodour Salhia, Shannon M. Mumenthaler, Aparna R. Parikh, Heinz-Josef Lenz

Br J Cancer. 2022 Jan 1; 126(1): 72–78. Published online 2021 Oct 23. doi: 10.1038/s41416-021-01592-7

PMCID:: PMC8727586

Abstract Article PDF–402K

Select item 810834119.

Activation of the clock gene TIMELESS by H3k27 acetylation promotes colorectal cancer tumorigenesis by binding to Myosin-9

Meng Cao, Yi Wang, Yijing Xiao, Dandan Zheng, Chunchun Zhi, Xin Xia, Xiaoqin Yuan

J Exp Clin Cancer Res. 2021; 40: 162. Published online 2021 May 10. doi: 10.1186/s13046-021-01936-4

PMCID:: PMC8108341

Abstract Article PDF–4.0M

Select item 638523220.

Overexpression of Claspin and Timeless protects cancer cells from replication stress in a checkpoint-independent manner

Julien N. Bianco, Valérie Bergoglio, Yea-Lih Lin, Marie-Jeanne Pillaire, Anne-Lyne Schmitz, Julia Gilhodes, Amelie Lusque, Julien Mazières, Magali Lacroix-Triki, Theodoros I. Roumeliotis, Jyoti Choudhary, Jérôme Moreaux, Jean-Sébastien Hoffmann, Hélène Tourrière, Philippe Pasero

Nat Commun. 2019; 10: 910. Published online 2019 Feb 22. doi: 10.1038/s41467-019-08886-8