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Select item 82271511.

The rs508487, rs236911, and rs236918 Genetic Variants of the Proprotein Convertase Subtilisin–Kexin Type 7 (PCSK7) Gene Are Associated with Acute Coronary Syndrome and with Plasma Concentrations of HDL-Cholesterol and Triglycerides

Gilberto Vargas-Alarcón, Oscar Pérez-Méndez, Héctor González-Pacheco, Julián Ramírez-Bello, Rosalinda Posadas-Sánchez, Galileo Escobedo, José Manuel Fragoso

Cells. 2021 Jun; 10(6): 1444. Published online 2021 Jun 9. doi: 10.3390/cells10061444

PMCID:: PMC8227151

Abstract Article PDF–911K

Select item 65476402.

PCSK7 gene variation bridges atherogenic dyslipidemia with hepatic inflammation in NAFLD patients

Paola Dongiovanni, Marica Meroni, Guido Baselli, Rosellina M. Mancina, Massimiliano Ruscica, Miriam Longo, Raffaela Rametta, Annalisa Cespiati, Serena Pelusi, Nicola Ferri, Valeria Ranzani, Valerio Nobili, Jussi Pihlajamaki, Anna Ludovica Fracanzani, Sara Badiali, Salvatore Petta, Silvia Fargion, Stefano Romeo, Julia Kozlitina, Luca Valenti

J Lipid Res. 2019 Jun; 60(6): 1144–1153. Published online 2019 Mar 27. doi: 10.1194/jlr.P090449

PMCID:: PMC6547640

Abstract Article PDF–903K

Select item 48766973.

PCSK7 Genotype Modifies Effect of a Weight-Loss Diet on 2-Year Changes of Insulin Resistance: The POUNDS LOST Trial

Tao Huang, Jinyan Huang, Qibin Qi, Yanping Li, George A. Bray, Jennifer Rood, Frank M. Sacks, Lu Qi

Diabetes Care. 2015 Mar; 38(3): 439–444. Published online 2014 Dec 12. doi: 10.2337/dc14-0473

PMCID:: PMC4876697

Abstract Article PDF–796K

Select item 33088044.

Internalization of Proprotein Convertase PC7 from Plasma Membrane Is Mediated by a Novel Motif

Jeroen Declercq, Sandra Meulemans, Evelyn Plets, John W. M. Creemers

J Biol Chem. 2012 Mar 16; 287(12): 9052–9060. Published online 2012 Jan 30. doi: 10.1074/jbc.M111.306407

PMCID:: PMC3308804

Abstract Article PDF–1.6M

Select item 12215235.

Dynamic palmitoylation of lymphoma proprotein convertase prolongs its half-life, but is not essential for trans-Golgi network localization.

J W van de Loo, M Teuchert, I Pauli, E Plets, W J Van de Ven, J W Creemers

Biochem J. 2000 Dec 15; 352(Pt 3): 827–833. doi: 10.1042/0264-6021:3520827

PMCID:: PMC1221523

Summary PDF–194K

Select item 12198786.

Gene organization and alternative splicing of human prohormone convertase PC8.

K A Goodge, R J Thomas, T J Martin, M T Gillespie

Biochem J. 1998 Dec 1; 336(Pt 2): 353–359. doi: 10.1042/bj3360353

PMCID:: PMC1219878

Summary PDF–231K

Select item 12171177.

C8, a new member of the convertase family.

A Bruzzaniti, K Goodge, P Jay, S A Taviaux, M H Lam, P Berta, T J Martin, J M Moseley, M T Gillespie

Biochem J. 1996 Mar 15; 314(Pt 3): 727–731. doi: 10.1042/bj3140727

Correction in:: Biochem J. 1996 Jun 15; 316(Pt 3): 1007.

PMCID:: PMC1217117

Summary PDF–711K

Select item 30247698.

The Proprotein Convertase PC7: UNIQUE ZYMOGEN ACTIVATION AND TRAFFICKING PATHWAYS

Estelle Rousselet, Suzanne Benjannet, Josée Hamelin, Maryssa Canuel, Nabil G. Seidah

J Biol Chem. 2011 Jan 28; 286(4): 2728–2738. Published online 2010 Nov 12. doi: 10.1074/jbc.M110.192344

PMCID:: PMC3024769

Abstract Article PDF–3.4M

Select item 86502939.

Variations in TM6SF2, PCSK9 and PCSK7 genes and risk of hepatic steatosis after liver transplantation: a cross-sectional study

Ahad Eshraghian, Elham Moasser, Negar Azarpira, Mohammad Reza Fattahi, Saman Nikeghbalian, Seyed Ali Malek-Hosseini, Bita Geramizadeh

BMC Gastroenterol. 2021; 21: 458. Published online 2021 Dec 7. doi: 10.1186/s12876-021-02041-8

PMCID:: PMC8650293

Abstract Article PDF–888K

Select item 702912110.

The motif EXEXXXL in the cytosolic tail of the secretory human proprotein convertase PC7 regulates its trafficking and cleavage activity

Loreleï Durand, Stéphanie Duval, Alexandra Evagelidis, Johann Guillemot, Vahid Dianati, Emilia Sikorska, Peter Schu, Robert Day, Nabil G. Seidah

J Biol Chem. 2020 Feb 14; 295(7): 2068–2083. Published online 2020 Jan 8. doi: 10.1074/jbc.RA119.011775

PMCID:: PMC7029121

Abstract Article PDF–4.4M

Select item 410107811.

Regulation of HIF-1 alpha by the proprotein convertases furin and PC7 in human squamous carcinoma cells

Jian Fu, Jirong Zhang, Yulan Gong, Courtney Lyons Testa, Andres J Klein-Szanto

Mol Carcinog. Author manuscript; available in PMC 2016 Sep 1.

Published in final edited form as: Mol Carcinog. 2015 Sep; 54(9): 698–706. Published online 2014 Jan 16. doi: 10.1002/mc.22131

PMCID:: PMC4101078

Abstract Article PDF–2.2M

Select item 122283612.

Effects of L- and D-REKR amino acid-containing peptides on HIV and SIV envelope glycoprotein precursor maturation and HIV and SIV replication.

Bouchaib Bahbouhi, Nathalie Chazal, Nabil Georges Seidah, Cristina Chiva, Marcelo Kogan, Fernando Albericio, Ernest Giralt, Elmostafa Bahraoui

Biochem J. 2002 Sep 15; 366(Pt 3): 863–872. doi: 10.1042/BJ20020052

PMCID:: PMC1222836

Summary PDF–358K

Select item 19115413.

The role of eukaryotic subtilisin-like endoproteases for the activation of human immunodeficiency virus glycoproteins in natural host cells.

S Hallenberger, M Moulard, M Sordel, H D Klenk, W Garten

J Virol. 1997 Feb; 71(2): 1036–1045. doi: 10.1128/jvi.71.2.1036-1045.1997

PMCID:: PMC191154

Summary PDF–750K

Select item 458960514.

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder

WooJin Kim, Erin Zekas, Robert Lodge, Delia Susan-Resiga, Edwidge Marcinkiewicz, Rachid Essalmani, Koichiro Mihara, Rithwik Ramachandran, Eugene Asahchop, Benjamin Gelman, Éric A. Cohen, Christopher Power, Morley D. Hollenberg, Nabil G. Seidah

Mol Cell Biol. 2015 Nov; 35(21): 3684–3700. Prepublished online 2015 Aug 17. Published online 2015 Sep 30. doi: 10.1128/MCB.00764-15

PMCID:: PMC4589605

Abstract Article PDF–5.0M

Select item 305902715.

Proprotein Convertase PC7 Enhances the Activation of the EGF Receptor Pathway through Processing of the EGF Precursor

Estelle Rousselet, Suzanne Benjannet, Edwidge Marcinkiewicz, Marie-Claude Asselin, Claude Lazure, Nabil G. Seidah

J Biol Chem. 2011 Mar 18; 286(11): 9185–9195. Published online 2011 Jan 5. doi: 10.1074/jbc.M110.189936

PMCID:: PMC3059027

Abstract Article PDF–1.7M

Select item 303318516.

Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels

Konrad Oexle, Janina S. Ried, Andrew A. Hicks, Toshiko Tanaka, Caroline Hayward, Mathias Bruegel, Martin Gögele, Peter Lichtner, Bertram Müller-Myhsok, Angela Döring, Thomas Illig, Christine Schwienbacher, Cosetta Minelli, Irene Pichler, G. Martin Fiedler, Joachim Thiery, Igor Rudan, Alan F. Wright, Harry Campbell, Luigi Ferrucci, Stefania Bandinelli, Peter P. Pramstaller, H.-Erich Wichmann, Christian Gieger, Juliane Winkelmann, Thomas Meitinger

Hum Mol Genet. 2011 Mar 1; 20(5): 1042–1047. Published online 2010 Dec 10. doi: 10.1093/hmg/ddq538

PMCID:: PMC3033185

Abstract Article PDF–187K

Select item 372460817.

The Multifaceted Proprotein Convertases: Their Unique, Redundant, Complementary, and Opposite Functions

Nabil G. Seidah, Mohamad S. Sadr, Michel Chrétien, Majambu Mbikay

J Biol Chem. 2013 Jul 26; 288(30): 21473–21481. Published online 2013 Jun 17. doi: 10.1074/jbc.R113.481549

PMCID:: PMC3724608

Abstract Article PDF–760K

Select item 372694818.

Proprotein convertases play an important role in regulating PKGI endoproteolytic cleavage and nuclear transport

Shin Kato, Ruiguang Zhang, Jesse D. Roberts, Jr.

Am J Physiol Lung Cell Mol Physiol. 2013 Jul 15; 305(2): L130–L140. Published online 2013 May 17. doi: 10.1152/ajplung.00391.2012

PMCID:: PMC3726948

Abstract Article

Select item 318911319.

Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits

Rita PS Middelberg, Manuel AR Ferreira, Anjali K Henders, Andrew C Heath, Pamela AF Madden, Grant W Montgomery, Nicholas G Martin, John B Whitfield

BMC Med Genet. 2011; 12: 123. Published online 2011 Sep 24. doi: 10.1186/1471-2350-12-123

PMCID:: PMC3189113

Abstract Article PDF–336K

Select item 268304720.

Ubiquitin-mediated proteolysis of HuR by heat shock

Kotb Abdelmohsen, Subramanya Srikantan, Xiaoling Yang, Ashish Lal, Hyeon Ho Kim, Yuki Kuwano, Stefanie Galban, Kevin G Becker, Davida Kamara, Rafael de Cabo, Myriam Gorospe

EMBO J. 2009 May 6; 28(9): 1271–1282. Published online 2009 Mar 26. doi: 10.1038/emboj.2009.67

PMCID:: PMC2683047

Abstract Article PDF–1.4M

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