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Select item 70488231.

Pharmacological LRH-1/Nr5a2 inhibition limits pro-inflammatory cytokine production in macrophages and associated experimental hepatitis

Juliane Schwaderer, Truong San Phan, Astrid Glöckner, Johannes Delp, Marcel Leist, Thomas Brunner, M. Eugenia Delgado

Cell Death Dis. 2020 Feb; 11(2): 154. Published online 2020 Feb 28. doi: 10.1038/s41419-020-2348-9

PMCID:: PMC7048823

Abstract Article PDF–1.4M

Select item 68913152.

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

Ko Fujimori, Yusuke Iguchi, Yukiko Yamashita, Keigo Gohda, Naoki Teno

Molecules. 2019 Nov; 24(22): 4155. Published online 2019 Nov 16. doi: 10.3390/molecules24224155

PMCID:: PMC6891315

Abstract Article PDF–2.7M

Select item 68816653.

Impaired Intestinal Farnesoid X Receptor Signaling in Cystic Fibrosis Mice

Pauline T. Ikpa, Marcela Doktorova, Kelly F. Meijsen, Natascha D.A. Nieuwenhuijze, Henkjan J. Verkade, Johan W. Jonker, Hugo R. de Jonge, Marcel J.C. Bijvelds

Cell Mol Gastroenterol Hepatol. 2020; 9(1): 47–60. Published online 2019 Aug 27. doi: 10.1016/j.jcmgh.2019.08.006

PMCID:: PMC6881665

Abstract Article PDF–2.1M

Select item 66720484.

The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

Shengyi Sun, Sherwin Kelekar, Steven A. Kliewer, David J. Mangelsdorf

Genes Dev. 2019 Aug 1; 33(15-16): 1083–1094. doi: 10.1101/gad.326868.119

PMCID:: PMC6672048

Abstract Article PDF–7.3M

Select item 64360455.

Human-specific dual regulations of FXR-activation for reduction of fatty liver using in vitro cell culture model

Teruo Miyazaki, Akira Honda, Tadashi Ikegami, Takashi Iida, Yasushi Matsuzaki

J Clin Biochem Nutr. 2019 Mar; 64(2): 112–123. Published online 2018 Nov 28. doi: 10.3164/jcbn.18-80

PMCID:: PMC6436045

Abstract Article PDF–1.2M

Select item 64091966.

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption

Young-Chae Kim, Sangwon Byun, Sunmi Seok, Grace Guo, H. Eric Xu, Byron Kemper, Jongsook Kim Kemper

Gastroenterology. Author manuscript; available in PMC 2020 Mar 1.

Published in final edited form as: Gastroenterology. 2019 Mar; 156(4): 1052–1065. Published online 2018 Dec 3. doi: 10.1053/j.gastro.2018.11.061

PMCID:: PMC6409196

Abstract Article PDF–1.3M

Select item 63797677.

Evidence for the involvement of FXR signaling in ovarian granulosa cell function

Kentaro TAKAE, Mizuho NAKATA, Takafumi WATANABE, Hiroshi SASADA, Hiroshi FUJII, Ikuo TOMIOKA

J Reprod Dev. 2019 Feb; 65(1): 47–55. Published online 2018 Nov 16. doi: 10.1262/jrd.2018-054

PMCID:: PMC6379767

Abstract Article PDF–2.7M

Select item 62760948.

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity

Tianpeng Zhang, Fangjun Yu, Lianxia Guo, Min Chen, Xue Yuan, Baojian Wu

Theranostics. 2018; 8(19): 5246–5258. Published online 2018 Oct 22. doi: 10.7150/thno.28676

PMCID:: PMC6276094

Abstract Article PDF–1.7M

Select item 58659599.

Small heterodimer partner deficiency exacerbates binge drinking-induced liver injury via modulation of natural killer T cell and neutrophil infiltration

Min-Jeong Go, Jung-Ran Noh, Jung Hwan Hwang, Kyoung-Shim Kim, Dong-Hee Choi, Jong-Soo Lee, Yong-Hoon Kim, Chul-Ho Lee

Mol Med Rep. 2018 Apr; 17(4): 4989–4998. Published online 2018 Jan 26. doi: 10.3892/mmr.2018.8505

PMCID:: PMC5865959

Abstract Article PDF–1.2M

Select item 550905610.

Mexneurin is a novel precursor of peptides in the central nervous system of rodents

Maura Epifanía Matus-Ortega, Philippe Leff Gelman, Juan Carlos Calva-Nieves, Anabel Flores-Zamora, Alberto Salazar-Juárez, Carlos-Alejandro Torner-Aguilar, Gerardo Gamba, Paola De Los Heros, Bonnie Peng, John E. Pintar, Heinrich S. Gompf, Charles N. Allen, Benito Antón-Palma

FEBS Lett. Author manuscript; available in PMC 2018 Jun 1.

Published in final edited form as: FEBS Lett. 2017 Jun; 591(12): 1627–1636. Published online 2017 Jun 1. doi: 10.1002/1873-3468.12679

PMCID:: PMC5509056

Abstract Article PDF–1.6M

Select item 547237511.

Androgen receptor-deficient islet β-cells exhibit alteration in genetic markers of insulin secretion and inflammation. A transcriptome analysis in the male mouse

Weiwei Xu, Tianhua Niu, Beibei Xu, Guadalupe Navarro, Matthew J. Schipma, Franck Mauvais-Jarvis

J Diabetes Complications. Author manuscript; available in PMC 2018 May 1.

Published in final edited form as: J Diabetes Complications. 2017 May; 31(5): 787–795. Published online 2017 Mar 9. doi: 10.1016/j.jdiacomp.2017.03.002

PMCID:: PMC5472375

Abstract Article PDF–1.0M

Select item 543859212.

Atorvastatin alters the expression of genes related to bile acid metabolism and circadian clock in livers of mice

Wen-Kai Li, Huan Li, Yuan-Fu Lu, Ying-Ying Li, Zidong Donna Fu, Jie Liu

PeerJ. 2017; 5: e3348. Published online 2017 May 18. doi: 10.7717/peerj.3348

PMCID:: PMC5438592

Abstract Article PDF–3.3M

Select item 340457113.

Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1^−/− mice fed low levels of cholic acid

Ryan D. Jones, Joyce J. Repa, David W. Russell, John M. Dietschy, Stephen D. Turley

Am J Physiol Gastrointest Liver Physiol. 2012 Jul 15; 303(2): G263–G274. Published online 2012 May 24. doi: 10.1152/ajpgi.00111.2012

PMCID:: PMC3404571

Abstract Article

Select item 322636314.

5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-Stimulated Hepatic Expression of Cyp4a10, Cyp4a14, Cyp4a31, and Other Peroxisome Proliferator-Activated Receptor α-Responsive Mouse Genes Is AICAR 5′-Monophosphate-Dependent and AMP-Activated Protein Kinase-Independent

Namandjé N. Bumpus, Eric F. Johnson

J Pharmacol Exp Ther. 2011 Dec; 339(3): 886–895. doi: 10.1124/jpet.111.184242

PMCID:: PMC3226363

Abstract Article PDF–2.7M

Select item 272695015.

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

Gwendal Le Martelot, Thierry Claudel, David Gatfield, Olivier Schaad, Benoît Kornmann, Giuseppe Lo Sasso, Antonio Moschetta, Ueli Schibler

PLoS Biol. 2009 Sep; 7(9): e1000181. Published online 2009 Sep 1. doi: 10.1371/journal.pbio.1000181

PMCID:: PMC2726950

Abstract Article PDF–565K

Select item 272404216.

Effect of dietary monosodium glutamate on trans fat-induced nonalcoholic fatty liver disease

Kate S. Collison, Zakia Maqbool, Soad M. Saleh, Angela Inglis, Nadine J. Makhoul, Razan Bakheet, Mohammed Al-Johi, Rana Al-Rabiah, Marya Z. Zaidi, Futwan A. Al-Mohanna

J Lipid Res. 2009 Aug; 50(8): 1521–1537. doi: 10.1194/jlr.M800418-JLR200