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Select item 79953341.

Type II Binders Targeting the “GLR-out” Conformation of the Pseudokinase STRADα

Ryan H.B. Smith, Zaigham M. Khan, Peter Man-Un Ung, Alex Scopton, Lisa Silber, Seshat M. Mack, Alexander Real, Avner Schlessinger, Arvin C. Dar

Biochemistry. Author manuscript; available in PMC 2021 Mar 26.

Published in final edited form as: Biochemistry. 2021 Feb 2; 60(4): 289–302. Published online 2021 Jan 13. doi: 10.1021/acs.biochem.0c00714

PMCID:: PMC7995334

Abstract Article PDF–2.1M

Select item 26862652.

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

Elton Zeqiraj, Beatrice Maria Filippi, Simon Goldie, Iva Navratilova, Jérôme Boudeau, Maria Deak, Dario R. Alessi, Daan M. F. van Aalten

PLoS Biol. 2009 Jun; 7(6): e1000126. Published online 2009 Jun 9. doi: 10.1371/journal.pbio.1000126

PMCID:: PMC2686265

Abstract Article PDF–3.2M

Select item 22914063.

STRADα Regulates LKB1 Localization by Blocking Access to Importin-α, and by Association with Crm1 and Exportin-7

Julia Dorfman, Ian G. Macara

Mol Biol Cell. 2008 Apr; 19(4): 1614–1626. doi: 10.1091/mbc.E07-05-0454

PMCID:: PMC2291406

Abstract Article PDF–3.3M

Select item 1621444.

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

A.F. Baas, J. Boudeau, G.P. Sapkota, L. Smit, R. Medema, N.A. Morrice, D.R. Alessi, H.C. Clevers

EMBO J. 2003 Jun 16; 22(12): 3062–3072. doi: 10.1093/emboj/cdg292

PMCID:: PMC162144

Abstract Article PDF–468K

Select item 26105105.

C-terminal Phosphorylation of LKB1 Is Not Required for Regulation of AMP-activated Protein Kinase, BRSK1, BRSK2, or Cell Cycle Arrest

Sarah Fogarty, D. Grahame Hardie

J Biol Chem. 2009 Jan 2; 284(1): 77–84. doi: 10.1074/jbc.M806152200

PMCID:: PMC2610510

Abstract Article PDF–534K

Select item 2044736.

MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Jérôme Boudeau, Annette F. Baas, Maria Deak, Nick A. Morrice, Agnieszka Kieloch, Mike Schutkowski, Alan R. Prescott, Hans C. Clevers, Dario R. Alessi

EMBO J. 2003 Oct 1; 22(19): 5102–5114. doi: 10.1093/emboj/cdg490

PMCID:: PMC204473

Abstract Article PDF–663K

Select item 35182687.

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

Elton Zeqiraj, Beatrice Maria Filippi, Maria Deak, Dario R. Alessi, Daan M. F. van Aalten

Science. Author manuscript; available in PMC 2012 Dec 10.

Published in final edited form as: Science. 2009 Dec 18; 326(5960): 1707–1711. Published online 2009 Nov 5. doi: 10.1126/science.1178377

PMCID:: PMC3518268

Abstract Article PDF–2.3M

Select item 31019898.

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

Beatrice M Filippi, Paola de los Heros, Youcef Mehellou, Iva Navratilova, Robert Gourlay, Maria Deak, Lorna Plater, Rachel Toth, Elton Zeqiraj, Dario R Alessi

EMBO J. 2011 May 4; 30(9): 1730–1741. Published online 2011 Mar 18. doi: 10.1038/emboj.2011.78

PMCID:: PMC3101989

Abstract Article PDF–740K

Select item 67612059.

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling

Nan Li, Yifan Wang, Shinya Neri, Yuanli Zhen, Lon Wolf R. Fong, Yawei Qiao, Xu Li, Zhen Chen, Clifford Stephan, Weiye Deng, Rui Ye, Wen Jiang, Shuxing Zhang, Yonghao Yu, Mien-Chie Hung, Junjie Chen, Steven H. Lin

Nat Commun. 2019; 10: 4363. Published online 2019 Sep 25. doi: 10.1038/s41467-019-12377-1

PMCID:: PMC6761205

Abstract Article PDF–2.2M

Select item 286090510.

STRADα deficiency results in aberrant mTORC1 signaling during corticogenesis in humans and mice

Ksenia A. Orlova, Whitney E. Parker, Gregory G. Heuer, Victoria Tsai, Jason Yoon, Marianna Baybis, Robert S. Fenning, Kevin Strauss, Peter B. Crino

J Clin Invest. 2010 May 3; 120(5): 1591–1602. Published online 2010 Apr 26. doi: 10.1172/JCI41592

PMCID:: PMC2860905

Abstract Article PDF–7.2M

Select item 256207311.

SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1: POSSIBLE ROLE IN AMP-ACTIVATED PROTEIN KINASE ACTIVATION

Fan Lan, Jose M. Cacicedo, Neil Ruderman, Yasuo Ido

J Biol Chem. 2008 Oct 10; 283(41): 27628–27635. doi: 10.1074/jbc.M805711200

PMCID:: PMC2562073

Abstract Article PDF–551K

Select item 533712012.

Skp2-dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress

Szu-Wei Lee, Chien-Feng Li, Guoxiang Jin, Zhen Cai, Fei Han, Chia-Hsin Chan, Wei-Lei Yang, Bin-Kui Li, Abdol Hossein Rezaeian, Hong-Yu Li, Hsuan-Ying Huang, Hui-Kuan Lin

Mol Cell. Author manuscript; available in PMC 2017 Mar 4.

Published in final edited form as: Mol Cell. 2015 Mar 19; 57(6): 1022–1033. Published online 2015 Feb 26. doi: 10.1016/j.molcel.2015.01.015

PMCID:: PMC5337120

Abstract Article PDF–3.2M

Select item 1011932213.

RBM4 dictates ESCC cell fate switch from cellular senescence to glutamine-addiction survival through inhibiting LKB1-AMPK-axis

Lei Chen, Wenjing Zhang, Dan Chen, Quan Yang, Siwen Sun, Zhenwei Dai, Zhengzheng Li, Xuemei Liang, Chaoqun Chen, Yuexia Jiao, Lili Zhi, Lianmei Zhao, Jinrui Zhang, Xuefeng Liu, Jinyao Zhao, Man Li, Yang Wang, Yangfan Qi

Signal Transduct Target Ther. 2023; 8: 159. Published online 2023 Apr 21. doi: 10.1038/s41392-023-01367-x

PMCID:: PMC10119322

Abstract Article PDF–7.7M

Select item 344241514.

Sequence and structural analyses of nuclear export signals in the NESdb database

Darui Xu, Alicia Farmer, Garen Collett, Nick V. Grishin, Yuh Min Chook

Mol Biol Cell. 2012 Sep 15; 23(18): 3677–3693. doi: 10.1091/mbc.E12-01-0046

PMCID:: PMC3442415

Abstract Article PDF–1.8M

Select item 38101415.

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Jose M Lizcano, Olga Göransson, Rachel Toth, Maria Deak, Nick A Morrice, Jérôme Boudeau, Simon A Hawley, Lina Udd, Tomi P Mäkelä, D Grahame Hardie, Dario R Alessi

EMBO J. 2004 Feb 25; 23(4): 833–843. Published online 2004 Feb 19. doi: 10.1038/sj.emboj.7600110

PMCID:: PMC381014

Abstract Article PDF–586K

Select item 398146816.

Parallel SCF Adaptor Capture Proteomics Reveals a Role for SCF^FBXL17 in NRF2 Activation via BACH1 Repressor Turnover

Meng-Kwang Marcus Tan, Hui-Jun Lim, Eric J. Bennett, Yang Shi, J. Wade Harper

Mol Cell. Author manuscript; available in PMC 2014 Oct 10.

Published in final edited form as: Mol Cell. 2013 Oct 10; 52(1): 9–24. Published online 2013 Sep 12. doi: 10.1016/j.molcel.2013.08.018

PMCID:: PMC3981468

Abstract Article PDF–5.8M

Select item 884216517.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 290199818.

Network organization of the human autophagy system

Christian Behrends, Mathew E. Sowa, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Nature. 2010 Jul 1; 466(7302): 68–76. Published online 2010 Jun 20. doi: 10.1038/nature09204

PMCID:: PMC2901998

Abstract Article PDF–1.4M

Select item 904055619.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 1007290620.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

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