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Select item 111264431.

Genetic Variations in EIF2AK3 are Associated with Neurocognitive Impairment in People Living with HIV

Cagla Akay-Espinoza, Sarah E.B. Newton, Beth A. Dombroski, Asha Kallianpur, Ajay Bharti, Donald R. Franklin, Gerard D. Schellenberg, Robert K. Heaton, Igor Grant, Ronald J. Ellis, Scott L. Letendre, Kelly L. Jordan-Sciutto

J Neuroimmune Pharmacol. 2024; 19(1): 25. Published online 2024 May 25. doi: 10.1007/s11481-024-10125-x

PMCID:: PMC11126443

Abstract Article PDF–1.5M

Select item 107244062.

The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells

Fang Liu, Zhun Liu, Weisheng Cheng, Qingquan Zhao, Xinyu Zhang, He Zhang, Miao Yu, He Xu, Yichen Gao, Qianrui Jiang, Guojun Shi, Likun Wang, Shanshan Gu, Jia Wang, Nan Cao, Zhongyan Chen

Adv Sci (Weinh) 2023 Dec; 10(35): 2303799. Published online 2023 Oct 27. doi: 10.1002/advs.202303799

PMCID:: PMC10724406

Abstract Article PDF–11M

Select item 103692583.

PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia

Tao Wang, Yunxia Zhou, Yunping Fan, Hao Duan, Xiaoyu Guo, Jinlong Chang, Youheng Jiang, Changxue Li, Zhang Fu, Yunfei Gao, Xiaoran Guo, Kastytis Sidlauskas, Zhenqiang He, Clive Da Costa, Xia Sheng, Dinglan Wu, Jinqiu Yuan, Huiliang Li, Yulong He, Yonggao Mou, Ningning Li

Adv Sci (Weinh) 2023 Jul; 10(20): 2205949. Published online 2023 May 11. doi: 10.1002/advs.202205949

PMCID:: PMC10369258

Abstract Article PDF–9.7M

Select item 93493214.

PERK/EIF2AK3 integrates endoplasmic reticulum stress-induced apoptosis, oxidative stress and autophagy responses in immortalised retinal pigment epithelial cells

Neil Saptarshi, Louise F. Porter, Luminita Paraoan

Sci Rep. 2022; 12: 13324. Published online 2022 Aug 3. doi: 10.1038/s41598-022-16909-6

PMCID:: PMC9349321

Abstract Article PDF–4.1M

Select item 86381795.

pERK-mediated IL8 secretion can enhance the migration, invasion, and cisplatin resistance of CD10-positive oral cancer cells

Yinfei Pu, Qingxiang Li, Yifei Wang, Le Xu, Qiao Qiao, Yuxing Guo, Chuanbin Guo

BMC Cancer. 2021; 21: 1283. Published online 2021 Dec 1. doi: 10.1186/s12885-021-09025-7

PMCID:: PMC8638179

Abstract Article PDF–7.8M

Select item 83488176.

The Role of PERK in Understanding Development of Neurodegenerative Diseases

Garrett Dalton Smedley, Keenan E. Walker, Shauna H. Yuan

Int J Mol Sci. 2021 Aug; 22(15): 8146. Published online 2021 Jul 29. doi: 10.3390/ijms22158146

PMCID:: PMC8348817

Abstract Article PDF–1.1M

Select item 82087167.

Targeting highly pathogenic coronavirus-induced apoptosis reduces viral pathogenesis and disease severity

Hin Chu, Huiping Shuai, Yuxin Hou, Xi Zhang, Lei Wen, Xiner Huang, Bingjie Hu, Dong Yang, Yixin Wang, Chaemin Yoon, Bosco Ho-Yin Wong, Cun Li, Xiaoyu Zhao, Vincent Kwok-Man Poon, Jian-Piao Cai, Kenneth Kak-Yuen Wong, Man-Lung Yeung, Jie Zhou, Rex Kwok-Him Au-Yeung, Shuofeng Yuan, Dong-Yan Jin, Kin-Hang Kok, Stanley Perlman, Jasper Fuk-Woo Chan, Kwok-Yung Yuen

Sci Adv. 2021 Jun; 7(25): eabf8577. Published online 2021 Jun 16. doi: 10.1126/sciadv.abf8577

PMCID:: PMC8208716

Abstract Article PDF–13M

Select item 81512268.

PERK Is Critical for Alphavirus Nonstructural Protein Translation

Bibha Dahal, Caitlin W. Lehman, Ivan Akhrymuk, Nicole R. Bracci, Lauren Panny, Michael D. Barrera, Nishank Bhalla, Jonathan L. Jacobs, Jonathan D. Dinman, Kylene Kehn-Hall

Viruses. 2021 May; 13(5): 892. Published online 2021 May 12. doi: 10.3390/v13050892

PMCID:: PMC8151226

Abstract Article PDF–2.1M

Select item 74992009.

Tumor cells rely on the thiol oxidoreductase PDI for PERK signaling in order to survive ER stress

Philip Kranz, Christopher Sänger, Alexandra Wolf, Jennifer Baumann, Eric Metzen, Melanie Baumann, Kirsten Göpelt, Ulf Brockmeier

Sci Rep. 2020; 10: 15299. Published online 2020 Sep 17. doi: 10.1038/s41598-020-72259-1

PMCID:: PMC7499200

Abstract Article PDF–3.2M

Select item 713931010.

The PERK-Dependent Molecular Mechanisms as a Novel Therapeutic Target for Neurodegenerative Diseases

Wioletta Rozpędek-Kamińska, Natalia Siwecka, Adam Wawrzynkiewicz, Radosław Wojtczak, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek

Int J Mol Sci. 2020 Mar; 21(6): 2108. Published online 2020 Mar 19. doi: 10.3390/ijms21062108

PMCID:: PMC7139310

Abstract Article PDF–1.4M

Select item 709983111.

A novel splice site indel alteration in the EIF2AK3 gene is responsible for the first cases of Wolcott-Rallison syndrome in Hungary

Andrea Sümegi, Zoltán Hendrik, Tamás Gáll, Enikő Felszeghy, Katalin Szakszon, Péter Antal-Szalmás, Lívia Beke, Ágnes Papp, Gábor Méhes, József Balla, György Balla

BMC Med Genet. 2020; 21: 61. Published online 2020 Mar 27. doi: 10.1186/s12881-020-0985-6

PMCID:: PMC7099831

Abstract Article PDF–7.6M

Select item 634464312.

PERK Signaling Regulates Extracellular Proteostasis of an Amyloidogenic Protein During Endoplasmic Reticulum Stress

Isabelle C. Romine, R. Luke Wiseman

Sci Rep. 2019; 9: 410. Published online 2019 Jan 23. doi: 10.1038/s41598-018-37207-0

PMCID:: PMC6344643

Abstract Article PDF–5.5M

Select item 610673913.

Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury

Tamás Dolinay, Chanat Aonbangkhen, William Zacharias, Edward Cantu, Jennifer Pogoriler, Alec Stablow, Gladys G. Lawrence, Yoshikazu Suzuki, David M. Chenoweth, Edward Morrisey, Jason D. Christie, Michael F. Beers, Susan S. Margulies

Respir Res. 2018; 19: 157. Published online 2018 Aug 22. doi: 10.1186/s12931-018-0856-2

PMCID:: PMC6106739

Abstract Article PDF–8.0M

Select item 519801314.

Wolcott-Rallison Syndrome with Novel EIF2AK3 Gene Mutation

Fatih Gürbüz, Bilgin Yüksel, Ali Kemal Topaloğlu

J Clin Res Pediatr Endocrinol. 2016 Dec; 8(4): 496–497. Published online 2016 Dec 1. doi: 10.4274/jcrpe.3065

PMCID:: PMC5198013

Article PDF–260K

Select item 513722515.

The ER stress sensor PERK luminal domain functions as a molecular chaperone to interact with misfolded proteins

Peng Wang, Jingzhi Li, Bingdong Sha

Acta Crystallogr D Struct Biol. 2016 Dec 1; 72(Pt 12): 1290–1297. Published online 2016 Nov 29. doi: 10.1107/S2059798316018064

PMCID:: PMC5137225

Abstract Article PDF–1.3M

Select item 485025416.

Chemical Genomics Identifies the PERK-Mediated Unfolded Protein Stress Response as a Cellular Target for Influenza Virus Inhibition

Sara Landeras-Bueno, Yolanda Fernández, Ana Falcón, Juan Carlos Oliveros, Juan Ortín

mBio. 2016 Mar-Apr; 7(2): e00085-16. Published online 2016 Apr 19. doi: 10.1128/mBio.00085-16

PMCID:: PMC4850254

Abstract Article PDF–3.6M

Select item 465073017.

Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate

Z Liu, Y Lv, N Zhao, G Guan, J Wang

Cell Death Dis. 2015 Jul; 6(7): e1822. Published online 2015 Jul 30. doi: 10.1038/cddis.2015.183

PMCID:: PMC4650730

Abstract Article PDF–1.2M

Select item 446646118.

PERK-mediated Autophagy in Osteosarcoma Cells Resists ER Stress-induced Cell Apoptosis

Guang-rong Ji, Nai-chun Yu, Xiang Xue, Zong-guang Li

Int J Biol Sci. 2015; 11(7): 803–812. Published online 2015 May 23. doi: 10.7150/ijbs.11100

PMCID:: PMC4466461

Abstract Article PDF–1.3M

Select item 435696019.

PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

Xu Hou, Yaohua Liu, Huailei Liu, Xin Chen, Min Liu, Hui Che, Fei Guo, Chunlei Wang, Daming Zhang, Jianing Wu, Xiaofeng Chen, Chen Shen, Chenguang Li, Fei Peng, Yunke Bi, Zhuowen Yang, Guang Yang, Jing Ai, Xin Gao, Shiguang Zhao

Sci Rep. 2015; 5: 9065. Published online 2015 Mar 12. doi: 10.1038/srep09065

PMCID:: PMC4356960

Abstract Article PDF–1.8M

Select item 411907820.

Generation and characterization of an analog-sensitive PERK allele

Nancy L Maas, Nickpreet Singh, J Alan Diehl

Cancer Biol Ther. 2014 Aug 1; 15(8): 1106–1111. Published online 2014 May 20. doi: 10.4161/cbt.29274

PMCID:: PMC4119078

Abstract Article PDF–1.1M

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