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Select item 102197051.

Strong correlation between F2RL3 in the blood and osteoarthritis based on a retrospective cohort study

Qi Su, Gufeng Shen, Guokang Xu

Medicine (Baltimore) 2023 May 26; 102(21): e33657. Published online 2023 May 26. doi: 10.1097/MD.0000000000033657

PMCID:: PMC10219705

Abstract Article PDF–516K

Select item 88124352.

Epigenetic Regulation of F2RL3 Associates With Myocardial Infarction and Platelet Function

Laura J. Corbin, Stephen J. White, Amy E. Taylor, Christopher M. Williams, Kurt Taylor, Marion T. van den Bosch, Jack E. Teasdale, Matthew Jones, Mark Bond, Matthew T. Harper, Louise Falk, Alix Groom, Georgina G.J. Hazell, Lavinia Paternoster, Marcus R. Munafò, Børge G. Nordestgaard, Anne Tybjærg-Hansen, Stig E. Bojesen, Caroline Relton, Josine L. Min, George Davey Smith, Andrew D. Mumford, Alastair W. Poole, Nicholas J. Timpson

Circ Res. 2022 Feb 4; 130(3): 384–400. Published online 2022 Jan 6. doi: 10.1161/CIRCRESAHA.121.318836

PMCID:: PMC8812435

Abstract Article PDF–2.1M

Select item 80193503.

PAR-4/Ca²⁺-calpain pathway activation stimulates platelet-derived microparticles in hyperglycemic type 2 diabetes

Alessandra Giannella, Giulio Ceolotto, Claudia Maria Radu, Arianna Cattelan, Elisabetta Iori, Andrea Benetti, Fabrizio Fabris, Paolo Simioni, Angelo Avogaro, Saula Vigili de Kreutzenberg

Cardiovasc Diabetol. 2021; 20: 77. Published online 2021 Apr 3. doi: 10.1186/s12933-021-01267-w

PMCID:: PMC8019350

Abstract Article PDF–2.5M

Select item 63749914.

Thrombin-induced platelet activation via PAR4: pivotal role for exosite II

Niklas Boknäs, Lars Faxälv, Daniel Sanchez Centellas, Maria Wallstedt, Sofia Ramström, Magnus Grenegård, Tomas L. Lindahl

Thromb Haemost. 2014 Sep; 112(3): 558–565. Published online 2017 Nov 20. doi: 10.1160/TH13-12-1013

PMCID:: PMC6374991

Abstract Article PDF–911K

Select item 63079845.

Frequency of PAR4 Ala120Thr variant associated with platelet reactivity significantly varies across sub-Saharan African populations

Menikae K. Heenkenda, Tomas L. Lindahl, Abdimajid Osman

Blood. 2018 Nov 8; 132(19): 2103–2106. Prepublished online 2018 Aug 24. doi: 10.1182/blood-2018-05-852335

PMCID:: PMC6307984

Abstract Article

Select item 60976326.

Effects of Genetic Variation in Protease Activated Receptor 4 after an Acute Coronary Syndrome: Analysis from the TRACER trial

Pierluigi Tricoci, Megan Neely, Michael J. Whitley, Leonard C. Edelstein, Lukas M. Simon, Chad Shaw, Paolo Fortina, David J. Moliterno, Paul W. Armstrong, Philip Aylward, Harvey White, Frans Van de Werf, Lisa K. Jennings, Lars Wallentin, Claes Held, Robert A Harrington, Kenneth W. Mahaffey, Paul F. Bray

Blood Cells Mol Dis. Author manuscript; available in PMC 2018 Sep 1.

Published in final edited form as: Blood Cells Mol Dis. 2018 Sep; 72: 37–43. Published online 2018 Jul 21. doi: 10.1016/j.bcmd.2018.07.004

PMCID:: PMC6097632

Abstract Article PDF–521K

Select item 60309397.

DNA methylation of the cancer-related genes F2RL3 and AHRR is associated with occupational exposure to polycyclic aromatic hydrocarbons

Ayman Alhamdow, Christian Lindh, Jessika Hagberg, Pål Graff, Håkan Westberg, Annette M Krais, Maria Albin, Per Gustavsson, Håkan Tinnerberg, Karin Broberg

Carcinogenesis. 2018 Jul; 39(7): 869–878. Published online 2018 May 2. doi: 10.1093/carcin/bgy059

PMCID:: PMC6030939

Abstract Article PDF–863K

Select item 60237648.

Genetic Variant in Human PAR (Protease-Activated Receptor) 4 Enhances Thrombus Formation Resulting in Resistance to Antiplatelet Therapeutics

Benjamin E. Tourdot, Hannah Stoveken, Derek Trumbo, Jennifer Yeung, Yogendra Kanthi, Leonard C. Edelstein, Paul F. Bray, Gregory G. Tall, Michael Holinstat

Arterioscler Thromb Vasc Biol. 2018 Jul; 38(7): 1632–1643. Published online 2018 Apr 5. doi: 10.1161/ATVBAHA.118.311112

PMCID:: PMC6023764

Abstract Article PDF–2.5M

Select item 45945889.

New insights into protease-activated receptor 4 signaling pathways in the pathogenesis of inflammation and neuropathic pain: a literature review

Yanju Bao, Yebo Gao, Liping Yang, Xiangying Kong, Honggang Zheng, Wei Hou, Baojin Hua

Channels (Austin) 2015 Jan-Feb; 9(1): 5–13. Published online 2015 Feb 9. doi: 10.4161/19336950.2014.995001

PMCID:: PMC4594588

Abstract Article PDF–397K

Select item 437185410.

Polymorphism in the Protease Activated Receptor-4 Gene Region Associates with Platelet Activation and Perioperative Myocardial Injury

Jochen D. Muehlschlegel, Tjörvi E. Perry, Kuang-Yu Liu, Amanda A. Fox, Shane Smith, Peter Lichtner, Charles D. Collard, Stanton K. Shernan, John H. Hartwig, Simon C. Body, Karin M. Hoffmeister

Am J Hematol. Author manuscript; available in PMC 2015 Mar 24.

Published in final edited form as: Am J Hematol. 2012 Feb; 87(2): 161–166. Published online 2012 Jan 7. doi: 10.1002/ajh.22244

PMCID:: PMC4371854

Abstract Article PDF–671K

Select item 425876511.

F2RL3 methylation in blood DNA is a strong predictor of mortality

Yan Zhang, Rongxi Yang, Barbara Burwinkel, Lutz P. Breitling, Bernd Holleczek, Ben Schöttker, Hermann Brenner

Int J Epidemiol. 2014 Aug; 43(4): 1215–1225. Published online 2014 Feb 7. doi: 10.1093/ije/dyu006

PMCID:: PMC4258765

Abstract Article PDF–691K

Select item 424604012.

Common variants in the human platelet PAR4 thrombin receptor alter platelet function and differ by race

Leonard C. Edelstein, Lukas M. Simon, Cory R. Lindsay, Xianguo Kong, Raúl Teruel-Montoya, Benjamin E. Tourdot, Edward S. Chen, Lin Ma, Shaun Coughlin, Marvin Nieman, Michael Holinstat, Chad A. Shaw, Paul F. Bray

Blood. 2014 Nov 27; 124(23): 3450–3458. Prepublished online 2014 Oct 7. doi: 10.1182/blood-2014-04-572479

PMCID:: PMC4246040

Abstract Article

Select item 423917513.

Mechanism of race-dependent platelet activation through the PAR4 and Gq signaling axis

Benjamin E. Tourdot, Stanley Conaway, Katrin Niisuke, Leonard C Edelstein, Paul F Bray, Michael Holinstat

Arterioscler Thromb Vasc Biol. Author manuscript; available in PMC 2015 Dec 1.

Published in final edited form as: Arterioscler Thromb Vasc Biol. 2014 Dec; 34(12): 2644–2650. Published online 2014 Oct 2. doi: 10.1161/ATVBAHA.114.304249

PMCID:: PMC4239175

Abstract Article PDF–1.4M

Select item 376632014.

Chemoprevention of Pancreatic Cancer: Characterization of Par-4 and its Modulation by 3,3′ Diindolylmethane (DIM)

Asfar Sohail Azmi, Aamir Ahmad, Sanjeev Banerjee, Vivek M. Rangnekar, Ramzi M. Mohammad, Fazlul H. Sarkar

Pharm Res. Author manuscript; available in PMC 2013 Sep 7.

Published in final edited form as: Pharm Res. 2008 Sep; 25(9): 2117–2124. Published online 2008 Apr 22. doi: 10.1007/s11095-008-9581-8

PMCID:: PMC3766320

Abstract Article PDF–2.2M

Select item 332299515.

Mapping Human Protease-activated Receptor 4 (PAR4) Homodimer Interface to Transmembrane Helix 4

María de la Fuente, Daniel N. Noble, Sheetal Verma, Marvin T. Nieman

J Biol Chem. 2012 Mar 23; 287(13): 10414–10423. Published online 2012 Feb 8. doi: 10.1074/jbc.M112.341438

PMCID:: PMC3322995

Abstract Article PDF–2.0M

Select item 122381616.

Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage.

Suzanne L Jacques, Athan Kuliopulos

Biochem J. 2003 Dec 15; 376(Pt 3): 733–740. doi: 10.1042/BJ20030954

PMCID:: PMC1223816

Summary PDF–256K

Select item 1800917.

Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity

Henrik Andersen, Daniel L. Greenberg, Kazuo Fujikawa, Wenfeng Xu, Dominic W. Chung, Earl W. Davie

Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20): 11189–11193. doi: 10.1073/pnas.96.20.11189

PMCID:: PMC18009

Abstract Article PDF–163K

Select item 1050380118.

The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes

Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nieman, Steven E. McKenzie, Christian Con Yost, Leslie A. Lange, Mary Cushman, Marguerite R. Irvin, Paul F. Bray, Robert A. Campbell

J Clin Invest. 2023 Sep 15; 133(18): e169608. Published online 2023 Sep 15. doi: 10.1172/JCI169608

PMCID:: PMC10503801

Abstract Article PDF–8.2M

Select item 865320719.

Disruption of the biological activity of protease‐activated receptors2/4 in adults rather than children in SARS CoV‐2 virus‐mediated mortality in COVID‐19 infection

Yogendra Singh, Neeraj Kumar Fuloria, Shivkanya Fuloria, Vetriselvan Subramaniyan, Waleed Hassan Almalki, Gaurav Gupta, Mohammad Arshad Javed Shaikh, Mahaveer Singh, Fahad A. Al‐Abbasi, Imran Kazmi

Drug Dev Res. 2021 Dec; 82(8): 1075–1078. Published online 2021 Sep 1. doi: 10.1002/ddr.21874

PMCID:: PMC8653207

Abstract Article PDF–823K

Select item 703957320.

Molecular basis for activation and biased signaling at the thrombin-activated GPCR proteinase activated receptor-4 (PAR4)

Pierre E. Thibeault, Jordan C. LeSarge, D'Arcy Arends, Michaela Fernandes, Peter Chidiac, Peter B. Stathopulos, Leonard G. Luyt, Rithwik Ramachandran

J Biol Chem. 2020 Feb 21; 295(8): 2520–2540. Published online 2019 Dec 31. doi: 10.1074/jbc.RA119.011461

PMCID:: PMC7039573

Abstract Article PDF–4.2M

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