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Select item 108219761.

Activation of cytotoxic lymphocytes through CD6 enhances killing of cancer cells

Mikel Gurrea-Rubio, Qi Wu, M. Asif Amin, Pei-Suen Tsou, Phillip L. Campbell, Camila I. Amarista, Yuzo Ikari, William D. Brodie, Megan N. Mattichak, Sei Muraoka, Peggy M. Randon, Matthew E. Lind, Jeffrey H. Ruth, Yang Mao-Draayer, Shengli Ding, Xiling Shen, Laura A. Cooney, Feng Lin, David A. Fox

Cancer Immunol Immunother. 2024 Feb; 73(2): 34. Published online 2024 Jan 27. doi: 10.1007/s00262-023-03578-1

PMCID:: PMC10821976

Abstract Article PDF–7.2M

Select item 107439542.

CD6 and Its Interacting Partners: Newcomers to the Block of Cancer Immunotherapies

Lucía Aragón-Serrano, Laura Carrillo-Serradell, Violeta Planells-Romeo, Marcos Isamat, María Velasco-de Andrés, Francisco Lozano

Int J Mol Sci. 2023 Dec; 24(24): 17510. Published online 2023 Dec 15. doi: 10.3390/ijms242417510

PMCID:: PMC10743954

Abstract Article PDF–942K

Select item 36348113.

Fine Mapping and Functional Analysis of the Multiple Sclerosis Risk Gene CD6

Bhairavi Swaminathan, Angélica Cuapio, Iraide Alloza, Fuencisla Matesanz, Antonio Alcina, Maria García-Barcina, Maria Fedetz, Óscar Fernández, Miguel Lucas, Teresa Órpez, Mª Jesus Pinto-Medel, David Otaegui, Javier Olascoaga, Elena Urcelay, Miguel A. Ortiz, Rafael Arroyo, Jorge R. Oksenberg, Alfredo Antigüedad, Eva Tolosa, Koen Vandenbroeck

PLoS One. 2013; 8(4): e62376. Published online 2013 Apr 24. doi: 10.1371/journal.pone.0062376

PMCID:: PMC3634811

Abstract Article PDF–891K

Select item 21908714.

Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors

J Exp Med. 1993 Jan 1; 177(1): 219–223. doi: 10.1084/jem.177.1.219

PMCID:: PMC2190871

Summary PDF–690K

Select item 21189575.

The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins

J Exp Med. 1991 Oct 1; 174(4): 949–952. doi: 10.1084/jem.174.4.949

PMCID:: PMC2118957

Summary PDF–680K

Select item 81584876.

Contribution of Evolutionary Selected Immune Gene Polymorphism to Immune-Related Disorders: The Case of Lymphocyte Scavenger Receptors CD5 and CD6

Sergi Casadó-Llombart, María Velasco-de Andrés, Cristina Català, Alejandra Leyton-Pereira, Francisco Lozano, Elena Bosch

Int J Mol Sci. 2021 May; 22(10): 5315. Published online 2021 May 18. doi: 10.3390/ijms22105315

PMCID:: PMC8158487

Abstract Article PDF–1.3M

Select item 77456757.

Targeting CD6 Attenuates Murine Collagen Induced Arthritis

Yan Li, Jeffrey H. Ruth, Stephanie M. Rasmussen, Kalana S. Athukorala, Daniel P. Weber, M. Asif Amin, Phillip L. Campbell, Nora G. Singer, David A. Fox, Feng Lin

Arthritis Rheumatol. Author manuscript; available in PMC 2021 Sep 1.

Published in final edited form as: Arthritis Rheumatol. 2020 Sep; 72(9): 1505–1513. Published online 2020 Aug 14. doi: 10.1002/art.41288

PMCID:: PMC7745675

Abstract Article PDF–948K

Select item 62075718.

Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis

Marta Consuegra-Fernández, Marc Julià, Mario Martínez-Florensa, Fernando Aranda, Cristina Català, Noelia Armiger-Borràs, María-Teresa Arias, Francisca Santiago, Antonio Guilabert, Anna Esteve, Carlos Muñoz, Carlos Ferrándiz, José- Manuel Carrascosa, Edurne Pedrosa, Jorge Romaní, Mercè Alsina, José- Manuel Mascaró-Galy, Francisco Lozano

Cell Mol Immunol. 2018 Oct; 15(10): 898–906. Published online 2017 Dec 11. doi: 10.1038/cmi.2017.119

PMCID:: PMC6207571

Abstract Article PDF–3.2M

Select item 53475859.

CD6 as a potential target for treating multiple sclerosis

Yan Li, Nora G. Singer, Joy Whitbred, Michael A. Bowen, David A. Fox, Feng Lin

Proc Natl Acad Sci U S A. 2017 Mar 7; 114(10): 2687–2692. Published online 2017 Feb 16. doi: 10.1073/pnas.1615253114

PMCID:: PMC5347585

Abstract Article PDF–1.0M

Select item 484295610.

Genetic polymorphisms of cell adhesion molecules in Behcet’s disease in a Chinese Han population

Minming Zheng, Lijun Zhang, Hongsong Yu, Jiayue Hu, Qingfeng Cao, Guo Huang, Yang Huang, Gangxiang Yuan, Aize Kijlstra, Peizeng Yang

Sci Rep. 2016; 6: 24974. Published online 2016 Apr 25. doi: 10.1038/srep24974

PMCID:: PMC4842956

Abstract Article PDF–653K

Select item 336985211.

CD6 and Syntaxin Binding Protein 6 Variants and Response to Tumor Necrosis Factor Alpha Inhibitors in Danish Patients with Rheumatoid Arthritis

Sophine B. Krintel, Laurent Essioux, Assaf Wool, Julia S. Johansen, Ehud Schreiber, Tomer Zekharya, Pinchas Akiva, Mikkel Østergaard, Merete L. Hetland

PLoS One. 2012; 7(6): e38539. Published online 2012 Jun 7. doi: 10.1371/journal.pone.0038539

PMCID:: PMC3369852

Abstract Article PDF–154K

Select item 329864112.

CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

Marta I Oliveira, Carine M Gonçalves, Mafalda Pinto, Stéphanie Fabre, Ana Mafalda Santos, Simon F Lee, Mónica A A Castro, Raquel J Nunes, Rita R Barbosa, Jane R Parnes, Chao Yu, Simon J Davis, Alexandra Moreira, Georges Bismuth, Alexandre M Carmo

Eur J Immunol. 2012 Jan; 42(1): 195–205. Published online 2011 Sep 28. doi: 10.1002/eji.201040528

PMCID:: PMC3298641

Abstract Article PDF–410K

Select item 299093713.

CD6 synergistic co-stimulation promoting proinflammatory response is modulated without interfering with the activated leucocyte cell adhesion molecule interaction

P Nair, R Melarkode, D Rajkumar, E Montero

Clin Exp Immunol. 2010 Oct; 162(1): 116–130. doi: 10.1111/j.1365-2249.2010.04235.x

PMCID:: PMC2990937

Abstract Article PDF–927K

Select item 191385514.

CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock

Maria-Rosa Sarrias, Montserrat Farnós, Rubén Mota, Fernando Sánchez-Barbero, Anna Ibáñez, Idoia Gimferrer, Jorge Vera, Rafael Fenutría, Cristina Casals, José Yélamos, Francisco Lozano

Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28): 11724–11729. Published online 2007 Jun 29. doi: 10.1073/pnas.0702815104

PMCID:: PMC1913855

Abstract Article PDF–869K

Select item 159284915.

CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76

Namir J. Hassan, Stephen J. Simmonds, Nicholas G. Clarkson, Sarah Hanrahan, Michael J. Puklavec, Martine Bomb, A. Neil Barclay, Marion H. Brown

Mol Cell Biol. 2006 Sep; 26(17): 6727–6738. doi: 10.1128/MCB.00688-06

Correction in:: Mol Cell Biol. 2009 Jun; 29(12): 3452.

Correction in:: Mol Cell Biol. 2019 Apr 1; 39(7): e00054-19.

PMCID:: PMC1592849

Abstract Article PDF–548K

Select item 954272616.

Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution

Sergi Casadó‐Llombart, Tarek Ajami, Marta Consuegra‐Fernández, Esther Carreras, Fernando Aranda, Noelia Armiger, Antonio Alcaraz, Lourdes Mengual, Francisco Lozano

Prostate. 2022 Oct 1; 82(14): 1331–1337. Published online 2022 Jun 29. doi: 10.1002/pros.24407

PMCID:: PMC9542726

Abstract Article PDF–867K

Select item 544064617.

T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex

Johannes Breuning, Marion H. Brown

Mol Cell Biol. 2017 Jun 1; 37(11): e00071-17. Prepublished online 2017 Mar 13. Published online 2017 May 16. doi: 10.1128/MCB.00071-17

PMCID:: PMC5440646

Abstract Article PDF–530K

Select item 308423318.

The Genetic Association of Variants in CD6, TNFRSF1A and IRF8 to Multiple Sclerosis: A Multicenter Case-Control Study

The International Multiple Sclerosis Genetics Consortium

PLoS One. 2011; 6(4): e18813. Published online 2011 Apr 28. doi: 10.1371/journal.pone.0018813

PMCID:: PMC3084233

Abstract Article PDF–266K

Select item 871815419.

The CD6/ALCAM pathway promotes lupus nephritis via T cell–mediated responses

Samantha A. Chalmers, Rajalakshmy Ayilam Ramachandran, Sayra J. Garcia, Evan Der, Leal Herlitz, Jeanette Ampudia, Dalena Chu, Nicole Jordan, Ting Zhang, Ioannis Parodis, Iva Gunnarsson, Huihua Ding, Nan Shen, Michelle Petri, Chi Chiu Mok, Ramesh Saxena, Krishna R. Polu, Stephen Connelly, Cherie T. Ng, Chandra Mohan, Chaim Putterman

J Clin Invest. 2022 Jan 4; 132(1): e147334. Published online 2022 Jan 4. doi: 10.1172/JCI147334