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Select item 81728591.

Claudin-2 promotes colorectal cancer liver metastasis and is a biomarker of the replacement type growth pattern

Sébastien Tabariès, Matthew G. Annis, Anthoula Lazaris, Stephanie K. Petrillo, Jennifer Huxham, Amri Abdellatif, Vincent Palmieri, Jaclyn Chabot, Radia M. Johnson, Steven Van Laere, Cornelis Verhoef, Yasmina Hachem, Sara Yumeen, Nicholas Meti, Atilla Omeroglu, Gulbeyaz Altinel, Zu-Hua Gao, Alan S. L. Yu, Dirk J. Grünhagen, Peter Vermeulen, Peter Metrakos, Peter M. Siegel

Commun Biol. 2021; 4: 657. Published online 2021 Jun 2. doi: 10.1038/s42003-021-02189-9

PMCID:: PMC8172859

Abstract Article PDF–9.3M

Select item 78253972.

Down-Regulation of Claudin-2 Expression by Cyanidin-3-Glucoside Enhances Sensitivity to Anticancer Drugs in the Spheroid of Human Lung Adenocarcinoma A549 Cells

Hiroaki Eguchi, Haruka Matsunaga, Saki Onuma, Yuta Yoshino, Toshiyuki Matsunaga, Akira Ikari

Int J Mol Sci. 2021 Jan; 22(2): 499. Published online 2021 Jan 6. doi: 10.3390/ijms22020499

PMCID:: PMC7825397

Abstract Article PDF–5.9M

Select item 68886273.

Claudin-2: Roles beyond Permeability Functions

Shruthi Venugopal, Shaista Anwer, Katalin Szászi

Int J Mol Sci. 2019 Nov; 20(22): 5655. Published online 2019 Nov 12. doi: 10.3390/ijms20225655

PMCID:: PMC6888627

Abstract Article PDF–1.0M

Select item 55285004.

Claudin‐2 is an independent negative prognostic factor in breast cancer and specifically predicts early liver recurrences

Siker Kimbung, Anikó Kovács, Pär-Ola Bendahl, Per Malmström, Mårten Fernö, Thomas Hatschek, Ingrid Hedenfalk

Mol Oncol. 2014 Feb; 8(1): 119–128. Published online 2013 Oct 14. doi: 10.1016/j.molonc.2013.10.002

PMCID:: PMC5528500

Abstract Article PDF–1.2M

Select item 53131105.

Down-regulation of Claudin-2 Expression and Proliferation by Epigenetic Inhibitors in Human Lung Adenocarcinoma A549 Cells

Asami Hichino, Miki Okamoto, Saeko Taga, Risa Akizuki, Satoshi Endo, Toshiyuki Matsunaga, Akira Ikari

J Biol Chem. 2017 Feb 10; 292(6): 2411–2421. Published online 2017 Jan 5. doi: 10.1074/jbc.M116.762807

PMCID:: PMC5313110

Abstract Article PDF–4.2M

Select item 52977906.

Inhibition of Autophagic Degradation Process Contributes to Claudin-2 Expression Increase and Epithelial Tight Junction Dysfunction in TNF-α Treated Cell Monolayers

Cong Zhang, Junkai Yan, Yongtao Xiao, Yujie Shen, Jiazheng Wang, Wensong Ge, Yingwei Chen

Int J Mol Sci. 2017 Jan; 18(1): 157. Published online 2017 Jan 17. doi: 10.3390/ijms18010157

PMCID:: PMC5297790

Abstract Article PDF–2.4M

Select item 47557547.

Claudin-2-dependent paracellular channels are dynamically gated

Christopher R Weber, Guo Hua Liang, Yitang Wang, Sudipto Das, Le Shen, Alan S L Yu, Deborah J Nelson, Jerrold R Turner

eLife. 2015; 4: e09906. Published online 2015 Nov 14. doi: 10.7554/eLife.09906

PMCID:: PMC4755754

Abstract Article PDF–3.6M

Select item 44903248.

Tumor necrosis factor-α induces a biphasic change in claudin-2 expression in tubular epithelial cells: role in barrier functions

Yasaman Amoozadeh, Qinghong Dan, Jenny Xiao, Faiza Waheed, Katalin Szászi

Am J Physiol Cell Physiol. 2015 Jul 1; 309(1): C38–C50. Published online 2015 May 6. doi: 10.1152/ajpcell.00388.2014

PMCID:: PMC4490324

Abstract Article

Select item 43581429.

Autophagy Enhances Intestinal Epithelial Tight Junction Barrier Function by Targeting Claudin-2 Protein Degradation

Prashant K. Nighot, Chien-An Andy Hu, Thomas Y. Ma

J Biol Chem. 2015 Mar 13; 290(11): 7234–7246. Published online 2015 Jan 23. doi: 10.1074/jbc.M114.597492

PMCID:: PMC4358142

Abstract Article PDF–3.3M

Select item 366270910.

Bovine Colostrum Increases Pore-Forming Claudin-2 Protein Expression but Paradoxically Not Ion Permeability Possibly by a Change of the Intestinal Cytokine Milieu

Peggy Bodammer, Claus Kerkhoff, Claudia Maletzki, Georg Lamprecht

PLoS One. 2013; 8(5): e64210. Published online 2013 May 23. doi: 10.1371/journal.pone.0064210

PMCID:: PMC3662709

Abstract Article PDF–493K

Select item 1003835611.

Downregulation of angulin-1/LSR induces malignancy via upregulation of EGF-dependent claudin-2 and TGF-β-dependent cell metabolism in human lung adenocarcinoma A549 cells

Wataru Arai, Takumi Konno, Takayuki Kohno, Yuki Kodera, Mitsuhiro Tsujiwaki, Yuma Shindo, Hirofumi Chiba, Masahiro Miyajima, Yuji Sakuma, Atsushi Watanabe, Takashi Kojima

Oncotarget. 2023; 14: 261–275. Published online 2023 Mar 24. doi: 10.18632/oncotarget.27728

PMCID:: PMC10038356

Abstract Article PDF–6.1M

Select item 957617012.

Loss of NKCC1 function increases epithelial tight junction permeability by upregulating claudin-2 expression

Rainelli Koumangoye, Parker Penny, Eric Delpire

Am J Physiol Cell Physiol. 2022 Oct 1; 323(4): C1251–C1263. Published online 2022 Aug 15. doi: 10.1152/ajpcell.00334.2022

PMCID:: PMC9576170

Abstract Article

Select item 946662313.

AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability

Ashwinkumar Subramenium Ganapathy, Kushal Saha, Eric Suchanec, Vikash Singh, Aayush Verma, Gregory Yochum, Walter Koltun, Meghali Nighot, Thomas Ma, Prashant Nighot

Autophagy. 2022; 18(9): 2086–2103. Published online 2021 Dec 29. doi: 10.1080/15548627.2021.2016233

PMCID:: PMC9466623

Abstract Article PDF–4.7M

Select item 823516814.

Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal

Ayaka Ito, Haruka Nasako, Risa Akizuki, Yui Takashina, Hiroaki Eguchi, Toshiyuki Matsunaga, Yuta Yoshino, Satoshi Endo, Akira Ikari

Int J Mol Sci. 2021 Jun; 22(12): 6582. Published online 2021 Jun 19. doi: 10.3390/ijms22126582

PMCID:: PMC8235168

Abstract Article PDF–2.4M

Select item 710890715.

Claudin-2 deficiency associates with hypercalciuria in mice and human kidney stone disease

Joshua N. Curry, Matthew Saurette, Masomeh Askari, Lei Pei, Michael B. Filla, Megan R. Beggs, Peter S.N. Rowe, Timothy Fields, Andre J. Sommer, Chizu Tanikawa, Yoichiro Kamatani, Andrew P. Evan, Mehdi Totonchi, R. Todd Alexander, Koichi Matsuda, Alan S.L. Yu

J Clin Invest. 2020 Apr 1; 130(4): 1948–1960. Published online 2020 Mar 9. doi: 10.1172/JCI127750

PMCID:: PMC7108907

Abstract Article PDF–7.0M

Select item 704761816.

Differential regulation of claudin-2 and claudin-15 expression in children and adults with malabsorptive disease

M. Lora D. M. Ong, Sunil Yeruva, Anne Sailer, Steven P. Nilsen, Jerrold R. Turner

Lab Invest. Author manuscript; available in PMC 2020 Apr 11.

Published in final edited form as: Lab Invest. 2020 Mar; 100(3): 483–490. Published online 2019 Oct 11. doi: 10.1038/s41374-019-0324-8

PMCID:: PMC7047618

Abstract Article PDF–3.0M

Select item 636281417.

Afadin cooperates with Claudin-2 to promote breast cancer metastasis

Sébastien Tabariès, Alexander McNulty, Véronique Ouellet, Matthew G. Annis, Mireille Dessureault, Maude Vinette, Yasmina Hachem, Brennan Lavoie, Atilla Omeroglu, Hans-Georg Simon, Logan A. Walsh, Siker Kimbung, Ingrid Hedenfalk, Peter M. Siegel

Genes Dev. 2019 Feb 1; 33(3-4): 180–193. doi: 10.1101/gad.319194.118

PMCID:: PMC6362814

Abstract Article PDF–8.2M

Select item 629088518.

Transcriptomic Landscape of Treatment—Naïve Ulcerative Colitis

Hagar Taman, Christopher G Fenton, Inga V Hensel, Endre Anderssen, Jon Florholmen, Ruth H Paulssen

J Crohns Colitis. 2018 Feb; 12(3): 327–336. Published online 2017 Oct 10. doi: 10.1093/ecco-jcc/jjx139

PMCID:: PMC6290885

Abstract Article PDF–327K

Select item 629078619.

Lack of Vitamin D Receptor Leads to Hyperfunction of Claudin-2 in Intestinal Inflammatory Responses

Yong-guo Zhang, Rong Lu, Yinglin Xia, David Zhou, Elaine Petrof, Erika C Claud, Jun Sun

Inflamm Bowel Dis. 2019 Jan; 25(1): 97–110. Published online 2018 Oct 4. doi: 10.1093/ibd/izy292

PMCID:: PMC6290786

Abstract Article PDF–1.0M

Select item 576857020.

T cell protein tyrosine phosphatase prevents STAT1 induction of claudin-2 expression in intestinal epithelial cells

Moorthy Krishnan, Declan F. McCole

Ann N Y Acad Sci. Author manuscript; available in PMC 2018 Oct 1.

Published in final edited form as: Ann N Y Acad Sci. 2017 Oct; 1405(1): 116–130. Published online 2017 Aug 14. doi: 10.1111/nyas.13439

PMCID:: PMC5768570

Abstract Article PDF–1.1M

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