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Items: 1 to 20 of 41

1.
Cytidine Deaminase Resolves Replicative Stress and Protects Pancreatic Cancer from DNA-Targeting Drugs
Audrey Lumeau, Nicolas Bery, Audrey Francès, Marion Gayral, Guillaume Labrousse, Cyril Ribeyre, Charlene Lopez, Adele Nevot, Abdessamad El Kaoutari, Naima Hanoun, Emeline Sarot, Marion Perrier, Frederic Pont, Juan-Pablo Cerapio, Jean-Jacques Fournié, Frederic Lopez, Miguel Madrid-Mencia, Vera Pancaldi, Marie-Jeanne Pillaire, Valerie Bergoglio, Jerome Torrisani, Nelson Dusetti, Jean-Sebastien Hoffmann, Louis Buscail, Malik Lutzmann, Pierre Cordelier
Cancer Res. 2024 Apr 1; 84(7): 1013–1028. Published online 2024 Jan 31. doi: 10.1158/0008-5472.CAN-22-3219
PMCID:
PMC10982645
AbstractArticlePDF–14M
2.
Neural stem cell-based anti-cancer gene therapy: a first-in-human study in recurrent high grade glioma patients
Jana Portnow, Timothy W. Synold, Behnam Badie, Revathiswari Tirughana, Simon F. Lacey, Massimo D’Apuzzo, Marianne Z. Metz, Joseph Najbauer, Victoria Bedell, Tien Vo, Margarita Gutova, Paul Frankel, Mike Chen, Karen S. Aboody
Clin Cancer Res. Author manuscript; available in PMC 2022 Feb 14.
Published in final edited form as: Clin Cancer Res. 2017 Jun 15; 23(12): 2951–2960. Published online 2016 Dec 15. doi: 10.1158/1078-0432.CCR-16-1518
PMCID:
PMC8843778
AbstractArticlePDF–563K
3.
An Initial Genetic Analysis of Gemcitabine-Induced High-Grade Neutropenia in Pancreatic Cancer Patients in CALGB 80303 (Alliance)
Federico Innocenti, Chen Jiang, Alexander B. Sibley, Stefanie Denning, Amy S. Etheridge, Dorothy Watson, Donna Niedzwiecki, Ace J. Hatch, Herbert I. Hurwitz, Andrew B. Nixon, Yoichi Furukawa, Michiaki Kubo, Daniel J. Crona, Hedy L. Kindler, Howard L. McLeod, Mark J. Ratain, Kouros Owzar
Pharmacogenet Genomics. Author manuscript; available in PMC 2020 Aug 1.
Published in final edited form as: Pharmacogenet Genomics. 2019 Aug; 29(6): 123–131. doi: 10.1097/FPC.0000000000000375
PMCID:
PMC6636684
AbstractArticlePDF–1023K
4.
CDA directs metabolism of epigenetic nucleosides revealing a therapeutic window in cancer
Melania Zauri, Georgina Berridge, Marie-Laëtitia Thézénas, Kathryn M. Pugh, Robert Goldin, Benedikt M. Kessler, Skirmantas Kriaucionis
Nature. Author manuscript; available in PMC 2016 May 13.
Published in final edited form as: Nature. 2015 Aug 6; 524(7563): 114–118. Published online 2015 Jul 22. doi: 10.1038/nature14948
PMCID:
PMC4866471
AbstractArticlePDF–5.1M
5.
Human cytidine deaminase: A biochemical characterization of its naturally occurring variants
Daniela Micozzi, Francesco Martino Carpi, Stefania Pucciarelli, Valeria Polzonetti, Paolo Polidori, Santiago Vilar, Brian Williams, Stefano Costanzi, Silvia Vincenzetti
Int J Biol Macromol. Author manuscript; available in PMC 2015 Feb 1.
Published in final edited form as: Int J Biol Macromol. 2014 Feb; 63: 64–74. Published online 2013 Oct 29. doi: 10.1016/j.ijbiomac.2013.10.029
Correction in:
volume 63 on page 262
PMCID:
PMC3904506
AbstractArticlePDF–2.4M
6.
Role of tyrosine 33 residue for the stabilization of the tetrameric structure of human cytidine deaminase
Daniela Micozzi, Stefania Pucciarelli, Francesco M Carpi, Stefano Costanzi, Giampiero De Sanctis, Valeria Polzonetti, Paolo Natalini, Ivano F Santarelli, Alberto Vita, Silvia Vincenzetti
Int J Biol Macromol. Author manuscript; available in PMC 2011 Nov 1.
Published in final edited form as: Int J Biol Macromol. 2010 Nov 1; 47(4): 471–482. Published online 2010 Jul 14. doi: 10.1016/j.ijbiomac.2010.07.001
Correction in:
volume 49 on page 439
PMCID:
PMC3020594
AbstractArticlePDF–1.1M
7.
Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism
Jan Gerard Maring, Floris M. Wachters, Monique Slijfer, J. Marina Maurer, H. Marike Boezen, Donald R. A. Uges, Elisabeth G. E. de Vries, Harry J. M. Groen
Eur J Clin Pharmacol. 2010; 66(6): 611–617. Published online 2010 Mar 6. doi: 10.1007/s00228-010-0799-0
PMCID:
PMC2868996
AbstractArticlePDF–152K
8.
Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients
H Ueno, N Kaniwa, T Okusaka, M Ikeda, C Morizane, S Kondo, E Sugiyama, S R Kim, R Hasegawa, Y Saito, T Yoshida, N Saijo, J Sawada
Br J Cancer. 2009 Mar 24; 100(6): 870–873. Published online 2009 Mar 17. doi: 10.1038/sj.bjc.6604971
PMCID:
PMC2661788
AbstractArticlePDF–97K
9.
Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A
Harikrishnan M. Kurup, Maksim V. Kvach, Stefan Harjes, Geoffrey B. Jameson, Elena Harjes, Vyacheslav V. Filichev
Org Biomol Chem. 2023 Jun 21; 21(24): 5117–5128. Published online 2023 Jun 7. doi: 10.1039/d3ob00392b
PMCID:
PMC10282898
AbstractArticle
10.
Upregulation of cytidine deaminase in NAT1 knockout breast cancer cells
Kyung U. Hong, Afi H. Tagnedji, Mark A. Doll, Kennedy M. Walls, David W. Hein
J Cancer Res Clin Oncol. Author manuscript; available in PMC 2024 Jul 1.
Published in final edited form as: J Cancer Res Clin Oncol. 2023 Jul; 149(8): 5047–5060. Published online 2022 Nov 3. doi: 10.1007/s00432-022-04436-w
PMCID:
PMC10193532
AbstractArticlePDF–1.2M
11.
MUC1 Oncoprotein Mitigates ER Stress via CDA-mediated Reprogramming of Pyrimidine Metabolism
Appolinaire A Olou, Ryan J King, Fang Yu, Pankaj K Singh
Oncogene. Author manuscript; available in PMC 2020 Aug 26.
Published in final edited form as: Oncogene. 2020 Apr; 39(16): 3381–3395. Published online 2020 Feb 26. doi: 10.1038/s41388-020-1225-4
PMCID:
PMC7165067
AbstractArticlePDF–2.7M
12.
Cytidine deaminase deficiency impairs sister chromatid disjunction by decreasing PARP-1 activity
Simon Gemble, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Christian Jaulin, Mounira Amor-Guéret
Cell Cycle. 2017; 16(11): 1128–1135. Published online 2017 May 2. doi: 10.1080/15384101.2017.1317413
PMCID:
PMC5499828
AbstractArticlePDF–947K
13.
Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA
Simon Gemble, Akshay Ahuja, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Julien Dairou, Denis S. F. Biard, Sarah Lambert, Massimo Lopes, Mounira Amor-Guéret
PLoS Genet. 2015 Jul; 11(7): e1005384. Published online 2015 Jul 16. doi: 10.1371/journal.pgen.1005384
PMCID:
PMC4504519
AbstractArticlePDF–3.1M
14.
Variants in CDA and ABCB1 are predictors of capecitabine-related adverse reactions in colorectal cancer
Xandra García-González, Lucía Cortejoso, María I. García, Pilar García-Alfonso, Luis Robles, Cristina Grávalos, Eva González-Haba, Pellicer Marta, María Sanjurjo, Luis A. López-Fernández
Oncotarget. 2015 Mar 20; 6(8): 6422–6430. Published online 2015 Jan 21. doi: 10.18632/oncotarget.3289
PMCID:
PMC4467446
AbstractArticlePDF–835K
15.
Role of Genetic Polymorphisms of Deoxycytidine Kinase and Cytidine Deaminase to Predict Risk of Death in Children with Acute Myeloid Leukemia
Aurora Medina-Sanson, Arturo Ramírez-Pacheco, Silvia Selene Moreno-Guerrero, Elisa María Dorantes-Acosta, Metzeri Sánchez-Preza, Alfonso Reyes-López
Biomed Res Int. 2015; 2015: 309491. Published online 2015 May 18. doi: 10.1155/2015/309491
PMCID:
PMC4450239
AbstractArticlePDF–798K
16.
Mechanisms of Resistance to Decitabine in the Myelodysplastic Syndrome
Taichun Qin, Ryan Castoro, Samih El Ahdab, Jaroslav Jelinek, Xiaodan Wang, Jiali Si, Jingmin Shu, Rong He, Nianxiang Zhang, Woonbok Chung, Hagop M. Kantarjian, Jean-Pierre J. Issa
PLoS One. 2011; 6(8): e23372. Published online 2011 Aug 17. doi: 10.1371/journal.pone.0023372
PMCID:
PMC3157379
AbstractArticlePDF–699K
17.
A decrease in NAMPT activity impairs basal PARP-1 activity in cytidine deaminase deficient-cells, independently of NAD+
Sandra Cunha Silveira, Géraldine Buhagiar-Labarchède, Rosine Onclercq-Delic, Simon Gemble, Elias Bou Samra, Hamza Mameri, Patricia Duchambon, Christelle Machon, Jérôme Guitton, Mounira Amor-Guéret
Sci Rep. 2020; 10: 13907. Published online 2020 Aug 17. doi: 10.1038/s41598-020-70874-6
PMCID:
PMC7431583
AbstractArticlePDF–1.2M
18.
RNA expression of genes involved in cytarabine metabolism and transport predicts cytarabine response in acute myeloid leukemia
Ajay Abraham, Savitha Varatharajan, Sreeja Karathedath, Chepsy Philip, Kavitha M Lakshmi, Ashok Kumar Jayavelu, Ezhilpavai Mohanan, Nancy Beryl Janet, Vivi M Srivastava, Ramachandran V Shaji, Wei Zhang, Aby Abraham, Auro Viswabandya, Biju George, Mammen Chandy, Alok Srivastava, Vikram Mathews, Poonkuzhali Balasubramanian
Pharmacogenomics. Author manuscript; available in PMC 2020 Aug 4.
Published in final edited form as: Pharmacogenomics. 2015 Jul 1; 16(8): 877–90. Published online 2015 Jun 17. doi: 10.2217/pgs.15.44
PMCID:
PMC7115907
AbstractArticlePDF–1.9M
19.
Pharmacogenetic variants in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity
A Loganayagam, M Arenas Hernandez, A Corrigan, L Fairbanks, C M Lewis, P Harper, N Maisey, P Ross, J D Sanderson, A M Marinaki
Br J Cancer. 2013 Jun 25; 108(12): 2505–2515. Published online 2013 Jun 4. doi: 10.1038/bjc.2013.262
PMCID:
PMC3694243
AbstractArticlePDF–467K
20.
Gemcitabine Metabolic and Transporter Gene Polymorphisms Are Associated with Drug Toxicity and Efficacy in Patients with Locally Advanced Pancreatic Cancer
Motofumi Tanaka, Milind Javle, Xiaoqun Dong, Cathy Eng, James L. Abbruzzese, Donghui Li
Cancer. Author manuscript; available in PMC 2011 Nov 15.
Published in final edited form as: Cancer. 2010 Nov 15; 116(22): 5325–5335. doi: 10.1002/cncr.25282
PMCID:
PMC2966859
AbstractArticlePDF–390K

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