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Items: 1 to 20 of 31

1.
IDH1-R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage response
Felipe J. Núñez, Flor M. Mendez, Padma Kadiyala, Mahmoud S. Alghamri, Masha G. Savelieff, Maria B. Garcia-Fabiani, Santiago Haase, Carl Koschmann, Anda-Alexandra Calinescu, Neha Kamran, Rohin Patel, Stephen Carney, Marissa Z. Guo, Marta Edwards, Mats Ljungman, Tingting Qin, Maureen A. Sartor, Rebecca Tagett, Sriram Venneti, Jacqueline Brosnan-Cashman, Alan Meeker, Vera Gorbunova, Lili Zhao, Daniel M. Kremer, Li Zhang, Costas A. Lyssiotis, Lindsey Jones, Cameron J. Herting, James L. Ross, Dolores Hambardzumyan, Shawn Hervey-Jumper, Maria E. Figueroa, Pedro R. Lowenstein, Maria G. Castro
Sci Transl Med. Author manuscript; available in PMC 2019 Mar 5.
Published in final edited form as: Sci Transl Med. 2019 Feb 13; 11(479): eaaq1427. doi: 10.1126/scitranslmed.aaq1427
PMCID:
PMC6400220
AbstractArticlePDF–1.5M
2.
Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis
Takae Kiyama, Ching-Kang Chen, Steven W Wang, Ping Pan, Zhenlin Ju, Jing Wang, Shinako Takada, William H Klein, Chai-An Mao
Mol Neurodegener. 2018; 13: 56. Published online 2018 Oct 17. doi: 10.1186/s13024-018-0287-z
PMCID:
PMC6192121
AbstractArticlePDF–12M
3.
Mutant IDH1 Promotes Glioma Formation In Vivo
Beatrice Philip, Diana X. Yu, Mark R. Silvis, Clifford H. Shin, James P. Robinson, Gemma L. Robinson, Adam E. Welker, Stephanie N. Angel, Sheryl R. Tripp, Joshua A. Sonnen, Matthew W. VanBrocklin, Richard J. Gibbons, Ryan E. Looper, Howard Colman, Sheri L. Holmen
Cell Rep. Author manuscript; available in PMC 2018 Jul 5.
Published in final edited form as: Cell Rep. 2018 May 1; 23(5): 1553–1564. doi: 10.1016/j.celrep.2018.03.133
PMCID:
PMC6032974
AbstractArticlePDF–1.9M
4.
JAK2/IDH-mutant–driven myeloproliferative neoplasm is sensitive to combined targeted inhibition
Anna Sophia McKenney, Allison N. Lau, Amritha Varshini Hanasoge Somasundara, Barbara Spitzer, Andrew M. Intlekofer, Jihae Ahn, Kaitlyn Shank, Franck T. Rapaport, Minal A. Patel, Efthymia Papalexi, Alan H. Shih, April Chiu, Elizaveta Freinkman, Esra A. Akbay, Mya Steadman, Raj Nagaraja, Katharine Yen, Julie Teruya-Feldstein, Kwok-Kin Wong, Raajit Rampal, Matthew G. Vander Heiden, Craig B. Thompson, Ross L. Levine
J Clin Invest. 2018 Feb 1; 128(2): 789–804. Published online 2018 Jan 22. doi: 10.1172/JCI94516
Correction in:
J Clin Invest. 2018 Oct 1; 128(10): 4743.
PMCID:
PMC5785272
AbstractArticlePDF–15M
5.
Adaptive evolution of the GDH2 allosteric domain promotes gliomagenesis by resolving IDH1R132H induced metabolic liabilities
Matthew S. Waitkus, Christopher J. Pirozzi, Casey J. Moure, Bill H. Diplas, Landon Hansen, Austin Carpenter, Rui Yang, Zhaohui Wang, Brian O. Ingram, Edward D. Karoly, Robert P. Mohney, Ivan Spasojevic, Roger E. McLendon, Henry S. Friedman, Yiping He, Darell D. Bigner, Hai Yan
Cancer Res. Author manuscript; available in PMC 2019 Jan 1.
Published in final edited form as: Cancer Res. 2018 Jan 1; 78(1): 36–50. Published online 2017 Nov 2. doi: 10.1158/0008-5472.CAN-17-1352
PMCID:
PMC5754242
AbstractArticlePDF–2.4M
6.
Mouse olfactory bulb methylome and hydroxymethylome maps reveal noncanonical active turnover of DNA methylation
Qin Ma, Huan Lu, Ziying Xu, Yuanyuan Zhou, Weimin Ci
Epigenetics. 2017; 12(8): 708–714. Published online 2017 Sep 25. doi: 10.1080/15592294.2017.1356958
PMCID:
PMC5687332
AbstractArticlePDF–826K
7.
Bacterial-excreted small volatile molecule 2-aminoacetophenone induces oxidative stress and apoptosis in murine skeletal muscle
ARUNAVA BANDYOPADHAYA, CATERINA CONSTANTINOU, NIKOLAOS PSYCHOGIOS, RYUSUKE UEKI, SHINGO YASUHARA, J.A. JEEVENDRA MARTYN, JULIE WILHELMY, MICHAEL MINDRINOS, LAURENCE G. RAHME, A. ARIA TZIKA
Int J Mol Med. 2016 Apr; 37(4): 867–878. Published online 2016 Feb 12. doi: 10.3892/ijmm.2016.2487
PMCID:
PMC4790710
AbstractArticlePDF–1003K
8.
Amelioration of intracellular stress and reduction of neural tube defects in embryos of diabetic mice by phytochemical quercetin
Lixue Cao, Chengyu Tan, Fantong Meng, Peiyan Liu, E. Albert Reece, Zhiyong Zhao
Sci Rep. 2016; 6: 21491. Published online 2016 Feb 18. doi: 10.1038/srep21491
PMCID:
PMC4757833
AbstractArticlePDF–1.2M
9.
SjCa8, a calcium-binding protein from Schistosoma japonicum, inhibits cell migration and suppresses nitric oxide release of RAW264.7 macrophages
Ji Liu, Tong Pan, Xu You, Yiyue Xu, Jinyi Liang, Yanin Limpanont, Xi Sun, Kamolnetr Okanurak, Huanqin Zheng, Zhongdao Wu, Zhiyue Lv
Parasit Vectors. 2015; 8: 513. Published online 2015 Oct 7. doi: 10.1186/s13071-015-1119-4
PMCID:
PMC4597762
AbstractArticlePDF–1.9M
10.
Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA mircoarray
Xiao-Jing Liu, Li Yang, Feng-Ming Luo, Hong-Bin Wu, Qu-Qiang
World J Gastroenterol. 2004 Jun 1; 10(11): 1600–1607. Published online 2004 Jun 1. doi: 10.3748/wjg.v10.i11.1600
PMCID:
PMC4572762
AbstractArticlePDF–180K
11.
The interplay between metabolic homeostasis and neurodegeneration: insights into the neurometabolic nature of amyotrophic lateral sclerosis
S. T. Ngo, F. J. Steyn
Cell Regen. 2015; 4: 5. Published online 2015 Aug 27. doi: 10.1186/s13619-015-0019-6
PMCID:
PMC4551561
AbstractArticlePDF–1.5M
12.
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
Serena Pellegatta, Lorella Valletta, Cristina Corbetta, Monica Patanè, Ileana Zucca, Federico Riccardi Sirtori, Maria Grazia Bruzzone, Gianpaolo Fogliatto, Antonella Isacchi, Bianca Pollo, Gaetano Finocchiaro
Acta Neuropathol Commun. 2015; 3: 4. Published online 2015 Jan 21. doi: 10.1186/s40478-014-0180-0
PMCID:
PMC4359524
AbstractArticlePDF–1.9M
13.
Targeting of Beta Adrenergic Receptors Results in Therapeutic Efficacy against Models of Hemangioendothelioma and Angiosarcoma
Jessica M. Stiles, Clarissa Amaya, Steven Rains, Dolores Diaz, Robert Pham, James Battiste, Jaime F. Modiano, Victor Kokta, Laura E. Boucheron, Dianne C. Mitchell, Brad A. Bryan
PLoS One. 2013; 8(3): e60021. Published online 2013 Mar 28. doi: 10.1371/journal.pone.0060021
PMCID:
PMC3610939
AbstractArticlePDF–3.4M
14.
Delayed activation of host innate immune pathways in streptozotocin-induced diabetic hosts leads to more severe disease during infection with Burkholderia pseudomallei
Chui-Yoke Chin, Denise M Monack, Sheila Nathan
Immunology. 2012 Apr; 135(4): 312–332. doi: 10.1111/j.1365-2567.2011.03544.x
PMCID:
PMC3372747
AbstractArticlePDF–630K
15.
Purification and Characterization of Cytoplasmic NADP+-Isocitrate Dehydrogenase, and Amplification of the Nadp+-IDH Gene from the Wing-Dimorphic Sand Field Cricket, Gryllus firmus
Anthony J. Zera, Susan Newman, David Berkheim, Christine Black, Lindsay Klug, Erica Crone
J Insect Sci. 2011; 11: 53. Published online 2011 Apr 18. doi: 10.1673/031.011.5301
PMCID:
PMC3281439
AbstractArticlePDF–921K
16.
Small Molecule Inhibition of Cytoskeletal Dynamics in Melanoma Tumors Results in Altered Transcriptional Expression Patterns of Key Genes Involved in Tumor Initiation and Progression
CARRIE SPENCER, JOHN MONTALVO, SARAH R. MCLAUGHLIN, BRAD A. BRYAN
Cancer Genomics Proteomics. Author manuscript; available in PMC 2011 Nov 7.
Published in final edited form as: Cancer Genomics Proteomics. 2011 Mar-Apr; 8(2): 77–85.
PMCID:
PMC3209963
AbstractArticlePDF–1.2M
17.
Targeted Deletion of Nrf2 Reduces Urethane-Induced Lung Tumor Development in Mice
Alison K. Bauer, Hye-Youn Cho, Laura Miller-DeGraff, Christopher Walker, Katherine Helms, Jennifer Fostel, Masayuki Yamamoto, Steven R. Kleeberger
PLoS One. 2011; 6(10): e26590. Published online 2011 Oct 21. doi: 10.1371/journal.pone.0026590
PMCID:
PMC3198791
AbstractArticlePDF–1.3M
18.
Candidate Agtr2 influenced genes and pathways identified by expression profiling in the developing brain of Agtr2−/y mice
Traci L. Pawlowski, Silvia Heringer-Walther, Chun-Huai Cheng, John G. Archie, Chin-Fu Chen, Thomas Walther, Anand K. Srivastava
Genomics. Author manuscript; available in PMC 2011 Aug 31.
Published in final edited form as: Genomics. 2009 Sep; 94(3): 188–195. Published online 2009 Jun 6. doi: 10.1016/j.ygeno.2009.05.011
PMCID:
PMC3164574
AbstractArticlePDF–2.0M
19.
Global expression profiling reveals gain-of-function onco-genic activity of a mutated thyroid hormone receptor in thyroid carcinogenesis
Changxue Lu, Alok Mishra, Yuelin J Zhu, Paul Meltzer, Sheue-yann Cheng
Am J Cancer Res. 2011; 1(2): 168–191. Published online 2010 Dec 11.
PMCID:
PMC3086765
AbstractArticlePDF–1.9M
20.
The autophagic tumor stroma model of cancer: Role of oxidative stress and ketone production in fueling tumor cell metabolism
Stephanos Pavlides, Aristotelis Tsirigos, Gemma Migneco, Diana Whitaker-Menezes, Barbara Chiavarina, Neal Flomenberg, Philippe G Frank, Mathew C Casimiro, Chenguang Wang, Richard G Pestell, Ubaldo E Martinez-Outschoorn, Anthony Howell, Federica Sotgia, Michael P Lisanti
Cell Cycle. 2010 Sep 1; 9(17): 3485–3505. Published online 2010 Sep 1. doi: 10.4161/cc.9.17.12721
PMCID:
PMC3047615
AbstractArticlePDF–3.9M

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