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Select item 92940101.

A multi-step genomic approach prioritized TBKBP1 gene as relevant for multiple sclerosis susceptibility

Melissa Sorosina, Nadia Barizzone, Ferdinando Clarelli, Santosh Anand, Sara Lupoli, Erika Salvi, Eleonora Mangano, Roberta Bordoni, Tina Roostaei, Elisabetta Mascia, Miriam Zuccalà, Domizia Vecchio, Paola Cavalla, Silvia Santoro, Laura Ferrè, Alen Zollo, PROGEMUS, Cristina Barlassina, Daniele Cusi, Vittorio Martinelli, Giancarlo Comi, Maurizio Leone, Massimo Filippi, Nikolaos A. Patsopoulos, Philip L. De Jager, Gianluca De Bellis, Federica Esposito, Sandra D’Alfonso, Filippo Martinelli Boneschi

J Neurol. 2022; 269(8): 4510–4522. Published online 2022 May 12. doi: 10.1007/s00415-022-11109-8

Correction in:: J Neurol. 2022; 269(8): 4523–4524.

PMCID:: PMC9294010

Abstract Article PDF–1.8M

Select item 36301172.

Analysis of PPARGC1B, RUNX3 and TBKBP1 Polymorphisms in Chinese Han Patients with Ankylosing Spondylitis: A Case-Control Study

Zijian Lian, Wei Chai, Lewis L. Shi, Chao Chen, Jingyi Liu, Yan Wang

PLoS One. 2013; 8(4): e61527. Published online 2013 Apr 18. doi: 10.1371/journal.pone.0061527

PMCID:: PMC3630117

Abstract Article PDF–328K

Select item 37003963.

Identification of Proteins that Interact with TANK Binding Kinase 1 and Testing for Mutations Associated with Glaucoma

Seongjin Seo, Frances Solivan-Timpe, Ben R. Roos, Alan L. Robin, Edwin M. Stone, Young H. Kwon, Wallace L.M. Alward, John H. Fingert

Curr Eye Res. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Curr Eye Res. 2013 Feb; 38(2): 310–315. Published online 2013 Jan 3. doi: 10.3109/02713683.2012.754047

PMCID:: PMC3700396

Abstract Article PDF–453K

Select item 31695504.

Functional Dissection of the TBK1 Molecular Network

Adriana Goncalves, Tilmann Bürckstümmer, Evelyn Dixit, Ruth Scheicher, Maria W. Górna, Evren Karayel, Cristina Sugar, Alexey Stukalov, Tiina Berg, Robert Kralovics, Melanie Planyavsky, Keiryn L. Bennett, Jacques Colinge, Giulio Superti-Furga

PLoS One. 2011; 6(9): e23971. Published online 2011 Sep 8. doi: 10.1371/journal.pone.0023971

PMCID:: PMC3169550

Abstract Article PDF–1.3M

Select item 64771525.

The Cargo Receptor NDP52 Initiates Selective Autophagy by Recruiting the ULK Complex to Cytosol-Invading Bacteria

Benjamin J. Ravenhill, Keith B. Boyle, Natalia von Muhlinen, Cara J. Ellison, Glenn R. Masson, Elsje G. Otten, Agnes Foeglein, Roger Williams, Felix Randow

Mol Cell. 2019 Apr 18; 74(2): 320–329.e6. doi: 10.1016/j.molcel.2019.01.041

PMCID:: PMC6477152

Abstract Article

Select item 69011166.

TBKBP1 and TBK1 form a growth factor signaling axis mediating immunosuppression and tumorigenesis

Lele Zhu, Yanchuan Li, Xiaoping Xie, Xiaofei Zhou, Meidi Gu, Zuliang Jie, Chun-Jung Ko, Tianxiao Gao, Blanca E Hernandez, Xuhong Cheng, Shao-Cong Sun

Nat Cell Biol. Author manuscript; available in PMC 2020 Jun 2.

Published in final edited form as: Nat Cell Biol. 2019 Dec; 21(12): 1604–1614. Published online 2019 Dec 2. doi: 10.1038/s41556-019-0429-8

PMCID:: PMC6901116

Abstract Article PDF–5.7M

Select item 48394147.

Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria

Benjamin Richter, Danielle A. Sliter, Lina Herhaus, Alexandra Stolz, Chunxin Wang, Petra Beli, Gabriele Zaffagnini, Philipp Wild, Sascha Martens, Sebastian A. Wagner, Richard J. Youle, Ivan Dikic

Proc Natl Acad Sci U S A. 2016 Apr 12; 113(15): 4039–4044. Published online 2016 Mar 30. doi: 10.1073/pnas.1523926113

PMCID:: PMC4839414

Abstract Article PDF–1.4M

Select item 31695488.

Vaccinia Virus Protein C6 Is a Virulence Factor that Binds TBK-1 Adaptor Proteins and Inhibits Activation of IRF3 and IRF7

Leonie Unterholzner, Rebecca P. Sumner, Marcin Baran, Hongwei Ren, Daniel S. Mansur, Nollaig M. Bourke, Felix Randow, Geoffrey L. Smith, Andrew G. Bowie

PLoS Pathog. 2011 Sep; 7(9): e1002247. Published online 2011 Sep 8. doi: 10.1371/journal.ppat.1002247

PMCID:: PMC3169548

Abstract Article PDF–2.5M

Select item 19140919.

SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK

Grigory Ryzhakov, Felix Randow

EMBO J. 2007 Jul 11; 26(13): 3180–3190. Published online 2007 Jun 14. doi: 10.1038/sj.emboj.7601743

PMCID:: PMC1914091

Abstract Article PDF–597K

Select item 364041310.

Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

David M Evans, Chris C A Spencer, Jennifer J Pointon, Zhan Su, David Harvey, Grazyna Kochan, Udo Oppermann, Alexander Dilthey, Matti Pirinen, Millicent A Stone, Louise Appleton, Loukas Moutsianas, Stephen Leslie, Tom Wordsworth, Tony J Kenna, Tugce Karaderi, Gethin P Thomas, Michael M Ward, Michael H Weisman, Claire Farrar, Linda A Bradbury, Patrick Danoy, Robert D Inman, Walter Maksymowych, Dafna Gladman, Proton Rahman, Spondyloarthritis Research Consortium of Canada (SPARCC), Ann Morgan, Helena Marzo-Ortega, Paul Bowness, Karl Gaffney, J S Hill Gaston, Malcolm Smith, Jacome Bruges-Armas, Ana-Rita Couto, Rosa Sorrentino, Fabiana Paladini, Manuel A Ferreira, Huji Xu, Yu Liu, Lei Jiang, Carlos Lopez-Larrea, Roberto Díaz-Peña, Antonio López-Vázquez, Tetyana Zayats, Gavin Band, Céline Bellenguez, Hannah Blackburn, Jenefer M Blackwell, Elvira Bramon, Suzannah J Bumpstead, Juan P Casas, Aiden Corvin, Nicholas Craddock, Panos Deloukas, Serge Dronov, Audrey Duncanson, Sarah Edkins, Colin Freeman, Matthew Gillman, Emma Gray, Rhian Gwilliam, Naomi Hammond, Sarah E Hunt, Janusz Jankowski, Alagurevathi Jayakumar, Cordelia Langford, Jennifer Liddle, Hugh S Markus, Christopher G Mathew, Owen T McCann, Mark I McCarthy, Colin N A Palmer, Leena Peltonen, Robert Plomin, Simon C Potter, Anna Rautanen, Radhi Ravindrarajah, Michelle Ricketts, Nilesh Samani, Stephen J Sawcer, Amy Strange, Richard C Trembath, Ananth C Viswanathan, Matthew Waller, Paul Weston, Pamela Whittaker, Sara Widaa, Nicholas W Wood, Gilean McVean, John D Reveille, B Paul Wordsworth, Matthew A Brown, Peter Donnelly, The Australo-Anglo-American Spondyloarthritis Consortium (TASC), the Wellcome Trust Case Control Consortium 2 (WTCCC2)

Nat Genet. Author manuscript; available in PMC 2013 May 1.

Published in final edited form as: Nat Genet. 2011 Jul 10; 43(8): 761–767. Published online 2011 Jul 10. doi: 10.1038/ng.873

Correction in:: volume 43 on page 919

PMCID:: PMC3640413

Abstract Article PDF–367K

Select item 569108311.

Autophagy acts through TRAF3 and RELB to regulate gene expression via antagonism of SMAD proteins

Alice C. Newman, Alain J. Kemp, Yvette Drabsch, Christian Behrends, Simon Wilkinson

Nat Commun. 2017; 8: 1537. Published online 2017 Nov 16. doi: 10.1038/s41467-017-00859-z

PMCID:: PMC5691083

Abstract Article PDF–2.3M

Select item 324707612.

Genomewide meta-analysis identifies novel multiple sclerosis susceptibility loci

Nikolaos A. Patsopoulos, the BSP MS Genetics working group and the steering committees of studies evaluating IFNb-1b and a CCR1-antagonist, ANZgene Consortium, GeneMSA, International Multiple Sclerosis Genetics Consortium, Paul I.W. de Bakker

Ann Neurol. Author manuscript; available in PMC 2012 Dec 1.

Published in final edited form as: Ann Neurol. 2011 Dec; 70(6): 897–912. doi: 10.1002/ana.22609

Correction in:: volume 73 on page 561

PMCID:: PMC3247076

Abstract Article PDF–620K

Select item 626810013.

TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation

Elodie Lafont, Peter Draber, Eva Rieser, Matthias Reichert, Sebastian Kupka, Diego de Miguel, Helena Draberova, Anne von Mässenhausen, Amandeep Bhamra, Stephen Henderson, Katarzyna Wojdyla, Avigayil Chalk, Silvia Surinova, Andreas Linkermann, Henning Walczak

Nat Cell Biol. Author manuscript; available in PMC 2019 May 12.

Published in final edited form as: Nat Cell Biol. 2018 Dec; 20(12): 1389–1399. Published online 2018 Nov 12. doi: 10.1038/s41556-018-0229-6

PMCID:: PMC6268100

Abstract Article PDF–2.8M

Select item 427406514.

Genetic loci associated with circulating levels of very long-chain saturated fatty acids

Rozenn N. Lemaitre, Irena B. King, Edmond K. Kabagambe, Jason H. Y. Wu, Barbara McKnight, Ani Manichaikul, Weihua Guan, Qi Sun, Daniel I. Chasman, Millennia Foy, Lu Wang, Jingwen Zhu, David S. Siscovick, Michael Y. Tsai, Donna K. Arnett, Bruce M. Psaty, Luc Djousse, Yii-Der I. Chen, Weihong Tang, Lu-Chen Weng, Hongyu Wu, Majken K. Jensen, Audrey Y. Chu, David R. Jacobs, Jr., Stephen S. Rich, Dariush Mozaffarian, Lyn Steffen, Eric B. Rimm, Frank B. Hu, Paul M. Ridker, Myriam Fornage, Yechiel Friedlander

J Lipid Res. 2015 Jan; 56(1): 176–184. doi: 10.1194/jlr.M052456

PMCID:: PMC4274065

Abstract Article PDF–1.1M

Select item 491053315.

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin‐2 to induce motor neuron dysfunction and cell death

Chantal Sellier, Maria‐Letizia Campanari, Camille Julie Corbier, Angeline Gaucherot, Isabelle Kolb‐Cheynel, Mustapha Oulad‐Abdelghani, Frank Ruffenach, Adeline Page, Sorana Ciura, Edor Kabashi, Nicolas Charlet‐Berguerand

EMBO J. 2016 Jun 15; 35(12): 1276–1297. Published online 2016 Apr 21. doi: 10.15252/embj.201593350

PMCID:: PMC4910533

Abstract Article PDF–1.5M

Select item 825771216.

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates

David Schlütermann, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Olena Friesen, Wenxian Wu, Fabian Stuhldreier, Yadong Sun, Lena Berning, Annabelle Friedrich, María José Mendiburo, Christoph Peter, Constanze Wiek, Helmut Hanenberg, Anja Stefanski, Kai Stühler, Björn Stork

Sci Rep. 2021; 11: 13863. Published online 2021 Jul 5. doi: 10.1038/s41598-021-92408-4

PMCID:: PMC8257712

Abstract Article PDF–3.2M

Select item 600581617.

Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B

Morag R. Hunter, Geoffrey G. Hesketh, Tomasz H. Benedyk, Anne-Claude Gingras, Stephen C. Graham

J Mol Biol. 2018 Jul 6; 430(14): 2153–2163. doi: 10.1016/j.jmb.2018.05.019

PMCID:: PMC6005816

Abstract Article PDF–1.6M

Select item 325365818.

Mapping a Dynamic Innate Immunity Protein Interaction Network Regulating Type I Interferon Production

Shitao Li, Lingyan Wang, Michael Berman, Young-Yun Kong, Martin E. Dorf

Immunity. Author manuscript; available in PMC 2012 Sep 23.

Published in final edited form as: Immunity. 2011 Sep 23; 35(3): 426–440. Published online 2011 Sep 8. doi: 10.1016/j.immuni.2011.06.014

Correction in:: volume 35 on page 647

PMCID:: PMC3253658

Abstract Article PDF–4.2M

Select item 743103019.

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O’Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Huettenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J.P. Mathy, Tina Perica, Kala B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Ramachandran Rakesh, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A. Wankowicz, Markus Bohn, Maliheh Safari, Fatima S. Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J Fletcher, Michael C. O’Neal, Yiming Cai, Jason C.J.Chang, David J. Broadhurst, Saker Klippsten, Phillip P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu, Hao-Yuan Wang, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M. Stroud, Alan D. Frankel, Oren S. Rosenberg, Kliment A Verba, David A. Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen N. Floor, James S. Fraser, John D. Gross, Andrej Sali, Bryan L. Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo García-Sastre, Kevan M. Shokat, Brian K. Shoichet, Nevan J. Krogan

Nature. Author manuscript; available in PMC 2020 Oct 30.

Published in final edited form as: Nature. 2020 Jul; 583(7816): 459–468. Published online 2020 Apr 30. doi: 10.1038/s41586-020-2286-9

PMCID:: PMC7431030

Abstract Article PDF–7.7M

Select item 1093326720.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

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