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Select item 12428541.

Proximity-induced activation of human Cdc34 through heterologous dimerization

Stefan Gazdoiu, Kosj Yamoah, Kenneth Wu, Carlos R. Escalante, Inger Tappin, Vladimir Bermudez, Aneel K. Aggarwal, Jerard Hurwitz, Zhen-Qiang Pan

Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42): 15053–15058. Published online 2005 Oct 6. doi: 10.1073/pnas.0507646102

PMCID:: PMC1242854

Abstract Article PDF–475K

Select item 71365932.

Targeting CDC34 E2 ubiquitin conjugating enzyme for lung cancer therapy

Shizhen Zhang, Yi Sun

EBioMedicine. 2020 Apr; 54: 102718. Published online 2020 Apr 5. doi: 10.1016/j.ebiom.2020.102718

PMCID:: PMC7136593

Article PDF–291K

Select item 59943463.

CLMSVault: a software suite for protein cross-linking mass spectrometry data analysis and visualization

Mathieu Courcelles, Jasmin Coulombe-Huntington, Émilie Cossette, Anne-Claude Gingras, Pierre Thibault, Mike Tyers

J Proteome Res. Author manuscript; available in PMC 2018 Jul 7.

Published in final edited form as: J Proteome Res. 2017 Jul 7; 16(7): 2645–2652. Published online 2017 Jun 5. doi: 10.1021/acs.jproteome.7b00205

PMCID:: PMC5994346

Abstract Article PDF–1.0M

Select item 32787984.

APC/C-mediated multiple monoubiquitination provides an alternative degradation signal for cyclin B1

Nevena V. Dimova, Nathaniel A. Hathaway, Byung-Hoon Lee, Donald S. Kirkpatrick, Marie Lea Berkowitz, Steven P. Gygi, Daniel Finley, Randall W. King

Nat Cell Biol. Author manuscript; available in PMC 2012 Aug 1.

Published in final edited form as: Nat Cell Biol. 2012 Feb; 14(2): 168–176. Published online 2012 Jan 29. doi: 10.1038/ncb2425

PMCID:: PMC3278798

Abstract Article PDF–1.0M

Select item 27947175.

The Acidic Tail of the Cdc34 Ubiquitin-conjugating Enzyme Functions in Both Binding to and Catalysis with Ubiquitin Ligase SCF^Cdc4

Gary Kleiger, Bing Hao, Dane A. Mohl, Raymond J. Deshaies

J Biol Chem. 2009 Dec 25; 284(52): 36012–36023. Published online 2009 Oct 29. doi: 10.1074/jbc.M109.058529

PMCID:: PMC2794717

Abstract Article PDF–3.3M

Select item 3140046.

The F-box protein Skp2 is a ubiquitylation target of a Cul1-based core ubiquitin ligase complex: evidence for a role of Cul1 in the suppression of Skp2 expression in quiescent fibroblasts

Christiane Wirbelauer, Hedwig Sutterlüty, Marc Blondel, Mathias Gstaiger, Matthias Peter, Francoise Reymond, Wilhelm Krek

EMBO J. 2000 Oct 16; 19(20): 5362–5375. doi: 10.1093/emboj/19.20.5362

PMCID:: PMC314004

Abstract Article PDF–1.4M

Select item 1229907.

Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0

Ryan Hagglund, Bernard Roizman

Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12): 7889–7894. doi: 10.1073/pnas.122246999

PMCID:: PMC122990

Abstract Article PDF–381K

Select item 70471928.

Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis

Xin-Chun Zhao, Gui-Zhen Wang, Zhe-Sheng Wen, Yong-Chun Zhou, Qian Hu, Bin Zhang, Li-Wei Qu, San-Hui Gao, Jie Liu, Liang Ma, Yan-Fei Zhang, Chen Zhang, Hong Yu, Da-Lin Zhang, Min Wang, Chang-Li Wang, Yun-Chao Huang, Zhi-hua Liu, Yong Zhao, Liang Chen, Guang-Biao Zhou

EBioMedicine. 2020 Mar; 53: 102689. Published online 2020 Feb 27. doi: 10.1016/j.ebiom.2020.102689

Correction in:: EBioMedicine. 2021 Apr; 66: 103295.

PMCID:: PMC7047192

Abstract Article PDF–8.4M

Select item 65869119.

Stabilization of E2-EPF UCP protein is implicated in hepatitis B virus-associated hepatocellular carcinoma progression

Jung Hwa Lim, Dae-Ghon Kim, Dae-Yeul Yu, Hyun Mi Kang, Kyung Hee Noh, Dae-Soo Kim, Dongmin Park, Tae Kyung Chang, Dong-Soo Im, Cho-Rok Jung

Cell Mol Life Sci. 2019 Jul; 76(13): 2647–2662. Published online 2019 Mar 22. doi: 10.1007/s00018-019-03066-9

PMCID:: PMC6586911

Abstract Article PDF–2.4M

Select item 635508610.

Stabilization of p27^Kip1/CDKN1B by UBCH7/UBE2L3 catalyzed ubiquitinylation: a new paradigm in cell-cycle control

Elizabeth A. Whitcomb, Yien Che Tsai, Johnvesly Basappa, Ke Liu, Aurélie K. Le Feuvre, Allan M. Weissman, Allen Taylor

FASEB J. 2019 Jan; 33(1): 1235–1247. Published online 2018 Aug 16. doi: 10.1096/fj.201800960R

PMCID:: PMC6355086

Abstract Article

Select item 479258111.

PPARα induces cell apoptosis by destructing Bcl2

Jiaming Gao, Qian Liu, Ying Xu, Xin Gong, Runyun Zhang, Chenglin Zhou, Zhaoliang Su, Jianhua Jin, Haifeng Shi, Juanjuan Shi, Yongzhong Hou

Oncotarget. 2015 Dec 29; 6(42): 44635–44642. Published online 2015 Nov 9. doi: 10.18632/oncotarget.5988

PMCID:: PMC4792581

Abstract Article PDF–1.8M

Select item 384310012.

Multimodal Mechanism of Action for the Cdc34 Acidic Loop: A CASE STUDY FOR WHY UBIQUITIN-CONJUGATING ENZYMES HAVE LOOPS AND TAILS

Amy Ziemba, Spencer Hill, Daniella Sandoval, Kristofor Webb, Eric J. Bennett, Gary Kleiger

J Biol Chem. 2013 Nov 29; 288(48): 34882–34896. Published online 2013 Oct 15. doi: 10.1074/jbc.M113.509190

PMCID:: PMC3843100

Abstract Article PDF–3.2M

Select item 321013313.

Nutrient Sensing Kinases PKA and Sch9 Phosphorylate the Catalytic Domain of the Ubiquitin-Conjugating Enzyme Cdc34

Ross Cocklin, Mark Goebl

PLoS One. 2011; 6(11): e27099. Published online 2011 Nov 7. doi: 10.1371/journal.pone.0027099

PMCID:: PMC3210133

Abstract Article PDF–961K

Select item 287850214.

The Human COP9 Signalosome Protects Ubiquitin-conjugating Enzyme 3 (UBC3/Cdc34) from β-Transducin Repeat-containing Protein (βTrCP)-mediated Degradation

Maria Elena Fernandez-Sanchez, Emmanuel Sechet, Florence Margottin-Goguet, Lars Rogge, Elisabetta Bianchi

J Biol Chem. 2010 Jun 4; 285(23): 17390–17397. Published online 2010 Apr 8. doi: 10.1074/jbc.M109.076661

PMCID:: PMC2878502

Abstract Article PDF–2.3M

Select item 265227115.

let-7 Overexpression Leads to an Increased Fraction of Cells in G₂/M, Direct Down-regulation of Cdc34, and Stabilization of Wee1 Kinase in Primary Fibroblasts

Aster Legesse-Miller, Olivier Elemento, Sarah J. Pfau, Joshua J. Forman, Saeed Tavazoie, Hilary A. Coller

J Biol Chem. 2009 Mar 13; 284(11): 6605–6609. doi: 10.1074/jbc.C900002200

PMCID:: PMC2652271

Abstract Article PDF–346K

Select item 29609116.

Herpes Simplex Virus 1 Mutant in Which the ICP0 HUL-1 E3 Ubiquitin Ligase Site Is Disrupted Stabilizes cdc34 but Degrades D-Type Cyclins and Exhibits Diminished Neurotoxicity

Ryan Hagglund, Bernard Roizman

J Virol. 2003 Dec; 77(24): 13194–13202. doi: 10.1128/JVI.77.24.13194-13202.2003

PMCID:: PMC296091

Abstract Article PDF–618K

Select item 12561717.

Independent function of two destruction domains in hypoxia-inducible factor-α chains activated by prolyl hydroxylation

Norma Masson, Carsten Willam, Patrick H. Maxwell, Christopher W. Pugh, Peter J. Ratcliffe

EMBO J. 2001 Sep 17; 20(18): 5197–5206. doi: 10.1093/emboj/20.18.5197

PMCID:: PMC125617

Abstract Article PDF–314K

Select item 10908418.

Phosphorylation of Nuclear MyoD Is Required for Its Rapid Degradation

An Song, Qi Wang, Mark G. Goebl, Maureen A. Harrington

Mol Cell Biol. 1998 Sep; 18(9): 4994–4999. doi: 10.1128/mcb.18.9.4994

PMCID:: PMC109084

Abstract Article PDF–479K

Select item 765713219.

FBXO15 regulates P‐glycoprotein/ABCB1 expression through the ubiquitin–proteasome pathway in cancer cells

Kazuhiro Katayama, Kohji Noguchi, Yoshikazu Sugimoto

Cancer Sci. 2013 Jun; 104(6): 694–702. Published online 2013 Apr 15. doi: 10.1111/cas.12145

PMCID:: PMC7657132

Abstract Article PDF–1.2M

Select item 644101920.

Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction

Kyle R. Simonetta, Joshua Taygerly, Kathleen Boyle, Stephen E. Basham, Chris Padovani, Yan Lou, Thomas J. Cummins, Stephanie L. Yung, Szerenke Kiss von Soly, Frank Kayser, John Kuriyan, Michael Rape, Mario Cardozo, Mark A. Gallop, Neil F. Bence, Paul A. Barsanti, Anjanabha Saha

Nat Commun. 2019; 10: 1402. Published online 2019 Mar 29. doi: 10.1038/s41467-019-09358-9