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Select item 108497801.

Activation of S1P₂ is protective against cisplatin‐induced peripheral neuropathy

Brenda Wan Shing Lam, Ping Xiang, Boya Peng, Ling Jun Joshua Soon, Amelia Ting Yu Yam, Claudine Ming Hui Lim, Yu Zheng, Long N. Nguyen, Deron R. Herr, Minh T. N. Le

Cell Prolif. 2024 Feb; 57(2): e13549. Published online 2023 Sep 19. doi: 10.1111/cpr.13549

PMCID:: PMC10849780

Article PDF–3.8M

Select item 102263372.

Down-regulation of S1PR2 is correlated with poor prognosis and immune infiltrates in cervical squamous cell carcinoma and endocervical adenocarcinoma

Yu Zhang, Haichuan Wang, Jie Lu, Qiang Lv, Bei Yun, Zhiru Ge, Li Yan

Int J Immunopathol Pharmacol. 2023 Jan-Dec; 37: 03946320231178131. Published online 2023 May 26. doi: 10.1177/03946320231178131

PMCID:: PMC10226337

Abstract Article PDF–2.5M

Select item 76821013.

Unveiling role of sphingosine-1-phosphate receptor 2 as a brake of epithelial stem cell proliferation and a tumor suppressor in colorectal cancer

Luciana Petti, Giulia Rizzo, Federica Rubbino, Sudharshan Elangovan, Piergiuseppe Colombo, Silvia Restelli, Andrea Piontini, Vincenzo Arena, Michele Carvello, Barbara Romano, Tommaso Cavalleri, Achille Anselmo, Federica Ungaro, Silvia D’Alessio, Antonino Spinelli, Sanja Stifter, Fabio Grizzi, Alessandro Sgambato, Silvio Danese, Luigi Laghi, Alberto Malesci, Stefania Vetrano

J Exp Clin Cancer Res. 2020; 39: 253. Published online 2020 Nov 23. doi: 10.1186/s13046-020-01740-6

PMCID:: PMC7682101

Abstract Article PDF–5.0M

Select item 64467214.

Endothelial Differentiation G Protein‐Coupled Receptor 5 Plays an Important Role in Induction and Maintenance of Pluripotency

Irina Neganova, Lewis Cotts, Peter Banks, Katja Gassner, Anvar Shukurov, Lyle Armstrong, Graham Ladds, Majlinda Lako

Stem Cells. 2019 Mar; 37(3): 318–331. Published online 2019 Feb 7. doi: 10.1002/stem.2954

PMCID:: PMC6446721

Abstract Article PDF–1.4M

Select item 59601485.

The conserved p.Arg108 residue in S1PR2 (DFNB68) is fundamental for proper hearing: evidence from a consanguineous Iranian family

Michaela A. H. Hofrichter, Majid Mojarad, Julia Doll, Clemens Grimm, Atiye Eslahi, Neda Sadat Hosseini, Mohsen Rajati, Tobias Müller, Marcus Dittrich, Reza Maroofian, Thomas Haaf, Barbara Vona

BMC Med Genet. 2018; 19: 81. Published online 2018 May 18. doi: 10.1186/s12881-018-0598-5

PMCID:: PMC5960148

Abstract Article PDF–3.2M

Select item 57543256.

Vitamin D attenuates sphingosine-1-phosphate (S1P)-mediated inhibition of extravillous trophoblast migration

Melissa Westwood, Khiria Al-Saghir, Sarah Finn-Sell, Cherlyn Tan, Elizabeth Cowley, Stéphane Berneau, Daman Adlam, Edward D. Johnstone

Placenta. 2017 Dec; 60: 1–8. doi: 10.1016/j.placenta.2017.09.009

PMCID:: PMC5754325

Abstract Article

Select item 47516007.

A role of the sphingosine-1-phosphate (S1P)–S1P receptor 2 pathway in epithelial defense against cancer (EDAC)

Sayaka Yamamoto, Yuta Yako, Yoichiro Fujioka, Mihoko Kajita, Takeshi Kameyama, Shunsuke Kon, Susumu Ishikawa, Yusuke Ohba, Yusuke Ohno, Akio Kihara, Yasuyuki Fujita

Mol Biol Cell. 2016 Feb 1; 27(3): 491–499. doi: 10.1091/mbc.E15-03-0161

PMCID:: PMC4751600

Abstract Article PDF–520K

Select item 45388718.

Antitumor Activity of a Novel Sphingosine-1-Phosphate 2 Antagonist, AB1, in Neuroblastoma

Mei-Hong Li, Rolf Swenson, Miriam Harel, Sampa Jana, Erik Stolarzewicz, Timothy Hla, Linda H. Shapiro, Fernando Ferrer

J Pharmacol Exp Ther. 2015 Sep; 354(3): 261–268. Published online 2015 Sep. doi: 10.1124/jpet.115.224519

PMCID:: PMC4538871

Abstract Article PDF–1.0M

Select item 30939479.

S1P₂ receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology

Grant M. Sumida, W. Daniel Stamer

Am J Physiol Cell Physiol. 2011 May; 300(5): C1164–C1171. Published online 2011 Feb 2. doi: 10.1152/ajpcell.00437.2010

PMCID:: PMC3093947

Abstract Article

Select item 290909410.

DFNB68, a novel autosomal recessive non-syndromic hearing impairment locus at chromosomal region 19p13.2

Regie Lyn P. Santos, Muhammad Jawad Hassan, Shaheen Sikandar, Kwanghyuk Lee, Ghazanfar Ali, Protacio E. Martin, Jr, Michael Angelo L. Wambangco, Wasim Ahmad, Suzanne M. Leal

Hum Genet. Author manuscript; available in PMC 2010 Jul 23.

Published in final edited form as: Hum Genet. 2006 Aug; 120(1): 85–92. Published online 2006 May 16. doi: 10.1007/s00439-006-0188-z

PMCID:: PMC2909094

Abstract Article PDF–1.2M

Select item 980123011.

Sphingosine 1-phosphate receptor 2 is central to maintaining epidermal barrier homeostasis

Satomi Igawa, Ayaka Ohzono, Phoebe Pham, Zhenping Wang, Teruaki Nakatsuji, Tatsuya Dokoshi, Anna Di Nardo

J Invest Dermatol. Author manuscript; available in PMC 2022 Dec 30.

Published in final edited form as: J Invest Dermatol. 2021 May; 141(5): 1188–1197.e5. Published online 2020 Nov 14. doi: 10.1016/j.jid.2020.09.026

PMCID:: PMC9801230

Abstract Article PDF–1.5M

Select item 874877512.

The sphingosine 1-phosphate receptor 2/4 antagonist JTE-013 elicits off-target effects on sphingolipid metabolism

Melissa R. Pitman, Alexander C. Lewis, Lorena T. Davies, Paul A. B. Moretti, Dovile Anderson, Darren J. Creek, Jason A. Powell, Stuart M. Pitson

Sci Rep. 2022; 12: 454. Published online 2022 Jan 10. doi: 10.1038/s41598-021-04009-w

PMCID:: PMC8748775

Abstract Article PDF–1.4M

Select item 802743813.

Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation

Yu-hang Zhang, Shu-xiang Cui, Sheng-biao Wan, Shu-hua Wu, Xian-jun Qu

Acta Pharmacol Sin. 2021 Mar; 42(3): 460–469. Published online 2020 Jul 9. doi: 10.1038/s41401-020-0460-0

PMCID:: PMC8027438

Abstract Article PDF–3.8M

Select item 689971114.

Bile acids increase steroidogenesis in cholemic mice and induce cortisol secretion in adrenocortical H295R cells via S1PR2, ERK and SF‐1

Lei Liu, Katrin Panzitt, Silvia Racedo, Martin Wagner, Wolfgang Platzer, Alex Zaufel, Verena Theiler‐Schwetz, Barbara Obermayer‐Pietsch, Helmut Müller, Gerald Höfler, Akos Heinemann, Gernot Zollner, Peter Fickert

Liver Int. 2019 Nov; 39(11): 2112–2123. Published online 2019 Feb 17. doi: 10.1111/liv.14052

Correction in:: Liver Int. 2021 May; 41(5): 1175.

PMCID:: PMC6899711

Abstract Article PDF–1.3M

Select item 670215715.

S1P₂ contributes to microglial activation and M1 polarization following cerebral ischemia through ERK1/2 and JNK

Arjun Sapkota, Bhakta Prasad Gaire, Min-Gu Kang, Ji Woong Choi

Sci Rep. 2019; 9: 12106. Published online 2019 Aug 20. doi: 10.1038/s41598-019-48609-z

PMCID:: PMC6702157

Abstract Article PDF–4.6M

Select item 610592316.

Conjugated Bile Acids Promote Invasive Growth of Esophageal Adenocarcinoma Cells and Cancer Stem Cell Expansion via Sphingosine 1-Phosphate Receptor 2–Mediated Yes-Associated Protein Activation

Runping Liu, Xiaojiaoyang Li, Phillip B. Hylemon, Huiping Zhou

Am J Pathol. 2018 Sep; 188(9): 2042–2058. doi: 10.1016/j.ajpath.2018.05.015

PMCID:: PMC6105923

Abstract Article

Select item 493595517.

S1PR2 variants associated with auditory function in humans and endocochlear potential decline in mouse

Neil J. Ingham, Francesca Carlisle, Selina Pearson, Morag A. Lewis, Annalisa Buniello, Jing Chen, Rivka L. Isaacson, Johanna Pass, Jacqueline K. White, Sally J. Dawson, Karen P. Steel

Sci Rep. 2016; 6: 28964. Published online 2016 Jul 7. doi: 10.1038/srep28964

PMCID:: PMC4935955

Abstract Article PDF–3.1M

Select item 474633318.

Autosomal-Recessive Hearing Impairment Due to Rare Missense Variants within S1PR2

Regie Lyn P. Santos-Cortez, Rabia Faridi, Atteeq U. Rehman, Kwanghyuk Lee, Muhammad Ansar, Xin Wang, Robert J. Morell, Rivka Isaacson, Inna A. Belyantseva, Hang Dai, Anushree Acharya, Tanveer A. Qaiser, Dost Muhammad, Rana Amjad Ali, Sulaiman Shams, Muhammad Jawad Hassan, Shaheen Shahzad, Syed Irfan Raza, Zil-e-Huma Bashir, Joshua D. Smith, Deborah A. Nickerson, Michael J. Bamshad, University of Washington Center for Mendelian Genomics, Sheikh Riazuddin, Wasim Ahmad, Thomas B. Friedman, Suzanne M. Leal

Am J Hum Genet. 2016 Feb 4; 98(2): 331–338. Published online 2016 Jan 21. doi: 10.1016/j.ajhg.2015.12.004

PMCID:: PMC4746333

Abstract Article PDF–464K

Select item 469222519.

Taurocholate Induces Cyclooxygenase-2 Expression via the Sphingosine 1-phosphate Receptor 2 in a Human Cholangiocarcinoma Cell Line

Runping Liu, Xiaojiaoyang Li, Xiaoyan Qiang, Lan Luo, Phillip B. Hylemon, Zhenzhou Jiang, Luyong Zhang, Huiping Zhou

J Biol Chem. 2015 Dec 25; 290(52): 30988–31002. Published online 2015 Oct 30. doi: 10.1074/jbc.M115.668277

PMCID:: PMC4692225

Abstract Article PDF–4.3M

Select item 458755920.

Critical role of sphingosine-1-phosphate receptor-2 in the disruption of cerebrovascular integrity in experimental stroke

Gab Seok Kim, Li Yang, Guoqi Zhang, Honggang Zhao, Magdy Selim, Louise D. McCullough, Michael J. Kluk, Teresa Sanchez

Nat Commun. 2015; 6: 7893. Published online 2015 Aug 5. doi: 10.1038/ncomms8893

PMCID:: PMC4587559

Abstract Article PDF–2.6M

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