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Select item 69424371.

Prostaglandin E₂ receptor EP4 regulates cell migration through Orai1

Kohei Osawa, Masanari Umemura, Rina Nakakaji, Ryo Tanaka, Rafikul Md Islam, Akane Nagasako, Takayuki Fujita, Utako Yokoyama, Toshiyuki Koizumi, Kenji Mitsudo, Yoshihiro Ishikawa

Cancer Sci. 2020 Jan; 111(1): 160–174. Published online 2019 Dec 18. doi: 10.1111/cas.14247

PMCID:: PMC6942437

Abstract Article PDF–2.7M

Select item 68876992.

Functional Hierarchy of Uterotonics Required for Successful Parturition in Mice

Masahide Yoshida, Yuki Takayanagi, Azusa Ichino-Yamashita, Kei Sato, Yukihiko Sugimoto, Tadashi Kimura, Katsuhiko Nishimori

Endocrinology. 2019 Dec; 160(12): 2800–2810. Published online 2019 Sep 13. doi: 10.1210/en.2019-00499

PMCID:: PMC6887699

Abstract Article

Select item 68115353.

Epithelial EP4 plays an essential role in maintaining homeostasis in colon

Yoshihide Matsumoto, Yuki Nakanishi, Takuto Yoshioka, Yuichi Yamaga, Tomonori Masuda, Yuichi Fukunaga, Makoto Sono, Takaaki Yoshikawa, Munemasa Nagao, Osamu Araki, Satoshi Ogawa, Norihiro Goto, Yukiko Hiramatsu, Richard M. Breyer, Akihisa Fukuda, Hiroshi Seno

Sci Rep. 2019; 9: 15244. Published online 2019 Oct 23. doi: 10.1038/s41598-019-51639-2

PMCID:: PMC6811535

Abstract Article PDF–2.3M

Select item 67255594.

Postsynaptically Synthesized Prostaglandin E2 (PGE2) Modulates Hippocampal Synaptic Transmission via a Presynaptic PGE2 EP2 Receptor

Nan Sang, Jian Zhang, Victor Marcheselli, Nicolas G. Bazan, Chu Chen

J Neurosci. 2005 Oct 26; 25(43): 9858–9870. doi: 10.1523/JNEUROSCI.2392-05.2005

PMCID:: PMC6725559

Abstract Article PDF–901K

Select item 65212215.

Calcium Ions Stimulate the Hyperphosphorylation of Tau by Activating Microsomal Prostaglandin E Synthase 1

Long-Long Cao, Pei-Pei Guan, Yun-Yue Liang, Xue-Shi Huang, Pu Wang

Front Aging Neurosci. 2019; 11: 108. Published online 2019 May 9. doi: 10.3389/fnagi.2019.00108

PMCID:: PMC6521221

Abstract Article PDF–5.1M

Select item 64788736.

The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury

Liyuan Zhu, Chuansheng Xu, Xingyu Huo, Huifeng Hao, Qing Wan, Hong Chen, Xu Zhang, Richard M. Breyer, Yu Huang, Xuetao Cao, De-Pei Liu, Garret A. FitzGerald, Miao Wang

Nat Commun. 2019; 10: 1888. Published online 2019 Apr 23. doi: 10.1038/s41467-019-09492-4

PMCID:: PMC6478873

Abstract Article PDF–2.5M

Select item 63827967.

Role of cyclooxygenase-2-mediated prostaglandin E2-prostaglandin E receptor 4 signaling in cardiac reprogramming

Naoto Muraoka, Kaori Nara, Fumiya Tamura, Hidenori Kojima, Hiroyuki Yamakawa, Taketaro Sadahiro, Kazutaka Miyamoto, Mari Isomi, Sho Haginiwa, Hidenori Tani, Shota Kurotsu, Rina Osakabe, Satoru Torii, Shigeomi Shimizu, Hideyuki Okano, Yukihiko Sugimoto, Keiichi Fukuda, Masaki Ieda

Nat Commun. 2019; 10: 674. Published online 2019 Feb 20. doi: 10.1038/s41467-019-08626-y

PMCID:: PMC6382796

Abstract Article PDF–3.4M

Select item 62133978.

Prostaglandin D₂ Induces Ca²⁺ Sensitization of Contraction without Affecting Cytosolic Ca²⁺ Level in Bronchial Smooth Muscle

Wataru Suto, Yusuke Ando, Takahiro Hirabayashi, Fumiko Takenoya, Seiji Shioda, Junzo Kamei, Hiroyasu Sakai, Yoshihiko Chiba

Int J Mol Sci. 2018 Oct; 19(10): 3036. Published online 2018 Oct 5. doi: 10.3390/ijms19103036

PMCID:: PMC6213397

Abstract Article PDF–2.4M

Select item 58318589.

Pharmacological characterisation of CR6086, a potent prostaglandin E₂ receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Gianfranco Caselli, Albino Bonazzi, Marco Lanza, Flora Ferrari, Daniele Maggioni, Cristian Ferioli, Roberto Giambelli, Eleonora Comi, Silvia Zerbi, Marco Perrella, Ornella Letari, Elena Di Luccio, Milena Colovic, Stefano Persiani, Tiziano Zanelli, Laura Mennuni, Tiziana Piepoli, Lucio Claudio Rovati

Arthritis Res Ther. 2018; 20: 39. Published online 2018 Mar 1. doi: 10.1186/s13075-018-1537-8

PMCID:: PMC5831858

Abstract Article PDF–4.5M

Select item 553150410.

Identification of RNA biomarkers for chemical safety screening in mouse embryonic stem cells using RNA deep sequencing analysis

Hidenori Tani, Jun-ichi Takeshita, Hiroshi Aoki, Kaoru Nakamura, Ryosuke Abe, Akinobu Toyoda, Yasunori Endo, Sadaaki Miyamoto, Masashi Gamo, Hiroaki Sato, Masaki Torimura

PLoS One. 2017; 12(7): e0182032. Published online 2017 Jul 27. doi: 10.1371/journal.pone.0182032

PMCID:: PMC5531504

Abstract Article PDF–1018K

Select item 531960211.

NEURON-SPECIFIC SUMO KNOCKDOWN SUPPRESSES GLOBAL GENE EXPRESSION RESPONSE AND WORSENS FUNCTIONAL OUTCOME AFTER TRANSIENT FOREBRAIN ISCHEMIA IN MICE

LIN ZHANG, XIAOZHI LIU, HUAXIN SHENG, SHUAI LIU, YING LI, JULIA Q. ZHAO, DAVID S. WARNER, WULF PASCHEN, WEI YANG

Neuroscience. Author manuscript; available in PMC 2018 Feb 20.

Published in final edited form as: Neuroscience. 2017 Feb 20; 343: 190–212. Published online 2016 Dec 3. doi: 10.1016/j.neuroscience.2016.11.036

PMCID:: PMC5319602

Abstract Article PDF–1.7M

Select item 523411012.

Differential expression of E-type prostanoid receptors 2 and 4 in microglia stimulated with lipopolysaccharide

Ester Bonfill-Teixidor, Amaia Otxoa-de-Amezaga, Miriam Font-Nieves, M. Glòria Sans-Fons, Anna M. Planas

J Neuroinflammation. 2017; 14: 3. Published online 2017 Jan 5. doi: 10.1186/s12974-016-0780-7

PMCID:: PMC5234110

Abstract Article PDF–2.2M

Select item 468330713.

Disruption of cyclooxygenase type 2 exacerbates apoptosis and renal damage during obstructive nephropathy

Line Nilsson, Kirsten Madsen, Søren Krag, Jørgen Frøkiær, Boye L. Jensen, Rikke Nørregaard

Am J Physiol Renal Physiol. 2015 Dec 15; 309(12): F1035–F1048. Published online 2015 Oct 14. doi: 10.1152/ajprenal.00253.2015

PMCID:: PMC4683307

Abstract Article

Select item 438350514.

Sequence Analysis and Identification of New Isoform of EP4 Receptors in Different Atlantic Salmon Tissues (Salmo salar L.) and Its Role in PGE2 Induced Immunomodulation In Vitro

Tz Chun Guo, Amr Ahmed Abdelrahim Gamil, Melanie Koenig, Øystein Evensen

PLoS One. 2015; 10(4): e0120483. Published online 2015 Apr 2. doi: 10.1371/journal.pone.0120483

PMCID:: PMC4383505

Abstract Article PDF–6.7M

Select item 389275015.

PPARγ Agonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice

Ying Sun, Zhanjun Jia, Gang Liu, Li Zhou, Mi Liu, Baoxue Yang, Tianxin Yang

PPAR Res. 2013; 2013: 612971. Published online 2013 Dec 30. doi: 10.1155/2013/612971

PMCID:: PMC3892750

Abstract Article PDF–2.9M

Select item 380887016.

Candidate genes for limiting cholestatic intestinal injury identified by gene expression profiling

Samuel M Alaish, Jennifer Timmons, Alexis Smith, Marguerite S Buzza, Ebony Murphy, Aiping Zhao, Yezhou Sun, Douglas J Turner, Terez Shea-Donahue, Toni M Antalis, Alan Cross, Susan G Dorsey

Physiol Rep. 2013 Sep; 1(4): e00073. Published online 2013 Sep 17. doi: 10.1002/phy2.73

PMCID:: PMC3808870

Abstract Article PDF–1.2M

Select item 343678817.

Synergistic Suppression of Early Phase of Adipogenesis by Microsomal PGE Synthase-1 (PTGES1)-Produced PGE₂ and Aldo-Keto Reductase 1B3-Produced PGF_2α

Ko Fujimori, Mutsumi Yano, Toshiyuki Ueno

PLoS One. 2012; 7(9): e44698. Published online 2012 Sep 7. doi: 10.1371/journal.pone.0044698

PMCID:: PMC3436788

Abstract Article PDF–1.6M

Select item 333080618.

Testosterone and interleukin-1β increase cardiac remodeling during coxsackievirus B3 myocarditis via serpin A 3n

Michael J. Coronado, Jessica E. Brandt, Eunyong Kim, Adriana Bucek, Djahida Bedja, Eric D. Abston, Jaewook Shin, Kathleen L. Gabrielson, Wayne Mitzner, DeLisa Fairweather

Am J Physiol Heart Circ Physiol. 2012 Apr 15; 302(8): H1726–H1736. Published online 2012 Feb 10. doi: 10.1152/ajpheart.00783.2011